Yeast sphingolipids: Metabolism and biology

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1585, Issue 2-3, 2002, Pages 163-171

  Obeid, Lina M ^a,b   Okamoto, Yasuo ^b   Mao, Cungui ^b  

^a RALPH H JOHNSON VA MEDICAL CENTER   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Cell regulation; Sphingolipid; Yeast

Indexed keywords

CERAMIDE; PROTEIN; SPHINGOLIPID; UBIQUITIN;

CELL GROWTH; ENDOCYTOSIS; ENDOPLASMIC RETICULUM; ENZYME INHIBITION; GOLGI COMPLEX; HEAT SHOCK RESPONSE; HEAT STRESS; INTRACELLULAR TRANSPORT; LIPID METABOLISM; MAMMAL CELL; NONHUMAN; NUTRIENT; PRIORITY JOURNAL; REVIEW; YEAST; YEAST CELL;

ACYLTRANSFERASES; CALCIUM-BINDING PROTEINS; CERAMIDES; ENDOPLASMIC RETICULUM; HEAT; HEXOSYLTRANSFERASES; MEMBRANE PROTEINS; MIXED FUNCTION OXYGENASES; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); REPRESSOR PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SERINE C-PALMITOYLTRANSFERASE; SPHINGOLIPIDS;

MAMMALIA; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0037203343     PISSN: 13881981     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1388-1981(02)00337-2     Document Type: Review

References (73)

1. Hannun Y.A., Obeid L.M. Ceramide and the eukaryotic stress response. Biochem. Soc. Trans. 25:1997;1171-1175.
2. Dickson R.C., Lester R.L. Yeast sphingolipids. Biochim. Biophys. Acta Gen. Subj. 1426:1999;347-357.
3. Buede R.et al. Cloning and characterization of LCB1, a Saccharomyces gene required for biosynthesis of the long-chain base component of sphingolipids. J. Bacteriol. 173:1991;4325-4332.
4. Nagiec M.M.et al. The LCB2 gene of Saccharomyces and the related LCB1 gene encode subunits of serine palmitoyltransferase, the initial enzyme in sphingolipid synthesis. Proc. Natl. Acad. Sci. U. S. A. 91:1994;7899-7902.
5. Hanada K.et al. A mammalian homolog of the yeast LCB1 encodes a component of serine palmitoyltransferase, the enzyme catalyzing the first step in sphingolipid synthesis. J. Biol. Chem. 272(51):1997;32108-32114.
6. Jenkins G.M., Hannun Y.A. Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae. J. Biol. Chem. 276(11):2001;8574-8581.
7. Gable K.et al. Tsc3p is an 80-amino acid protein associated with serine palmitoyltransferase and required for optimal enzyme activity. J. Biol. Chem. 275(11):2000;7597-7603.
8. Perry D.K. The role of de novo ceramide synthesis in chemotherapy-induced apoptosis. Ann. N.Y. Acad. Sci. 905:2000;91-96.
9. 2+-sensitive csg2Delta mutant. J. Biol. Chem. 273:1998;30688-30694.
10. Haak D.et al. Hydroxylation of Saccharomyces cerevisiae ceramides requires Sur2p and Scs7p. J. Biol. Chem. 272:1997;29704-29710.
11. Grilley M.M.et al. Syringomycin action gene SYR2 is essential for sphingolipid 4-hydroxylation in Saccharomyces cerevisiae. J. Biol. Chem. 273(18):1998;11062-11068.
12. Chung N.et al. Phytosphingosine as a specific inhibitor of growth and nutrient import in Saccharomyces cerevisiae. J. Biol. Chem. 276(38):2001;35614-35621.
13. Kok J.W.et al. Dihydroceramide biology - structure-specific metabolism and intracellular localization. J. Biol. Chem. 272:1997;21128-21136.
14. Oh C.S.et al. ELO2 and ELO3, homologues of the Saccharomyces cerevisiae ELO1 gene, function in fatty acid elongation and are required for sphingolipid formation. J. Biol. Chem. 272(28):1997;17376-17384.
15. Kohlwein S.D.et al. Tsc13p is required for fatty acid elongation and localizes to a novel structure at the nuclear-vacuolar interface in Saccharomyces cerevisiae. Mol. Cell. Biol. 21(1):2001;109-125.
16. 1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ. J. Biol. Chem. 268:1993;27299-27306.
17. Schorling S.et al. Lag1p and Lac1p are essential for the Acyl-CoA-dependent ceramide synthase reaction in Saccharomyces cerevisae. Mol. Biol. Cell. 12(11):2001;3417-3427.
18. Guillas I.et al. C26-CoA-dependent ceramide synthesis of Saccharomyces cerevisiae is operated by Lag1p and Lac1p. EMBO J. 20(11):2001;2655-2665.
19. D'Mello N.P.et al. Cloning and characterization of LAG1, a longevity-assurance gene in yeast. J. Biol. Chem. 269(22):1994;15451-15459.
20. Venable M.E.et al. Role of ceramide in cellular senescence. J. Biol. Chem. 270:1995;30701-30708.
21. Jiang J.C.et al. Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human. Genome Res. 8(12):1998;1259-1272.
22. Bose R.et al. Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals. Cell. 82:1995;405-414.
23. Nagiec M.M.et al. Sphingolipid synthesis as a target for antifungal drugs - complementation of the inositol phosphorylceramide synthase defect in strain of Saccharomyces cerevisiae by the AUR1 gene. J. Biol. Chem. 272:1997;9809-9817.
24. Luberto C.et al. Roles for inositol-phosphoryl ceramide synthase 1 (IPC1) in pathogenesis of C. neoformans. Genes Dev. 15(2):2001;201-212.
25. 2+ concentrations at 37°C, is required for mannosylation of inositolphosphorylceramide. Mol. Gen. Genet. 255:1997;570-579.
26. 2-ceramide, the major sphingolipid in Saccharomyces cerevisiae, requires the IPT1 (YDR072c) gene. J. Biol. Chem. 272:1997;29620-29625.
27. Beeler T.et al. A novel protein, CSG2p, is required for Ca2+ regulation in Saccharomyces cerevisiae. J. Biol. Chem. 269(10):1994;7279-7284.
28. Zhao C., Beeler T., Dunn T. Suppressors of the Ca(2+)-sensitive yeast mutant (csg2) identify genes involved in sphingolipid biosynthesis. Cloning and characterization of SCS1, a gene required for serine palmitoyltransferase activity. J. Biol. Chem. 269(34):1994;21480-21488.
29. Sawai H.et al. Identification of ISC1 (YER019w) as inositol phosphosphingolipid phospholipase C in Saccharomyces cerevisiae. J. Biol. Chem. 275:2000;39793-39798.
30. Tomiuk S.et al. Cloned mammalian neutral sphingomyelinase: functions in sphingolipid signaling? Proc. Natl. Acad. Sci. U. S. A. 95:1998;3638-3643.
31. Sawai H.et al. Function of the cloned putative neutral sphingomyelinase as lyso-platelet activating factor-phospholipase C. J. Biol. Chem. 274:1999;27397-27405.
32. Mao C.G.et al. Cloning of an alkaline ceramidase from Saccharomyces cerevisiae - an enzyme with reverse (CoA-independent) ceramide synthase activity. J. Biol. Chem. 275:2000;6876-6884.
33. Mao C.G.et al. Cloning and characterization of a Saccharomyces cerevisiae alkaline ceramidase with specificity for dihydroceramide. J. Biol. Chem. 275:2000;31369-31378.
34. Mao C.G.et al. Cloning and characterization of a novel human alkaline ceramidase - a mammalian enzyme that hydrolyzes phytoceramide. J. Biol. Chem. 276:2001;26577-26588.
35. Bielawska A.et al. (1S,2R)-D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol (D-e-MAPP) as an inhibitor of ceramidase. J. Biol. Chem. 271:1996;12646-12654.
36. Nagiec M.M.et al. The LCB4 (YOR171c) and LCB5 (YLR260w) genes of Saccharomyces encode sphingoid long chain base kinases. J. Biol. Chem. 273(31):1998;19437-19442.
37. Hla T.et al. Lysophospholipids - receptor revelations. Science. 294(5548):2001;1875-1878.
38. Qie L.et al. Identification of a Saccharomyces gene, LCB3, necessary for incorporation of exogenous long chain bases into sphingolipids. J. Biol. Chem. 272(26):1997;16110-16117.
39. Mao C.et al. Identification and characterization of Saccharomyces cerevisiae dihydrosphingosine-1-phosphate phosphatase. J. Biol. Chem. 272(45):1997;28690-28694.
40. Mandala S.M.et al. Sphingoid base 1-phosphate phosphatase: a key regulator of sphingolipid metabolism and stress response. Proc. Natl. Acad. Sci. U. S. A. 95:1998;150-155.
41. Mao C.G.et al. Identification and characterization of Saccharomyces cerevisiae dihydrosphingosine-1-phosphate phosphatase. J. Biol. Chem. 272:1997;28690-28694.
42. Mao C.G., Saba J.D., Obeid L.M. The dihydrosphingosine-1-phosphate phosphatases of Saccharomyces cerevisiae are important regulators of cell proliferation and heat stress responses. Biochem. J. 342:1999;667-675.
43. Mandala S.M.et al. Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1-phosphate and induces cell death. Proc. Natl. Acad. Sci. U. S. A. 97(14):2000;7859-7864.
44. Saba J.D.et al. The BST1 gene of Saccharomyces cerevisiae is the sphingosine-1-phosphate lyase. J. Biol. Chem. 272:1997;26087-26090.
45. Gottlieb D., Heideman W., Saba J.D. The DPL1 gene is involved in mediating the response to nutrient deprivation in Saccharomyces cerevisiae. Mol. Cell Biol. Res. Commun. 1(1):1999;66-71.
46. Dickson R.C.et al. Isolation of mutant Saccharomyces cerevisiae strains that survive without sphingolipids. Mol. Cell. Biol. 10(5):1990;2176-2181.
47. Wu W.I.et al. Regulation of lipid biosynthesis in Saccharomyces cerevisiae by fumonisin B1. J. Biol. Chem. 270(22):1995;13171-13178.
48. Nagiec M.M.et al. Sphingolipid synthesis as a target for antifungal drugs. Complementation of the inositol phosphorylceramide synthase defect in a mutant strain of Saccharomyces cerevisiae by the AUR1 gene. J. Biol. Chem. 272(15):1997;9809-9817.
49. Fishbein J.D.et al. Ceramide-mediated growth inhibition and CAPP are conserved in Saccharomyces cerevisiae. J. Biol. Chem. 268(13):1993;9255-9261.
50. Nickels J.T., Broach J.R. A ceramide-activated protein phosphatase mediates ceramide-induced G1 arrest of Saccharomyces cerevisiae. Genes Dev. 10(4):1996;382-394.
51. Spiegel S. Sphingosine 1-phosphate: a prototype of a new class of second messengers. J. Leukoc. Biol. 65(3):1999;341-344.
52. Kim S., Fyrst H., Saba J. Accumulation of phosphorylated sphingoid long chain bases results in cell growth inhibition in Saccharomyces cerevisiae. Genetics. 156(4):2000;1519-1529.
53. Zhang X.et al. Elevation of endogenous sphingolipid long-chain base phosphates kills Saccharomyces cerevisiae cells. Curr. Genet. 40(4):2001;221-233.
54. Patton J.L.et al. Phenotypes of sphingolipid-dependent strains of Saccharomyces cerevisiae. J. Bacteriol. 174:1992;7180-7184.
55. Lester R.L.et al. Mutant strains of Saccharomyces cerevisiae lacking sphingolipids synthesize novel inositol glycerophospholipids that mimic sphingolipid structures. J. Biol. Chem. 268:1993;845-856.
56. Jenkins G.M.et al. Involvement of yeast sphingolipids in the heat stress response of Saccharomyces cerevisiae. J. Biol. Chem. 272:1997;32566-32572.
57. Dickson R.C.et al. Sphingolipids are potential heat stress signals in Saccharomyces. J. Biol. Chem. 272(48):1997;30196-30200.
58. Skrzypek M.S.et al. Analysis of phosphorylated sphingolipid long-chain bases reveals potential roles in heat stress and growth control in Saccharomyces. J. Bacteriol. 181(4):1999;1134-1140.
59. Wells G.B., Dickson R.C., Lester R.L. Heat-induced elevation of ceramide in Saccharomyces cerevisiae via de novo synthesis. J. Biol. Chem. 273:1998;7235-7243.
60. Skrzypek M.S.et al. Inhibition of amino acid transport by sphingoid long chain bases in Saccharomyces cerevisiae. J. Biol. Chem. 273(5):1998;2829-2834.
61. Chung N.et al. Sphingolipids signal heat stress-induced ubiquitin-dependent proteolysis. J. Biol. Chem. 275:2000;17229-17232.
62. Munn A.L., Riezman H. Endocytosis is required for the growth of vacuolar H(+)-ATPase-defective yeast: identification of six new END genes. J. Cell Biol. 127(2):1994;373-386.
63. Zanolari B.et al. Sphingoid base synthesis requirement for endocytosis in Saccharomyces cerevisiae. EMBO J. 19:2000;2824-2833.
64. Friant S., Zanolari B., Riezman H. Increased protein kinase or decreased PP2A activity bypasses sphingoid base requirement in endocytosis. EMBO J. 19:2000;2834-2844.
65. Friant S.et al. Sphingoid base signaling via Pkh kinases is required for endocytosis in yeast. EMBO J. 20(23):2001;6783-6792.
66. deHart A.et al. The conserved Pkh-Ypk kinase cascade is required for endocytosis in yeast. J. Cell Biol. 156(2):2002;241-248.
67. Sutterlin C.et al. Specific requirements for the ER to Golgi transport of GPI-anchored proteins in yeast. J. Cell Sci. 110(Part 21):1997;2703-2714.
68. Horvath A.et al. Ceramide synthesis enhances transport of GPI-anchored proteins to the Golgi apparatus in yeast. EMBO J. 13:1994;3687-3695.
69. Skrzypek M., Lester R.L., Dickson R.C. Suppressor gene analysis reveals an essential role for sphingolipids in transport of glycosylphosphatidylinositol-anchored proteins in Saccharomyces cerevisiae. J. Bacteriol. 179(5):1997;1513-1520.
70. Barz W.P., Walter P. Two endoplasmic reticulum (ER) membrane proteins that facilitate ER-to-Golgi transport of glycosylphosphatidylinositol-anchored proteins. Mol. Biol. Cell. 10(4):1999;1043-1059.
71. Doering T.L., Schekman R. GPI anchor attachment is required for Gas1p transport from the endoplasmic reticulum in COP II vesicles. EMBO J. 15(1):1996;182-191.
72. Miyake Y.et al. Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin. Biochem. Biophys. Res. Commun. 211(2):1995;396-403.
73. Mandala S.M.et al. The discovery of australifungin, a novel inhibitor of sphinganine N-acyltransferase from Sporormiella australis. Producing organism, fermentation, isolation, and biological activity. J. Antibiot. (Tokyo). 48(5):1995;349-356.