Orm1 and Orm2 are conserved endoplasmic reticulum membrane proteins regulating lipid homeostasis and protein quality control

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 13, 2010, Pages 5851-5856

  Han, Sumin ^a   Lone, Museer A ^b   Schneiter, Roger ^b   Chang, Amy ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF FRIBOURG   (Switzerland)

Author keywords

Membrane biogenesis; Sphingolipid synthesis; Unfolded protein response

Indexed keywords

INOSITOL; LIPID; MEMBRANE PROTEIN; ORM1 PROTEIN; ORM2 PROTEIN; SERINE PALMITOYLTRANSFERASE; SPHINGOLIPID; UNCLASSIFIED DRUG;

ARTICLE; AUXOTROPHY; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ENZYME SYNTHESIS; GENETIC CODE; HOMEOSTASIS; NONHUMAN; PHENOTYPE; PHOSPHOLIPID SYNTHESIS; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN QUALITY; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; TRANSCRIPTION REGULATION;

ENDOPLASMIC RETICULUM; GENES, FUNGAL; GOLGI APPARATUS; HOMEOSTASIS; INOSITOL; LIPID METABOLISM; MEMBRANE PROTEINS; MUTATION; PHENOTYPE; PROTEIN TRANSPORT; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SPHINGOLIPIDS; STRESS, PHYSIOLOGICAL;

EID: 77950541324     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0911617107     Document Type: Article

References (45)

1. Hebert DN, Molinari M (2007) In and out of the ER: Protein folding, quality control, degradation, and related human diseases. Physiol Rev 87:1377-1408.
2. Travers KJ, et al. (2000) Functional and genomic analysis reveal essential coordination between the unfolded protein response and endoplasmic reticulum-associated degradation. Cell 101:249-258.
3. Funato K, Vallée B, Riezman H (2002) Biosynthesis and trafficking of sphingolipids in the yeast Saccharomyces cerevisiae.. Biochemistry 41:15105-15114. (Pubitemid 36008117)
4. Carman GM, Henry SA (1999) Phospholipid biosynthesis in the yeast Saccharomyces cerevisiae and interrelationship with other metabolic processes. Prog Lipid Res 38:361-399.
5. Hjelmqvist L, et al. (2002) ORMDL proteins are a conserved new family of endoplasmic reticulum membrane proteins.. Genome Biology 3, RESEARCH0027.
6. Moffatt MF, et al. (2007) Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature 448:470-473.
7. Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425:686-691. (Pubitemid 37314307)
8. Jung U, Sobering A, Romeo M, Levin D (2002) Regulation of the yeast Rlm1 transcription factor gy the Mpk1 cell wall integrity MAP kinase. Mol Microbiol 46:781-789. (Pubitemid 35365613)
9. Liu XD, Morano KA, Thiele DJ (1999) The yeast Hsp110 family member, Sse1, is an Hsp90 cochaperone. J Biol Chem 274:26654-26660. (Pubitemid 129520179)
10. Gasch AP, et al. (2000) Genomic expression programs in the response of yeast cells to environmental changes. Mol Biol Cell 11:4241-4257.
11. Liu Y, Chang A (2008) Heat shock response relieves ER stress. EMBO J 27:1049-1059.
12. Sewell AK, et al. (1995) Mutated yeast heat shock transcription factor exhibits elevated basal transcriptional activation and confers metal resistance. J Biol Chem 270:25079-25086.
13. Schuldiner M, et al. (2005) Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile. Cell 123:507-519. (Pubitemid 41546679)
14. Tarassov K, et al. (2008) An in vivo map of the yeast protein interactome. Science 320:1465-1470.
15. Skrzypek MS, Nagiec MM, Lester RL, Dickson RC (1998) Inhibition of amino acid transport by sphingoid long chain bases in Saccharomyces cerevisiae. J Biol Chem 273:2829-2834.
16. Panwar SL, Moye-Rowley WS (2006) Long chain base tolerance in Saccharomyces cerevisiae is induced by retrograde signals from the mitochondria. J Biol Chem 281:6376-6384.
17. Mallory JC, et al. (2005) Dap1p, a heme-binding protein that regulates the cytochrome P450 protein Erg11p/Cyp51p in Saccharomyces cerevisiae. Mol Cell Biol 25:1669-1679.
18. Gable K, et al. (2002) Mutations in the yeast LCB1 and LCB2 genes, including those corresponding to the hereditary sensory neuropathy type I mutations, dominantly inactivate serine palmitoyltransferase. J Biol Chem 277:10194-10200.
19. Loewen CJR, Levine TP (2005) A highly conserved binding site in vesicle-associated membrane protein-associated protein (VAP) for the FFAT motif of lipid-binding proteins. J Biol Chem 280:14097-14104.
20. Loewen CJR, et al. (2004) Phospholipid metabolism regulated by a transcription factor sensing phosphatidic acid. Science 304:1644-1647.
21. Carman GM, Han G-S (2009) Phosphatidic acid phosphatase, a key enzyme in the regulation of lipid synthesis. J Biol Chem 284:2593-2597.
22. Jenkins GM (2003) The emerging role for sphingolipids in the eukaryotic heat shock response. Cell Mol Life Sci 60:701-710.
23. Levin DE (2005) Cell wall integrity signaling in Saccharomyces cerevisiae. Microbiol Mol Biol Rev 69:262-291.
24. Wells GB, Dickson RC, Lester RL (1998) Heat-induced elevation of ceramide in Saccharomyces cerevisiae via de novo synthesis. J Biol Chem 273:7235-7243.
25. Brice SE, Alford CW, Cowart LA (2009) Modulation of sphingolipid metabolism by the phosphatidylinositol-4-phosphate phosphatase Sac1p through regulation of phosphatidylinositol in Saccharomyces cerevisiae. J Biol Chem284:7588-7596.
26. Dickson RC (2008) Thematic review series: Sphingolipids. New insights into sphingolipid metabolism and function in budding yeast. J Lipid Res 49:909-921.
27. Jesch SA, Zhao X, Wells MT, Henry SA (2005) Genome-wide analysis reveals inositol, not choline, as the major effector of Ino2p-Ino4p and unfolded protein response target gene expression in yeast. J Biol Chem 280:9106-9118. (Pubitemid 40409605)
28. Fernández-Murray JP, Gaspard GJ, Jesch SA, McMaster CR (2009) NTE1-encoded phosphatidylcholine phospholipase b regulates transcription of phospholipid biosynthetic genes. J Biol Chem 284:36034-36046.
29. Araki W, et al. (2008) A family of membrane proteins associated with presenilin expression and gamma secretase function. FASEB J 22:819-827.
30. Giussani P, et al. (2006) Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide. Mol Cell Biol 26:5055-5069. (Pubitemid 43955819)
31. Maceyka M, Machamer CE (1997) Ceramide accumulation uncovers a cycling pathway for the cis-Golgi network marker, infectious bronchitis virus M protein. J Cell Biol 139:1411-1418. (Pubitemid 28013662)
32. Pathre P, et al. (2003) Activation of phospholipase D by the small GTPase Sar1p is required to support COPII assembly and ER export. EMBO J 22:4059-4069. (Pubitemid 37021735)
33. Runz H, Miura K, Weiss M, Pepperkok R (2006) Sterols regulate ER-export dynamics of secretory cargo protein ts-O45-G. EMBO J 25:2953-2965. (Pubitemid 44106749)
34. Gaspar ML, et al. (2008) A block in endoplasmic reticulum-to-Golgi trafficking inhibits phospholipid synthesis and induces neutral lipid accumulation. J Biol Chem 283:25735-25751.
35. Pineau L, et al. (2009) Lipid-induced ER stress: Synergistic effects of sterols and saturated fatty acids. Traffic 10:673-690.
36. Chang HJ, Jesch SA, Gaspar ML, Henry SA (2004) Role of the unfolded protein response pathway in secretory stress and regulation of INO1 expression in Saccharomyces cerevisiae. Genetics 168:1899-1913.
37. Cox JS, Chapman RE, Walter P (1997) The unfolded protein response coordinates the production of endoplasmic reticulum protein and endoplasmic reticulum membrane. Mol Biol Cell 8:1805-1814. (Pubitemid 27411143)
38. Ron D, Hampton RY (2004) Membrane biogenesis and the unfolded protein response. J Cell Biol 167:23-25. (Pubitemid 39363410)
39. Toulmay A, Schneiter R (2007) Lipid-dependent surface transport of the proton pumping ATPase: A model to study plasma membrane biogenesis in yeast. Biochimie 89:249-254. (Pubitemid 46161950)
40. Proszynski TJ, et al. (2005) A genome-wide visual screen reveals a role for sphingolipids and ergosterol in cell surface delivery in yeast. Proc Natl Acad Sci USA 102:17981-17986.
41. Sherman F, Hicks JB, Fink GR (1986) Methods in Yeast Genetics: a Laboratory Manual (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY).
42. Gable K, Slife H, Bacikova D, Monaghan E, Dunn TM (2000) Tsc3p is an 80-amino acid protein associated with serine palmitoyltransferase and required for optimal enzyme activity. J Biol Chem 275:7597-7603. (Pubitemid 30159659)
43. +]ATPase involves phosphorylation during intracellular transport. J Cell Biol 115:289-295.
44. Ejsing CS, et al. (2009) Global analysis of the yeast lipidome by quantitative shotgun mass spectrometry. Proc Natl Acad Sci USA 106:2136-2141.
45. Rose MD, Winston F, Hieter P (1990) Methods in Yeast Genetics: A Laboratory Manual (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY).