Defects in very long chain fatty acid synthesis enhance alpha-synuclein toxicity in a yeast model of Parkinson's disease

PLoS ONE

Volumn 6, Issue 1, 2011, Pages

  Lee, Yong Joo ^a   Wang, Shaoxiao ^a   Slone, Sunny R ^b   Yacoubian, Talene A ^b   Witt, Stephan N ^a  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b The University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; CERAMIDE; ELONGASE; ELONGASE 2P; ELONGASE 3P; ENHANCED GREEN FLUORESCENT PROTEIN; FUMONISIN B1; MEDIUM CHAIN FATTY ACID; REACTIVE OXYGEN METABOLITE; SACCHAROMYCES CEREVISIAE PROTEIN; SPHINGOLIPID; THERMOZYMOCIDIN; UNCLASSIFIED DRUG; VERY LONG CHAIN FATTY ACID; ACYLTRANSFERASE; FEN1 PROTEIN, S CEREVISIAE; MEMBRANE PROTEIN; SPHINGOMYELIN;

ARTICLE; CATALYSIS; CELL SURVIVAL; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME INHIBITION; ENZYME MECHANISM; FATTY ACID SYNTHESIS; FLUORESCENCE MICROSCOPY; FUNGAL STRAIN; FUNGUS GROWTH; LIPID METABOLISM; NONHUMAN; PARKINSON DISEASE; PHENOTYPE; PLASMID; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TRANSPORT; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; BIOSYNTHESIS; GENETICS; METABOLISM;

ACETYLTRANSFERASES; ALPHA-SYNUCLEIN; CERAMIDES; ENDOPLASMIC RETICULUM; MEMBRANE PROTEINS; PARKINSON DISEASE; PROTEIN TRANSPORT; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SPHINGOMYELINS;

EID: 79251550710     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0015946     Document Type: Article

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