Rapid and refined separation of human IgG2 disulfide isomers using superficially porous particles

Journal of Separation Science

Volumn 33, Issue 17-18, 2010, Pages 2671-2680

  Wang, Qian ^a   Lacher, Nathan A ^a   Muralidhara, Bilikallahalli K ^a   Schlittler, Michael R ^a   Aykent, Serdar ^a   Demarest, Charles W ^a  

^a PFIZER INC   (United States)

Author keywords

IgG2 disulfide isomers; Monoclonal antibody; RP HPLC; Superficially porous particles

Indexed keywords

ANALYTICAL TECHNIQUES; CAPILLARY GEL ELECTROPHORESIS; COLUMN TEMPERATURE; DENATURATION TEMPERATURES; HIGH-FLOW RATE; HUMAN IMMUNOGLOBULIN; IGG2 DISULFIDE ISOMERS; ION EXCHANGE CHROMATOGRAPHY; ISO-PROPANOLS; MOBILE PHASIS; OPTIMAL CONDITIONS; PEAK PROFILES; PEPTIDE MAPPING; REVERSED PHASE HPLC; REVERSED-PHASE HPLC METHOD; RP-HPLC; SUPERFICIALLY POROUS PARTICLES; TEMPERATURE DEPENDENT;

CAPILLARY ELECTROPHORESIS; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; GELS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ION CHROMATOGRAPHY; ION EXCHANGE; MONOCLONAL ANTIBODIES; PHASE SEPARATION; POROUS MATERIALS; SURFACE PLASMON RESONANCE; TEMPERATURE;

ISOMERS;

DISULFIDE; IMMUNOGLOBULIN G2; MONOCLONAL ANTIBODY; PARAPROTEIN;

ARTICLE; DRUG SYNTHESIS; FLOW RATE; HUMAN; ISOMER; PHASE SEPARATION; PRIORITY JOURNAL; PROTEIN DENATURATION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; TEMPERATURE MEASUREMENT; THERMODYNAMICS;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DISULFIDES; HUMANS; IMMUNOGLOBULIN G; ISOMERISM; MODELS, MOLECULAR; POROSITY; PROTEIN CONFORMATION; TEMPERATURE; THERMODYNAMICS;

EID: 77956943767     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.201000230     Document Type: Article

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