DNTP-dependent conformational transitions in the fingers subdomain of Klentaq1 DNA polymerase: Insights into the role of the "nucleotide- binding" state

Journal of Biological Chemistry

Volumn 288, Issue 19, 2013, Pages 13575-13591

  Rothwell, Paul J ^a   Allen, William J ^b,d   Sisamakis, Evangelos ^a,c   Kalinin, Stanislav ^a   Felekyan, Suren ^a   Widengren, Jerker ^c   Waksman, Gabriel ^b,d   Seidel, Claus A M ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b UNIVERSITY OF LONDON   (United Kingdom)

^c ALBANOVA UNIVERSITY CENTER   (Sweden)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONAL EQUILIBRIUM; CONFORMATIONAL SELECTION; CONFORMATIONAL TRANSITIONS; DNA POLYMERASE; REACTION PATHWAYS; SUBDOMAIN;

BIOCHEMISTRY; BIOLOGY;

NUCLEOTIDES;

DEOXYRIBONUCLEOSIDE TRIPHOSPHATE; DNA POLYMERASE; KLENOW FRAGMENT OF THERMUS AQUATICUS DNA POLYMERASE 1; UNCLASSIFIED DRUG;

ARTICLE; BASE PAIRING; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; FLUORESCENCE RESONANCE ENERGY TRANSFER; FLUORESCENCE SPECTROSCOPY; GEOBACILLUS STEAROTHERMOPHILUS; NONHUMAN; NUCLEOTIDE BINDING SITE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; THERMUS AQUATICUS; X RAY CRYSTALLOGRAPHY;

CONFORMATIONAL SELECTION; DNA ENZYMES; DNA POLYMERASE; ENZYME KINETICS; FLUORESCENCE RESONANCE ENERGY TRANSFER (FRET); SINGLE MOLECULE BIOPHYSICS;

BACTERIAL PROTEINS; CATALYTIC DOMAIN; DEOXYADENINE NUCLEOTIDES; DNA POLYMERASE I; FLUORESCENCE RESONANCE ENERGY TRANSFER; FLUORESCENT DYES; HYDRAZINES; KINETICS; MODELS, MOLECULAR; PROTEIN BINDING; STAINING AND LABELING; SUBSTRATE SPECIFICITY; THERMUS; THYMINE NUCLEOTIDES;

EID: 84877707944     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.432690     Document Type: Article

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