Single-molecule Förster resonance energy transfer reveals an innate fidelity checkpoint in DNA polymerase i

Journal of the American Chemical Society

Volumn 134, Issue 27, 2012, Pages 11261-11268

  Berezhna, Svitlana Y ^a   Gill, Joshua P ^a   Lamichhane, Rajan ^a   Millar, David P ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; BASE PAIRS; COMPLEX DYNAMICS; CONFORMATIONAL DYNAMICS; CONFORMATIONAL STATE; DISSOCIATION RATES; DNA POLYMERASE; DNA REPLICATIONS; ENZYMATIC REACTION; EXONUCLEASE; INTERMEDIATE CONFORMATION; KLENOW FRAGMENT; NONCOVALENT; POLYMERASE ACTIVE SITE; PRODUCT RELEASE; REACTION PATHWAYS; RESONANCE ENERGY TRANSFER; SINGLE-MOLECULE; SUBDOMAIN; SUBSTRATE BINDING; SUBSTRATE SELECTION;

DISSOCIATION; DNA; DYNAMICS; ENERGY TRANSFER; ENZYMES; ESCHERICHIA COLI; MOLECULES; NUCLEOTIDES; POLYMERS; SUBSTRATES;

CONFORMATIONS;

DNA; DNA DIRECTED DNA POLYMERASE BETA; EXONUCLEASE; NUCLEOTIDE;

ARTICLE; BASE PAIRING; CATALYSIS; DISSOCIATION; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME CONFORMATION; ENZYME KINETICS; ENZYME STABILITY; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; ESCHERICHIA COLI; PROTEIN DOMAIN; SINGLE MOLECULE FORSTER RESONANCE ENERGY TRANSFER;

DNA POLYMERASE I; ESCHERICHIA COLI; FLUORESCENCE RESONANCE ENERGY TRANSFER; MODELS, MOLECULAR; NUCLEOTIDES; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY;

EID: 84863826327     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja3038273     Document Type: Article

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