메뉴 건너뛰기




Volumn 32, Issue 19, 2013, Pages 2452-2462

DNA-PK, ATM and ATR collaboratively regulate p53-RPA interaction to facilitate homologous recombination DNA repair

Author keywords

ATM; ATR; DNA PK; homologous recombination repair; nonhomologous recombination end joining; p53 RPA interaction

Indexed keywords

ATM PROTEIN; ATR PROTEIN; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; DNA DEPENDENT PROTEIN KINASE; PROTEIN P53; REPLICATION FACTOR A; SINGLE STRANDED DNA;

EID: 84877619314     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2012.257     Document Type: Article
Times cited : (81)

References (63)
  • 1
    • 3943107573 scopus 로고    scopus 로고
    • Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
    • Sancar A, Lindsey-Boltz LA, Unsal-Kacmaz K, Linn S. Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu Rev Biochem 2004; 73: 39-85.
    • (2004) Annu Rev Biochem , vol.73 , pp. 39-85
    • Sancar, A.1    Lindsey-Boltz, L.A.2    Unsal-Kacmaz, K.3    Linn, S.4
  • 2
    • 75949124023 scopus 로고    scopus 로고
    • Assembly of checkpoint and repair machineries at DNA damage sites
    • Huen MS, Chen J. Assembly of checkpoint and repair machineries at DNA damage sites. Trends Biochem Sci 2009; 35: 101-108.
    • (2009) Trends Biochem Sci , vol.35 , pp. 101-108
    • Huen, M.S.1    Chen, J.2
  • 3
    • 36749022214 scopus 로고    scopus 로고
    • The DNA damage response: Ten years after
    • Harper JW, Elledge SJ. The DNA damage response: ten years after. Mol Cell 2007; 28: 739-745.
    • (2007) Mol Cell , vol.28 , pp. 739-745
    • Harper, J.W.1    Elledge, S.J.2
  • 4
    • 52949144228 scopus 로고    scopus 로고
    • DNA-damage checkpoints: Location, location, location
    • Wood JL, Chen J. DNA-damage checkpoints: location, location, location. Trends Cell Biol 2008; 18: 451-455.
    • (2008) Trends Cell Biol , vol.18 , pp. 451-455
    • Wood, J.L.1    Chen, J.2
  • 5
    • 33745607897 scopus 로고    scopus 로고
    • Functions of human replication protein A (RPA): From DNA replication to DNA damage and stress responses
    • Zou Y, Liu Y, Wu X, Shell SM. Functions of human replication protein A (RPA): from DNA replication to DNA damage and stress responses. J Cell Physiol 2006; 208: 267-273.
    • (2006) J Cell Physiol , vol.208 , pp. 267-273
    • Zou, Y.1    Liu, Y.2    Wu, X.3    Shell, S.M.4
  • 6
    • 84877624243 scopus 로고    scopus 로고
    • Protein-protein interactions in Ataxia telangiectesia
    • Ahmad S, Hanaoka F (eds) Landes Bioscience, Austin, TX, USA
    • Shell SM, Zou Y. Protein-protein interactions in Ataxia telangiectesia. In: Ahmad S, Hanaoka F (eds). Molecular Mechanisms of Ataxia Telangiectasia. Landes Bioscience, Austin, TX, USA 42-51, 2009.
    • (2009) Molecular Mechanisms of Ataxia Telangiectasia , pp. 42-51
    • Shell, S.M.1    Zou, Y.2
  • 7
    • 0035853295 scopus 로고    scopus 로고
    • DNA double-strand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cells
    • Arnaudeau C, Lundin C, Helleday T. DNA double-strand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cells. J Mol Biol 2001; 307: 1235-1245.
    • (2001) J Mol Biol , vol.307 , pp. 1235-1245
    • Arnaudeau, C.1    Lundin, C.2    Helleday, T.3
  • 8
    • 33749034730 scopus 로고    scopus 로고
    • Topoisomerase i inhibitors: Camptothecins and beyond
    • Pommier Y. Topoisomerase I inhibitors: camptothecins and beyond. Nat Rev Cancer 2006; 6: 789-802.
    • (2006) Nat Rev Cancer , vol.6 , pp. 789-802
    • Pommier, Y.1
  • 9
    • 2642573591 scopus 로고    scopus 로고
    • Collaboration of homologous recombination and nonhomologous end-joining factors for the survival and integrity of mice and cells
    • Couedel C, Mills KD, Barchi M, Shen L, Olshen A, Johnson RD et al. Collaboration of homologous recombination and nonhomologous end-joining factors for the survival and integrity of mice and cells. Genes Dev 2004; 18: 1293-1304.
    • (2004) Genes Dev , vol.18 , pp. 1293-1304
    • Couedel, C.1    Mills, K.D.2    Barchi, M.3    Shen, L.4    Olshen, A.5    Johnson, R.D.6
  • 11
    • 77956401853 scopus 로고    scopus 로고
    • The DNA-dependent protein kinase (DNA-PK): More than just a case of making ends meet?
    • Hill R, Lee PW. The DNA-dependent protein kinase (DNA-PK): more than just a case of making ends meet? Cell Cycle 2010; 9: 3460-3469.
    • (2010) Cell Cycle , vol.9 , pp. 3460-3469
    • Hill, R.1    Lee, P.W.2
  • 12
    • 57949116437 scopus 로고    scopus 로고
    • DNA-PK: The means to justify the ends?
    • Meek K, Dang V, Lees-Miller SP. DNA-PK: the means to justify the ends? Adv Immunol 2008; 99: 33-58.
    • (2008) Adv Immunol , vol.99 , pp. 33-58
    • Meek, K.1    Dang, V.2    Lees-Miller, S.P.3
  • 13
    • 27744588177 scopus 로고    scopus 로고
    • Preferential localization of hyperphosphorylated replication protein A to double-strand break repair and checkpoint complexes upon DNA damage
    • Wu X, Yang Z, Liu Y, Zou Y. Preferential localization of hyperphosphorylated replication protein A to double-strand break repair and checkpoint complexes upon DNA damage. Biochem J. 2005; 391: 473-480.
    • (2005) Biochem J. , vol.391 , pp. 473-480
    • Wu, X.1    Yang, Z.2    Liu, Y.3    Zou, Y.4
  • 14
    • 22744449724 scopus 로고    scopus 로고
    • Interaction and colocalization of Rad9/Rad1/Hus1 checkpoint complex with replication protein A in human cells
    • Wu X, Shell SM, Zou Y. Interaction and colocalization of Rad9/Rad1/Hus1 checkpoint complex with replication protein A in human cells. Oncogene 2005; 24: 4728-4735.
    • (2005) Oncogene , vol.24 , pp. 4728-4735
    • Wu, X.1    Shell, S.M.2    Zou, Y.3
  • 15
    • 0345564858 scopus 로고    scopus 로고
    • Replication protein A-mediated recruitment and activation of Rad17 complexes
    • Zou L, Liu D, Elledge SJ. Replication protein A-mediated recruitment and activation of Rad17 complexes. Proc Natl Acad Sci USA 2003; 100: 13827-13832.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 13827-13832
    • Zou, L.1    Liu, D.2    Elledge, S.J.3
  • 16
    • 0037567268 scopus 로고    scopus 로고
    • Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
    • Zou L, Elledge SJ. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 2003; 300: 1542-1548.
    • (2003) Science , vol.300 , pp. 1542-1548
    • Zou, L.1    Elledge, S.J.2
  • 17
    • 0037195277 scopus 로고    scopus 로고
    • Dimerization of human XPA and formation of XPA2-RPA protein complex
    • Yang ZG, Liu Y, Mao LY, Zhang JT, Zou Y. Dimerization of human XPA and formation of XPA2-RPA protein complex. Biochemistry 2002; 41: 13012-13020.
    • (2002) Biochemistry , vol.41 , pp. 13012-13020
    • Yang, Z.G.1    Liu, Y.2    Mao, L.Y.3    Zhang, J.T.4    Zou, Y.5
  • 18
    • 35848967336 scopus 로고    scopus 로고
    • Replication protein A is required for etoposide-induced assembly of MRE11/RAD50/NBS1 complex repair foci
    • Robison JG, Bissler JJ, Dixon K. Replication protein A is required for etoposide-induced assembly of MRE11/RAD50/NBS1 complex repair foci. Cell Cycle 2007; 6: 2408-2416.
    • (2007) Cell Cycle , vol.6 , pp. 2408-2416
    • Robison, J.G.1    Bissler, J.J.2    Dixon, K.3
  • 19
    • 0034721654 scopus 로고    scopus 로고
    • Structural basis for the recognition of DNA repair proteins UNG2, XPA, and RAD52 by replication factor RPA
    • Mer G, Bochkarev A, Gupta R, Bochkareva E, Frappier L, Ingles CJ et al. Structural basis for the recognition of DNA repair proteins UNG2, XPA, and RAD52 by replication factor RPA. Cell 2000; 103: 449-456.
    • (2000) Cell , vol.103 , pp. 449-456
    • Mer, G.1    Bochkarev, A.2    Gupta, R.3    Bochkareva, E.4    Frappier, L.5    Ingles, C.J.6
  • 20
    • 67349131296 scopus 로고    scopus 로고
    • Dynamic regulatory interactions of rad51, rad52, and replication protein-A in recombination intermediates
    • Sugiyama T, Kantake N. Dynamic regulatory interactions of rad51, rad52, and replication protein-a in recombination intermediates. J Mol Biol 2009; 390: 45-55.
    • (2009) J Mol Biol , vol.390 , pp. 45-55
    • Sugiyama, T.1    Kantake, N.2
  • 21
    • 2942532181 scopus 로고    scopus 로고
    • Physical interaction between replication protein A and Rad51 promotes exchange on single-stranded DNA
    • Stauffer ME, Chazin WJ. Physical interaction between replication protein A and Rad51 promotes exchange on single-stranded DNA. J Biol Chem 2004; 279: 25638-25645.
    • (2004) J Biol Chem , vol.279 , pp. 25638-25645
    • Stauffer, M.E.1    Chazin, W.J.2
  • 22
    • 0036349930 scopus 로고    scopus 로고
    • Analysis of the human replication protein A:Rad52 complex: Evidence for crosstalk between RPA32, RPA70, Rad52 and DNA
    • Jackson D, Dhar K, Wahl JK, Wold MS, Borgstahl GE. Analysis of the human replication protein A:Rad52 complex: evidence for crosstalk between RPA32, RPA70, Rad52 and DNA. J Mol Biol 2002; 321: 133-148.
    • (2002) J Mol Biol , vol.321 , pp. 133-148
    • Jackson, D.1    Dhar, K.2    Wahl, J.K.3    Wold, M.S.4    Borgstahl, G.E.5
  • 24
    • 10944230682 scopus 로고    scopus 로고
    • The interaction of p53 with replication protein A mediates suppression of homologous recombination
    • Romanova LY, Willers H, Blagosklonny MV, Powell SN. The interaction of p53 with replication protein A mediates suppression of homologous recombination. Oncogene 2004; 23: 9025-9033.
    • (2004) Oncogene , vol.23 , pp. 9025-9033
    • Romanova, L.Y.1    Willers, H.2    Blagosklonny, M.V.3    Powell, S.N.4
  • 26
    • 77955435598 scopus 로고    scopus 로고
    • Functional characterization of a cancer causing mutation in human replication protein A
    • Hass CS, Gakhar L, Wold MS. Functional characterization of a cancer causing mutation in human replication protein A. Mol Cancer Res 2010; 8: 1017-1026.
    • (2010) Mol Cancer Res , vol.8 , pp. 1017-1026
    • Hass, C.S.1    Gakhar, L.2    Wold, M.S.3
  • 27
    • 22844436867 scopus 로고    scopus 로고
    • Mutation in Rpa1 results in defective DNA double-strand break repair, chromosomal instability and cancer in mice
    • Wang Y, Putnam CD, Kane MF, Zhang W, Edelmann L, Russell R et al. Mutation in Rpa1 results in defective DNA double-strand break repair, chromosomal instability and cancer in mice. Nat Genet 2005; 37: 750-755.
    • (2005) Nat Genet , vol.37 , pp. 750-755
    • Wang, Y.1    Putnam, C.D.2    Kane, M.F.3    Zhang, W.4    Edelmann, L.5    Russell, R.6
  • 28
    • 3442896884 scopus 로고    scopus 로고
    • Replication protein A phosphorylation and the cellular response to DNA damage
    • Binz SK, Sheehan AM, Wold MS. Replication protein A phosphorylation and the cellular response to DNA damage. DNA Repair 2004; 3: 1015-1024.
    • (2004) DNA Repair , vol.3 , pp. 1015-1024
    • Binz, S.K.1    Sheehan, A.M.2    Wold, M.S.3
  • 29
    • 1342325347 scopus 로고    scopus 로고
    • Replication protein A (RPA) phosphorylation prevents RPA association with replication centers
    • Vassin VM, Wold MS, Borowiec JA. Replication protein A (RPA) phosphorylation prevents RPA association with replication centers. Mol Cell Biol 2004; 24: 1930-1943.
    • (2004) Mol Cell Biol , vol.24 , pp. 1930-1943
    • Vassin, V.M.1    Wold, M.S.2    Borowiec, J.A.3
  • 30
    • 20444392406 scopus 로고    scopus 로고
    • DNA damage induced hyperpho-sphorylation of replication protein A. 2. Characterization of DNA binding activity, protein interactions, and activity in DNA replication and repair
    • Patrick SM, Oakley GG, Dixon K, Turchi JJ. DNA damage induced hyperpho-sphorylation of replication protein A. 2. Characterization of DNA binding activity, protein interactions, and activity in DNA replication and repair. Biochemistry 2005; 44: 8438-8448.
    • (2005) Biochemistry , vol.44 , pp. 8438-8448
    • Patrick, S.M.1    Oakley, G.G.2    Dixon, K.3    Turchi, J.J.4
  • 31
    • 33746855461 scopus 로고    scopus 로고
    • Regulation of replication protein A functions in DNA mismatch repair by phosphorylation
    • Guo S, Zhang Y, Yuan F, Gao Y, Gu L, Wong I et al. Regulation of replication protein A functions in DNA mismatch repair by phosphorylation. J Biol Chem 2006; 281: 21607-21616.
    • (2006) J Biol Chem , vol.281 , pp. 21607-21616
    • Guo, S.1    Zhang, Y.2    Yuan, F.3    Gao, Y.4    Gu, L.5    Wong, I.6
  • 32
    • 25444485251 scopus 로고    scopus 로고
    • Modulation of replication protein A function by its hyperphosphorylation- induced conformational change involving DNA binding domain B
    • Liu Y, Kvaratskhelia M, Hess S, Qu Y, Zou Y. Modulation of replication protein A function by its hyperphosphorylation-induced conformational change involving DNA binding domain B. J Biol Chem 2005; 280: 32775-32783.
    • (2005) J Biol Chem , vol.280 , pp. 32775-32783
    • Liu, Y.1    Kvaratskhelia, M.2    Hess, S.3    Qu, Y.4    Zou, Y.5
  • 33
    • 77953932126 scopus 로고    scopus 로고
    • The role of RPA2 phosphorylation in homologous recombination in response to replication arrest
    • Shi W, Feng Z, Zhang J, Gonzalez-Suarez I, Vanderwaal RP, Wu X et al. The role of RPA2 phosphorylation in homologous recombination in response to replication arrest. Carcinogenesis 2010; 31: 994-1002.
    • (2010) Carcinogenesis , vol.31 , pp. 994-1002
    • Shi, W.1    Feng, Z.2    Zhang, J.3    Gonzalez-Suarez, I.4    Vanderwaal, R.P.5    Wu, X.6
  • 34
    • 33845991538 scopus 로고    scopus 로고
    • RPA2 Is a Direct downstream target for ATR to regulate the S-phase checkpoint
    • Olson E, Nievera CJ, Klimovich V, Fanning E, Wu X. RPA2 Is a Direct downstream target for ATR to regulate the S-phase checkpoint. J Biol Chem 2006; 281: 39517-39533.
    • (2006) J Biol Chem , vol.281 , pp. 39517-39533
    • Olson, E.1    Nievera, C.J.2    Klimovich, V.3    Fanning, E.4    Wu, X.5
  • 35
    • 20444375871 scopus 로고    scopus 로고
    • DNA damage induced hyperphosphorylation of replication protein A. 1. Identification of novel sites of phosphorylation in response to DNA damage
    • Nuss JE, Patrick SM, Oakley GG, Alter GM, Robison JG, Dixon K et al. DNA damage induced hyperphosphorylation of replication protein A. 1. Identification of novel sites of phosphorylation in response to DNA damage. Biochemistry 2005; 44: 8428-8437.
    • (2005) Biochemistry , vol.44 , pp. 8428-8437
    • Nuss, J.E.1    Patrick, S.M.2    Oakley, G.G.3    Alter, G.M.4    Robison, J.G.5    Dixon, K.6
  • 36
    • 17544381252 scopus 로고    scopus 로고
    • NMR chemical shift and relaxation measurements provide evidence for the coupled folding and binding of the p53 transactivation domain
    • Vise PD, Baral B, Latos AJ, Daughdrill GW. NMR chemical shift and relaxation measurements provide evidence for the coupled folding and binding of the p53 transactivation domain. Nucleic Acids Res 2005; 33: 2061-2077.
    • (2005) Nucleic Acids Res , vol.33 , pp. 2061-2077
    • Vise, P.D.1    Baral, B.2    Latos, A.J.3    Daughdrill, G.W.4
  • 37
    • 27344449049 scopus 로고    scopus 로고
    • Single-stranded DNA mimicry in the p53 transactivation domain interaction with replication protein A
    • Bochkareva E, Kaustov L, Ayed A, Yi G-S, Lu Y, Pineda-Lucena A et al. Single-stranded DNA mimicry in the p53 transactivation domain interaction with replication protein A. Proc Natl Acad Sci USA 2005; 102: 15412-15417.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 15412-15417
    • Bochkareva, E.1    Kaustov, L.2    Ayed, A.3    Yi, G.-S.4    Lu, Y.5    Pineda-Lucena, A.6
  • 38
    • 0030899811 scopus 로고    scopus 로고
    • Complex formation between p53 and replication protein A inhibits the sequence-specific DNA binding of p53 and is regulated by single-stranded DNA
    • Miller S, Moses K, Jayaraman L, Prives C. Complex formation between p53 and replication protein A inhibits the sequence-specific DNA binding of p53 and is regulated by single-stranded DNA. Mol Cell Biol 1997; 17: 2194-2201.
    • (1997) Mol Cell Biol , vol.17 , pp. 2194-2201
    • Miller, S.1    Moses, K.2    Jayaraman, L.3    Prives, C.4
  • 39
    • 0030872645 scopus 로고    scopus 로고
    • Interaction between replication protein A and p53 is disrupted after UV damage in a DNA repair-dependent manner
    • Abramova NA, Russell J, Botchan M, Li R. Interaction between replication protein A and p53 is disrupted after UV damage in a DNA repair-dependent manner. Proc Natl Acad Sci USA 1997; 94: 7186-7191.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 7186-7191
    • Abramova, N.A.1    Russell, J.2    Botchan, M.3    Li, R.4
  • 40
    • 0033590652 scopus 로고    scopus 로고
    • Surface plasmon resonance measurements reveal stable complex formation between p53 and DNA polymerase alpha
    • Kuhn C, Muller F, Melle C, Nasheuer HP, Janus F, Deppert W et al. Surface plasmon resonance measurements reveal stable complex formation between p53 and DNA polymerase alpha. Oncogene 1999; 18: 769-774.
    • (1999) Oncogene , vol.18 , pp. 769-774
    • Kuhn, C.1    Muller, F.2    Melle, C.3    Nasheuer, H.P.4    Janus, F.5    Deppert, W.6
  • 42
    • 0030941458 scopus 로고    scopus 로고
    • P53, the cellular gatekeeper for growth and division
    • Levine AJ. p53, the cellular gatekeeper for growth and division. Cell 1997; 88: 323-331.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 43
    • 0029972806 scopus 로고    scopus 로고
    • P53: Puzzle and paradigm
    • Ko LJ, Prives C. p53: puzzle and paradigm. Genes Dev 1996; 10: 1054-1072.
    • (1996) Genes Dev , vol.10 , pp. 1054-1072
    • Ko, L.J.1    Prives, C.2
  • 44
    • 34248185454 scopus 로고    scopus 로고
    • P53: Guardian of the genome and policeman of the onco-genes
    • Efeyan A, Serrano M. p53: guardian of the genome and policeman of the onco-genes. Cell Cycle 2007; 6: 1006-1010.
    • (2007) Cell Cycle , vol.6 , pp. 1006-1010
    • Efeyan, A.1    Serrano, M.2
  • 46
    • 0033104517 scopus 로고    scopus 로고
    • Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-depen-dent protein kinase and dissociates RPA:DNA-PK complexes
    • Shao RG, Cao CX, Zhang H, Kohn KW, Wold MS, Pommier Y. Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-depen-dent protein kinase and dissociates RPA:DNA-PK complexes. Embo J 1999; 18: 1397-1406.
    • (1999) Embo J , vol.18 , pp. 1397-1406
    • Shao, R.G.1    Cao, C.X.2    Zhang, H.3    Kohn, K.W.4    Wold, M.S.5    Pommier, Y.6
  • 47
    • 0242417571 scopus 로고    scopus 로고
    • RPA phosphorylation in mitosis alters DNA binding and protein-protein interactions
    • Oakley GG, Patrick SM, Yao J, Carty MP, Turchi JJ, Dixon K. RPA phosphorylation in mitosis alters DNA binding and protein-protein interactions. Biochemistry 2003; 42: 3255-3264.
    • (2003) Biochemistry , vol.42 , pp. 3255-3264
    • Oakley, G.G.1    Patrick, S.M.2    Yao, J.3    Carty, M.P.4    Turchi, J.J.5    Dixon, K.6
  • 48
    • 72949105139 scopus 로고    scopus 로고
    • Proteasome inhibition suppresses DNA-dependent protein kinase activation caused by camptothecin
    • Sakasai R, Teraoka H, Tibbetts RS. Proteasome inhibition suppresses DNA-dependent protein kinase activation caused by camptothecin. DNA Repair 2009; 9: 76-82.
    • (2009) DNA Repair , vol.9 , pp. 76-82
    • Sakasai, R.1    Teraoka, H.2    Tibbetts, R.S.3
  • 49
    • 0037931365 scopus 로고    scopus 로고
    • The recombination-deficient mutant RPA (rfa1-t11) is displaced slowly from single-stranded DNA by Rad51 protein
    • Kantake N, Sugiyama T, Kolodner RD, Kowalczykowski SC. The recombination-deficient mutant RPA (rfa1-t11) is displaced slowly from single-stranded DNA by Rad51 protein. J Biol Chem 2003; 278: 23410-23417.
    • (2003) J Biol Chem , vol.278 , pp. 23410-23417
    • Kantake, N.1    Sugiyama, T.2    Kolodner, R.D.3    Kowalczykowski, S.C.4
  • 50
    • 33751560821 scopus 로고    scopus 로고
    • Rad52-mediated DNA annealing after Rad51-mediated DNA strand exchange promotes second ssDNA capture
    • Sugiyama T, Kantake N, Wu Y, Kowalczykowski SC. Rad52-mediated DNA annealing after Rad51-mediated DNA strand exchange promotes second ssDNA capture. The EMBO J 2006; 25: 5539-5548.
    • (2006) The EMBO J , vol.25 , pp. 5539-5548
    • Sugiyama, T.1    Kantake, N.2    Wu, Y.3    Kowalczykowski, S.C.4
  • 51
    • 57649143095 scopus 로고    scopus 로고
    • Interaction with RPA is necessary for Rad52 repair center formation and for its mediator activity
    • Plate I, Hallwyl SC, Shi I, Krejci L, Muller C, Albertsen L et al. Interaction with RPA is necessary for Rad52 repair center formation and for its mediator activity. J Biol Chem 2008; 283: 29077-29085.
    • (2008) J Biol Chem , vol.283 , pp. 29077-29085
    • Plate, I.1    Hallwyl, S.C.2    Shi, I.3    Krejci, L.4    Muller, C.5    Albertsen, L.6
  • 52
    • 0035893363 scopus 로고    scopus 로고
    • Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells
    • Pierce AJ, Hu P, Han M, Ellis N, Jasin M. Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells. Genes Dev 2001; 15: 3237-3242.
    • (2001) Genes Dev , vol.15 , pp. 3237-3242
    • Pierce, A.J.1    Hu, P.2    Han, M.3    Ellis, N.4    Jasin, M.5
  • 53
    • 0033598437 scopus 로고    scopus 로고
    • Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination
    • Johnson RD, Liu N, Jasin M. Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination. Nature 1999; 401: 397-399.
    • (1999) Nature , vol.401 , pp. 397-399
    • Johnson, R.D.1    Liu, N.2    Jasin, M.3
  • 54
    • 0030667702 scopus 로고    scopus 로고
    • DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
    • Shieh SY, Ikeda M, Taya Y, Prives C. DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell 1997; 91: 325-334.
    • (1997) Cell , vol.91 , pp. 325-334
    • Shieh, S.Y.1    Ikeda, M.2    Taya, Y.3    Prives, C.4
  • 55
    • 0000303499 scopus 로고    scopus 로고
    • ATM associates with and phosphorylates p53: Mapping the region of interaction
    • Khanna KK, Keating KE, Kozlov S, Scott S, Gatei M, Hobson K et al. ATM associates with and phosphorylates p53: mapping the region of interaction. Nat Genet 1998; 20: 398-400.
    • (1998) Nat Genet , vol.20 , pp. 398-400
    • Khanna, K.K.1    Keating, K.E.2    Kozlov, S.3    Scott, S.4    Gatei, M.5    Hobson, K.6
  • 56
    • 0032508608 scopus 로고    scopus 로고
    • Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
    • Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K et al. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 1998; 281: 1677-1679.
    • (1998) Science , vol.281 , pp. 1677-1679
    • Canman, C.E.1    Lim, D.S.2    Cimprich, K.A.3    Taya, Y.4    Tamai, K.5    Sakaguchi, K.6
  • 58
    • 0034142325 scopus 로고    scopus 로고
    • Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53
    • Chehab NH, Malikzay A, Appel M, Halazonetis TD. Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53. Genes Dev 2000; 14: 278-288.
    • (2000) Genes Dev , vol.14 , pp. 278-288
    • Chehab, N.H.1    Malikzay, A.2    Appel, M.3    Halazonetis, T.D.4
  • 60
    • 0029950859 scopus 로고    scopus 로고
    • Loss of transactivation and transrepression function, and not RPA binding, alters growth suppression by p53
    • Leiter LM, Chen J, Marathe T, Tanaka M, Dutta A. Loss of transactivation and transrepression function, and not RPA binding, alters growth suppression by p53. Oncogene 1996; 12: 2661-2668.
    • (1996) Oncogene , vol.12 , pp. 2661-2668
    • Leiter, L.M.1    Chen, J.2    Marathe, T.3    Tanaka, M.4    Dutta, A.5
  • 62
    • 78149447526 scopus 로고    scopus 로고
    • ATM modulates the loading of recombination proteins onto a chromosomal translocation breakpoint hotspot
    • Sun J, Oma Y, Harata M, Kono K, Shima H, Kinomura A et al. ATM modulates the loading of recombination proteins onto a chromosomal translocation breakpoint hotspot. PLoS One 2010; 5: e13554.
    • (2010) PLoS One , vol.5
    • Sun, J.1    Oma, Y.2    Harata, M.3    Kono, K.4    Shima, H.5    Kinomura, A.6
  • 63
    • 51349140504 scopus 로고    scopus 로고
    • RPA phosphorylation facilitates mitotic exit in response to mitotic DNA damage
    • Anantha RW, Sokolova E, Borowiec JA. RPA phosphorylation facilitates mitotic exit in response to mitotic DNA damage. Proc Natl Acad Sci USA. 2008; 105: 12903-12908.
    • (2008) Proc Natl Acad Sci USA. , vol.105 , pp. 12903-12908
    • Anantha, R.W.1    Sokolova, E.2    Borowiec, J.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.