메뉴 건너뛰기




Volumn 32, Issue 19, 2013, Pages 2380-2389

An apoptosis-independent role of SMAC in tumor suppression

Author keywords

cIAP; colon cancer; NF B; proliferation; SMAC

Indexed keywords

APC PROTEIN; AZOXYMETHANE; BETA CATENIN; DEXTRAN SULFATE; I KAPPA B BETA; INHIBITOR OF APOPTOSIS PROTEIN 1; INHIBITOR OF APOPTOSIS PROTEIN 2; MITOCHONDRIAL PROTEIN; PROTEIN SECOND MITOCHONDRIA DERIVED ACTIVATOR OF CASPASE; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84877611266     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2012.265     Document Type: Article
Times cited : (13)

References (50)
  • 1
    • 0034616945 scopus 로고    scopus 로고
    • Smac a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition
    • Du C, Fang M, Li Y, Li L, Wang X. Smac a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell 2000; 102: 33-42.
    • (2000) Cell , vol.102 , pp. 33-42
    • Du, C.1    Fang, M.2    Li, Y.3    Li, L.4    Wang, X.5
  • 2
    • 0034616942 scopus 로고    scopus 로고
    • Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins
    • Verhagen AM, Ekert PG, Pakusch M, Silke J, Connolly LM, Reid GE et al. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell 2000; 102: 43-53.
    • (2000) Cell , vol.102 , pp. 43-53
    • Verhagen, A.M.1    Ekert, P.G.2    Pakusch, M.3    Silke, J.4    Connolly, L.M.5    Reid, G.E.6
  • 3
    • 77954930632 scopus 로고    scopus 로고
    • IAPs: From caspase inhibitors to modulators of NF-kappaB, inflammation and cancer
    • Gyrd-Hansen M, Meier P. IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer. Nat Rev Cancer 2010; 10: 561-574.
    • (2010) Nat Rev Cancer , vol.10 , pp. 561-574
    • Gyrd-Hansen, M.1    Meier, P.2
  • 4
    • 34250880206 scopus 로고    scopus 로고
    • SMAC/Diablo mediates the pro-apoptotic function of PUMA by regulating PUMA-induced mitochondrial events
    • Yu J, Wang P, Ming L, Wood MA, Zhang L. SMAC/Diablo mediates the pro-apoptotic function of PUMA by regulating PUMA-induced mitochondrial events. Oncogene 2007; 26: 4189-4198.
    • (2007) Oncogene , vol.26 , pp. 4189-4198
    • Yu, J.1    Wang, P.2    Ming, L.3    Wood, M.A.4    Zhang, L.5
  • 5
    • 79954623871 scopus 로고    scopus 로고
    • Smac modulates chemosensitivity in head and neck cancer cells through the mitochondrial apoptotic pathway
    • Sun Q, Zheng X, Zhang L, Yu J. Smac modulates chemosensitivity in head and neck cancer cells through the mitochondrial apoptotic pathway. Clin Cancer Res 2011; 17: 2361-2372.
    • (2011) Clin Cancer Res , vol.17 , pp. 2361-2372
    • Sun, Q.1    Zheng, X.2    Zhang, L.3    Yu, J.4
  • 6
    • 10044265235 scopus 로고    scopus 로고
    • SMAC/Diablo-dependent apoptosis induced by nonsteroidal antiinflammatory drugs (NSAIDs) in colon cancer cells
    • Kohli M, Yu J, Seaman C, Bardelli A, Kinzler KW, Vogelstein B et al. SMAC/Diablo-dependent apoptosis induced by nonsteroidal antiinflammatory drugs (NSAIDs) in colon cancer cells. Proc Natl Acad Sci USA 2004; 101: 16897-16902.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 16897-16902
    • Kohli, M.1    Yu, J.2    Seaman, C.3    Bardelli, A.4    Kinzler, K.W.5    Vogelstein, B.6
  • 7
    • 39149102155 scopus 로고    scopus 로고
    • SMAC mimetics sensitize nonsteroidal anti-inflammatory drug-induced apoptosis by promoting caspase-3-mediated cytochrome c release
    • Bank A, Wang P, Du C, Yu J, Zhang L. SMAC mimetics sensitize nonsteroidal anti-inflammatory drug-induced apoptosis by promoting caspase-3-mediated cytochrome c release. Cancer Res 2008; 68: 276-284.
    • (2008) Cancer Res , vol.68 , pp. 276-284
    • Bank, A.1    Wang, P.2    Du, C.3    Yu, J.4    Zhang, L.5
  • 8
    • 0036341291 scopus 로고    scopus 로고
    • Smac agonists sensitize for Apo2L/TRAIL-or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo
    • Fulda S, Wick W, Weller M, Debatin KM. Smac agonists sensitize for Apo2L/TRAIL-or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo. Nat Med 2002; 8: 808-815.
    • (2002) Nat Med , vol.8 , pp. 808-815
    • Fulda, S.1    Wick, W.2    Weller, M.3    Debatin, K.M.4
  • 9
    • 0036233590 scopus 로고    scopus 로고
    • Generation and characterization of Smac/DIABLO-deficient mice
    • Okada H, Suh WK, Jin J, Woo M, Du C, Elia A et al. Generation and characterization of Smac/DIABLO-deficient mice. Mol Cell Biol 2002; 22: 3509-3517.
    • (2002) Mol Cell Biol , vol.22 , pp. 3509-3517
    • Okada, H.1    Suh, W.K.2    Jin, J.3    Woo, M.4    Du, C.5    Elia, A.6
  • 11
    • 80051689473 scopus 로고    scopus 로고
    • Role of smac in determining the chemotherapeutic response of esophageal squamous cell carcinoma
    • Xu Y, Zhou L, Huang J, Liu F, Yu J, Zhan Q et al. Role of smac in determining the chemotherapeutic response of esophageal squamous cell carcinoma. Clin Cancer Res 2011; 17: 5412-5422.
    • (2011) Clin Cancer Res , vol.17 , pp. 5412-5422
    • Xu, Y.1    Zhou, L.2    Huang, J.3    Liu, F.4    Yu, J.5    Zhan, Q.6
  • 12
    • 62849124148 scopus 로고    scopus 로고
    • Clinical significance of Smac/DIABLO expression in colorectal cancer
    • Endo K, Kohnoe S, Watanabe A, Tashiro H, Sakata H, Morita M et al. Clinical significance of Smac/DIABLO expression in colorectal cancer. Oncol Rep 2009; 21: 351-355.
    • (2009) Oncol Rep , vol.21 , pp. 351-355
    • Endo, K.1    Kohnoe, S.2    Watanabe, A.3    Tashiro, H.4    Sakata, H.5    Morita, M.6
  • 14
    • 36048999753 scopus 로고    scopus 로고
    • IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis
    • Varfolomeev E, Blankenship JW, Wayson SM, Fedorova AV, Kayagaki N, Garg P et al. IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis. Cell 2007; 131: 669-681.
    • (2007) Cell , vol.131 , pp. 669-681
    • Varfolomeev, E.1    Blankenship, J.W.2    Wayson, S.M.3    Fedorova, A.V.4    Kayagaki, N.5    Garg, P.6
  • 15
    • 37549000486 scopus 로고    scopus 로고
    • A Smac mimetic rescue screen reveals roles for inhibitor of apoptosis proteins in tumor necrosis factor-alpha signaling
    • Gaither A, Porter D, Yao Y, Borawski J, Yang G, Donovan J et al. A Smac mimetic rescue screen reveals roles for inhibitor of apoptosis proteins in tumor necrosis factor-alpha signaling. Cancer Res 2007; 67: 11493-11498.
    • (2007) Cancer Res , vol.67 , pp. 11493-11498
    • Gaither, A.1    Porter, D.2    Yao, Y.3    Borawski, J.4    Yang, G.5    Donovan, J.6
  • 16
    • 36148954336 scopus 로고    scopus 로고
    • IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis
    • Vince JE, Wong WW, Khan N, Feltham R, Chau D, Ahmed AU et al. IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis. Cell 2007; 131: 682-693.
    • (2007) Cell , vol.131 , pp. 682-693
    • Vince, J.E.1    Wong, W.W.2    Khan, N.3    Feltham, R.4    Chau, D.5    Ahmed, A.U.6
  • 17
    • 43049152912 scopus 로고    scopus 로고
    • TNF alpha induces two distinct caspase-8 activation pathways
    • Wang L, Du F, Wang X. TNF alpha induces two distinct caspase-8 activation pathways. Cell 2008; 133: 693-703.
    • (2008) Cell , vol.133 , pp. 693-703
    • Wang, L.1    Du, F.2    Wang, X.3
  • 20
    • 34249287671 scopus 로고    scopus 로고
    • Epidemiology of colonic aberrant crypt foci: Review and analysis of existing studies
    • Stevens RG, Swede H, Rosenberg DW. Epidemiology of colonic aberrant crypt foci: review and analysis of existing studies. Cancer Lett 2007; 252: 171-183.
    • (2007) Cancer Lett , vol.252 , pp. 171-183
    • Stevens, R.G.1    Swede, H.2    Rosenberg, D.W.3
  • 21
    • 33746808398 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling in development and disease
    • Clevers H. Wnt/beta-catenin signaling in development and disease. Cell 2006; 127: 469-480.
    • (2006) Cell , vol.127 , pp. 469-480
    • Clevers, H.1
  • 22
    • 0034122380 scopus 로고    scopus 로고
    • Frequent mutations of the beta-catenin gene in mouse colon tumors induced by azoxymethane
    • Takahashi M, Nakatsugi S, Sugimura T, Wakabayashi K. Frequent mutations of the beta-catenin gene in mouse colon tumors induced by azoxymethane. Carcino-genesis 2000; 21: 1117-1120.
    • (2000) Carcino-genesis , vol.21 , pp. 1117-1120
    • Takahashi, M.1    Nakatsugi, S.2    Sugimura, T.3    Wakabayashi, K.4
  • 23
    • 0030018556 scopus 로고    scopus 로고
    • Early alterations of apoptosis and cell proliferation in azoxymethane-initiated rat colonic epithelium
    • Hirose Y, Yoshimi N, Makita H, Hara A, Tanaka T, Mori H. Early alterations of apoptosis and cell proliferation in azoxymethane-initiated rat colonic epithelium. Jpn J Cancer Res 1996; 87: 575-582.
    • (1996) Jpn J Cancer Res , vol.87 , pp. 575-582
    • Hirose, Y.1    Yoshimi, N.2    Makita, H.3    Hara, A.4    Tanaka, T.5    Mori, H.6
  • 24
    • 79955501236 scopus 로고    scopus 로고
    • PUMAmediated intestinal epithelial apoptosis contributes to ulcerative colitis in humans and mice
    • Qiu W, Wu B, Wang X, Buchanan ME, Regueiro MD, Hartman DJ et al. PUMAmediated intestinal epithelial apoptosis contributes to ulcerative colitis in humans and mice. J Clin Invest 2011; 121: 1722-1732.
    • (2011) J Clin Invest , vol.121 , pp. 1722-1732
    • Qiu, W.1    Wu, B.2    Wang, X.3    Buchanan, M.E.4    Regueiro, M.D.5    Hartman, D.J.6
  • 25
    • 0026562404 scopus 로고
    • Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene
    • Su LK, Kinzler KW, Vogelstein B, Preisinger AC, Moser AR, Luongo C et al. Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science 1992; 256: 668-670.
    • (1992) Science , vol.256 , pp. 668-670
    • Su, L.K.1    Kinzler, K.W.2    Vogelstein, B.3    Preisinger, A.C.4    Moser, A.R.5    Luongo, C.6
  • 26
    • 78650569570 scopus 로고    scopus 로고
    • Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis
    • Qiu W, Wang X, Leibowitz B, Liu H, Barker N, Okada H et al. Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis. Proc Natl Acad Sci USA 2010; 107: 20027-20032.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 20027-20032
    • Qiu, W.1    Wang, X.2    Leibowitz, B.3    Liu, H.4    Barker, N.5    Okada, H.6
  • 27
    • 77955376177 scopus 로고    scopus 로고
    • Overcoming cancer cell resistance to Smac mimetic induced apoptosis by modulating cIAP-2 expression
    • Petersen SL, Peyton M, Minna JD, Wang X. Overcoming cancer cell resistance to Smac mimetic induced apoptosis by modulating cIAP-2 expression. Proc Natl Acad Sci USA 2010; 107: 11936-11941.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 11936-11941
    • Petersen, S.L.1    Peyton, M.2    Minna, J.D.3    Wang, X.4
  • 28
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144: 646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 30
    • 16244377737 scopus 로고    scopus 로고
    • Posttranscrip-tional downregulation of c-IAP2 by the ubiquitin protein ligase c-IAP1 in vivo
    • Conze DB, Albert L, Ferrick DA, Goeddel DV, Yeh WC, Mak T et al. Posttranscrip-tional downregulation of c-IAP2 by the ubiquitin protein ligase c-IAP1 in vivo. Mol Cell Biol 2005; 25: 3348-3356.
    • (2005) Mol Cell Biol , vol.25 , pp. 3348-3356
    • Conze, D.B.1    Albert, L.2    Ferrick, D.A.3    Goeddel, D.V.4    Yeh, W.C.5    Mak, T.6
  • 31
    • 4043088499 scopus 로고    scopus 로고
    • IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer
    • Greten FR, Eckmann L, Greten TF, Park JM, Li ZW, Egan LJ et al. IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 2004; 118: 285-296.
    • (2004) Cell , vol.118 , pp. 285-296
    • Greten, F.R.1    Eckmann, L.2    Greten, T.F.3    Park, J.M.4    Li, Z.W.5    Egan, L.J.6
  • 32
    • 57749093121 scopus 로고    scopus 로고
    • Inflammation and stem cells in gastrointestinal carcino-genesis
    • Quante M, Wang TC. Inflammation and stem cells in gastrointestinal carcino-genesis. Physiology 2008; 23: 350-359.
    • (2008) Physiology , vol.23 , pp. 350-359
    • Quante, M.1    Wang, T.C.2
  • 33
    • 77950346282 scopus 로고    scopus 로고
    • Immunity, inflammation, and cancer
    • Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell 2010; 140: 883-899.
    • (2010) Cell , vol.140 , pp. 883-899
    • Grivennikov, S.I.1    Greten, F.R.2    Karin, M.3
  • 34
    • 79959944892 scopus 로고    scopus 로고
    • Constitutive IKK2 activation in intestinal epithelial cells induces intestinal tumors in mice
    • Vlantis K, Wullaert A, Sasaki Y, Schmidt-Supprian M, Rajewsky K, Roskams T et al. Constitutive IKK2 activation in intestinal epithelial cells induces intestinal tumors in mice. J Clin Invest 2011; 121: 2781-2793.
    • (2011) J Clin Invest , vol.121 , pp. 2781-2793
    • Vlantis, K.1    Wullaert, A.2    Sasaki, Y.3    Schmidt-Supprian, M.4    Rajewsky, K.5    Roskams, T.6
  • 35
    • 34447296425 scopus 로고    scopus 로고
    • Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88
    • Rakoff-Nahoum S, Medzhitov R. Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science 2007; 317: 124-127.
    • (2007) Science , vol.317 , pp. 124-127
    • Rakoff-Nahoum, S.1    Medzhitov, R.2
  • 36
    • 38849171267 scopus 로고    scopus 로고
    • Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis
    • Popivanova BK, Kitamura K, Wu Y, Kondo T, Kagaya T, Kaneko S et al. Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis. J Clin Invest 2008; 118: 560-570.
    • (2008) J Clin Invest , vol.118 , pp. 560-570
    • Popivanova, B.K.1    Kitamura, K.2    Wu, Y.3    Kondo, T.4    Kagaya, T.5    Kaneko, S.6
  • 38
    • 34250344092 scopus 로고    scopus 로고
    • Loss of functional Fas ligand enhances intestinal tumorigenesis in the Min mouse model
    • Fingleton B, Carter KJ, Matrisian LM. Loss of functional Fas ligand enhances intestinal tumorigenesis in the Min mouse model. Cancer Res 2007; 67: 4800-4806.
    • (2007) Cancer Res , vol.67 , pp. 4800-4806
    • Fingleton, B.1    Carter, K.J.2    Matrisian, L.M.3
  • 39
    • 76149104286 scopus 로고    scopus 로고
    • Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment
    • Geserick P, Hupe M, Moulin M, Wong WW, Feoktistova M, Kellert B et al. Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment. J Cell Biol 2009; 187: 1037-1054.
    • (2009) J Cell Biol , vol.187 , pp. 1037-1054
    • Geserick, P.1    Hupe, M.2    Moulin, M.3    Wong, W.W.4    Feoktistova, M.5    Kellert, B.6
  • 40
    • 2442520504 scopus 로고    scopus 로고
    • Apoptosis in human cancer cells
    • Yu J, Zhang L. Apoptosis in human cancer cells. Curr Opin Oncol 2004; 16: 19-24.
    • (2004) Curr Opin Oncol , vol.16 , pp. 19-24
    • Yu, J.1    Zhang, L.2
  • 41
    • 77953712167 scopus 로고    scopus 로고
    • Mitochondrial signaling in cell death via the Bcl-2 family
    • Leibowitz B, Yu J. Mitochondrial signaling in cell death via the Bcl-2 family. Cancer Biol Ther 2010; 9: 417-422.
    • (2010) Cancer Biol Ther , vol.9 , pp. 417-422
    • Leibowitz, B.1    Yu, J.2
  • 42
    • 44949240664 scopus 로고    scopus 로고
    • CIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination
    • Bertrand MJ, Milutinovic S, Dickson KM, Ho WC, Boudreault A, Durkin J et al. cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination. Mol Cell 2008; 30: 689-700.
    • (2008) Mol Cell , vol.30 , pp. 689-700
    • Bertrand, M.J.1    Milutinovic, S.2    Dickson, K.M.3    Ho, W.C.4    Boudreault, A.5    Durkin, J.6
  • 44
    • 34247504546 scopus 로고    scopus 로고
    • P53 independent induction of PUMA mediates intestinal apoptosis in response to ischaemia-reperfusion
    • Wu B, Qiu W, Wang P, Yu H, Cheng T, Zambetti GP et al. p53 independent induction of PUMA mediates intestinal apoptosis in response to ischaemia-reperfusion. Gut 2007; 56: 645-654.
    • (2007) Gut , vol.56 , pp. 645-654
    • Wu, B.1    Qiu, W.2    Wang, P.3    Yu, H.4    Cheng, T.5    Zambetti, G.P.6
  • 46
    • 79956006207 scopus 로고    scopus 로고
    • Uncoupling p53 functions in radiation-induced intestinal damage via PUMA and p21
    • Leibowitz BJ, Qiu W, Liu H, Cheng T, Zhang L, Yu J. Uncoupling p53 functions in radiation-induced intestinal damage via PUMA and p21. Mol Cancer Res 2011; 9: 616-625.
    • (2011) Mol Cancer Res , vol.9 , pp. 616-625
    • Leibowitz, B.J.1    Qiu, W.2    Liu, H.3    Cheng, T.4    Zhang, L.5    Yu, J.6
  • 48
    • 34547673238 scopus 로고    scopus 로고
    • Frequent inactivation of RAMP2, EFEMP1 and Dutt1 in lung cancer by promoter hypermethylation
    • Yue W, Dacic S, Sun Q, Landreneau R, Guo M, Zhou W et al. Frequent inactivation of RAMP2, EFEMP1 and Dutt1 in lung cancer by promoter hypermethylation. Clin Cancer Res 2007; 13: 4336-4344.
    • (2007) Clin Cancer Res , vol.13 , pp. 4336-4344
    • Yue, W.1    Dacic, S.2    Sun, Q.3    Landreneau, R.4    Guo, M.5    Zhou, W.6
  • 49
  • 50
    • 69049103034 scopus 로고    scopus 로고
    • PUMA is directly activated by NF-kappaB and contributes to TNF-alpha-induced apoptosis
    • Wang P, Qiu W, Dudgeon C, Liu H, Huang C, Zambetti GP et al. PUMA is directly activated by NF-kappaB and contributes to TNF-alpha-induced apoptosis. Cell Death Differ 2009; 16: 1192-1202.
    • (2009) Cell Death Differ , vol.16 , pp. 1192-1202
    • Wang, P.1    Qiu, W.2    Dudgeon, C.3    Liu, H.4    Huang, C.5    Zambetti, G.P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.