Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 46, 2010, Pages 20027-20032

  Qiu, Wei ^a   Wang, Xinwei ^a   Leibowitz, Brian ^a   Liu, Hongtao ^a   Barker, Nick ^b   Okada, Hitoshi ^c   Oue, Naohide ^d   Yasui, Wataru ^d   Clevers, Hans ^b   Schoen, Robert E ^a   Yu, Jian ^a   Zhang, Lin ^a  

^a UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^b HUBRECHT INSTITUTE   (Netherlands)

^c PRINCESS MARGARET HOSPITAL   (Canada)

^d HIROSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; BETA CATENIN; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; SULINDAC; WNT PROTEIN;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ATTENUATION; CASE REPORT; CHEMOPROPHYLAXIS; COLON CANCER; CONFERENCE PAPER; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; INTESTINAL STEM CELL; INTESTINE CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STEM CELL;

MUS; RODENTIA;

EID: 78650569570     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1010430107     Document Type: Article

References (37)

1. Hong WK, Sporn MB (1997) Recent advances in chemoprevention of cancer. Science 278:1073-1077.
2. Stoner GD (2009) Foodstuffs for preventing cancer: The preclinical and clinical development of berries. Cancer Prev Res (Phila) 2:187-194.
3. Thun MJ, Henley SJ, Patrono C (2002) Nonsteroidal anti-inflammatory drugs as anticancer agents: Mechanistic, pharmacologic, and clinical issues. J Natl Cancer Inst 94:252-266.
4. Rao CV, Reddy BS (2004) NSAIDs and chemoprevention. Curr Cancer Drug Targets 4: 29-42.
5. Vogelstein B, Kinzler KW (2004) Cancer genes and the pathways they control. Nat Med 10:789-799.
6. Su LK, et al. (1992) Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science 256:668-670.
7. Barker N, et al. (2009) Crypt stem cells as the cells-of-origin of intestinalcancer. Nature 457:608-611.
8. Sangiorgi E, Capecchi MR (2008) Bmi1 is expressed in vivo in intestinal stem cells. Nat Genet 40:915-920.
9. Li L, Clevers H (2010) Coexistence of quiescent and active adultstem cells in mammals. Science 327:542-545.
10. Barker N, et al. (2007) Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 449:1003-1007.
11. van der Flier LG, Haegebarth A, Stange DE, van de Wetering M, Clevers H (2009) OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells. Gastroenterology 137:15-17.
12. Yu J, Zhang L (2004) Apoptosis in human cancer cells. Curr Opin Oncol 16:19-24.
13. Sun SY, Hail N, Jr., Lotan R (2004) Apoptosis as a novel target for cancer chemoprevention. J Natl Cancer Inst 96:662-672.
14. Zhang L, Yu J, Park BH, Kinzler KW, Vogelstein B (2000) Role of BAX in the apoptotic response to anticancer agents. Science 290:989-992.
15. Du C, Fang M, Li Y, Li L, Wang X (2000) Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell 102: 33-42.
16. Bank A, Wang P, Du C, Yu J, Zhang L (2008) SMAC mimetics sensitize nonsteroidal anti-inflammatory drug-induced apoptosis by promoting caspase-3-mediated cytochrome c release. Cancer Res 68:276-284.
17. Kohli M, et al. (2004) SMAC/Diablo-dependent apoptosis induced by nonsteroidal antiinflammatory drugs (NSAIDs) in colon cancer cells. Proc Natl Acad Sci USA 101: 16897-16902.
18. Beazer-Barclay Y, et al. (1996) Sulindac suppresses tumorigenesis in the Min mouse. Carcinogenesis 17:1757-1760.
19. McEntee MF, Chiu CH, Whelan J (1999) Relationship of beta-catenin and Bcl-2 expression to sulindac-induced regression of intestinal tumors in Min mice. Carcinogenesis 20:635-640.
20. Corpet DE, Pierre F (2003) Point: From animal models to prevention of colon cancer. Systematic review of chemoprevention in min mice and choice of the model system. Cancer Epidemiol Biomarkers Prev 12:391-400.
21. Qiu W, et al. (2008) PUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndrome. Cell Stem Cell 2:576-583.
22. Shoemaker AR, Gould KA, Luongo C, Moser AR, Dove WF (1997) Studies of neoplasia in the Min mouse. Biochim Biophys Acta 1332:F25-F48.
23. Clevers H (2006) Wnt/beta-catenin signaling in development and disease. Cell 127: 469-480.
24. He XC, et al. (2007) PTEN-deficient intestinal stem cells initiate intestinal polyposis. Nat Genet 39:189-198.
25. Oue N, et al. (2009) Serum olfactomedin 4 (GW112, hGC-1) in combination with Reg IV is a highly sensitive biomarker for gastric cancer patients. Int J Cancer 125: 2383-2392.
26. Rosen JM, Jordan CT (2009) The increasing complexity of the cancer stem cell paradigm. Science 324:1670-1673.
27. Yu J (2009) PUMA kills stem cells to stall cancer? Mol Cell Pharmacol (Windsor Mill) 1: 112-118.
28. Hall PA, Coates PJ, Ansari B, Hopwood D (1994) Regulation of cell number in the mammalian gastrointestinal tract: The importance of apoptosis. J Cell Sci 107: 3569-3577.
29. Keller JJ, Giardiello FM (2003) Chemoprevention strategies using NSAIDs and COX-2 inhibitors. Cancer Biol Ther 2(suppl 1):S140-S149.
30. Deng Y, Ren X, Yang L, Lin Y, Wu X (2003) A JNK-dependent pathway is required for TNFalpha-induced apoptosis. Cell 115:61-70.
31. Zhang L, et al. (2010) Chemoprevention of colorectal cancer by targeting APC-deficient cells for apoptosis. Nature 464:1058-1061.
32. Yu J, et al. (2007) Induced pluripotent stem cell lines derived from human somatic cells. Science 318:1917-1920.
33. Hermeking H, Eick D (1994) Mediation of c-Myc-induced apoptosis by p53. Science 265:2091-2093.
34. Meyskens FL, Jr., et al. (2008) Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: Arandomized placebo-controlled, double-blind trial. Cancer Prev Res (Phila) 1:32-38.
35. Okada H, et al. (2002) Generation and characterization of Smac/DIABLO-deficient mice. Mol Cell Biol 22:3509-3517.
36. Qiu W, Carson-Walter EB, Kuan SF, Zhang L, Yu J (2009) PUMA suppresses intestinal tumorigenesis in mice. Cancer Res 69:4999-5006.
37. Qiu W, Leibowitz B, Zhang L, Yu J (2010) Growth factors protect intestinal stem cells from radiation-induced apoptosis by suppressing PUMA through the PI3K/AKT/p53 axis. Oncogene 29:1622-1632.