Activation of the alternative complement pathway by mannose-binding lectin via a C2-bypass pathway

Microbiology and Immunology

Volumn 55, Issue 11, 2011, Pages 817-821

  Tateishi, Koichiro ^a   Matsushita, Misao ^a  

^a TOKAI UNIVERSITY   (Japan)

Author keywords

Alternative pathway; Complement; Mannose binding lectin

Indexed keywords

ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; COMPLEMENT COMPONENT C2; COMPLEMENT COMPONENT C3B; COMPLEMENT COMPONENT C4; COMPLEMENT COMPONENT C4B; MANNAN BINDING LECTIN ASSOCIATED SERINE PROTEINASE; MANNOSE BINDING LECTIN; OLIGOSACCHARIDE; PROTEIN MASP 1; PROTEIN MASP 2; PROTEIN MASP 3; UNCLASSIFIED DRUG;

ASPERGILLUS; COMPLEMENT ACTIVATION; COMPLEMENT ALTERNATIVE PATHWAY; COMPLEMENT C2 BYPASS PATHWAY; COMPLEMENT CLASSICAL PATHWAY; COMPLEMENT DEPOSITION; COMPLEMENT LECTIN PATHWAY; COMPLEMENT SYSTEM; COMPLEX FORMATION; CONIDIUM; CONTROLLED STUDY; HUMAN; NOTE; SALMONELLA;

COMPLEMENT ACTIVATION; COMPLEMENT C2; COMPLEMENT C4; COMPLEMENT PATHWAY, ALTERNATIVE; HUMANS; MANNOSE-BINDING LECTIN; MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE PROTEASES; SALMONELLA;

SALMONELLA;

EID: 81155123215     PISSN: 03855600     EISSN: 13480421     Source Type: Journal    
DOI: 10.1111/j.1348-0421.2011.00378.x     Document Type: Note

References (20)

1. Ricklin D., Hajishengallis G., Yang K., Lambris J.D. (2010) Complement: a key system for immune surveillance and homeostasis. Nat Immunol 11: 785-97.
2. Fujita T., Matsushita M., Endo Y. (2004) The lectin-complement pathway--its role in innate immunity and evolution. Immunol Rev 198:185-202.
3. Ip W.K., Takahashi K., Ezekowitz R.A., Stuart L.M. (2009) Mannose-binding lectin and innate immunity. Immunol Rev 230: 9-21.
4. Matsushita M., Fujita T. (1992) Activation of the classical complement pathway by mannose-binding protein in association with a novel C1s-like serine protease. J Exp Med 176: 1497-502.
5. Sato T., Endo Y., Matsushita M., Fujita T. (1994) Molecular characterization of a novel serine protease involved in activation of the complement system by mannose-binding protein. Int Immunol 6: 665-9.
6. Thiel, S., Vorup-Jensen, T., Stover, C.M., Schwaeble, W., Laursen, S.B., Poulsen, K., Willis, A.C., Eggleton, P., Hansen, S., Holmskov, U., Reid, K.B., Jensenius, J.C. (1997) A second serine protease associated with mannan-binding lectin that activates complement. Nature 386: 506-10.
7. Dahl M.R., Thiel S., Matsushita M., Fujita T., Willis A.C., Christensen T., Vorup-Jensen T., Jensenius J.C. (2001) MASP-3 and its association with distinct complexes of the mannan-binding lectin complement activation pathway. Immunity 15: 127-35.
8. Takahashi M., Endo Y., Fujita T., Matsushita M. (1999) A truncated form of mannose-binding lectin-associated serine protease (MASP)-2 expressed by alternative polyadenylation is a component of the lectin complement pathway. Int Immunol 11: 859-63.
9. Stover C.M., Thiel S., Thelen M., Lynch N.J., Vorup-Jensen T., Jensenius J.C., Schwaeble W.J. (1999) Two constituents of the initiation complex of the mannan-binding lectin activation pathway of complement are encoded by a single structural gene. J Immunol 162: 3481-90.
10. Degn S.E., Hansen A.G., Steffensen R., Jacobsen C., Jensenius J.C., Thiel S. (2009) MAp44, a human protein associated with pattern recognition molecules of the complement system and regulating the lectin pathway of complement activation. J Immunol 183: 7371-8.
11. Skjoedt M.O., Hummelshoj T., Palarasah Y., Honore C., Koch C., Skjodt K., Garred P. (2010) A novel mannose-binding lectin/ficolin-associated protein is highly expressed in heart and skeletal muscle tissues and inhibits complement activation. J Biol Chem 285: 8234-43.
12. Vorup-Jensen T., Petersen S.V., Hansen A.G., Poulsen K., Schwaeble W., Sim R.B, Reid K.B., Davis S.J, Thiel S., Jensenius J.C. (2000) Distinct pathways of mannan-binding lectin (MBL)- and C1-complex autoactivation revealed by reconstitution of MBL with recombinant MBL-associated serine protease-2. J Immunol 165: 2093-100.
13. Matsushita M., Thiel S., Jensenius J.C., Terai I., Fujita T. (2000) Proteolytic activities of two types of mannose-binding lectin-associated serine protease. J Immunol 165: 2637-42.
14. Matsushita M., Okada H. (1986) Alternative pathway activation by C4b deposited during classical pathway activation. J Immunol 136: 2994-8.
15. Farries T.C., Steuer K.L., Atkinson J.P. (1990) The mechanism of activation of the alternative pathway of complement by cell-bound C4b. Mol Immunol 27: 1155-61.
16. Meri S., Pangburn M.K. (1990) A mechanism of activation of the alternative complement pathway by the classical pathway: protection of C3b from inactivation by covalent attachment to C4b. Eur J Immunol 20; 2555-61.
17. Selander B., Martensson U., Weintraub A., Holmstrom E., Matsushita M., Thiel S., Jensenius J.C., Truedsson L., Sjoholm A.G. (2006) Mannan-binding lectin activates C3 and the alternative complement pathway without involvement of C2. J Clin Invest 116: 1425-34.
18. Thiel S., Petersen S.V., Vorup-Jensen T., Matsushita M., Fujita T., Stover C.M., Schwable W.J., Jensenius J.C. (2000) Interaction of C1q and mannan-binding lectin (MBL) with C1r, C1s, MBL-associated serine protease 1 and 2 and small MBL associated protein (MAp19). J Immunol 165: 878-87.
19. Tateishi K., Kanemoto T., Fujita T., Matsushita M. (2011) Characterization of the complex between mannose-binding lectin trimer and mannose-binding lectin-associated serine proteases. Microbiol Immunol 55: 427-33.
20. Dumestre-Perard C., Lamy B., Aldebert D., Lemaire-Vielle C., Grillot R., Brion J-P., Gagnon J., Cesbron J-Y. (2008) Aspergillus Conidia activate the complement by the mannan-binding lectin C2 bypass mechanism. J Immunol 181: 7100-5.