C-reactive protein and complement factor H in aged human eyes and eyes with age-related macular degeneration

British Journal of Ophthalmology

Volumn 95, Issue 9, 2011, Pages 1323-1330

  Bhutto, Imran A ^a   Baba, Takayuki ^a   Merges, Carol ^a   Juriasinghani, Vikash ^a   McLeod, D Scott ^a   Lutty, Gerard A ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; C REACTIVE PROTEIN; CD34 ANTIGEN; COMPLEMENT FACTOR H; IMMUNOGLOBULIN G; POLYCLONAL ANTIBODY;

AGED; AGING; ARTICLE; BRUCH MEMBRANE; CHOROID; CHOROID CAPILLARY LAYER; CHOROID STROMA; CLINICAL ARTICLE; CONTROLLED STUDY; CRYOPRESERVATION; DRUSEN; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOLOCALIZATION; MALE; OPTIC DISK; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RETINA ARTERY; RETINA MACULA AGE RELATED DEGENERATION; RETINA MACULA LUTEA; RETINA VEIN; SUBRETINAL NEOVASCULARIZATION; TISSUE SECTION;

AGED; AGED, 80 AND OVER; AGING; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; COMPLEMENT FACTOR H; DISEASE PROGRESSION; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MACULAR DEGENERATION; MALE; PROGNOSIS; RETINAL PIGMENT EPITHELIUM;

EID: 80052135068     PISSN: 00071161     EISSN: 14682079     Source Type: Journal    
DOI: 10.1136/bjo.2010.199216     Document Type: Article

References (31)

1. Ambati J, Ambati BK, Yoo SH, et al. Age-related macular degeneration: etiology, pathogenesis, and therapeutic strategies. Surv Ophthalmol 2003;48:257-93.
2. Johnson LV, Ozaki S, Staples MK, et al. A potential role for immune complex pathogenesis in drusen formation. Exp Eye Res 2000;70:441-9. (Pubitemid 30662042)
3. Johnson LV, Leitner WP, Staples MK, et al. Complement activation and inflammatory processes in Drusen formation and age Related macular degeneration. Exp Eye Res 2001;73:887-96. (Pubitemid 34112114)
4. Crabb JW, Miyagi M, Gu X, et al. Drusen proteome analysis: an approach to the etiology of age-related macular degeneration. Proc Natl Acad Sci U S A 2002;99:14682-7. (Pubitemid 35334544)
5. Hageman GS, Mullins RF, Russell SR, et al. Vitronectin is a constituent of ocular drusen and the vitronectin gene is expressed in human retinal pigmented epithelial cells. FASEB J 1999;13:477-84. (Pubitemid 29115565)
6. Mullins RF, Russell SR, Anderson DH, et al. Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease. FASEB J 2000;14:835-46. (Pubitemid 30241660)
7. Anderson DH, Mullins RF, Hageman GS, et al. A role for local inflammation in the formation of drusen in the aging eye. Am J Ophthalmol 2002;134:411-31.
8. Pepys MB, Hirschfield GM. C-reactive protein: a critical update. J Clin Invest 2003;111:1805-12.
9. Pearson TA, Mensah GA, Alexander RW, et al. Markers of inflammation and cardiovascular disease: Application of clinical and public health practice: Application of clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation 2003;107:499-511. (Pubitemid 36158056)
10. Dehghan A, Van Hoek M, Sijbrands EJ, et al. Risk of type 2 diabetes attributable to C-reactive protein and other risk factors. Diabetes Care 2007;30:2695-9. (Pubitemid 47547822)
11. Seddon JM, George S, Rosner B, et al. Progression of age-related macular degeneration: prospective assessment of C-reactive protein, interleukin 6, and other cardiovascular biomarkers. Arch Ophthalmol 2005;123:774-82. (Pubitemid 41056598)
12. Kaplan MH, Volanakis JE. Interaction of C-reactive protein complexes with the complement system. 1. Consumption of human complement associated with the reaction of C-reactive protein with pneumococcal C-polysaccharide and with the choline phosphatides, lecithin and sphingomyelin. J Immunol 1974;112:2135-47.
13. Barna BP, Deodhar SD, Gautam S, et al. Macrophage activation and generation of tumoricidal activity by liposome-associated human C-reactive protein. Cancer Res 1984;44:305-10. (Pubitemid 14177755)
14. Fiedel BA. Platelet agonist synergism by the acute phase reactant C-reactive protein. Blood 1985;65:264-9. (Pubitemid 15163559)
15. Rodriguez de Cordoba S, Esparza-Gordillo J, Goicoechea de Jorge E, et al. The human complement factor H: Functional roles, genetic variations and disease associations. Mol Immunol 2004;41:355-67. (Pubitemid 38639887)
16. Hageman GS, Anderson DH, Johnson LV, et al. A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proc Natl Acad Sci U S A 2005;102:7227-32. (Pubitemid 40696361)
17. Edwards AO, Ritter R 3rd, Abel KJ, et al. Complement factor H polymorphism and age related macular degeneration. Science 2005;308:421-4. (Pubitemid 40530082)
18. Haines JL, Hauser MA, Schmidt S, et al. Complement factor H variant increases the risk of age-related macular degeneration. Science 2005;308:419-21. (Pubitemid 40530081)
19. Klein RJ, Zeiss C, Chew EY, et al. Complement factor H polymorphism in age-related macular degeneration. Science 2005;308:385-9. (Pubitemid 40530070)
20. Johnson PT, Betts KE, Radeke MJ, et al. Individuals homozygous for the age-related macular degeneration risk-conferring variant of complement factor H have elevated levels of CRP in the choroid. Proc Natl Acad Sci U S A 2006;103:17456-61. (Pubitemid 44788990)
21. Anderson DH, Radeke MJ, Gallo NB, et al. The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited. Prog Retin Eye Res 2010;29:95-112.
22. Lutty GA, Merges C, Threlkeld AB, et al. Heterogeneity in localization of isoforms of TGF-beta in human retina, vitreous, and choroid. Invest Ophthalmol Vis Sci 1993;34:477-87. (Pubitemid 23095198)
23. Bhutto IA, Kim SY, McLeod DS, et al. Localization of collagen XVIII and the endostatin portion of collagen XVIII in aged human control eyes and eyes with age-related macular degeneration. Invest Ophthalmol Vis Sci 2004;45:1544-52. (Pubitemid 38859336)
24. Yeh ET. CRP as a mediator of disease. Circulation 2004;109:11-14.
25. Devaraj S, Du Clos TW, Jialal I. Binding and internalization of C-reactive protein by Fcgamma receptors on human aortic endothelial cells mediates biological effects. Arterioscler Thromb Vasc Biol 2005;26:1359-63. (Pubitemid 40923352)
26. Devaraj S, Davis B, Simon SI, et al. CRP promotes monocyte-endothelial cell adhesion via Fcgamma receptors in human aortic endothelial cells under static and shear flow conditions. Am J Physiol Heart Circ Physiol 2006;291:H170-6.
27. McLeod DS, Grebe R, Bhutto I, et al. Relationship between RPE and choriocapillaris in age-related macular degeneration. Invest Ophthalmol Vis Sci 2009;50:4982-91.
28. Mullins RF, Skeie JM, Malone EA, et al. Macular and peripheral distribution of ICAM- 1 in the human choriocapillaris and retina. Mol Vis 2006;12:224-35.
29. Venugopal SK, Devaraj S, Yuhanna I, et al. Demonstration that C-reactive protein decreases eNOS expression and bioactivity in human aortic endothelial cells. Circulation 2002;106:1439-41.
30. Bhutto IA, Baba T, Merges C, et al. Low nitric oxide synthases (NOSs) in eyes with age-related macular degeneration (AMD). Exp Eye Res 2010;90:155-67.
31. Chen M, Forrester JV, Xu H. Synthesis of complement factor H by retinal pigment epithelial cells is down-regulated by oxidized photoreceptor outer segments. Exp Eye Res 2007;84:635-45. (Pubitemid 46400631)