VEGF modulation of retinal pigment epithelium resistance

Experimental Eye Research

Volumn 85, Issue 6, 2007, Pages 762-771

  Ablonczy, Zsolt ^a   Crosson, Craig E ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

macular edema; polarity; receptor; resistance; RPE; tight junction; VEGF

Indexed keywords

GENISTEIN; SEMAXANIB; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN E; VASCULOTROPIN INHIBITOR; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; ZM 323881;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLOOD RETINA BARRIER; CELL ADHESION; CELL MEMBRANE PERMEABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIABETIC RETINOPATHY; NONHUMAN; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RETINA MACULA AGE RELATED DEGENERATION; RETINA MACULA EDEMA; SWINE;

ANIMALS; CELL LINE; CELL MEMBRANE PERMEABILITY; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC IMPEDANCE; HUMANS; INDOLES; PIGMENT EPITHELIUM OF EYE; PYRROLES; QUINAZOLINES; RETINA; SUS SCROFA; TIGHT JUNCTIONS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 36448935689     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2007.08.010     Document Type: Article

References (36)

1. Antcliff R.J., and Marshall J. The pathogenesis of edema in diabetic maculopathy. Semin. Ophthalmol. 14 4 (1999) 223-232
2. Autiero M., Waltenberger J., Communi D., Kranz A., Moons L., Lambrechts D., Kroll J., Plaisance S., De Mol M., Bono F., Kliche S., Fellbrich G., Ballmer-Hofer K., Maglione D., Mayr-Beyrle U., Dewerchin M., Dombrowski S., Stanimirovic D., Van Hummelen P., Dehio C., Hicklin D.J., Persico G., Herbert J.M., Shibuya M., Collen D., Conway E.M., and Carmeliet P. Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1. Nat. Med. 9 7 (2003) 936-943
3. Barber A.J., and Antonetti D.A. Mapping the blood vessels with paracellular permeability in the retinas of diabetic rats. Invest. Ophthalmol. Vis. Sci. 44 12 (2003) 5410-5416
4. Becker P.M., Waltenberger J., Yachechko R., Mirzapoiazova T., Sham J.S., Lee C.G., Elias J.A., and Verin A.D. Neuropilin-1 regulates vascular endothelial growth factor-mediated endothelial permeability. Circ. Res. 96 12 (2005) 1257-1265
5. Blaauwgeers H.G., Holtkamp G.M., Rutten H., Witmer A.N., Koolwijk P., Partanen T.A., Alitalo K., Kroon M.E., Kijlstra A., van Hinsbergh V.W., and Schlingemann R.O. Polarized vascular endothelial growth factor secretion by human retinal pigment epithelium and localization of vascular endothelial growth factor receptors on the inner choriocapillaris. Evidence for a trophic paracrine relation. Am. J. Pathol. 155 2 (1999) 421-428
6. Cai J., Jiang W.G., Grant M.B., and Boulton M. Pigment epithelium-derived factor inhibits angiogenesis via regulated intracellular proteolysis of vascular endothelial growth factor receptor 1. J. Biol. Chem. 281 6 (2006) 3604-3613
7. Caldwell R.B., Bartoli M., Behzadian M.A., El-Remessy A.E., Al-Shabrawey M., Platt D.H., Liou G.I., and Caldwell R.W. Vascular endothelial growth factor and diabetic retinopathy: role of oxidative stress. Curr. Drug Targets 6 4 (2005) 511-524
8. Davis R.J. Transcriptional regulation by MAP kinases. Mol. Reprod. Dev. 42 4 (1995) 459-467
9. Dunn K.C., Aotaki-Keen A.E., Putkey F.R., and Hjelmeland L.M. ARPE-19, a human retinal pigment epithelial cell line with differentiated properties. Exp. Eye Res. 62 2 (1996) 155-169
10. Geisen P., McColm J.R., King B.M., and Hartnett M.E. Characterization of barrier properties and inducible VEGF expression of several types of retinal pigment epithelium in medium-term culture. Curr. Eye Res. 31 9 (2006) 739-748
11. - and mediates trans-epithelial resistance in cultured endothelial and epithelial cells. Cell Tissue Res. 323 1 (2006) 117-125
12. Gille H., Kowalski J., Li B., LeCouter J., Moffat B., Zioncheck T.F., Pelletier N., and Ferrara N. Analysis of biological effects and signaling properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2). A reassessment using novel receptor-specific vascular endothelial growth factor mutants. J. Biol. Chem. 276 5 (2001) 3222-3230
13. Glass C.A., Harper S.J., and Bates D.O. The anti-angiogenic VEGF isoform VEGF165b transiently increases hydraulic conductivity, probably through VEGF receptor 1 in vivo. J. Physiol. 572 Pt 1 (2006) 243-257
14. Gragoudas E.S., Adamis A.P., Cunningham Jr. E.T., Feinsod M., and Guyer D.R. Pegaptanib for neovascular age-related macular degeneration. N. Engl. J. Med. 351 27 (2004) 2805-2816
15. Hartnett M.E., Lappas A., Darland D., McColm J.R., Lovejoy S., and D'Amore P.A. Retinal pigment epithelium and endothelial cell interaction causes retinal pigment epithelial barrier dysfunction via a soluble VEGF-dependent mechanism. Exp. Eye Res. 77 5 (2003) 593-599
16. Heier J.S., Antoszyk A.N., Pavan P.R., Leff S.R., Rosenfeld P.J., Ciulla T.A., Dreyer R.F., Gentile R.C., Sy J.P., Hantsbarger G., and Shams N. Ranibizumab for treatment of neovascular age-related macular degeneration: a phase I/II multicenter, controlled, multidose study. Ophthalmology 113 4 (2006) e641-e644 642
17. Jin M., Barron E., He S., Ryan S.J., and Hinton D.R. Regulation of RPE intercellular junction integrity and function by hepatocyte growth factor. Invest. Ophthalmol. Vis. Sci. 43 8 (2002) 2782-2790
18. Kannan R., Zhang N., Sreekumar P.G., Spee C.K., Rodriguez A., Barron E., and Hinton D.R. Stimulation of apical and basolateral VEGF-A and VEGF-C secretion by oxidative stress in polarized retinal pigment epithelial cells. Mol. Vis. 12 (2006) 1649-1659
19. Konari K., Sawada N., Zhong Y., Isomura H., Nakagawa T., and Mori M. Development of the blood-retinal barrier in vitro: formation of tight junctions as revealed by occludin and ZO-1 correlates with the barrier function of chick retinal pigment epithelial cells. Exp. Eye Res. 61 1 (1995) 99-108
20. Li Y., and Sarkar F.H. Inhibition of nuclear factor kappaB activation in PC3 cells by genistein is mediated via Akt signaling pathway. Clin. Cancer Res. 8 7 (2002) 2369-2377
21. Maminishkis A., Chen S., Jalickee S., Banzon T., Shi G., Wang F.E., Ehalt T., Hammer J.A., and Miller S.S. Confluent monolayers of cultured human fetal retinal pigment epithelium exhibit morphology and physiology of native tissue. Invest. Ophthalmol. Vis. Sci. 47 8 (2006) 3612-3624
22. Marmor M.F. Mechanisms of fluid accumulation in retinal edema. Doc. Ophthalmol. 97 3-4 (1999) 239-249
23. Marneros A.G., Fan J., Yokoyama Y., Gerber H.P., Ferrara N., Crouch R.K., and Olsen B.R. Vascular endothelial growth factor expression in the retinal pigment epithelium is essential for choriocapillaris development and visual function. Am. J. Pathol. 167 5 (2005) 1451-1459
24. Miyamoto N., de Kozak Y., Jeanny J.C., Glotin A., Mascarelli F., Massin P., Benezra D., and Behar-Cohen F. Placental growth factor-1 and epithelial haemato-retinal barrier breakdown: potential implication in the pathogenesis of diabetic retinopathy. Diabetologia 50 2 (2007) 461-470
25. Neufeld G., Cohen T., Gengrinovitch S., and Poltorak Z. Vascular endothelial growth factor (VEGF) and its receptors. FASEB J. 13 1 (1999) 9-22
26. Nozaki M., Sakurai E., Raisler B.J., Baffi J.Z., Witta J., Ogura Y., Brekken R.A., Sage E.H., Ambati B.K., and Ambati J. Loss of SPARC-mediated VEGFR-1 suppression after injury reveals a novel antiangiogenic activity of VEGF-A. J. Clin. Invest. 116 2 (2006) 422-429
27. Ohno-Matsui K., Yoshida T., Uetama T., Mochizuki M., and Morita I. Vascular endothelial growth factor upregulates pigment epithelium-derived factor expression via VEGFR-1 in human retinal pigment epithelial cells. Biochem. Biophys. Res. Commun. 303 3 (2003) 962-967
28. Pe'er J., Shweiki D., Itin A., Hemo I., Gnessin H., and Keshet E. Hypoxia-induced expression of vascular endothelial growth factor by retinal cells is a common factor in neovascularizing ocular diseases. Lab. Invest. 72 6 (1995) 638-645
29. Schneeberger E.E., and Lynch R.D. The tight junction: a multifunctional complex. Am. J. Physiol. Cell Physiol 286 6 (2004) C1213-C1228
30. Shen B.Q., Lee D.Y., and Zioncheck T.F. Vascular endothelial growth factor governs endothelial nitric-oxide synthase expression via a KDR/Flk-1 receptor and a protein kinase C signaling pathway. J. Biol. Chem. 274 46 (1999) 33057-33063
31. Slomiany M.G., and Rosenzweig S.A. IGF-1-induced VEGF and IGFBP-3 secretion correlates with increased HIF-1 alpha expression and activity in retinal pigment epithelial cell line D407. Invest. Ophthalmol. Vis. Sci. 45 8 (2004) 2838-2847
32. Spaide R.F., Laud K., Fine H.F., Klancnik Jr. J.M., Meyerle C.B., Yannuzzi L.A., Sorenson J., Slakter J., Fisher Y.L., and Cooney M.J. Intravitreal bevacizumab treatment of choroidal neovascularization secondary to age-related macular degeneration. Retina 26 4 (2006) 383-390
33. Tranos P.G., Wickremasinghe S.S., Stangos N.T., Topouzis F., Tsinopoulos I., and Pavesio C.E. Macular edema. Surv. Ophthalmol. 49 5 (2004) 470-490
34. Yamazaki Y., and Morita T. Molecular and functional diversity of vascular endothelial growth factors. Mol. Divers 10 4 (2006) 515-527
35. Zachary I. Signaling mechanisms mediating vascular protective actions of vascular endothelial growth factor. Am. J. Physiol. Cell Physiol. 280 6 (2001) C1375-C1386
36. Zech J.C., Pouvreau I., Cotinet A., Goureau O., Le Varlet B., and de Kozak Y. Effect of cytokines and nitric oxide on tight junctions in cultured rat retinal pigment epithelium. Invest. Ophthalmol. Vis. Sci. 39 9 (1998) 1600-1608