Chaperone peptides of α-crystallin inhibit epithelial cell apoptosis, protein insolubilization, and opacification in experimental cataracts

Journal of Biological Chemistry

Volumn 288, Issue 18, 2013, Pages 13022-13035

  Nahomi, Rooban B ^a   Wang, Benlian ^a   Raghavan, Cibin T ^a   Voss, Oliver ^b   Doseff, Andrea I ^b   Santhoshkumar, Puttur ^c   Nagaraj, Ram H ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c University of Missouri   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELL DEATH; MAMMALS;

APOPTOSIS PROTEINS; CELL APOPTOSIS; CRYSTALLIN; EPITHELIAL CELLS; OPACIFICATION; PROTEIN FAMILY; SMALL HEAT SHOCK PROTEINS; STRESS-INDUCED; Α-CRYSTALLINS; ΑB-CRYSTALLIN;

PEPTIDES;

ACETIC ACID DERIVATIVE; AGENTS ACTING ON THE EYE; ALPHA CRYSTALLIN; ASPARTYLARGINYLPHENYLALANYLSERYLVALYLASPARAGYLLEUCYLASPARTYLVALYLLYSYLHISTIDYLPHENYLALANYLSERYLPROLYLGLUTAMYLGLUTAMYLLEUCYLLYSYLVALYLLYSYLACETYLVALINE; ASPARTYLARGINYLPHENYLALANYLSERYLVALYLASPARAGYLLEUCYLASPARTYLVALYLLYSYLHISTIDYLPHENYLALANYLSERYLPROLYLGLUTAMYLGLUTAMYLLEUCYLLYSYLVALYLLYSYLVALINE; ASPARTYLLYSYLACETYLPHENYLALANYLVALYLISOLEUCYLPHENYLALANYLLEUCYLASPARTYLVALYLLYSYLHISTIDYLPHENYLALANYLSERYLPROLYLGLUTAMYLASPARTYLLEUCYLTHREONYLVALYLLYSINE; ASPARTYLLYSYLPHENYLALANYLVALYLISOLEUCYLPHENYLALANYLLEUCYLASPARTYLVALYLLYSYLHISTIDYLPHENYLALANYLSERYLPROLYLGLUTAMYLASPARTYLLEUCYLTHREONYLVALYLLYSINE; ASPARTYLPHENYLALANYLVALYLISOLEUCYLASPARTYLSERYLPROLYLPHENYALANYLLYSYLLEUCYLVALYLASPARTYLLEUCYLGLUTAMYLLYSYLVALYLHISTIDYLPHENYLALANYLTHREONYLLYSINE; BETA CRYSTALLIN; CALCIMYCIN; CASPASE 3; CASPASE 9; CHAPERONE; CYTOCHROME C; GLUTATHIONE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ACETYLATION; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CATARACT; CELL ACTIVITY; CELL STRESS; CONTROLLED STUDY; DISEASE CONTROL; DRUG DOSE COMPARISON; DRUG MECHANISM; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; EPITHELIUM CELL; HUMAN; HUMAN CELL; LENS; LENS EPITHELIUM; MITOCHONDRION; NEWBORN; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN INSOLUBILIZATION; PROTEIN MODIFICATION; PROTEIN SECRETION; RAT; SINGLE DRUG DOSE;

EID: 84877113373     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.440214     Document Type: Article

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