Serine 59 phosphorylation of αB-crystallin down-regulates its anti-apoptotic function by binding and sequestering Bcl-2 in breast cancer cells

Journal of Biological Chemistry

Volumn 285, Issue 48, 2010, Pages 37324-37332

  Launay, Nathalie ^a,b,c   Tarze, Agathe ^a,d   Vicart, Patrick ^a   Lilienbaum, Alain ^a  

^a Groupe Hospitalier Pitié Salpêtrière   (France)

^b BELLVITGE BIOMEDICAL RESEARCH INSTITUTE IDIBELL   (Spain)

^c CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE ENFERMEDADES RARAS CIBERER   (Spain)

^d UNIVERSITÉ PARIS EST CRÉTEIL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-APOPTOTIC PROTEIN; ANTI-CANCER AGENTS; ANTIAPOPTOTIC; APOPTOSIS; APOPTOTIC FUNCTION; BREAST CANCER; BREAST CANCER CELLS; BREAST CARCINOMAS; CANCER CELLS; CANCER TREATMENT; CARCINOMA CELLS; CLINICAL OUTCOME; CRYSTALLIN; DOWN-REGULATION; ENDOGENOUS LEVEL; FUNCTIONAL PROPERTIES; MCF-7 CELLS; MICROTUBULES; MOLECULAR MECHANISM; NEW STRATEGY; ONCOPROTEINS; OVER-EXPRESSION; PHOSPHORYLATION SITES; POST-TRANSLATIONAL MODIFICATIONS; SMALL HEAT SHOCK PROTEINS; VINBLASTINE; WILD TYPES;

AMINO ACIDS; CELL DEATH;

PHOSPHORYLATION;

ALPHA CRYSTALLIN; PROTEIN BCL 2; SERINE; SHORT HAIRPIN RNA; VINBLASTINE;

APOPTOSIS; ARTICLE; BREAST ADENOCARCINOMA; BREAST EPITHELIUM; CANCER RESISTANCE; CARCINOMA CELL; CELL PROTECTION; CELL STRAIN MCF 7; CONTROLLED STUDY; DOWN REGULATION; GENE OVEREXPRESSION; GENE TRANSLOCATION; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS INHIBITION; WILD TYPE;

ALPHA-CRYSTALLIN B CHAIN; APOPTOSIS; BREAST NEOPLASMS; CELL LINE, TUMOR; DOWN-REGULATION; FEMALE; HUMANS; PHOSPHORYLATION; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-BCL-2; SERINE;

EID: 78549288555     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.124388     Document Type: Article

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