Chaperone activity of small heat shock proteins underlies therapeutic efficacy in experimental autoimmune encephalomyelitis

Journal of Biological Chemistry

Volumn 287, Issue 43, 2012, Pages 36423-36434

  Kurnellas, Michael P ^a   Brownell, Sara E ^a   Su, Leon ^a   Malkovskiy, Andrey V ^a   Rajadas, Jayakumar ^a   Dolganov, Gregory ^a   Chopra, Sidharth ^a   Schoolnik, Gary K ^a   Sobel, Raymond A ^a   Webster, Jonathan ^a   Ousman, Shalina S ^a   Becker, Rachel A ^a   Steinman, Lawrence ^a   Rothbard, Jonathan B ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADDITIONAL STRUCTURES; AMYLOID FIBRIL; CHAPERONE ACTIVITY; CRYSTALLIN; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; HYDROPHOBIC AMINO ACIDS; LINEAR REGION; MYCOBACTERIAL; SMALL HEAT SHOCK PROTEINS; THERAPEUTIC ACTIVITY; THERAPEUTIC EFFICACY; THERAPEUTIC FUNCTIONS;

AMINO ACIDS; RECOMBINANT PROTEINS;

GENE ENCODING;

CHAPERONE; GAMMA INTERFERON; HEAT SHOCK PROTEIN B5; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 6; SMALL HEAT SHOCK PROTEIN; THIOFLAVINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG EFFICACY; DRUG POTENCY; DRUG SAFETY; ENZYME ACTIVITY; FEMALE; HYDROPHOBICITY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PURIFICATION; PROTEIN STRUCTURE;

ALPHA-CRYSTALLIN B CHAIN; AMINO ACID SUBSTITUTION; ANIMALS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; HUMANS; MICE; MUTATION, MISSENSE; PARALYSIS;

EID: 84867808822     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.371229     Document Type: Article

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