메뉴 건너뛰기




Volumn 24, Issue 9, 2013, Pages 1363-1374

Progesterone receptor isoforms PRA and PRB differentially contribute to breast cancer cell migration through interaction with focal adhesion kinase complexes

Author keywords

[No Author keywords available]

Indexed keywords

BETA1 INTEGRIN; FOCAL ADHESION KINASE; GESTAGEN; MIFEPRISTONE; PROGESTERONE RECEPTOR A; PROGESTERONE RECEPTOR B; PROMEGESTONE; TYROSINE; UROKINASE;

EID: 84877111621     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E12-11-0807     Document Type: Article
Times cited : (24)

References (85)
  • 2
    • 4243196028 scopus 로고    scopus 로고
    • Metastasis-associated protein 1 deregulation causes inappropriate mammary gland development and tumorigenesis
    • Bagheri-Yarmand R, Talukder AH, Wang RA, Vadlamudi RK, Kumar R (2004). Metastasis-associated protein 1 deregulation causes inappropriate mammary gland development and tumorigenesis. Development 131, 3469-3479.
    • (2004) Development , vol.131 , pp. 3469-3479
    • Bagheri-Yarmand, R.1    Talukder, A.H.2    Wang, R.A.3    Vadlamudi, R.K.4    Kumar, R.5
  • 3
    • 0037371863 scopus 로고    scopus 로고
    • Two domains of the progesterone receptor interact with the estrogen receptor and are required for progesterone activation of the C-Src/Erk pathway in mammalian cells
    • Ballare C, Uhrig M, Bechtold T, Sancho E, Di Domenico M, Migliaccio A, Auricchio F, Beato M (2003). Two domains of the progesterone receptor interact with the estrogen receptor and are required for progesterone activation of the c-Src/Erk pathway in mammalian cells. Mol Cell Biol 23, 1994-2008.
    • (2003) Mol Cell Biol , vol.23 , pp. 1994-2008
    • Ballare, C.1    Uhrig, M.2    Bechtold, T.3    Sancho, E.4    Di Domenico, M.5    Migliaccio, A.6    Auricchio, F.7    Beato, M.8
  • 5
    • 38949107640 scopus 로고    scopus 로고
    • Quantitative RT-PCR assays for the determination of urokinase-type plasminogen activator and plasminogen activator inhibitor type 1 mRNA in primary tumor tissue of breast cancer patients: Comparison to antigen quantification by ELISA
    • Biermann JC, Holzscheiter L, Kotzsch M, Luther T, Kiechle-Bahat M, Sweep FC, Span PN, Schmitt M, Magdolen V (2008). Quantitative RT-PCR assays for the determination of urokinase-type plasminogen activator and plasminogen activator inhibitor type 1 mRNA in primary tumor tissue of breast cancer patients: comparison to antigen quantification by ELISA. Int J Mol Med 21, 251-259.
    • (2008) Int J Mol Med , vol.21 , pp. 251-259
    • Biermann, J.C.1    Holzscheiter, L.2    Kotzsch, M.3    Luther, T.4    Kiechle-Bahat, M.5    Sweep, F.C.6    Span, P.N.7    Schmitt, M.8    Magdolen, V.9
  • 6
    • 79959936894 scopus 로고    scopus 로고
    • Comparison of hormonal receptor and HER-2 status between breast primary tumours and relapsing tumours: Clinical implications of progesterone receptor loss
    • Bogina G, Bortesi L, Marconi M, Venturini M, Lunardi G, Coati F, Massocco A, Manfrin E, Pegoraro C, Zamboni G (2011). Comparison of hormonal receptor and HER-2 status between breast primary tumours and relapsing tumours: clinical implications of progesterone receptor loss. Virchows Arch 459, 1-10.
    • (2011) Virchows Arch , vol.459 , pp. 1-10
    • Bogina, G.1    Bortesi, L.2    Marconi, M.3    Venturini, M.4    Lunardi, G.5    Coati, F.6    Massocco, A.7    Manfrin, E.8    Pegoraro, C.9    Zamboni, G.10
  • 7
    • 44549083120 scopus 로고    scopus 로고
    • The role and mechanism of progesterone receptor activation of extra-nuclear signaling pathways in regulating gene transcription and cell cycle progression
    • Boonyaratanakornkit V, Bi Y, Rudd M, Edwards DP (2008). The role and mechanism of progesterone receptor activation of extra-nuclear signaling pathways in regulating gene transcription and cell cycle progression. Steroids 73, 922-928.
    • (2008) Steroids , vol.73 , pp. 922-928
    • Boonyaratanakornkit, V.1    Bi, Y.2    Rudd, M.3    Edwards, D.P.4
  • 8
    • 33846581488 scopus 로고    scopus 로고
    • The role of extranuclear signaling actions of progesterone receptor in mediating progesterone regulation of gene expression and the cell cycle
    • Boonyaratanakornkit V, McGowan E, Sherman L, Mancini MA, Cheskis BJ, Edwards DP (2007). The role of extranuclear signaling actions of progesterone receptor in mediating progesterone regulation of gene expression and the cell cycle. Mol Endocrinol 21, 359-375.
    • (2007) Mol Endocrinol , vol.21 , pp. 359-375
    • Boonyaratanakornkit, V.1    McGowan, E.2    Sherman, L.3    Mancini, M.A.4    Cheskis, B.J.5    Edwards, D.P.6
  • 9
    • 0034852802 scopus 로고    scopus 로고
    • Progesterone receptor contains a proline-rich motif that directly interacts with SH3 domains and activates c-src family tyrosine kinases
    • Boonyaratanakornkit V, Scott M P, Ribon V, Sherman L, Anderson SM, Maller JL, Miller WT, Edwards DP (2001). Progesterone receptor contains a proline-rich motif that directly interacts with SH3 domains and activates c-Src family tyrosine kinases. Mol Cell 8, 269-280.
    • (2001) Mol Cell , vol.8 , pp. 269-280
    • Boonyaratanakornkit, V.1    Scott, M.P.2    Ribon, V.3    Sherman, L.4    Anderson, S.M.5    Maller, J.L.6    Miller, W.T.7    Edwards, D.P.8
  • 10
    • 0028305433 scopus 로고
    • Induction of cell migration by pro-urokinase binding to its receptor: Possible mechanism for signal transduction in human epithelial cells
    • Busso N, Masur SK, Lazega D, Waxman S, Ossowski L (1994). Induction of cell migration by pro-urokinase binding to its receptor: possible mechanism for signal transduction in human epithelial cells. J Cell Biol 126, 259-270.
    • (1994) J Cell Biol , vol.126 , pp. 259-270
    • Busso, N.1    Masur, S.K.2    Lazega, D.3    Waxman, S.4    Ossowski, L.5
  • 11
    • 34250883219 scopus 로고    scopus 로고
    • Progestin effects on breast cancer cell proliferation, proteases activation, and in vivo development of metastatic phenotype all depend on progesterone receptor capacity to activate cytoplasmic signaling pathways
    • Carnevale RP et al. (2007). Progestin effects on breast cancer cell proliferation, proteases activation, and in vivo development of metastatic phenotype all depend on progesterone receptor capacity to activate cytoplasmic signaling pathways. Mol Endocrinol 21, 1335-1358.
    • (2007) Mol Endocrinol , vol.21 , pp. 1335-1358
    • Carnevale, R.P.1
  • 12
    • 0030842795 scopus 로고    scopus 로고
    • Plasminogen activators, integrins, and the coordinated regulation of cell adhesion and migration
    • Chapman HA (1997). Plasminogen activators, integrins, and the coordinated regulation of cell adhesion and migration. Curr Opin Cell Biol 9, 714-724.
    • (1997) Curr Opin Cell Biol , vol.9 , pp. 714-724
    • Chapman, H.A.1
  • 13
  • 14
    • 78751485662 scopus 로고    scopus 로고
    • A novel sialyltransferase inhibitor suppresses FAK/paxillin signaling and cancer angiogenesis and metastasis pathways
    • Chen JY et al. (2011). A novel sialyltransferase inhibitor suppresses FAK/paxillin signaling and cancer angiogenesis and metastasis pathways. Cancer Res 71, 473-483.
    • (2011) Cancer Res , vol.71 , pp. 473-483
    • Chen, J.Y.1
  • 15
    • 58149102321 scopus 로고    scopus 로고
    • Molecular basis of metastasis
    • Chiang AC, Massague J (2008). Molecular basis of metastasis. N Engl J Med 359, 2814-2823.
    • (2008) N Engl J Med , vol.359 , pp. 2814-2823
    • Chiang, A.C.1    Massague, J.2
  • 16
    • 77958138780 scopus 로고    scopus 로고
    • Estrogen plus progestin and breast cancer incidence and mortality in postmenopausal women
    • Chlebowski RT et al. (2010). Estrogen plus progestin and breast cancer incidence and mortality in postmenopausal women. J Am Med Assoc 304, 1684-1692.
    • (2010) J Am Med Assoc , vol.304 , pp. 1684-1692
    • Chlebowski, R.T.1
  • 17
    • 0037830132 scopus 로고    scopus 로고
    • Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women: The women's health initiative randomized trial
    • Chlebowski RT et al. (2003). Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women: the Women's Health Initiative Randomized Trial. J Am Med Assoc 289, 3243-3253.
    • (2003) J Am Med Assoc , vol.289 , pp. 3243-3253
    • Chlebowski, R.T.1
  • 19
    • 36749093009 scopus 로고    scopus 로고
    • A structural basis for differential cell signalling by PAI-1 and PAI-2 in breast cancer cells
    • Croucher DR, Saunders DN, Stillfried GE, Ranson M (2007). A structural basis for differential cell signalling by PAI-1 and PAI-2 in breast cancer cells. Biochem J 408, 203-210.
    • (2007) Biochem J , vol.408 , pp. 203-210
    • Croucher, D.R.1    Saunders, D.N.2    Stillfried, G.E.3    Ranson, M.4
  • 20
    • 10044284103 scopus 로고    scopus 로고
    • Unexpected role of plasminogen activator inhibitor 1 in cell adhesion and detachment
    • Czekay RP, Loskutoff DJ (2004). Unexpected role of plasminogen activator inhibitor 1 in cell adhesion and detachment. Exp Biol Med (Maywood) 229, 1090-1096.
    • (2004) Exp Biol Med (Maywood) , vol.229 , pp. 1090-1096
    • Czekay, R.P.1    Loskutoff, D.J.2
  • 21
    • 18044380913 scopus 로고    scopus 로고
    • Inhibition of the 26S proteasome blocks progesterone receptor-dependent transcription through failed recruitment of RNA polymerase II
    • Dennis A P, Lonard DM, Nawaz Z, O'Malley BW (2005). Inhibition of the 26S proteasome blocks progesterone receptor-dependent transcription through failed recruitment of RNA polymerase II. J Steroid Biochem Mol Biol 94, 337-346.
    • (2005) J Steroid Biochem Mol Biol , vol.94 , pp. 337-346
    • Dennis, A.P.1    Lonard, D.M.2    Nawaz, Z.3    O'Malley, B.W.4
  • 23
    • 63849333755 scopus 로고    scopus 로고
    • PAI-1 and functional blockade of SNAI1 in breast cancer cell migration
    • Fabre-Guillevin E et al. (2008). PAI-1 and functional blockade of SNAI1 in breast cancer cell migration. Breast Cancer Res 10, R100.
    • (2008) Breast Cancer Res , vol.10
    • Fabre-Guillevin, E.1
  • 27
    • 21644466387 scopus 로고    scopus 로고
    • Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transac-tivation domain of p53
    • Golubovskaya VM, Finch R, Cance WG (2005). Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transac-tivation domain of p53. J Biol Chem 280, 25008-25021.
    • (2005) J Biol Chem , vol.280 , pp. 25008-25021
    • Golubovskaya, V.M.1    Finch, R.2    Cance, W.G.3
  • 28
    • 27644482809 scopus 로고    scopus 로고
    • Altered progesterone receptor isoform expression remodels progestin responsiveness of breast cancer cells
    • Graham JD, Yager ML, Hill HD, Byth K, O'Neill GM, Clarke CL (2005). Altered progesterone receptor isoform expression remodels progestin responsiveness of breast cancer cells. Mol Endocrinol 19, 2713-2735.
    • (2005) Mol Endocrinol , vol.19 , pp. 2713-2735
    • Graham, J.D.1    Yager, M.L.2    Hill, H.D.3    Byth, K.4    O'Neill, G.M.5    Clarke, C.L.6
  • 30
    • 0028233394 scopus 로고
    • Nuclear localization signals also mediate the outward movement of proteins from the nucleus
    • Guiochon-Mantel A, Delabre K, Lescop P, Milgrom E (1994). Nuclear localization signals also mediate the outward movement of proteins from the nucleus. Proc Natl Acad Sci USA 91, 7179-7183.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 7179-7183
    • Guiochon-Mantel, A.1    Delabre, K.2    Lescop, P.3    Milgrom, E.4
  • 32
    • 27644570788 scopus 로고    scopus 로고
    • Regulation of focal adhesion dynamics and disassembly by phosphorylation of FAK at tyrosine 397
    • Hamadi A, Bouali M, Dontenwill M, Stoeckel H, Takeda K, Ronde P (2005). Regulation of focal adhesion dynamics and disassembly by phosphorylation of FAK at tyrosine 397. J Cell Sci 118, 4415-4425.
    • (2005) J Cell Sci , vol.118 , pp. 4415-4425
    • Hamadi, A.1    Bouali, M.2    Dontenwill, M.3    Stoeckel, H.4    Takeda, K.5    Ronde, P.6
  • 33
    • 37349081370 scopus 로고    scopus 로고
    • Extranuclear steroid receptors: Nature and actions
    • Hammes SR, Levin ER (2007). Extranuclear steroid receptors: nature and actions. Endocr Rev 28, 726-741.
    • (2007) Endocr Rev , vol.28 , pp. 726-741
    • Hammes, S.R.1    Levin, E.R.2
  • 35
    • 79151480076 scopus 로고    scopus 로고
    • Inhibition of focal adhesion kinase suppresses the adverse phenotype of endocrine-resistant breast cancer cells and improves endocrine response in endocrine-sensitive cells
    • Hiscox S, Barnfather P, Hayes E, Bramble P, Christensen J, Nicholson RI, Barrett-Lee P (2010). Inhibition of focal adhesion kinase suppresses the adverse phenotype of endocrine-resistant breast cancer cells and improves endocrine response in endocrine-sensitive cells. Breast Cancer Res Treat 125, 659-669.
    • (2010) Breast Cancer Res Treat , vol.125 , pp. 659-669
    • Hiscox, S.1    Barnfather, P.2    Hayes, E.3    Bramble, P.4    Christensen, J.5    Nicholson, R.I.6    Barrett-Lee, P.7
  • 37
    • 14844304709 scopus 로고    scopus 로고
    • Progesterone-independent effects of human progesterone receptors (PRs) in estrogen receptor-positive breast cancer: Pr isoform-specific gene regulation and tumor biology
    • Jacobsen BM, Schittone SA, Richer JK, Horwitz KB (2005). Progesterone-independent effects of human progesterone receptors (PRs) in estrogen receptor-positive breast cancer: PR isoform-specific gene regulation and tumor biology. Mol Endocrinol 19, 574-587.
    • (2005) Mol Endocrinol , vol.19 , pp. 574-587
    • Jacobsen, B.M.1    Schittone, S.A.2    Richer, J.K.3    Horwitz, K.B.4
  • 38
    • 0035918882 scopus 로고    scopus 로고
    • Randomized adjuvant chemotherapy trial in high-risk, lymph node-negative breast cancer patients identified by urokinase-type plasminogen activator and plasmino-gen activator inhibitor type 1
    • Janicke F, Prechtl A, Thomssen C, Harbeck N, Meisner C, Untch M, Sweep CG, Selbmann HK, Graeff H, Schmitt M (2001). Randomized adjuvant chemotherapy trial in high-risk, lymph node-negative breast cancer patients identified by urokinase-type plasminogen activator and plasmino-gen activator inhibitor type 1. J Natl Cancer Inst 93, 913-920.
    • (2001) J Natl Cancer Inst , vol.93 , pp. 913-920
    • Janicke, F.1    Prechtl, A.2    Thomssen, C.3    Harbeck, N.4    Meisner, C.5    Untch, M.6    Sweep, C.G.7    Selbmann, H.K.8    Graeff, H.9    Schmitt, M.10
  • 39
    • 20444478292 scopus 로고    scopus 로고
    • Dynamic assembly of the urokinase-type plasminogen activator signaling receptor complex determines the mitogenic activity of urokinase-type plasminogen activator
    • Jo M, Thomas KS, Marozkina N, Amin TJ, Silva CM, Parsons SJ, Gonias SL (2005). Dynamic assembly of the urokinase-type plasminogen activator signaling receptor complex determines the mitogenic activity of urokinase-type plasminogen activator. J Biol Chem 280, 17449-17457.
    • (2005) J Biol Chem , vol.280 , pp. 17449-17457
    • Jo, M.1    Thomas, K.S.2    Marozkina, N.3    Amin, T.J.4    Silva, C.M.5    Parsons, S.J.6    Gonias, S.L.7
  • 40
    • 20044395274 scopus 로고    scopus 로고
    • Progesterone increases tissue factor gene expression, procoagulant activity, and invasion in the breast cancer cell line ZR-75-1
    • Kato S et al. (2005). Progesterone increases tissue factor gene expression, procoagulant activity, and invasion in the breast cancer cell line ZR-75-1. J Clin Endocrinol Metab 90, 1181-1188.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 1181-1188
    • Kato, S.1
  • 41
    • 80053351732 scopus 로고    scopus 로고
    • P38 and p42/44 MAPKs differentially regulate progesterone receptor A and B isoform stabilization
    • Khan JA, Amazit L, Bellance C, Guiochon-Mantel A, Lombes M, Loosfelt H (2011). p38 and p42/44 MAPKs differentially regulate progesterone receptor A and B isoform stabilization. Mol Endocrinol 25, 1710-1724.
    • (2011) Mol Endocrinol , vol.25 , pp. 1710-1724
    • Khan, J.A.1    Amazit, L.2    Bellance, C.3    Guiochon-Mantel, A.4    Lombes, M.5    Loosfelt, H.6
  • 42
    • 84866699934 scopus 로고    scopus 로고
    • Differential regulation of breast cancer-associated genes by progesterone receptor isoforms PRA and PRB in a new bi-inducible breast cancer cell line
    • Khan JA, Bellance C, Guiochon-Mantel A, Lombes M, Loosfelt H (2012). Differential regulation of breast cancer-associated genes by progesterone receptor isoforms PRA and PRB in a new bi-inducible breast cancer cell line. PLoS One 7, e45993.
    • (2012) PLoS One , vol.7
    • Khan, J.A.1    Bellance, C.2    Guiochon-Mantel, A.3    Lombes, M.4    Loosfelt, H.5
  • 43
    • 0037305884 scopus 로고    scopus 로고
    • Heregulin induces transcriptional activation of the progesterone receptor by a mechanism that requires functional ErbB-2 and mitogen-activated protein kinase activation in breast cancer cells
    • Labriola L, Salatino M, Proietti CJ, Pecci A, Coso OA, Kornblihtt AR, Charreau EH, Elizalde PV (2003). Heregulin induces transcriptional activation of the progesterone receptor by a mechanism that requires functional ErbB-2 and mitogen-activated protein kinase activation in breast cancer cells. Mol Cell Biol 23, 1095-1111.
    • (2003) Mol Cell Biol , vol.23 , pp. 1095-1111
    • Labriola, L.1    Salatino, M.2    Proietti, C.J.3    Pecci, A.4    Coso, O.A.5    Kornblihtt, A.R.6    Charreau, E.H.7    Elizalde, P.V.8
  • 44
    • 0033967491 scopus 로고    scopus 로고
    • Phosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 26S proteasome
    • Lange CA, Shen T, Horwitz KB (2000). Phosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 26S proteasome. Proc Natl Acad Sci USA 97, 1032-1037.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 1032-1037
    • Lange, C.A.1    Shen, T.2    Horwitz, K.B.3
  • 45
    • 0030045346 scopus 로고    scopus 로고
    • Cell migration: A physically integrated molecular process
    • Lauffenburger DA, Horwitz AF (1996). Cell migration: a physically integrated molecular process. Cell 84, 359-369.
    • (1996) Cell , vol.84 , pp. 359-369
    • Lauffenburger, D.A.1    Horwitz, A.F.2
  • 47
    • 33748873891 scopus 로고    scopus 로고
    • Prognostic significance of urokinase plasminogen activator and plasminogen activator inhibitor-1 mRNA expression in lymph node - And hormone receptor-positive breast cancer
    • Leissner P, Verjat T, Bachelot T, Paye M, Krause A, Puisieux A, Mougin B (2006). Prognostic significance of urokinase plasminogen activator and plasminogen activator inhibitor-1 mRNA expression in lymph node - and hormone receptor-positive breast cancer. BMC Cancer 6, 216.
    • (2006) BMC Cancer , vol.6 , pp. 216
    • Leissner, P.1    Verjat, T.2    Bachelot, T.3    Paye, M.4    Krause, A.5    Puisieux, A.6    Mougin, B.7
  • 48
    • 27144486280 scopus 로고    scopus 로고
    • Gene regulation profile reveals consistent anticancer properties of progesterone in hormone-independent breast cancer cells transfected with progesterone receptor
    • Leo JC, Wang SM, Guo CH, Aw SE, Zhao Y, Li JM, Hui KM, Lin VC (2005). Gene regulation profile reveals consistent anticancer properties of progesterone in hormone-independent breast cancer cells transfected with progesterone receptor. Int J Cancer 117, 561-568.
    • (2005) Int J Cancer , vol.117 , pp. 561-568
    • Leo, J.C.1    Wang, S.M.2    Guo, C.H.3    Aw, S.E.4    Zhao, Y.5    Li, J.M.6    Hui, K.M.7    Lin, V.C.8
  • 50
    • 0034803185 scopus 로고    scopus 로고
    • Effect of progesterone on the invasive properties and tumor growth of progesterone receptor-transfected breast cancer cells MDA-MB-231
    • Lin VC, Eng AS, Hen NE, Ng EH, Chowdhury SH (2001). Effect of progesterone on the invasive properties and tumor growth of progesterone receptor-transfected breast cancer cells MDA-MB-231. Clin Cancer Res 7, 2880-2886.
    • (2001) Clin Cancer Res , vol.7 , pp. 2880-2886
    • Lin, V.C.1    Eng, A.S.2    Hen, N.E.3    Ng, E.H.4    Chowdhury, S.H.5
  • 51
    • 0034465068 scopus 로고    scopus 로고
    • Progesterone induces focal adhesion in breast cancer cells MDA-MB-231 transfected with progesterone receptor complementary DNA
    • Lin VC, Ng EH, Aw SE, Tan MG, Bay BH (2000). Progesterone induces focal adhesion in breast cancer cells MDA-MB-231 transfected with progesterone receptor complementary DNA. Mol Endocrinol 14, 348-358.
    • (2000) Mol Endocrinol , vol.14 , pp. 348-358
    • Lin, V.C.1    Ng, E.H.2    Aw, S.E.3    Tan, M.G.4    Bay, B.H.5
  • 53
    • 0023690317 scopus 로고
    • A rapid method of epitope mapping. Application to the study of immunogenic domains and to the characterization of various forms of rabbit progesterone receptor
    • Lorenzo F, Jolivet A, Loosfelt H, Thuvu Hai M, Brailly S, Perrot-Applanat M, Milgrom E (1988). A rapid method of epitope mapping. Application to the study of immunogenic domains and to the characterization of various forms of rabbit progesterone receptor. Eur J Biochem 176, 53-60.
    • (1988) Eur J Biochem , vol.176 , pp. 53-60
    • Lorenzo, F.1    Jolivet, A.2    Loosfelt, H.3    Thuvu Hai, M.4    Brailly, S.5    Perrot-Applanat, M.6    Milgrom, E.7
  • 54
    • 76849100707 scopus 로고    scopus 로고
    • Focal adhesion kinase: A prominent determinant in breast cancer initiation, progression and metastasis
    • Luo M, Guan JL (2010). Focal adhesion kinase: a prominent determinant in breast cancer initiation, progression and metastasis. Cancer Lett 289, 127-139.
    • (2010) Cancer Lett , vol.289 , pp. 127-139
    • Luo, M.1    Guan, J.L.2
  • 56
    • 0027049396 scopus 로고
    • Progesterone regulates the activity of collagenase and related gelatinases A and B in human endometrial explants
    • Marbaix E, Donnez J, Courtoy PJ, Eeckhout Y (1992). Progesterone regulates the activity of collagenase and related gelatinases A and B in human endometrial explants. Proc Natl Acad Sci USA 89, 11789-11793.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 11789-11793
    • Marbaix, E.1    Donnez, J.2    Courtoy, P.J.3    Eeckhout, Y.4
  • 57
    • 84860389952 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and cancer stem cells: A dangerously dynamic duo in breast cancer progression
    • May CD, Sphyris N, Evans KW, Werden SJ, Guo W, Mani SA (2011). Epithelial-mesenchymal transition and cancer stem cells: a dangerously dynamic duo in breast cancer progression. Breast Cancer Res 13, 202.
    • (2011) Breast Cancer Res , vol.13 , pp. 202
    • May, C.D.1    Sphyris, N.2    Evans, K.W.3    Werden, S.J.4    Guo, W.5    Mani, S.A.6
  • 58
    • 0033305311 scopus 로고    scopus 로고
    • Effect of overexpression of progesterone receptor A on endogenous progestin-sensitive endpoints in breast cancer cells
    • McGowan EM, Clarke CL (1999). Effect of overexpression of progesterone receptor A on endogenous progestin-sensitive endpoints in breast cancer cells. Mol Endocrinol 13, 1657-1671.
    • (1999) Mol Endocrinol , vol.13 , pp. 1657-1671
    • McGowan, E.M.1    Clarke, C.L.2
  • 60
    • 65649135420 scopus 로고    scopus 로고
    • Focal adhesion kinase modulates cell adhesion strengthening via integrin activation
    • Michael KE, Dumbauld DW, Burns KL, Hanks SK, Garcia AJ (2009). Focal adhesion kinase modulates cell adhesion strengthening via integrin activation. Mol Biol Cell 20, 2508-2519.
    • (2009) Mol Biol Cell , vol.20 , pp. 2508-2519
    • Michael, K.E.1    Dumbauld, D.W.2    Burns, K.L.3    Hanks, S.K.4    Garcia, A.J.5
  • 62
    • 33746481375 scopus 로고    scopus 로고
    • Intrinsic focal adhesion kinase activity controls orthotopic breast carcinoma metastasis via the regulation of urokinase plasminogen activator expression in a syngeneic tumor model
    • Mitra SK, Lim ST, Chi A, Schlaepfer DD (2006). Intrinsic focal adhesion kinase activity controls orthotopic breast carcinoma metastasis via the regulation of urokinase plasminogen activator expression in a syngeneic tumor model. Oncogene 25, 4429-4440.
    • (2006) Oncogene , vol.25 , pp. 4429-4440
    • Mitra, S.K.1    Lim, S.T.2    Chi, A.3    Schlaepfer, D.D.4
  • 63
    • 33748286819 scopus 로고    scopus 로고
    • Integrin-regulated FAK-src signaling in normal and cancer cells
    • Mitra SK, Schlaepfer DD (2006). Integrin-regulated FAK-Src signaling in normal and cancer cells. Curr Opin Cell Biol 18, 516-523.
    • (2006) Curr Opin Cell Biol , vol.18 , pp. 516-523
    • Mitra, S.K.1    Schlaepfer, D.D.2
  • 64
    • 0036112855 scopus 로고    scopus 로고
    • Loss of co-ordinate expression of progesterone receptors A and B is an early event in breast carcino-genesis
    • Mote PA, Bartow S, Tran N, Clarke CL (2002). Loss of co-ordinate expression of progesterone receptors A and B is an early event in breast carcino-genesis. Breast Cancer Res Treat 72, 163-172.
    • (2002) Breast Cancer Res Treat , vol.72 , pp. 163-172
    • Mote, P.A.1    Bartow, S.2    Tran, N.3    Clarke, C.L.4
  • 66
    • 33845315093 scopus 로고    scopus 로고
    • Prevention of brca1-mediated mammary tumorigenesis in mice by a progesterone antagonist
    • Poole AJ, Li Y, Kim Y, Lin SC, Lee WH, Lee EY (2006). Prevention of Brca1-mediated mammary tumorigenesis in mice by a progesterone antagonist. Science 314, 1467-1470.
    • (2006) Science , vol.314 , pp. 1467-1470
    • Poole, A.J.1    Li, Y.2    Kim, Y.3    Lin, S.C.4    Lee, W.H.5    Lee, E.Y.6
  • 67
    • 20344391678 scopus 로고    scopus 로고
    • Progestins induce transcriptional activation of signal transducer and activator of transcription 3 (Stat3) via a jak - And src-dependent mechanism in breast cancer cells
    • Proietti C et al. (2005). Progestins induce transcriptional activation of signal transducer and activator of transcription 3 (Stat3) via a Jak - and Src-dependent mechanism in breast cancer cells. Mol Cell Biol 25, 4826-4840.
    • (2005) Mol Cell Biol , vol.25 , pp. 4826-4840
    • Proietti, C.1
  • 68
    • 3042775025 scopus 로고    scopus 로고
    • PAI-1 expression is required for epithelial cell migration in two distinct phases of in vitro wound repair
    • Providence KM, Higgins PJ (2004). PAI-1 expression is required for epithelial cell migration in two distinct phases of in vitro wound repair. J Cell Physiol 200, 297-308.
    • (2004) J Cell Physiol , vol.200 , pp. 297-308
    • Providence, K.M.1    Higgins, P.J.2
  • 69
    • 80054030191 scopus 로고    scopus 로고
    • P38gamma promotes breast cancer cell motility and metastasis through regulation of RhoC GTPase, cytoskeletal architecture, and a novel leading edge behavior
    • Rosenthal DT, Iyer H, Escudero S, Bao L, Wu Z, Ventura AC, Kleer CG, Arruda EM, Garikipati K, Merajver SD (2011). p38gamma promotes breast cancer cell motility and metastasis through regulation of RhoC GTPase, cytoskeletal architecture, and a novel leading edge behavior. Cancer Res 71, 6338-6349.
    • (2011) Cancer Res , vol.71 , pp. 6338-6349
    • Rosenthal, D.T.1    Iyer, H.2    Escudero, S.3    Bao, L.4    Wu, Z.5    Ventura, A.C.6    Kleer, C.G.7    Arruda, E.M.8    Garikipati, K.9    Merajver, S.D.10
  • 70
    • 0037125379 scopus 로고    scopus 로고
    • Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the women's health initiative randomized controlled trial
    • Rossouw JE et al. (2002). Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. J Am Med Assoc 288, 321-333.
    • (2002) J Am Med Assoc , vol.288 , pp. 321-333
    • Rossouw, J.E.1
  • 71
    • 1642312903 scopus 로고    scopus 로고
    • Plasmi-nogen activator inhibitor-1 as a potential marker for the malignancy of esophageal squamous cell carcinoma
    • Sakakibara T, Hibi K, Kodera Y, Ito K, Akiyama S, Nakao A (2004). Plasmi-nogen activator inhibitor-1 as a potential marker for the malignancy of esophageal squamous cell carcinoma. Clin Cancer Res 10, 1375-1378.
    • (2004) Clin Cancer Res , vol.10 , pp. 1375-1378
    • Sakakibara, T.1    Hibi, K.2    Kodera, Y.3    Ito, K.4    Akiyama, S.5    Nakao, A.6
  • 72
    • 77951184829 scopus 로고    scopus 로고
    • Cellular functions of FAK kinases: Insight into molecular mechanisms and novel functions
    • Schaller MD (2010). Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions. J Cell Sci 123, 1007-1013.
    • (2010) J Cell Sci , vol.123 , pp. 1007-1013
    • Schaller, M.D.1
  • 73
    • 0033861697 scopus 로고    scopus 로고
    • Cellular accumulation of uPA-PAI-1 [correction of UPA-PAI-1] and uPA-PAI-2 [correction of UPA-PAI-2] complexes in early (pT1) breast cancer: A new link in the uPA-UPAr-PAI chain
    • Schneider J, Lucas R, Sanchez J, Tejerina A, Ruibal A (2000). Cellular accumulation of uPA-PAI-1 [correction of UPA-PAI-1] and uPA-PAI-2 [correction of UPA-PAI-2] complexes in early (pT1) breast cancer: a new link in the uPA-UPAr-PAI chain. In Vivo 14, 507-511.
    • (2000) Vivo , vol.14 , pp. 507-511
    • Schneider, J.1    Lucas, R.2    Sanchez, J.3    Tejerina, A.4    Ruibal, A.5
  • 76
    • 0028338844 scopus 로고
    • Binding of urokinase to its receptor promotes migration and invasion of human melanoma cells in vitro
    • Stahl A, Mueller BM (1994). Binding of urokinase to its receptor promotes migration and invasion of human melanoma cells in vitro. Cancer Res 54, 3066-3071.
    • (1994) Cancer Res , vol.54 , pp. 3066-3071
    • Stahl, A.1    Mueller, B.M.2
  • 77
    • 0032540943 scopus 로고    scopus 로고
    • The urokinase-type plasminogen activator receptor mediates tyrosine phosphorylation of focal adhesion proteins and activation of mitogen-activated protein kinase in cultured endothelial cells
    • Tang H, Kerins DM, Hao Q, Inagami T, Vaughan DE (1998). The urokinase-type plasminogen activator receptor mediates tyrosine phosphorylation of focal adhesion proteins and activation of mitogen-activated protein kinase in cultured endothelial cells. J Biol Chem 273, 18268-18272.
    • (1998) J Biol Chem , vol.273 , pp. 18268-18272
    • Tang, H.1    Kerins, D.M.2    Hao, Q.3    Inagami, T.4    Vaughan, D.E.5
  • 78
    • 0031725138 scopus 로고    scopus 로고
    • Mechanisms of progesterone receptor export from nuclei: Role of nuclear localization signal, nuclear export signal, and ran guanosine triphosphate
    • Tyagi RK, Amazit L, Lescop P, Milgrom E, Guiochon-Mantel A (1998). Mechanisms of progesterone receptor export from nuclei: role of nuclear localization signal, nuclear export signal, and ran guanosine triphosphate. Mol Endocrinol 12, 1684-1695.
    • (1998) Mol Endocrinol , vol.12 , pp. 1684-1695
    • Tyagi, R.K.1    Amazit, L.2    Lescop, P.3    Milgrom, E.4    Guiochon-Mantel, A.5
  • 79
    • 0036099773 scopus 로고    scopus 로고
    • Decreased tissue inhibitor of metalloproteinase in the endometrium of women using depot medroxyprogesterone acetate: A role for altered endometrial matrix metalloproteinase/tissue inhibitor of metalloproteinase balance in the pathogenesis of abnormal uterine bleeding
    • Vincent AJ, Zhang J, Ostor A, Rogers PA, Affandi B, Kovacs G, Salamonsen LA (2002). Decreased tissue inhibitor of metalloproteinase in the endometrium of women using depot medroxyprogesterone acetate: a role for altered endometrial matrix metalloproteinase/tissue inhibitor of metalloproteinase balance in the pathogenesis of abnormal uterine bleeding. Hum Reprod 17, 1189-1198.
    • (2002) Hum Reprod , vol.17 , pp. 1189-1198
    • Vincent, A.J.1    Zhang, J.2    Ostor, A.3    Rogers, P.A.4    Affandi, B.5    Kovacs, G.6    Salamonsen, L.A.7
  • 80
    • 0030757506 scopus 로고    scopus 로고
    • Plasmin and plasminogen activator inhibitor type 1 promote cellular motility by regulating the interaction between the urokinase receptor and vitronectin
    • Waltz DA, Natkin LR, Fujita RM, Wei Y, Chapman HA (1997). Plasmin and plasminogen activator inhibitor type 1 promote cellular motility by regulating the interaction between the urokinase receptor and vitronectin. J Clin Invest 100, 58-67.
    • (1997) J Clin Invest , vol.100 , pp. 58-67
    • Waltz, D.A.1    Natkin, L.R.2    Fujita, R.M.3    Wei, Y.4    Chapman, H.A.5
  • 82
    • 33947542987 scopus 로고    scopus 로고
    • Urokinase receptors are required for alpha 5 beta 1 integrin-mediated signaling in tumor cells
    • Wei Y, Tang CH, Kim Y, Robillard L, Zhang F, Kugler MC, Chapman HA (2007). Urokinase receptors are required for alpha 5 beta 1 integrin-mediated signaling in tumor cells. J Biol Chem 282, 3929-3939.
    • (2007) J Biol Chem , vol.282 , pp. 3929-3939
    • Wei, Y.1    Tang, C.H.2    Kim, Y.3    Robillard, L.4    Zhang, F.5    Kugler, M.C.6    Chapman, H.A.7
  • 84
    • 34247251943 scopus 로고    scopus 로고
    • PAI-1 is a critical upstream regulator of the TGF-beta1/EGF-induced invasive phenotype in mutant p53 human cutaneous squamous cell carcinoma
    • Wilkins-Port CE, Higgins CE, Freytag J, Higgins SP, Carlson JA, Higgins PJ (2007). PAI-1 is a critical upstream regulator of the TGF-beta1/EGF-induced invasive phenotype in mutant p53 human cutaneous squamous cell carcinoma. J Biomed Biotechnol 85208.
    • (2007) J Biomed Biotechnol , pp. 85208
    • Wilkins-Port, C.E.1    Higgins, C.E.2    Freytag, J.3    Higgins, S.P.4    Carlson, J.A.5    Higgins, P.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.