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Volumn 71, Issue 20, 2011, Pages 6338-6349

p38γ promotes breast cancer cell motility and metastasis through regulation of RhoC GTPase, cytoskeletal architecture, and a novel leading edge behavior

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN SERINE THREONINE KINASE; RHO GUANINE NUCLEOTIDE BINDING PROTEIN;

EID: 80054030191     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-11-1291     Document Type: Article
Times cited : (60)

References (48)
  • 2
    • 0035282334 scopus 로고    scopus 로고
    • Mammalian MAP kinase signalling cascades
    • DOI 10.1038/35065000
    • Chang L, Karin M. Mammalian MAP kinase signalling cascades. Nature 2001;410:37-40. (Pubitemid 32225829)
    • (2001) Nature , vol.410 , Issue.6824 , pp. 37-40
    • Chang, L.1    Karin, M.2
  • 3
    • 34547154349 scopus 로고    scopus 로고
    • p38 MAP-kinases pathway regulation, function and role in human diseases
    • Cuenda A, Rousseau S. p38 MAP-kinases pathway regulation, function and role in human diseases. Biochim Biophys Acta 2007;1773:1358-75.
    • (2007) Biochim Biophys Acta , vol.1773 , pp. 1358-1375
    • Cuenda, A.1    Rousseau, S.2
  • 4
    • 0031939753 scopus 로고    scopus 로고
    • Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family
    • DOI 10.1074/jbc.273.4.2161
    • Wang Y, Huang S, Sah VP, Ross J Jr, Brown JH, Han J, et al. Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family. J Biol Chem 1998;273:2161-8. (Pubitemid 28069266)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.4 , pp. 2161-2168
    • Wang, Y.1    Huang, S.2    Sah, V.P.3    Ross Jr., J.4    Brown, J.H.5    Han, J.6    Chien, K.R.7
  • 5
    • 0038792224 scopus 로고    scopus 로고
    • Map kinase signaling pathways and hematologic malignancies
    • Platanias LC. Map kinase signaling pathways and hematologic malignancies. Blood 2003;101:4667-79. (Pubitemid 36857719)
    • (2003) Blood , vol.101 , Issue.12 , pp. 4667-4679
    • Platanias, L.C.1
  • 6
    • 67749117934 scopus 로고    scopus 로고
    • Signal integration by JNK and p38 MAPK pathways in cancer development
    • Wagner EF, Nebreda AR. Signal integration by JNK and p38 MAPK pathways in cancer development. Nat Rev Cancer 2009;9:537-49.
    • (2009) Nat Rev Cancer , vol.9 , pp. 537-549
    • Wagner, E.F.1    Nebreda, A.R.2
  • 7
    • 35748932065 scopus 로고    scopus 로고
    • p38alpha antagonizes p38gamma activity through c-jun-dependent ubiquitin-proteasome pathways in regulating ras transformation and stress response
    • DOI 10.1074/jbc.M703857200
    • Qi X, Pohl NM, Loesch M, Hou S, Li R, Qin JZ, et al. p38alpha antagonizes p38gamma activity through c-Jun-dependent ubiquitin- proteasome pathways in regulating Ras transformation and stress response. J Biol Chem 2007;282:31398-408. (Pubitemid 350044894)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.43 , pp. 31398-31408
    • Qi, X.1    Pohl, N.M.2    Loesch, M.3    Hou, S.4    Li, R.5    Qin, J.-Z.6    Cuenda, A.7    Chen, G.8
  • 8
  • 9
    • 0033548233 scopus 로고    scopus 로고
    • Stress-activated protein kinase-2/p38 and a rapamycin-sensitive pathway are required for C2C12 myogenesis
    • Cuenda A, Cohen P. Stress-activated protein kinase-2/p38 and a rapamycin-sensitive pathway are required for C2C12 myogenesis. J Biol Chem 1999;274:4341-6.
    • (1999) J Biol Chem , vol.274 , pp. 4341-4346
    • Cuenda, A.1    Cohen, P.2
  • 12
    • 21244490119 scopus 로고    scopus 로고
    • Essential role of p38gamma in K-ras transformation independent of phosphorylation
    • DOI 10.1074/jbc.M500699200
    • Tang J, Qi X, Mercola D, Han J, Chen G. Essential role of p38gamma in K-Ras transformation independent of phosphorylation. J Biol Chem 2005;280:23910-7. (Pubitemid 40884879)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.25 , pp. 23910-23917
    • Tang, J.1    Qi, X.2    Mercola, D.3    Han, J.4    Chen, G.5
  • 13
    • 42949102509 scopus 로고    scopus 로고
    • The p38 MAPK stress pathway as a tumor suppressor or more?
    • DOI 10.2741/2951
    • Loesch M, Chen G. The p38 MAPK stress pathway as a tumor suppressor or more? Front Biosci 2008;13:3581-93. (Pubitemid 351606106)
    • (2008) Frontiers in Bioscience , vol.13 , Issue.9 , pp. 3581-3593
    • Loesch, M.1    Chen, G.2
  • 14
    • 33747872178 scopus 로고    scopus 로고
    • p38gamma mitogen-activated protein kinase integrates signaling crosstalk between Ras and estrogen receptor to increase breast cancer invasion
    • DOI 10.1158/0008-5472.CAN-05-4639
    • Qi X, Tang J, Loesch M, Pohl N, Alkan S, Chen G. p38gamma mitogen-activated protein kinase integrates signaling crosstalk between Ras and estrogen receptor to increase breast cancer invasion. Cancer Res 2006;66:7540-7. (Pubitemid 44289209)
    • (2006) Cancer Research , vol.66 , Issue.15 , pp. 7540-7547
    • Qi, X.1    Tang, J.2    Loesch, M.3    Pohl, N.4    Alkan, S.5    Chen, G.6
  • 15
    • 77952058710 scopus 로고    scopus 로고
    • p38{gamma} MAPK cooperates with c-Jun in trans-activating matrix metalloproteinase 9
    • Loesch M, Zhi HY, Hou SW, Qi XM, Li RS, Basir Z, et al. p38{gamma} MAPK cooperates with c-Jun in trans-activating matrix metalloproteinase 9. J Biol Chem 2010;285:15149-58.
    • (2010) J Biol Chem , vol.285 , pp. 15149-15158
    • Loesch, M.1    Zhi, H.Y.2    Hou, S.W.3    Qi, X.M.4    Li, R.S.5    Basir, Z.6
  • 17
    • 29844434293 scopus 로고    scopus 로고
    • Automated quantitative analysis (AQUA) of in situ protein expression, antibody concentration, and prognosis
    • DOI 10.1093/jnci/dji427
    • McCabe A, Dolled-Filhart M, Camp RL, Rimm DL. Automated quantitative analysis (AQUA) of in situ protein expression, antibody concentration, and prognosis. J Natl Cancer Inst 2005;97:1808-15. (Pubitemid 43033901)
    • (2005) Journal of the National Cancer Institute , vol.97 , Issue.24 , pp. 1808-1815
    • McCabe, A.1    Dolled-Filhart, M.2    Camp, R.L.3    Rimm, D.L.4
  • 18
    • 0030783156 scopus 로고    scopus 로고
    • The search for physiological substrates of MAP and SAP kinases in mammalian cells
    • DOI 10.1016/S0962-8924(97)01105-7
    • Cohen P. The search for physiological substrates of MAP and SAP kinases in mammalian cells. Trends Cell Biol 1997;7:353-61. (Pubitemid 27384781)
    • (1997) Trends in Cell Biology , vol.7 , Issue.9 , pp. 353-361
    • Cohen, P.1
  • 19
    • 0031916832 scopus 로고    scopus 로고
    • Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6
    • DOI 10.1074/jbc.273.3.1741
    • Enslen H, Raingeaud J, Davis RJ. Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6. J Biol Chem 1998;273:1741-8. (Pubitemid 28133705)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.3 , pp. 1741-1748
    • Enslen, H.1    Raingeaud, J.2    Davis, R.J.3
  • 20
    • 44449097488 scopus 로고    scopus 로고
    • On the Rho'd: The regulation of membrane protrusions by Rho-GTPases
    • Ladwein M, Rottner K. On the Rho'd: the regulation of membrane protrusions by Rho-GTPases. FEBS Lett 2008;582:2066-74.
    • (2008) FEBS Lett , vol.582 , pp. 2066-2074
    • Ladwein, M.1    Rottner, K.2
  • 23
    • 0028961293 scopus 로고
    • Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
    • Nobes CD, Hall A. Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 1995;81:53-62.
    • (1995) Cell , vol.81 , pp. 53-62
    • Nobes, C.D.1    Hall, A.2
  • 24
    • 6344231714 scopus 로고    scopus 로고
    • Why three Rho proteins? RhoA, RhoB, RhoC, and cell motility
    • DOI 10.1016/j.yexcr.2004.08.012, PII S0014482704004793
    • Wheeler AP, Ridley AJ. Why three Rho proteins? RhoA, RhoB, RhoC, and cell motility. Exp Cell Res 2004;301:43-9. (Pubitemid 39388895)
    • (2004) Experimental Cell Research , vol.301 , Issue.1 , pp. 43-49
    • Wheeler, A.P.1    Ridley, A.J.2
  • 26
    • 78049453780 scopus 로고    scopus 로고
    • A comparison of PAM50 intrinsic subtyping with immunohistochemistry and clinical prognostic factors in tamoxifen-treated estrogen receptor-positive breast cancer
    • Nielsen TO, Parker JS, Leung S, Voduc D, Ebbert M, Vickery T, et al. A comparison of PAM50 intrinsic subtyping with immunohistochemistry and clinical prognostic factors in tamoxifen-treated estrogen receptor-positive breast cancer. Clin Cancer Res 2010;16:5222-32.
    • (2010) Clin Cancer Res , vol.16 , pp. 5222-5232
    • Nielsen, T.O.1    Parker, J.S.2    Leung, S.3    Voduc, D.4    Ebbert, M.5    Vickery, T.6
  • 27
    • 0032520916 scopus 로고    scopus 로고
    • Inhibition of the p38 mitogen-activated protein kinase by SB 203580 blocks PMA-induced M(r) 92,000 type IV collagenase secretion and in vitro invasion
    • Simon C, Goepfert H, Boyd D. Inhibition of the p38 mitogen-activated protein kinase by SB 203580 blocks PMA-induced Mr 92,000 type IV collagenase secretion and in vitro invasion. Cancer Res 1998;58:1135-9. (Pubitemid 28183199)
    • (1998) Cancer Research , vol.58 , Issue.6 , pp. 1135-1139
    • Simon, C.1    Goepfert, H.2    Boyd, D.3
  • 28
    • 71549116718 scopus 로고    scopus 로고
    • Inhibition of the p38 kinase suppresses the proliferation of human ER-negative breast cancer cells
    • Chen L, Mayer JA, Krisko TI, SpeersCW, Wang T, Hilsenbeck SG, et al. Inhibition of the p38 kinase suppresses the proliferation of human ER-negative breast cancer cells. Cancer Res 2009;69:8853-61.
    • (2009) Cancer Res , vol.69 , pp. 8853-8861
    • Chen, L.1    Mayer, J.A.2    Krisko, T.I.3    Speers, C.W.4    Wang, T.5    Hilsenbeck, S.G.6
  • 30
    • 79954523530 scopus 로고    scopus 로고
    • Psidin, a conserved protein that regulates protrusion dynamics and cell migration
    • Kim JH, Cho A, Yin H, Schafer DA, Mouneimne G, Simpson KJ, et al. Psidin, a conserved protein that regulates protrusion dynamics and cell migration. Genes Dev 2011;25:730-41.
    • (2011) Genes Dev , vol.25 , pp. 730-741
    • Kim, J.H.1    Cho, A.2    Yin, H.3    Schafer, D.A.4    Mouneimne, G.5    Simpson, K.J.6
  • 34
    • 0033784843 scopus 로고    scopus 로고
    • The transcription factor snail controls epithelialmesenchymal transitions by repressing E-cadherin expression
    • Cano A, Perez-Moreno MA, Rodrigo I, Locascio A, Blanco MJ, del Barrio MG, et al. The transcription factor snail controls epithelialmesenchymal transitions by repressing E-cadherin expression. Nat Cell Biol 2000;2:76-83.
    • (2000) Nat Cell Biol , vol.2 , pp. 76-83
    • Cano, A.1    Perez-Moreno, M.A.2    Rodrigo, I.3    Locascio, A.4    Blanco, M.J.5    Del Barrio, M.G.6
  • 36
    • 58149102321 scopus 로고    scopus 로고
    • Molecular basis of metastasis
    • Chiang AC, Massague J. Molecular basis of metastasis. N Engl J Med 2008;359:2814-23.
    • (2008) N Engl J Med , vol.359 , pp. 2814-2823
    • Chiang, A.C.1    Massague, J.2
  • 37
    • 0034667370 scopus 로고    scopus 로고
    • GTPase, a novel transforming oncogene for human mammary epithelial cells that partially recapitulates the inflammatory breast cancer phenotype
    • van Golen KL, Wu ZF, Qiao XT, Bao LW, Merajver SD. RhoC GTPase, a novel transforming oncogene for human mammary epithelial cells that partially recapitulates the inflammatory breast cancer phenotype. Cancer Res 2000;60:5832-8.
    • (2000) Cancer Res , vol.60 , pp. 5832-5838
    • Van Golen, K.L.1    Wu, Z.F.2    Qiao, X.T.3    Bao, L.W.4    Merajver, S.D.5    Rho, C.6
  • 38
    • 34250698332 scopus 로고    scopus 로고
    • Rho proteins and cell-matrix interactions in cancer
    • DOI 10.1159/000101309
    • Wu M, Wu ZF, Merajver SD. Rho proteins and cell-matrix interactions in cancer. Cells Tissues Organs 2007;185:100-3. (Pubitemid 46956849)
    • (2007) Cells Tissues Organs , vol.185 , Issue.1-3 , pp. 100-103
    • Wu, M.1    Wu, Z.-F.2    Merajver, S.D.3
  • 39
    • 0036280716 scopus 로고    scopus 로고
    • Mitogen activated protein kinase pathway is involved in RhoC GTPase induced motility, invasion and angiogenesis in inflammatory breast cancer
    • DOI 10.1023/A:1015518114931
    • van Golen KL, Bao LW, Pan Q, Miller FR, Wu ZF, Merajver SD. Mitogen activated protein kinase pathway is involved in RhoC GTPase induced motility, invasion and angiogenesis in inflammatory breast cancer. Clin Exp Metastasis 2002;19:301-11. (Pubitemid 34606755)
    • (2002) Clinical and Experimental Metastasis , vol.19 , Issue.4 , pp. 301-311
    • Van Golen, K.L.1    Wei, B.L.2    Pan, Q.3    Miller, F.R.4    Fen, W.Z.5    Merajver, S.D.6
  • 40
    • 0034601487 scopus 로고    scopus 로고
    • Genomic analysis of metastasis reveals an essential role for RhoC
    • DOI 10.1038/35020106
    • Clark EA, Golub TR, Lander ES, Hynes RO. Genomic analysis of metastasis reveals an essential role for RhoC. Nature 2000;406:532-5. (Pubitemid 30625739)
    • (2000) Nature , vol.406 , Issue.6795 , pp. 532-535
    • Clark, E.A.1    Golub, T.R.2    Lander, E.S.3    Hynes, R.O.4
  • 43
    • 77952709202 scopus 로고    scopus 로고
    • Characterization of the roles of RhoC and RhoA GTPases in invasion, motility, and matrix adhesion in inflammatory and aggressive breast cancers
    • Wu M, Wu ZF, Rosenthal DT, Rhee EM, Merajver SD. Characterization of the roles of RhoC and RhoA GTPases in invasion, motility, and matrix adhesion in inflammatory and aggressive breast cancers. Cancer 2010;116:2768-82.
    • (2010) Cancer , vol.116 , pp. 2768-2782
    • Wu, M.1    Wu, Z.F.2    Rosenthal, D.T.3    Rhee, E.M.4    Merajver, S.D.5
  • 44
    • 0034865456 scopus 로고    scopus 로고
    • Rho GTPases and cell migration
    • Ridley AJ. Rho GTPases and cell migration. J Cell Sci 2001;114:2713-22. (Pubitemid 32785451)
    • (2001) Journal of Cell Science , vol.114 , Issue.15 , pp. 2713-2722
    • Ridley, A.J.1
  • 46
    • 14644400387 scopus 로고    scopus 로고
    • TNF-alpha acts via p38 MAPK to stimulate expression of the ubiquitin ligase atrogin1/MAFbx in skeletal muscle
    • DOI 10.1096/fj.04-2364com
    • Li YP, Chen Y, John J, Moylan J, Jin B, Mann DL, et al. TNF-alpha acts via p38 MAPK to stimulate expression of the ubiquitin ligase atrogin1/MAFbx in skeletal muscle. FASEB J 2005;19:362-70. (Pubitemid 40316524)
    • (2005) FASEB Journal , vol.19 , Issue.3 , pp. 362-370
    • Li, Y.-P.1    Chen, Y.2    John, J.3    Moylan, J.4    Jin, B.5    Mann, D.L.6    Reid, M.B.7
  • 48
    • 78649729521 scopus 로고    scopus 로고
    • The role of ubiquitylation and degradation in RhoGTPase signalling
    • Nethe M, Hordijk PL. The role of ubiquitylation and degradation in RhoGTPase signalling. J Cell Sci 2010;123:4011-8.
    • (2010) J Cell Sci , vol.123 , pp. 4011-4018
    • Nethe, M.1    Hordijk, P.L.2


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