Inhibition of focal adhesion kinase suppresses the adverse phenotype of endocrine-resistant breast cancer cells and improves endocrine response in endocrine-sensitive cells

Breast Cancer Research and Treatment

Volumn 125, Issue 3, 2011, Pages 659-669

  Hiscox, Stephen ^a   Barnfather, Peter ^a   Hayes, Edd ^a   Bramble, Pamela ^b   Christensen, James ^c   Nicholson, Robert I ^a   Barrett Lee, Peter ^d  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^c PFIZER INC   (United States)

^d VELINDRE CANCER CENTRE   (United Kingdom)

Author keywords

Adhesion; Breast cancer; Endocrine resistance; Focal adhesion kinase; Fulvestrant; Migration; Tamoxifen

Indexed keywords

FOCAL ADHESION KINASE; FOCAL ADHESION KINASE INHIBITOR; PF 573228; TAMOXIFEN; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CANCER CELL; CANCER RESISTANCE; CELL ADHESION; CELL GROWTH; CELL INTERACTION; CELL MIGRATION; CELL SURVIVAL; CONTROLLED STUDY; DENSITOMETRY; ENZYME ACTIVATION; ENZYME INHIBITION; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL ADHESION; CELL LINE, TUMOR; CELL MOVEMENT; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOCRINE SYSTEM; ENZYME INHIBITORS; ESTRADIOL; FOCAL ADHESION PROTEIN-TYROSINE KINASES; HUMANS; INHIBITORY CONCENTRATION 50; PHENOTYPE; QUINOLONES; SULFONES; TAMOXIFEN;

EID: 79151480076     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-010-0857-4     Document Type: Article

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