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Volumn 8, Issue 5, 2013, Pages 733-739

Crystal Structures of a Bioactive 6′-Hydroxy Variant of Sisomicin Bound to the Bacterial and Protozoal Ribosomal Decoding Sites

(5) Kondo, Jiro a Koganei, Mai a Maianti, Juan Pablo b Ly, Vu Linh b Hanessian, Stephen b

a SOPHIA UNIVERSITY (Japan)

b UNIVERSITÉ DE MONTRÉAL (Canada)

Author keywords

Aminoglycosides; Antibacterial activity; Antiprotozoal activity; Ribosomal decoding sites; X ray crystallography

Indexed keywords

6' HYDROXYSISOMICIN; AMINOGLYCOSIDE; ANTIPROTOZOAL AGENT; GUANIDINE; HYDROXYL GROUP; RIBOSOME RNA; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIPROTOZOAL ACTIVITY; ARTICLE; CRYSTAL STRUCTURE; DRUG STRUCTURE; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; X RAY ANALYSIS;

ANTI-BACTERIAL AGENTS; ANTIPROTOZOAL AGENTS; BACTERIA; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; LEISHMANIA DONOVANI; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; RNA, RIBOSOMAL; SISOMICIN; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOSOMA BRUCEI RHODESIENSE;

EID: 84877066894 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.201200579 Document Type: Article

Times cited : (14)

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