-
1
-
-
77955336572
-
-
Leishmaniasis - magnitude of the problem on World Wide Web URL
-
Leishmaniasis - magnitude of the problem on World Wide Web URL: http://www.who.int/leishmaniasis/burden/magnitude/burden_magnitude/en/index.html.
-
-
-
-
2
-
-
58449083522
-
Anthropometrically derived dosing and drug costing calculations for treating visceral leishmaniasis in Bihar, India
-
Olliaro P., Sundar S. Anthropometrically derived dosing and drug costing calculations for treating visceral leishmaniasis in Bihar, India. Trop Med Int Health 2009, 14:88-92.
-
(2009)
Trop Med Int Health
, vol.14
, pp. 88-92
-
-
Olliaro, P.1
Sundar, S.2
-
3
-
-
33646055156
-
Development of miltefosine for the leishmaniases
-
Berman J. Development of miltefosine for the leishmaniases. Minirev Med Chem 2006, 6:145-151.
-
(2006)
Minirev Med Chem
, vol.6
, pp. 145-151
-
-
Berman, J.1
-
4
-
-
59749105928
-
In vitro susceptibility of field isolates of Leishmania donovani to miltefosine and amphotericin B: correlation with sodium antimony gluconate susceptibility and implications for treatment in areas of endemicity
-
Kumar D., Kulshrestha A., Singh R., Salotra P. In vitro susceptibility of field isolates of Leishmania donovani to miltefosine and amphotericin B: correlation with sodium antimony gluconate susceptibility and implications for treatment in areas of endemicity. Antimicrob Agents Chemother 2009, 53:835-838.
-
(2009)
Antimicrob Agents Chemother
, vol.53
, pp. 835-838
-
-
Kumar, D.1
Kulshrestha, A.2
Singh, R.3
Salotra, P.4
-
5
-
-
53349151814
-
New treatment approach in Indian visceral leishmaniasis: single-dose liposomal amphotericin B followed by short-course oral miltefosine
-
Sundar S., Rai M., Chakravarty J., Agarwal D., Agrawal N., Vaillant M., Olliaro P., Murray H. New treatment approach in Indian visceral leishmaniasis: single-dose liposomal amphotericin B followed by short-course oral miltefosine. Clin Infect Dis 2008, 47:1000-1006.
-
(2008)
Clin Infect Dis
, vol.47
, pp. 1000-1006
-
-
Sundar, S.1
Rai, M.2
Chakravarty, J.3
Agarwal, D.4
Agrawal, N.5
Vaillant, M.6
Olliaro, P.7
Murray, H.8
-
6
-
-
70049103388
-
Short-course paromomycin treatment of visceral leishmaniasis in India: 14-day vs 21-day treatment
-
Sundar S., Agrawal N., Arora R., Agarwal D., Rai M., Chakravarty J. Short-course paromomycin treatment of visceral leishmaniasis in India: 14-day vs 21-day treatment. Clin Infect Dis 2009, 49:914-918.
-
(2009)
Clin Infect Dis
, vol.49
, pp. 914-918
-
-
Sundar, S.1
Agrawal, N.2
Arora, R.3
Agarwal, D.4
Rai, M.5
Chakravarty, J.6
-
7
-
-
65849094308
-
WR279,396, a third generation aminoglycoside ointment for the treatment of Leishmania major cutaneous leishmaniasis: a phase 2, randomized, double blind, placebo controlled study
-
Ben Salah A., Buffet P., Morizot G., Ben Massoud N., Zâatour A., Ben Alaya N., Hamida N., El Ahmadi Z., Downs M., Smith P., et al. WR279,396, a third generation aminoglycoside ointment for the treatment of Leishmania major cutaneous leishmaniasis: a phase 2, randomized, double blind, placebo controlled study. PLoS Negl Trop Dis 2009, 3:e432.
-
(2009)
PLoS Negl Trop Dis
, vol.3
-
-
Ben Salah, A.1
Buffet, P.2
Morizot, G.3
Ben Massoud, N.4
Zâatour, A.5
Ben Alaya, N.6
Hamida, N.7
El Ahmadi, Z.8
Downs, M.9
Smith, P.10
-
8
-
-
35548987998
-
Visceral leishmaniasis: what are the needs for diagnosis, treatment and control?
-
Chappuis F., Sundar S., Hailu A., Ghalib H., Rijal S., Peeling R., Alvar J., Boelaert M. Visceral leishmaniasis: what are the needs for diagnosis, treatment and control?. Nat Rev Microbiol 2007, 5:873-882.
-
(2007)
Nat Rev Microbiol
, vol.5
, pp. 873-882
-
-
Chappuis, F.1
Sundar, S.2
Hailu, A.3
Ghalib, H.4
Rijal, S.5
Peeling, R.6
Alvar, J.7
Boelaert, M.8
-
9
-
-
64549094687
-
Current treatment for cutaneous leishmaniasis: a review
-
Palumbo E. Current treatment for cutaneous leishmaniasis: a review. Am J Therapeutics 2009, 16:178-182.
-
(2009)
Am J Therapeutics
, vol.16
, pp. 178-182
-
-
Palumbo, E.1
-
10
-
-
63149112758
-
Leishmaniasis: current treatment and prospects for new drugs and vaccines
-
Kedzierski L., Sakthianandeswaren A., Curtis J., Andrews P., Junk P., Kedzierska K. Leishmaniasis: current treatment and prospects for new drugs and vaccines. Curr Med Chem 2009, 16:599-614.
-
(2009)
Curr Med Chem
, vol.16
, pp. 599-614
-
-
Kedzierski, L.1
Sakthianandeswaren, A.2
Curtis, J.3
Andrews, P.4
Junk, P.5
Kedzierska, K.6
-
11
-
-
72249097281
-
Neglected tropical diseases: multi-target-directed ligands in the search for novel lead candidates against Trypanosoma and Leishmania
-
Cavalli A., Bolognesi M. Neglected tropical diseases: multi-target-directed ligands in the search for novel lead candidates against Trypanosoma and Leishmania. J Med Chem 2009, 52:7339-7359.
-
(2009)
J Med Chem
, vol.52
, pp. 7339-7359
-
-
Cavalli, A.1
Bolognesi, M.2
-
12
-
-
70349131162
-
In vitro susceptibilities of Leishmania donovani promastigote and amastigote stages to antileishmanial reference drugs: practical relevance of stage-specific differences
-
Vermeersch M., da Luz R., Toté K., Timmermans J., Cos P., Maes L. In vitro susceptibilities of Leishmania donovani promastigote and amastigote stages to antileishmanial reference drugs: practical relevance of stage-specific differences. Antimicrob Agents Chemother 2009, 53:3855-3859.
-
(2009)
Antimicrob Agents Chemother
, vol.53
, pp. 3855-3859
-
-
Vermeersch, M.1
da Luz, R.2
Toté, K.3
Timmermans, J.4
Cos, P.5
Maes, L.6
-
13
-
-
39749129681
-
Design and synthesis of potent antileishmanial cycloalkylidene-substituted ether phospholipid derivatives
-
Calogeropoulou T., Angelou P., Detsi A., Fragiadaki I., Scoulica E. Design and synthesis of potent antileishmanial cycloalkylidene-substituted ether phospholipid derivatives. J Med Chem 2008, 51:897-908.
-
(2008)
J Med Chem
, vol.51
, pp. 897-908
-
-
Calogeropoulou, T.1
Angelou, P.2
Detsi, A.3
Fragiadaki, I.4
Scoulica, E.5
-
14
-
-
48649098491
-
Parallel synthesis and antileishmanial activity of ether-linked phospholipids
-
Coghi P., Vaiana N., Pezzano M., Rizzi L., Kaiser M., Brun R., Romeo S. Parallel synthesis and antileishmanial activity of ether-linked phospholipids. Bioorg Med Chem Lett 2008, 18:4658-4660.
-
(2008)
Bioorg Med Chem Lett
, vol.18
, pp. 4658-4660
-
-
Coghi, P.1
Vaiana, N.2
Pezzano, M.3
Rizzi, L.4
Kaiser, M.5
Brun, R.6
Romeo, S.7
-
15
-
-
65649143532
-
2+ homeostasis and biosynthesis of sterols in Leishmania mexicana
-
2+ homeostasis and biosynthesis of sterols in Leishmania mexicana. Antimicrob Agents Chemother 2009, 53:1403-1410.
-
(2009)
Antimicrob Agents Chemother
, vol.53
, pp. 1403-1410
-
-
Serrano-Martín, X.1
García-Marchan, Y.2
Fernandez, A.3
Rodriguez, N.4
Rojas, H.5
Visbal, G.6
Benaim, G.7
-
16
-
-
71249161926
-
Amiodarone and miltefosine act synergistically against Leishmania mexicana and can induce parasitological cure in a murine model of cutaneous leishmaniasis
-
Serrano-Martín X., Payares G., De Lucca M., Martinez J., Mendoza-León A., Benaim G. Amiodarone and miltefosine act synergistically against Leishmania mexicana and can induce parasitological cure in a murine model of cutaneous leishmaniasis. Antimicrob Agents Chemother 2009, 53:5108-5113.
-
(2009)
Antimicrob Agents Chemother
, vol.53
, pp. 5108-5113
-
-
Serrano-Martín, X.1
Payares, G.2
De Lucca, M.3
Martinez, J.4
Mendoza-León, A.5
Benaim, G.6
-
17
-
-
0037453179
-
Formulation of amphotericin B as nanosuspension for oral administration
-
Kayser O., Olbrich C., Yardley V., Kiderlen A., Croft S. Formulation of amphotericin B as nanosuspension for oral administration. Int J Pharm 2003, 254:73-75.
-
(2003)
Int J Pharm
, vol.254
, pp. 73-75
-
-
Kayser, O.1
Olbrich, C.2
Yardley, V.3
Kiderlen, A.4
Croft, S.5
-
18
-
-
67249146920
-
Highly effective oral amphotericin B formulation against murine visceral leishmaniasis
-
Wasan K., Wasan E., Gershkovich P., Zhu X., Tidwell R., Werbovetz K., Clement J., Thornton S. Highly effective oral amphotericin B formulation against murine visceral leishmaniasis. J Infect Dis 2009, 200:357-360.
-
(2009)
J Infect Dis
, vol.200
, pp. 357-360
-
-
Wasan, K.1
Wasan, E.2
Gershkovich, P.3
Zhu, X.4
Tidwell, R.5
Werbovetz, K.6
Clement, J.7
Thornton, S.8
-
19
-
-
76049098694
-
Synthesis and antiprotozoal activity of 4-arylcoumarins
-
Pierson J., Dumètre A., Hutter S., Delmas F., Laget M., Finet J., Azas N., Combes S. Synthesis and antiprotozoal activity of 4-arylcoumarins. Eur J Med Chem 2010, 45:864-869.
-
(2010)
Eur J Med Chem
, vol.45
, pp. 864-869
-
-
Pierson, J.1
Dumètre, A.2
Hutter, S.3
Delmas, F.4
Laget, M.5
Finet, J.6
Azas, N.7
Combes, S.8
-
20
-
-
37549011407
-
Azaterphenyl diamidines as antileishmanial agents
-
Hu L., Arafa R., Ismail M., Wenzler T., Brun R., Munde M., Wilson W., Nzimiro S., Samyesudhas S., Werbovetz K., et al. Azaterphenyl diamidines as antileishmanial agents. Bioorg Med Chem Lett 2008, 18:247-251.
-
(2008)
Bioorg Med Chem Lett
, vol.18
, pp. 247-251
-
-
Hu, L.1
Arafa, R.2
Ismail, M.3
Wenzler, T.4
Brun, R.5
Munde, M.6
Wilson, W.7
Nzimiro, S.8
Samyesudhas, S.9
Werbovetz, K.10
-
21
-
-
77952612936
-
Novel arylimidamides for the treatment of visceral leishmaniasis
-
doi:10.1128/AAC.00250-10, (in press)
-
Wang M, Zhu X, Srivastava A, Liu Q, Sweat J, Pandharkar T, Stephens C, Riccio E, Mandal S, Madhubala R, et al.: Novel arylimidamides for the treatment of visceral leishmaniasis. Antimicrob Agents Chemother (in press), doi:10.1128/AAC.00250-10.
-
Antimicrob Agents Chemother
-
-
Wang, M.1
Zhu, X.2
Srivastava, A.3
Liu, Q.4
Sweat, J.5
Pandharkar, T.6
Stephens, C.7
Riccio, E.8
Mandal, S.9
Madhubala, R.10
-
22
-
-
0036171419
-
In vivo activities of farnesyl pyrophosphate synthase inhibitors against Leishmania donovani and Toxoplasma gondii
-
Yardley V., Khan A., Martin M., Slifer T., Araujo F., Moreno S., Docampo R., Croft S., Oldfield E. In vivo activities of farnesyl pyrophosphate synthase inhibitors against Leishmania donovani and Toxoplasma gondii. Antimicrob Agents Chemother 2002, 46:929-931.
-
(2002)
Antimicrob Agents Chemother
, vol.46
, pp. 929-931
-
-
Yardley, V.1
Khan, A.2
Martin, M.3
Slifer, T.4
Araujo, F.5
Moreno, S.6
Docampo, R.7
Croft, S.8
Oldfield, E.9
-
23
-
-
51449109024
-
Synthesis and biological evaluation of indolyl bisphosphonates as anti-bone resorptive and anti-leishmanial agents
-
Singh U., Shankar R., Kumar A., Trivedi R., Chattopadhyay N., Shakya N., Palne S., Gupta S., Hajela K. Synthesis and biological evaluation of indolyl bisphosphonates as anti-bone resorptive and anti-leishmanial agents. Bioorg Med Chem 2008, 16:8482-8491.
-
(2008)
Bioorg Med Chem
, vol.16
, pp. 8482-8491
-
-
Singh, U.1
Shankar, R.2
Kumar, A.3
Trivedi, R.4
Chattopadhyay, N.5
Shakya, N.6
Palne, S.7
Gupta, S.8
Hajela, K.9
-
24
-
-
0028223416
-
Antileishmanial activity of licochalcone A in mice infected with Leishmania major and in hamsters infected with Leishmania donovani
-
Chen M., Christensen S., Theander T., Kharazmi A. Antileishmanial activity of licochalcone A in mice infected with Leishmania major and in hamsters infected with Leishmania donovani. Antimicrob Agents Chemother 1994, 38:1339-1344.
-
(1994)
Antimicrob Agents Chemother
, vol.38
, pp. 1339-1344
-
-
Chen, M.1
Christensen, S.2
Theander, T.3
Kharazmi, A.4
-
25
-
-
54049086675
-
Chemotherapy of leishmaniasis part VIII: synthesis and bioevaluation of novel chalcones
-
Suryawanshi S., Chandra N., Kumar P., Porwal J., Gupta S. Chemotherapy of leishmaniasis part VIII: synthesis and bioevaluation of novel chalcones. Eur J Med Chem 2008, 43:2473-2478.
-
(2008)
Eur J Med Chem
, vol.43
, pp. 2473-2478
-
-
Suryawanshi, S.1
Chandra, N.2
Kumar, P.3
Porwal, J.4
Gupta, S.5
-
26
-
-
39149140718
-
2-(3-Aryl-3-oxopropen-1-yl)-9-tert-butyl-paullones: a new antileishmanial chemotype
-
Rechwald C., Shimony O., Dunkel U., Sacerdoti-Sierra N., Jaffe C., Kunick C. 2-(3-Aryl-3-oxopropen-1-yl)-9-tert-butyl-paullones: a new antileishmanial chemotype. J Med Chem 2008, 51:659-665.
-
(2008)
J Med Chem
, vol.51
, pp. 659-665
-
-
Rechwald, C.1
Shimony, O.2
Dunkel, U.3
Sacerdoti-Sierra, N.4
Jaffe, C.5
Kunick, C.6
-
27
-
-
37849010534
-
Oral therapy with amlodipine and lacidipine, 1,4-dihydropyridine derivatives showing activity against experimental visceral leishmaniasis
-
Palit P., Ali N. Oral therapy with amlodipine and lacidipine, 1,4-dihydropyridine derivatives showing activity against experimental visceral leishmaniasis. Antimicrob Agents Chemother 2008, 52:374-377.
-
(2008)
Antimicrob Agents Chemother
, vol.52
, pp. 374-377
-
-
Palit, P.1
Ali, N.2
-
28
-
-
51149091689
-
Activity of a hydroxybibenzyl bryophyte constituent against Leishmania spp. and Trypanosoma cruzi: in silico, in vitro and in vivo activity studies
-
Roldos V., Nakayama H., Rolón M., Trucco F., Torres S., Vega C., Marrero-Ponce Y., Heguaburu V., Yaluff G., Gómez-Barrio A., et al. Activity of a hydroxybibenzyl bryophyte constituent against Leishmania spp. and Trypanosoma cruzi: in silico, in vitro and in vivo activity studies. Eur J Med Chem 2008, 43:1797-1807.
-
(2008)
Eur J Med Chem
, vol.43
, pp. 1797-1807
-
-
Roldos, V.1
Nakayama, H.2
Rolón, M.3
Trucco, F.4
Torres, S.5
Vega, C.6
Marrero-Ponce, Y.7
Heguaburu, V.8
Yaluff, G.9
Gómez-Barrio, A.10
-
29
-
-
54049094432
-
Activity of hydroxyurea against Leishmania mexicana
-
Martinez-Rojano H., Mancilla-Ramirez J., Quiñonez-Diaz L., Galindo-Sevilla N. Activity of hydroxyurea against Leishmania mexicana. Antimicrob Agents Chemother 2008, 52:3642-3647.
-
(2008)
Antimicrob Agents Chemother
, vol.52
, pp. 3642-3647
-
-
Martinez-Rojano, H.1
Mancilla-Ramirez, J.2
Quiñonez-Diaz, L.3
Galindo-Sevilla, N.4
-
30
-
-
58749093729
-
Ivermectin-derived leishmanicidal compounds
-
dos Santos A., Falcão C., Muzitano M., Kaiser C., Rossi-Bergmann B., Férézou J. Ivermectin-derived leishmanicidal compounds. Bioorg Med Chem 2009, 17:496-502.
-
(2009)
Bioorg Med Chem
, vol.17
, pp. 496-502
-
-
dos Santos, A.1
Falcão, C.2
Muzitano, M.3
Kaiser, C.4
Rossi-Bergmann, B.5
Férézou, J.6
-
31
-
-
58549093170
-
Redox-active dinitrophenylthioethers against Leishmania: synthesis, structure-activity relationships and mechanism of action studies
-
Delfín D., Morgan R., Zhu X., Werbovetz K. Redox-active dinitrophenylthioethers against Leishmania: synthesis, structure-activity relationships and mechanism of action studies. Bioorg Med Chem 2009, 17:820-829.
-
(2009)
Bioorg Med Chem
, vol.17
, pp. 820-829
-
-
Delfín, D.1
Morgan, R.2
Zhu, X.3
Werbovetz, K.4
-
32
-
-
0025030523
-
Inhibition of Leishmanias but not host macrophages by the antitubulin herbicide trifluralin
-
Chan M., Fong D. Inhibition of Leishmanias but not host macrophages by the antitubulin herbicide trifluralin. Science 1990, 249:924-926.
-
(1990)
Science
, vol.249
, pp. 924-926
-
-
Chan, M.1
Fong, D.2
-
33
-
-
72149117690
-
Synthesis and biological evaluation of trifluralin analogues as antileishmanial agents
-
Esteves M., Fragiadaki I., Lopes R., Scoulica E., Cruz M. Synthesis and biological evaluation of trifluralin analogues as antileishmanial agents. Bioorg Med Chem 2010, 18:274-281.
-
(2010)
Bioorg Med Chem
, vol.18
, pp. 274-281
-
-
Esteves, M.1
Fragiadaki, I.2
Lopes, R.3
Scoulica, E.4
Cruz, M.5
-
34
-
-
42149170805
-
Synthesis and in vitro anti-leishmanial activity of 1-[5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-yl]- and 1-[5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazol-2-yl]-4-aroylpiperazines
-
Behrouzi-Fardmoghadam M., Poorrajab F., Ardestani S., Emami S., Shafiee A., Foroumadi A. Synthesis and in vitro anti-leishmanial activity of 1-[5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-yl]- and 1-[5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazol-2-yl]-4-aroylpiperazines. Bioorg Med Chem 2008, 16:4509-4515.
-
(2008)
Bioorg Med Chem
, vol.16
, pp. 4509-4515
-
-
Behrouzi-Fardmoghadam, M.1
Poorrajab, F.2
Ardestani, S.3
Emami, S.4
Shafiee, A.5
Foroumadi, A.6
-
35
-
-
61349161162
-
Nitroimidazolyl-1,3,4-thiadiazole-based anti-leishmanial agents: synthesis and in vitro biological evaluation
-
Poorajab F., Ardestani S., Emami S., Behrouzi-Fardmoghadam M., Shafiee A., Foroumadi A. Nitroimidazolyl-1,3,4-thiadiazole-based anti-leishmanial agents: synthesis and in vitro biological evaluation. Eur J Med Chem 2009, 44:1758-1762.
-
(2009)
Eur J Med Chem
, vol.44
, pp. 1758-1762
-
-
Poorajab, F.1
Ardestani, S.2
Emami, S.3
Behrouzi-Fardmoghadam, M.4
Shafiee, A.5
Foroumadi, A.6
-
36
-
-
67049145660
-
Effect of topical liposomes containing paromomycin sulfate in the course of Leishmania major infection in susceptible BALB/c mice
-
Jaafari M., Bavarsad N., Fazly Bazzaz B., Samiei A., Soroush D., Ghorbani S., Lotfi Heravi, Khamesipour A. Effect of topical liposomes containing paromomycin sulfate in the course of Leishmania major infection in susceptible BALB/c mice. Antimicrob Agents Chemother 2009, 53:2259-2265.
-
(2009)
Antimicrob Agents Chemother
, vol.53
, pp. 2259-2265
-
-
Jaafari, M.1
Bavarsad, N.2
Fazly Bazzaz, B.3
Samiei, A.4
Soroush, D.5
Ghorbani, S.6
Lotfi Heravi7
Khamesipour, A.8
-
37
-
-
64249084534
-
Peganine hydrochloride dihydrate an orally active antileishmanial agent
-
Khaliq T., Misra P., Gupta S., Reddy K., Kant R., Maulik P., Dube A., Narender T. Peganine hydrochloride dihydrate an orally active antileishmanial agent. Bioorg Med Chem Lett 2009, 19:2585-2586.
-
(2009)
Bioorg Med Chem Lett
, vol.19
, pp. 2585-2586
-
-
Khaliq, T.1
Misra, P.2
Gupta, S.3
Reddy, K.4
Kant, R.5
Maulik, P.6
Dube, A.7
Narender, T.8
-
38
-
-
71249131221
-
The antituberculosis drug pyrazinamide affects the course of cutaneous leishmaniasis in vivo and increases activation of macrophages and dendritic cells
-
Mendez S., Traslavina R., Hinchman M., Huang L., Green P., Cynamon M., Welch J. The antituberculosis drug pyrazinamide affects the course of cutaneous leishmaniasis in vivo and increases activation of macrophages and dendritic cells. Antimicrob Agents Chemother 2009, 53:5114-5121.
-
(2009)
Antimicrob Agents Chemother
, vol.53
, pp. 5114-5121
-
-
Mendez, S.1
Traslavina, R.2
Hinchman, M.3
Huang, L.4
Green, P.5
Cynamon, M.6
Welch, J.7
-
39
-
-
64249139717
-
Synthesis and antileishmanial activity of novel 2,4,6-trisubstituted pyrimidines and 1,3,5-triazines
-
Sunduru N., Nishi, Palne S., Chauhan P., Gupta S. Synthesis and antileishmanial activity of novel 2,4,6-trisubstituted pyrimidines and 1,3,5-triazines. Eur J Med Chem 2009, 44:2473-2481.
-
(2009)
Eur J Med Chem
, vol.44
, pp. 2473-2481
-
-
Sunduru, N.1
Nishi2
Palne, S.3
Chauhan, P.4
Gupta, S.5
-
40
-
-
68949149073
-
Design and synthesis of novel substituted quinazoline derivatives as antileishmanial agents
-
Agarwal K., Sharma V., Shakya N., Gupta S. Design and synthesis of novel substituted quinazoline derivatives as antileishmanial agents. Bioorg Med Chem Lett 2009, 19:5474-5477.
-
(2009)
Bioorg Med Chem Lett
, vol.19
, pp. 5474-5477
-
-
Agarwal, K.1
Sharma, V.2
Shakya, N.3
Gupta, S.4
-
41
-
-
0019161590
-
Analogues of 8-[[6-diethylamino)hexyl]amino]-6-methoxy-4-methylquinoline as candidate antileishmanial agents
-
LaMontagne M., Dagli D., Khan S., Blumbergs P. Analogues of 8-[[6-diethylamino)hexyl]amino]-6-methoxy-4-methylquinoline as candidate antileishmanial agents. J Med Chem 1980, 23:981-985.
-
(1980)
J Med Chem
, vol.23
, pp. 981-985
-
-
LaMontagne, M.1
Dagli, D.2
Khan, S.3
Blumbergs, P.4
-
42
-
-
0027948991
-
Phase 2 efficacy trial of an oral 8-aminoquinoline (WR6026) for treatment of visceral leishmaniasis
-
Sherwood J., Gachihi G., Muiagi R., Skillman D., Mugo M., Rashid J., Wasunna K., Were J., Kasili S., Mbugua J., et al. Phase 2 efficacy trial of an oral 8-aminoquinoline (WR6026) for treatment of visceral leishmaniasis. Clin Infect Dis 1994, 19:1034-1039.
-
(1994)
Clin Infect Dis
, vol.19
, pp. 1034-1039
-
-
Sherwood, J.1
Gachihi, G.2
Muiagi, R.3
Skillman, D.4
Mugo, M.5
Rashid, J.6
Wasunna, K.7
Were, J.8
Kasili, S.9
Mbugua, J.10
-
43
-
-
29844441606
-
A phase II dose-ranging study of sitamaquine for the treatment of visceral leishmaniasis in India
-
Jha T., Sundar S., Thakur C., Felton J., Sabin A., Horton J. A phase II dose-ranging study of sitamaquine for the treatment of visceral leishmaniasis in India. Am J Trop Med Hyg 2005, 73:1005-1011.
-
(2005)
Am J Trop Med Hyg
, vol.73
, pp. 1005-1011
-
-
Jha, T.1
Sundar, S.2
Thakur, C.3
Felton, J.4
Sabin, A.5
Horton, J.6
-
44
-
-
44449113132
-
Antiparasitic activities and toxicities of individual enantiomers of the 8-aminoquinoline 8-[(4-amino-1-methylbutyl)amino]-6-methoxy-4-methyl-5-[3,4-dichlorophenoxy]quinoline succinate
-
Nanayakkara N., Ager A., Bartlett S., Yardley V., Croft S., Khan I., McChesney J., Walker L. Antiparasitic activities and toxicities of individual enantiomers of the 8-aminoquinoline 8-[(4-amino-1-methylbutyl)amino]-6-methoxy-4-methyl-5-[3,4-dichlorophenoxy]quinoline succinate. Antimicrob Agents Chemother 2008, 52:2130-2137.
-
(2008)
Antimicrob Agents Chemother
, vol.52
, pp. 2130-2137
-
-
Nanayakkara, N.1
Ager, A.2
Bartlett, S.3
Yardley, V.4
Croft, S.5
Khan, I.6
McChesney, J.7
Walker, L.8
-
45
-
-
70449622750
-
A new series of amodiaquine analogues modified in the basic side chain with in vitro antileishmanial and antiplasmodial activity
-
Guglielmo S., Bertinaria M., Rolando B., Crosetti M., Fruttero R., Yardley V., Croft S., Gasco A. A new series of amodiaquine analogues modified in the basic side chain with in vitro antileishmanial and antiplasmodial activity. Eur J Med Chem 2009, 44:5071-5079.
-
(2009)
Eur J Med Chem
, vol.44
, pp. 5071-5079
-
-
Guglielmo, S.1
Bertinaria, M.2
Rolando, B.3
Crosetti, M.4
Fruttero, R.5
Yardley, V.6
Croft, S.7
Gasco, A.8
-
46
-
-
38149131407
-
Synthesis and antiprotozoal activities of simplified analogs of naphthylisoquinoline alkaloids
-
Bringmann G., Brun R., Kaiser M., Neumann S. Synthesis and antiprotozoal activities of simplified analogs of naphthylisoquinoline alkaloids. Eur J Med Chem 2008, 43:32-42.
-
(2008)
Eur J Med Chem
, vol.43
, pp. 32-42
-
-
Bringmann, G.1
Brun, R.2
Kaiser, M.3
Neumann, S.4
-
47
-
-
61449228501
-
Structure-activity relationship and studies on the molecular mechanism of leishmanicidal N,C-coupled arylisoquinolinium salts
-
Ponte-Sucre A., Gulder T., Wegehaupt A., Albert C., Rikanovic C., Schaeflein L., Frank A., Schultheis M., Unger M., Holzgrabe U., et al. Structure-activity relationship and studies on the molecular mechanism of leishmanicidal N,C-coupled arylisoquinolinium salts. J Med Chem 2009, 52:626-636.
-
(2009)
J Med Chem
, vol.52
, pp. 626-636
-
-
Ponte-Sucre, A.1
Gulder, T.2
Wegehaupt, A.3
Albert, C.4
Rikanovic, C.5
Schaeflein, L.6
Frank, A.7
Schultheis, M.8
Unger, M.9
Holzgrabe, U.10
-
48
-
-
60149100798
-
Phase transfer catalyzed synthesis of bis-quinolines: antileishmanial activity in experimental visceral leishmaniasis and in vitro antibacterial evaluation
-
Palit P., Paira P., Hazra A., Banerjee S., Gupta A., Dastidar S., Mondal N. Phase transfer catalyzed synthesis of bis-quinolines: antileishmanial activity in experimental visceral leishmaniasis and in vitro antibacterial evaluation. Eur J Med Chem 2009, 44:845-853.
-
(2009)
Eur J Med Chem
, vol.44
, pp. 845-853
-
-
Palit, P.1
Paira, P.2
Hazra, A.3
Banerjee, S.4
Gupta, A.5
Dastidar, S.6
Mondal, N.7
-
49
-
-
74849092571
-
Fluorinated rhodacyanine (SJL-01) possessing high efficacy for visceral leishmaniasis (VL)
-
Yang M., Arai C., Bakar A., Lu J., Ge J., Pudhom K., Takasu K., Kasai K., Kaiser M., Brun R., et al. Fluorinated rhodacyanine (SJL-01) possessing high efficacy for visceral leishmaniasis (VL). J Med Chem 2010, 53:368-373.
-
(2010)
J Med Chem
, vol.53
, pp. 368-373
-
-
Yang, M.1
Arai, C.2
Bakar, A.3
Lu, J.4
Ge, J.5
Pudhom, K.6
Takasu, K.7
Kasai, K.8
Kaiser, M.9
Brun, R.10
-
50
-
-
55849131057
-
In vitro activities of ER-119884 and E5700, two potent squalene synthase inhibitors, against Leishmania amazonensis: antiproliferative, biochemical, and ultrastructural effects
-
Fernandes Rodrigues J., Concepcion J., Rodrigues C., Caldera A., Urbina J., de Souza W. In vitro activities of ER-119884 and E5700, two potent squalene synthase inhibitors, against Leishmania amazonensis: antiproliferative, biochemical, and ultrastructural effects. Antimicrob Agents Chemother 2008, 52:4098-4114.
-
(2008)
Antimicrob Agents Chemother
, vol.52
, pp. 4098-4114
-
-
Fernandes Rodrigues, J.1
Concepcion, J.2
Rodrigues, C.3
Caldera, A.4
Urbina, J.5
de Souza, W.6
-
51
-
-
57749116985
-
Aryloxy cyclohexyl imidazoles: a novel class of antileishmanial agents
-
Srinivas N., Palne S., Nishi, Gupta S., Bhandari K. Aryloxy cyclohexyl imidazoles: a novel class of antileishmanial agents. Bioorg Med Chem Lett 2009, 19:324-327.
-
(2009)
Bioorg Med Chem Lett
, vol.19
, pp. 324-327
-
-
Srinivas, N.1
Palne, S.2
Nishi3
Gupta, S.4
Bhandari, K.5
-
52
-
-
72049108895
-
Synthesis of substituted aryloxy alkyl and aryloxy aryl alkyl imidazoles as antileishmanial agents
-
Bhandari K., Srinivas N., Marrapu V., Verma A., Srivastava S., Gupta S. Synthesis of substituted aryloxy alkyl and aryloxy aryl alkyl imidazoles as antileishmanial agents. Bioorg Med Chem Lett 2010, 20:291-293.
-
(2010)
Bioorg Med Chem Lett
, vol.20
, pp. 291-293
-
-
Bhandari, K.1
Srinivas, N.2
Marrapu, V.3
Verma, A.4
Srivastava, S.5
Gupta, S.6
-
54
-
-
0035253601
-
The hamster as a model of human visceral leishmaniasis: progressive disease and impaired generation of nitric oxide in the face of a prominent Th1-like cytokine response
-
Melby P., Chandrasekar B., Zhao W., Coe J. The hamster as a model of human visceral leishmaniasis: progressive disease and impaired generation of nitric oxide in the face of a prominent Th1-like cytokine response. J Immunol 2001, 166:1912-1920.
-
(2001)
J Immunol
, vol.166
, pp. 1912-1920
-
-
Melby, P.1
Chandrasekar, B.2
Zhao, W.3
Coe, J.4
|