Examination of the mode of action of the almiramide family of natural products against the kinetoplastid parasite Trypanosoma brucei

Journal of Natural Products

Volumn 76, Issue 4, 2013, Pages 630-641

  Sanchez, Laura M ^a   Knudsen, Giselle M ^b   Helbig, Claudia ^c   De Muylder, Geraldine ^b   Mascuch, Samantha M ^d   MacKey, Zachary B ^b   Gerwick, Lena ^d   Clayton, Christine ^c   McKerrow, James H ^b   Linington, Roger G ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALMIRAMIDE A; ALMIRAMIDE B; ALMIRAMIDE C; ALMIRAMIDE DERIVATIVE; AMIDE; ANTIPROTOZOAL AGENT; NATURAL PRODUCT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIPROTOZOAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL LYSATE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG SCREENING; DRUG TARGETING; EMBRYO; EPIFLUORESCENCE MICROSCOPY; FEMALE; FLUORESCENCE IMAGING; GLYCOLYSIS; GLYCOSOME; IN VIVO STUDY; KINETOPLASTID LIFE CYCLE STAGE; LEISHMANIA; MALE; NONHUMAN; PARASITE SURVIVAL; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTON NUCLEAR MAGNETIC RESONANCE; TOXICITY TESTING; TRYPANOSOMA BRUCEI; VERO CELL; ZEBRA FISH;

ANIMALS; BIOLOGICAL AGENTS; CHAGAS DISEASE; GLYCOLYSIS; HUMANS; LEISHMANIA DONOVANI; LIPOPEPTIDES; MICROBODIES; MICROSCOPY, FLUORESCENCE; TRYPANOSOMA BRUCEI BRUCEI; ZEBRAFISH;

DANIO RERIO; KINETOPLASTIDA; LEISHMANIA DONOVANI; TRYPANOSOMA BRUCEI;

EID: 84876946971     PISSN: 01633864     EISSN: 15206025     Source Type: Journal    
DOI: 10.1021/np300834q     Document Type: Article

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