Blocking c-Jun-N-terminal kinase signaling can prevent hearing loss induced by both electrode insertion trauma and neomycin ototoxicity

Hearing Research

Volumn 226, Issue 1-2, 2007, Pages 168-177

  Eshraghi, Adrien A ^a   Wang, Jing ^b   Adil, Eelam ^a   He, Jiao ^a   Zine, Azel ^b   Bublik, Michael ^a   Bonny, Christophe ^c   Puel, Jean Luc ^b   Balkany, Thomas J ^a   Van De Water, Thomas R ^a  

^a UNIVERSITY OF MIAMI EAR INSTITUTE   (United States)

^b INSERM   (France)

^c UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

Aminoglycoside ototoxicity; Apoptosis; D JNKI 1 peptide (AM 111); Electrode insertion trauma; Hair cells; Hearing loss; JNK signaling; Otoprotection

Indexed keywords

2,3 DIHYDROXYBENZOIC ACID; ACETYLSALICYLIC ACID; AMINOGLYCOSIDE; CEP 1347; DEFEROXAMINE; GLUTATHIONE; METHIONINE; NEOMYCIN; SALICYLIC ACID; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; SUPEROXIDE DISMUTASE; TANSHINONE;

APOPTOSIS; ARTICLE; CELL DEATH; CYTOLOGY; ELECTRODE; ENZYME ACTIVATION; ENZYME INACTIVATION; HAIR CELL; HEARING LOSS; HUMAN; NOISE INJURY; NONHUMAN; OTOTOXICITY; PRIORITY JOURNAL;

ANIMALS; ANTI-BACTERIAL AGENTS; APOPTOSIS; CASPASES; ELECTRODES; FREE RADICALS; GUINEA PIGS; HEARING LOSS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE SIGNALING SYSTEM; NEOMYCIN; PEPTIDES; SIGNAL TRANSDUCTION;

EID: 33947316135     PISSN: 03785955     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.heares.2006.09.008     Document Type: Article

References (48)

1. Balkany T.J., Eshraghi A.A., He J., Polak M., Mou C., Dietrich W.D., and Van De Water T.R. Mild hypothermia protects auditory function during cochlear implant surgery. Laryngoscope 115 (2005) 1543-1547
2. Bonny C., Oberson A., Negri S., Sauser C., and Schorderet D.F. Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death. Diabetes 50 (2001) 77-82
3. Bosch-Morell F., Flohe L., Marin N., and Romero F.J. 4-Hydroxynonenal inhibits glutathione peroxidase: protection by glutathione. Free Radic. Biol. Med. 26 (1999) 1383-1387
4. Boyce M., and Yuan J. Cellular response to endoplasmic reticulum stress: a matter of life or death. Cell Death Differ. 13 (2006) 363-373
5. Bredberg G. Cellular pattern and nerve supply of the human organ of Corti. Acta Otolaryngol. Suppl. 236 (1968) 1
6. Camandola S., Poli G., and Mattson M. The lipid peroxidation product 4-hydroxy-2,3-nonenal increases AP-1 binding activity through caspase activation in neurons. J. Neurochem. 74 (2000) 159-168
7. Cunningham L.L., Cheng A.G., and Rubel E.W. Caspase activation in hair cells of the mouse utricle exposed to neomycin. J. Neurosci. 22 (2002) 8532-8540
8. Dehne N., Rauen U., de Groot H., and Lautermann J. Involvement of the mitochondrial permeability transition in gentamicin ototoxicity. Hear. Res. 169 (2002) 47-55
9. Dickens M., Rogers J.S., Cavanagh J., Raitano A., Xia Z., Halpern J.R., Greenberg M.E., Sawyers C.L., and Davis R.J. A cytoplasmic inhibitor of the JNK signal transduction pathway. Science 277 (1997) 693-696
10. Dietrich W.D., Busto R., Globus M.Y., and Ginsberg M.D. Brain damage and temperature: cellular and molecular mechanisms. Adv. Neurol. 71 (1996) 177-194
11. Do K., Baker K., Praetorius M., and Staecker H. A mouse model of implantation trauma. Int. Cong. Ser. 1273 (2004) 167-170
12. Eshraghi A.A., and Van De Water T.R. Cochlear function, physical trauma, oxidative stress, induction of apoptosis and therapeutic strategies. Anat. Rec. Part A 288A (2006) 473-481
13. Eshraghi A.A., Yang N., and Balkany T.J. Comparative study of cochlear damage with three perimodiolar electrode designs. Laryngoscope 113 (2003) 415-419
14. Eshraghi A.A., Jolly C., and Balkany T.J. Small fenestra cochleostomy for MED-EL Flex electrode. Cochlear Implant Int. 5 (2004) 71-75
15. Eshraghi A.A., Polak M., He J., Balkany T.J., and Van De Water T.R. The pattern of hearing loss in a rat model of cochlear implantation trauma. Otol. Neurotol. 26 (2005) 442-447
16. Eshraghi A.A., He J., Mou CH., Polak M., Zine A., Bonny C., Balkany TJ., and Van De Water TR. D-JNKI-1 treatment prevents the progression of hearing loss in a model of cochlear implantation trauma. Otol. Neurotol. 27 (2006) 504-511
17. Fischel-Ghodsian N. Mitochondrial deafness. Ear Hear. 24 (2003) 303-313
18. Forge A., and Li L. Apoptotic death of hair cells in mammalian vestibular sensory epithelia. Hear. Res. 139 (2000) 97-115
19. Forge A., and Schacht J. Aminoglycoside antibiotics. Audiol. Neurootol. 5 (2000) 03-22
20. Guzman J., Ruiz J., Eshraghi A.A., Polak M., Garnham C., Balkany T.J., and Van De Water T.R. Triamcinolone acetonide protects auditory hair cells from 4-hydroxy-2,3-nonenal (HNE) toxicity in vitro. Acta Oto-Laryngol. 126 (2006) 685-690
21. Hu B.H., Henderson D., and Nicotera T.M. Extremely rapid induction of outer hair cell apoptosis in the chinchilla cochlea following exposure to impulse noise. Hear. Res. 211 (2006) 16-25
22. Jiang H., Sha S.-H., Forge A., and Schacht J. Caspase-independent pathways of hair cell death induced by kanamycin in vivo. Cell Death Differ. 13 (2006) 20-30
23. Kyriakis J.M., Banerjee P., Nikolakaki E., Dai T., Rubie E.A., Ahmad M.F., Avruch J., and Woodgett J.R. The stress-activated protein kinase subfamily of c-Jun kinases. Nature 369 (1994) 156-160
24. Lefebvre P.P., Malgrange B., Lallemend F., Staecker H., Moonen G., and Van De Water T.R. Mechanisms of cell death in the injured auditory system: otoprotective strategies. Audiol. Neurootol. 7 (2002) 165-170
25. Leist M., and Jaattela M. Four deaths and a funeral: from caspases to alternative mechanisms. Nat. Rev. Mol. Cell Biol. 2 (2001) 01-10
26. Nicotera T.M., Hu B.H., and Henderson D. The caspase pathway in noise-induced apoptosis of the chinchilla cochlea. J. Assoc. Res. Otolaryngol. 4 (2003) 466-477
27. Pirvola U., Xing-Qun L., Virkkala J., Saarma M., Murakata C., Camoratto A.M., Walton K.M., and Ylikoski J. Rescue of hearing, auditory hair cells, and neurons by CEP-1347/KT7515, an inhibitor of c-Jun N-terminal kinase activation. J. Neurosci. 20 (2000) 43-50
28. Priuska E.M., and Schacht J. Formation of free radicals by gentamicin and iron and evidence for an iron/gentamicin complex. Biochem. Pharmacol. 50 (1995) 1749-1752
29. Ray S.K., Patel S.J., Welsh C.T., Wilford G.G., Hogan E.L., and Banik N.L. Molecular evidence of apoptotic death in malignant brain tumors including glioblastoma multiforme: upregulation of calpain and caspase 3. J. Neurosci. Res. 69 (2002) 197-206
30. Ruben R.J. Development of the inner ear of the mouse: a radioautographic study of terminal mitoses. Acta Otolaryngol. Suppl. 220 (1967) 01-44
31. Ruiz, J., Guzman, J., Polak, M., Eshraghi, A.A., Balkany, T.J., Van De Water, T.R., in press. Glutathionine ester protects against hydroxynonenal induced loss of auditory hair cells. Otolaryngology-HNS.
32. Schacht J. Antioxidant therapy attenuates aminoglycoside-induced hearing loss. In: Henderson, Salvi, Quaranta, McFadden, and Burkhard (Eds). Ototoxicity. Ann. N. Y. Acad. Sci. 884 (1999) 125-130
33. Seidman M., and Van De Water T.R. Pharmacological manipulation of the inner ear. ENT J. 82 (2003) 276-288
34. Sha S.-H., and Schacht J. Salicylate attenuates gentamicin-induced ototoxicity. Lab. Invest. 79 (1999) 807-813
35. Sha S.-H., and Schacht J. Antioxidants attenuate gentamicin-induced free radical formation in vitro and ototoxicity in vivo: d-methionine is a potential protectant. Hear. Res. 142 (2000) 34-40
36. Sha S.-H., Taylor R., Forge A., and Schacht J. Differential vulnerability of basal and apical hair cells is based on intrinsic susceptibility to free radicals. Hear. Res. 155 (2001) 1-8
37. Sha S.-H., Zajic G., Epstein C.J., and Schacht J. Overexpression of copper/zinc-superoxide dismutase protects from kanamycin-induced hearing loss. Audiol. Neurootol. 6 (2001) 117-123
38. Sha S.-H., Qui J.-H., and Schacht J. Aspirin to prevent gentamicin-induced hearing loss. N. Engl. J. Med. 354 (2006) 1856-1857
39. Song B.B., and Schacht J. Variable efficacy of radical scavengers and iron chelators to attenuate gentamicin ototoxicity in guinea pig in vivo. Hear. Res. 94 (1996) 87-93
40. Sperandio S., Poksay K., de Belle I., Lafuente M.J., Liu B., Nasir J., and Bredesen D.E. Paraptosis: mediation of MAP kinases and inhibition by AIP-1/Alix. Cell Death Differ. 11 (2004) 1066-1075
41. Van De Water T.R., Lallemend F., Eshraghi A.A., Ahsan S., He J., Guzman J., Polak M., Malgrange B., Lefebvre P.P., Staecker H., and Balkany T.J. Caspases, the enemy within, and their role in oxidative stress-induced apoptosis of inner ear sensory cells. Otol. Neurotol. 25 (2004) 627-632
42. Wang J., Van De Water T.R., Bonny C., de Ribaupierre F., Puel J.L., and Zine A. A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss. J. Neurosci. 23 (2003) 8596-8607
43. Wang A.M., Sha S.-H., Lesniak W., and Schacht J. Tanshione (Salviae miltiorrhizae extract) preparations attenuate aminoglycoside-induced free radical formationin vitro and ototoxicity in vivo. Antimicrob. Agents Chemother. 47 (2003) 1836-1841
44. Wang J., Ladrech S., Pujol R., Barbet P., Van De Water T.R., and Puel J.L. Caspase inhibitors, but not c-Jun NH2-terminal kinase inhibitor treatment, prevent cisplatin-induced hearing loss. Cancer Res. 64 (2004) 9217-9224
45. Yamashita D., Jiang H.-Y., Schacht J., and Miller J.M. Delayed production of free radicals following noise exposure. Brain Res. 1019 (2004) 2001-2009
46. Yang W.P., Henderson D., Hu B.H., and Nicotera T.M. Quantitative analysis of apoptotic and necrotic outer hair cells after exposure to different levels of continuous noise. Hear. Res. 196 (2004) 69-76
47. Ylikoski J., Xing-Qun L., Virkkala J., and Pirvola U. Blockade of c-Jun N-terminal kinase pathway attenuates gentamicin-induced cochlear and vestibular hair cell death. Hear. Res. 166 (2002) 33-43
48. Zine A., and Van De Water T.R. The MAPK/JNK signalling pathway offers potential therapeutic targets for the prevention of acquired deafness. Curr. Drug Targets CNS Neurol. Disord. 3 (2004) 325-332