-
3
-
-
35548959525
-
Human African trypanosomiasis: Pharmacological re-engagement with a neglected disease
-
Barrett MP, Boykin DW, Brun R, Tidwell RR. Human African trypanosomiasis: pharmacological re-engagement with a neglected disease. Br J Pharmacol 2007; 152:1155-1171.
-
(2007)
Br J Pharmacol
, vol.152
, pp. 1155-1171
-
-
Barrett, M.P.1
Boykin, D.W.2
Brun, R.3
Tidwell, R.R.4
-
4
-
-
0016979622
-
Chemotherapy of African trypanosomiasis
-
Williamson J. Chemotherapy of African trypanosomiasis. Trop Dis Bull 1976; 73:531-542.
-
(1976)
Trop Dis Bull
, vol.73
, pp. 531-542
-
-
Williamson, J.1
-
5
-
-
0027241137
-
Pharmacokinetic properties of the trypano-cidal drug melarsoprol
-
Burri C, Baltz T, Giroud C, et al. Pharmacokinetic properties of the trypano-cidal drug melarsoprol. Chemotherapy 1993; 39:225-234.
-
(1993)
Chemotherapy
, vol.39
, pp. 225-234
-
-
Burri, C.1
Baltz, T.2
Giroud, C.3
-
6
-
-
0034087423
-
Investigations of the metabolites of the trypanocidal drug melarsoprol
-
Keiser J, Ericsson O, Burri C. Investigations of the metabolites of the trypanocidal drug melarsoprol. Clin Pharmacol Ther 2000; 67:478-488.
-
(2000)
Clin Pharmacol Ther
, vol.67
, pp. 478-488
-
-
Keiser, J.1
Ericsson, O.2
Burri, C.3
-
7
-
-
0034701571
-
Efficacy of new, concise schedule for melarsoprol in treatment of sleeping sickness caused by Trypanosoma brucei gambiense: A randomised trial
-
Burri C, Nkunku S, Merolle A, et al. Efficacy of new, concise schedule for melarsoprol in treatment of sleeping sickness caused by Trypanosoma brucei gambiense: a randomised trial. Lancet 2000; 355:1419-1425.
-
(2000)
Lancet
, vol.355
, pp. 1419-1425
-
-
Burri, C.1
Nkunku, S.2
Merolle, A.3
-
8
-
-
21044444153
-
Effectiveness of a 10-day melarsoprol schedule for the treatment of late-stage human African trypanosomiasis: Confirmation from a multinational study (IMPAMEL II)
-
Schmid C, Richer M, BilengeCM, et al. Effectiveness of a 10-day melarsoprol schedule for the treatment of late-stage human African trypanosomiasis: confirmation from a multinational study (IMPAMEL II). J Infect Dis 2005; 191:1922-1931.
-
(2005)
J Infect Dis
, vol.191
, pp. 1922-1931
-
-
Schmid, C.1
Bilengecm, R.M.2
-
9
-
-
34247346912
-
Three drug combinations for late-stage Trypanosoma brucei gambiense sleeping sickness: A randomized clinical trial in Uganda
-
Priotto G, Fogg C, Balasegaram M, et al. Three drug combinations for late-stage Trypanosoma brucei gambiense sleeping sickness: a randomized clinical trial in Uganda. PLoS Clin Trials 2006; 1:e39.
-
(2006)
PLoS Clin Trials
, vol.1
-
-
Priotto, G.1
Fogg, C.2
Balasegaram, M.3
-
10
-
-
38449084743
-
Nifurtimox-eflornithine combination therapy for second-stage Trypanosoma brucei gambiense sleeping sickness: A randomized clinical trial in Congo
-
Priotto G, KasparianS, NgouamaD, et al. Nifurtimox-eflornithine combination therapy for second-stage Trypanosoma brucei gambiense sleeping sickness: a randomized clinical trial in Congo. Clin Infect Dis 2007; 45:1435-1442.
-
(2007)
Clin Infect Dis
, vol.45
, pp. 1435-1442
-
-
Priotto, G.1
Ngouamad, K.2
-
11
-
-
67649635323
-
Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: A multicentre, randomised, phase III, noninferiority trial
-
Priotto G, Kasparian S, Mutombo W, et al. Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, noninferiority trial. Lancet 2009; 374:56-64.
-
(2009)
Lancet
, vol.374
, pp. 56-64
-
-
Priotto, G.1
Kasparian, S.2
Mutombo, W.3
-
12
-
-
77954978118
-
NECT is next: Implementing the new drug combination therapy for Trypanosoma brucei gambiense sleeping sickness
-
Yun O, Priotto G, Tong J, et al. NECT is next: implementing the new drug combination therapy for Trypanosoma brucei gambiense sleeping sickness. PLoS Negl Trop Dis 2010; 4:e720.
-
(2010)
PLoS Negl Trop Dis
, vol.4
-
-
Yun, O.1
Priotto, G.2
Tong, J.3
-
14
-
-
0020024466
-
Trypanosoma rhodesiense: Evaluation of the antitrypanosomal action of 2,5-bis(4-guanylphenyl)furan dihydrochloride
-
Steck EA, Kinnamon KE, Davidson DE Jr, et al. Trypanosoma rhodesiense: evaluation of the antitrypanosomal action of 2,5-bis(4-guanylphenyl)furan dihydrochloride. Exp Parasitol 1982; 53:133-134.
-
(1982)
Exp Parasitol
, vol.53
, pp. 133-134
-
-
Steck, E.A.1
Kinnamon, K.E.2
Davidson Jr., D.E.3
-
15
-
-
33744486606
-
Accumulation and intracellular distribution of antitrypanosomal diamidine compounds DB75 and DB820 in African trypanosomes
-
Mathis AM, Holman JL, Sturk LM, et al. Accumulation and intracellular distribution of antitrypanosomal diamidine compounds DB75 and DB820 in African trypanosomes. Antimicrob Agents Chemother 2006; 50:2185-2191.
-
(2006)
Antimicrob Agents Chemother
, vol.50
, pp. 2185-2191
-
-
Mathis, A.M.1
Holman, J.L.2
Sturk, L.M.3
-
16
-
-
70349334612
-
New treatment option for second-stage African sleeping sickness: In vitro and in vivo efficacy of aza analogs of DB289
-
Wenzler T, Boykin DW, Ismail MA, et al. New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289. Antimicrob Agents Chemother 2009; 53:4185-4192.
-
(2009)
Antimicrob Agents Chemother
, vol.53
, pp. 4185-4192
-
-
Wenzler, T.1
Boykin, D.W.2
Ismail, M.A.3
-
17
-
-
0020323313
-
A nitroimidazole-thiadiazole derivative with curative action in experimental Trypanosoma cruzi infections
-
Filardi LS, Brener Z. A nitroimidazole-thiadiazole derivative with curative action in experimental Trypanosoma cruzi infections. Ann Trop Med Parasitol 1982; 76:293-297.
-
(1982)
Ann Trop Med Parasitol
, vol.76
, pp. 293-297
-
-
Filardi, L.S.1
Brener, Z.2
-
18
-
-
0028973387
-
Effect of megazol on Trypanosoma brucei brucei acute and subacute infections in Swiss mice
-
Bouteille B, Marie-Daragon A, Chauvière G, et al. Effect of megazol on Trypanosoma brucei brucei acute and subacute infections in Swiss mice. Acta Trop 1995; 60:73-80.
-
(1995)
Acta Trop
, vol.60
, pp. 73-80
-
-
Bouteille, B.1
Marie-Daragon, A.2
Chauvière, G.3
-
19
-
-
0033952123
-
Uptake of the nitroimidazole drug megazol by African trypanosomes
-
Barrett MP, Fairlamb AH, Rousseau B, et al. Uptake of the nitroimidazole drug megazol by African trypanosomes. Biochem Pharmacol 2000; 59:615-620.
-
(2000)
Biochem Pharmacol
, vol.59
, pp. 615-620
-
-
Barrett, M.P.1
Fairlamb, A.H.2
Rousseau, B.3
-
20
-
-
0036889990
-
Cytotoxic and genotoxic effects of megazol, an anti-Chagas' disease drug, assessed by different short-term tests
-
Poli P, Aline de Mello M, Buschini A, et al. Cytotoxic and genotoxic effects of megazol, an anti-Chagas' disease drug, assessed by different short-term tests. Biochem Pharmacol 2002; 64:1617-1627.
-
(2002)
Biochem Pharmacol
, vol.64
, pp. 1617-1627
-
-
Poli, P.1
Aline De Mello, M.2
Buschini, A.3
-
21
-
-
2442472289
-
In vitro and in vivo chromosomal aberrations induced by megazol
-
Nesslany F, Brugier S, Mouriès MA, et al. In vitro and in vivo chromosomal aberrations induced by megazol. Mutat Res 2004; 560:147-158.
-
(2004)
Mutat Res
, vol.560
, pp. 147-158
-
-
Nesslany, F.1
Brugier, S.2
Mouriès, M.A.3
-
22
-
-
42449155428
-
A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes
-
Wilkinson SR, Taylor MC, Horn D, et al. A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes. Proc Natl Acad Sci USA 2008; 105:5022-5027.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 5022-5027
-
-
Wilkinson, S.R.1
Taylor, M.C.2
Horn, D.3
-
23
-
-
0034702247
-
A small-molecule nitroimi-dazopyran drug candidate for the treatment of tuberculosis
-
Stover CK, Warrener P, VanDevanter DR, et al. A small-molecule nitroimi-dazopyran drug candidate for the treatment of tuberculosis. Nature 2000; 405:962-966.
-
(2000)
Nature
, vol.405
, pp. 962-966
-
-
Stover, C.K.1
Warrener, P.2
Vandevanter, D.R.3
-
24
-
-
34548345811
-
Nitazoxanide: A review of its use in the treatment of gastrointestinal infections
-
Anderson VR, Curran MP. Nitazoxanide: a review of its use in the treatment of gastrointestinal infections. Drugs 2007; 67:1947-1967.
-
(2007)
Drugs
, vol.67
, pp. 1947-1967
-
-
Anderson, V.R.1
Curran, M.P.2
-
25
-
-
0020606013
-
The use of the 2 substituted 5-nitroimidazole, fexinidazole (Hoe 239) in the treatment of chronic T brucei infections in mice
-
Jennings FW, Urquhart GM. The use of the 2 substituted 5-nitroimidazole, fexinidazole (Hoe 239) in the treatment of chronic T brucei infections in mice. Z Parasitenkd 1983; 69:577-581.
-
(1983)
Z Parasitenkd
, vol.69
, pp. 577-581
-
-
Jennings, F.W.1
Urquhart, G.M.2
-
26
-
-
77953760001
-
Cross-resistance to nitro drugs and implications for treatment of human African trypanosomiasis
-
Sokolova AY, Wyllie S, Patterson S, et al. Cross-resistance to nitro drugs and implications for treatment of human African trypanosomiasis. Antimicrob Agents Chemother 2010; 54:2893-2900.
-
(2010)
Antimicrob Agents Chemother
, vol.54
, pp. 2893-2900
-
-
Sokolova, A.Y.1
Wyllie, S.2
Patterson, S.3
-
27
-
-
0020685084
-
The activity of fexinidazole (HOE 239) against experimental infections with Trypanosoma cruzi, trichomonads and Entamoe-ba histolytica
-
Raether W, Seidenath H. The activity of fexinidazole (HOE 239) against experimental infections with Trypanosoma cruzi, trichomonads and Entamoe-ba histolytica. Ann Trop Med Parasitol 1983; 77:13-26.
-
(1983)
Ann Trop Med Parasitol
, vol.77
, pp. 13-26
-
-
Raether, W.1
Seidenath, H.2
-
28
-
-
23944452267
-
Design and synthesis of a series of melamine-based nitroheterocycles with activity against Trypanosomatid parasites
-
Baliani A, Bueno GJ, Stewart ML, et al. Design and synthesis of a series of melamine-based nitroheterocycles with activity against Trypanosomatid parasites. J Med Chem 2005; 48:5570-5579.
-
(2005)
J Med Chem
, vol.48
, pp. 5570-5579
-
-
Baliani, A.1
Bueno, G.J.2
Stewart, M.L.3
-
29
-
-
77149159732
-
Exploiting the drug-activating properties of a novel trypanosomal nitroreductase
-
Hall BS, Wu X, Hu L, Wilkinson SR. Exploiting the drug-activating properties of a novel trypanosomal nitroreductase. Antimicrob Agents Chemother 2010; 54:1193-1199.
-
(2010)
Antimicrob Agents Chemother
, vol.54
, pp. 1193-1199
-
-
Hall, B.S.1
Wu, X.2
Hu, L.3
Wilkinson, S.R.4
-
31
-
-
0037470198
-
Myristoyl-CoA:protein N-myr-istoyltransferase an essential enzyme and potential drug target in kinetoplas-tid parasites
-
Price HP, Menon MR, Panethymitaki C, et al. Myristoyl-CoA:protein N-myr-istoyltransferase, an essential enzyme and potential drug target in kinetoplas-tid parasites. J Biol Chem 2003; 278:7206-7214.
-
(2003)
J Biol Chem
, vol.278
, pp. 7206-7214
-
-
Price, H.P.1
Menon, M.R.2
Panethymitaki, C.3
-
32
-
-
77950406212
-
N-myristoyltransferase inhibitors as new leads to treat sleeping sickness
-
Frearson JA, Brand S, McElroy SP, et al. N-myristoyltransferase inhibitors as new leads to treat sleeping sickness. Nature 2010; 464:728-732.
-
(2010)
Nature
, vol.464
, pp. 728-732
-
-
Frearson, J.A.1
Brand, S.2
McElroy, S.P.3
-
33
-
-
77952759972
-
Discovery of potent and selective inhibitors of Trypanosoma brucei ornithine decarboxylase
-
Smithson DC, Lee J, Shelat AA, et al. Discovery of potent and selective inhibitors of Trypanosoma brucei ornithine decarboxylase. J Biol Chem 2010; 285:16771-16781.
-
(2010)
J Biol Chem
, vol.285
, pp. 16771-16781
-
-
Smithson, D.C.1
Lee, J.2
Shelat, A.A.3
-
34
-
-
54049150827
-
Glycogen synthase kinase 3 is a potential drug target for African trypanosomiasis therapy
-
Ojo KK, Gillespie JR, Riechers AJ, et al. Glycogen synthase kinase 3 is a potential drug target for African trypanosomiasis therapy. Antimicrob Agents Chemother 2008; 52:3710-3717.
-
(2008)
Antimicrob Agents Chemother
, vol.52
, pp. 3710-3717
-
-
Ojo, K.K.1
Gillespie, J.R.2
Riechers, A.J.3
-
35
-
-
77952409132
-
A target-based high throughput screen yields Trypanosoma brucei hexokinase small molecule inhibitors with antiparasitic activity
-
Sharlow ER, Lyda TA, Dodson HC, et al. A target-based high throughput screen yields Trypanosoma brucei hexokinase small molecule inhibitors with antiparasitic activity. PLoS Negl Trop Dis 2010; 4:e659.
-
(2010)
PLoS Negl Trop Dis
, vol.4
-
-
Sharlow, E.R.1
Lyda, T.A.2
Dodson, H.C.3
-
36
-
-
77955330853
-
Virtual fragment screening for novel inhibitors of 6-phosphogluconate dehydrogenase
-
Ruda GF, Campbell G, Alibu VP, et al. Virtual fragment screening for novel inhibitors of 6-phosphogluconate dehydrogenase. Bioorg Med Chem 2010; 18:5056-5062.
-
(2010)
Bioorg Med Chem
, vol.18
, pp. 5056-5062
-
-
Ruda, G.F.1
Campbell, G.2
Alibu, V.P.3
-
37
-
-
33750579770
-
Drug discovery in jeopardy
-
Cuatrecasas P. Drug discovery in jeopardy. J Clin Invest 2006; 116:2837-2842.
-
(2006)
J Clin Invest
, vol.116
, pp. 2837-2842
-
-
Cuatrecasas, P.1
-
38
-
-
54249155522
-
Network pharmacology: The next paradigm in drug discovery
-
Hopkins AL. Network pharmacology: the next paradigm in drug discovery. Nat Chem Biol 2008; 4:682-690.
-
(2008)
Nat Chem Biol
, vol.4
, pp. 682-690
-
-
Hopkins, A.L.1
-
39
-
-
77954052283
-
Systems approaches to polypharmacology and drug discovery
-
Boran AD, Iyengar R. Systems approaches to polypharmacology and drug discovery. Curr Opin Drug Discov Dev 2010; 13:297-309.
-
(2010)
Curr Opin Drug Discov Dev
, vol.13
, pp. 297-309
-
-
Boran, A.D.1
Iyengar, R.2
-
40
-
-
0030612893
-
The Alamar blue assay to determine drug sensitivity of African trypanosomes (T. b. rhodesiense and T b. gam-biense) in vitro
-
Räz B, Iten M, Grether-Bühler Y, et al. The Alamar Blue assay to determine drug sensitivity of African trypanosomes (T. b. rhodesiense and T b. gam-biense) in vitro. Acta Trop 1997; 68:139-147.
-
(1997)
Acta Trop
, vol.68
, pp. 139-147
-
-
Räz, B.1
Iten, M.2
Grether-Bühler, Y.3
-
41
-
-
33745199861
-
Discovery of trypanocidal compounds by whole cell HTS of Trypanosoma brucei
-
Mackey ZB, Baca AM, Mallari JP, et al. Discovery of trypanocidal compounds by whole cell HTS of Trypanosoma brucei. Chem Biol Drug Des 2006; 67:355-363.
-
(2006)
Chem Biol Drug des
, vol.67
, pp. 355-363
-
-
MacKey, Z.B.1
Baca, A.M.2
Mallari, J.P.3
-
42
-
-
77952583878
-
Enhancements of screening collections to address areas of unmet medical need: An industry perspective
-
Drewry DH, Macarron R. Enhancements of screening collections to address areas of unmet medical need: an industry perspective. Curr Opin Chem Biol 2010; 14:289-298.
-
(2010)
Curr Opin Chem Biol
, vol.14
, pp. 289-298
-
-
Drewry, D.H.1
MacArron, R.2
-
43
-
-
0017259974
-
Pentamidine transport in Trypanosoma brucei: Kinetics and specificity
-
Damper D, Patton CL. Pentamidine transport in Trypanosoma brucei: kinetics and specificity. Biochem Pharmacol 1976; 25:271-276.
-
(1976)
Biochem Pharmacol
, vol.25
, pp. 271-276
-
-
Damper, D.1
Patton, C.L.2
-
44
-
-
56649116028
-
Compartmentation prevents a lethal turbo-explosion of glycolysis in trypanosomes
-
Haanstra JR, van Tuijl A, Kessler P, et al. Compartmentation prevents a lethal turbo-explosion of glycolysis in trypanosomes. Proc Natl Acad Sci USA 2008; 105:17718-17723.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 17718-17723
-
-
Haanstra, J.R.1
Van Tuijl, A.2
Kessler, P.3
|