Rationale design of biotinylated antimalarial endoperoxide carbon centered radical prodrugs for applications in proteomics

Journal of Medicinal Chemistry

Volumn 53, Issue 11, 2010, Pages 4555-4559

  Barton, Victoria ^a   Ward, Steven A ^b   Chadwick, James ^a   Hill, Alasdair ^b   O'Neill, Paul M ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; ARTEMETHER; ARTEMISIN DERIVATIVE; ARTESUNATE; CARBON; DISPIRO[ADAMANTANE 2,3' [1,2,4]TRIOXOLANE 5',4'' CYCLOHEXANEACETIC ACID 2 AMINO 2 METHYLPROPYLAMIDE]; ENDOPEROXIDE; HEME; IRON; PRODRUG; PROTEIN; RADICAL;

ARTICLE; BIOTINYLATION; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; NONHUMAN; PLASMODIUM FALCIPARUM; PROTEIN ANALYSIS; PROTEOMICS; PROTON NUCLEAR MAGNETIC RESONANCE;

ANTIMALARIALS; ARTEMISININS; BIOTINYLATION; CARBON; DRUG DESIGN; INHIBITORY CONCENTRATION 50; PLASMODIUM FALCIPARUM; PRODRUGS; PROTEOMICS;

EID: 77953215317     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm100201j     Document Type: Article

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