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The exploitation of siderophore uptake systems to deliver siderophore conjugates that contain antibiotic moieties (sideromycins or "Trojan-horse antibiotics") into bacterial cells has been studied more extensively than the inhibition of siderophore uptake (see Ref. [1] for an overview).
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Using a related methodology, the siderophore pyoverdin, immobilized on gold-plated glass chips, has recently been used to capture and identify the bacterium Pseudomonas aeruginosa (but no specific importer).
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Using a related methodology, the siderophore pyoverdin, immobilized on gold-plated glass chips, has recently been used to capture and identify the bacterium Pseudomonas aeruginosa (but no specific importer):, D. D. Doorneweerd, W. A. Henne, R. G. Reifenberger, P. S. Low, Langmuir 2010, 26, 15424-15429.
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FpiA could show higher affinity for biotinyl petrobactin 2 on a solid support because of a multivalent binding mode.
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FpiA could show higher affinity for biotinyl petrobactin 2 on a solid support because of a multivalent binding mode.
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