Discovery of trypanocidal compounds by whole cell HTS of Trypanosoma brucei

Chemical Biology and Drug Design

Volumn 67, Issue 5, 2006, Pages 355-363

  MacKey, Zachary B ^a   Baca, Arthur M ^a   Mallari, Jeremy P ^b   Apsel, Beth ^b   Shelat, Anang ^b   Hansell, Elizabeth J ^a   Chiang, Peter K ^a   Wolff, Brian ^b   Guy, Kiplin R ^b   Williams, Janice ^b   McKerrow, James H ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Biological screening; FDA; Natural products; Trypanosoma brucei

Indexed keywords

2 [1 (3 DIMETHYLAMINOPROPYL) 5 METHOXY 1H INDOL 3 YL] 3 (1H INDOL 3 YL)MALEIMIDE; 2 MORPHOLINO 8 PHENYLCHROMONE; ABT 51; ACLARUBICIN; ACRIFLAVINE; ALEXIDINE; ANISOMYCIN; ANTITRYPANOSOMAL AGENT; ARTEETHER; BLEOMYCIN; CRYSTAL VIOLET; DACTINOMYCIN; DEQUALINIUM; DIGITONIN; FUMAGILLOL CHLOROACETYLCARBAMATE; GRAMICIDIN; GW 5074; MEFLOQUINE; MITOMYCIN C; MONENSIN; NIGERICIN; PACLITAXEL; PENTAMIDINE; PENTAMIDINE ISETHIONATE; PHENYLMERCURIC ACETATE; PHOSPHOTRANSFERASE INHIBITOR; ROTTLERIN; STAUROSPORINE; SURAMIN; THIOMERSAL; UNCLASSIFIED DRUG; UNINDEXED DRUG;

AFRICAN TRYPANOSOMIASIS; ANTIMALARIAL ACTIVITY; ARTICLE; BIOLUMINESCENCE; CONCENTRATION RESPONSE; COST EFFECTIVENESS ANALYSIS; CYTOTOXICITY; HIGH THROUGHPUT SCREENING; NONHUMAN; PRIORITY JOURNAL; TRYPANOSOMA BRUCEI; VALIDATION STUDY;

ANIMALS; DIAZOMETHANE; DRUG EVALUATION, PRECLINICAL; HUMANS; LUMINESCENT MEASUREMENTS; MOLECULAR STRUCTURE; PARASITIC SENSITIVITY TESTS; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI;

TRYPANOSOMA BRUCEI;

EID: 33745199861     PISSN: 17470277     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2006.00389.x     Document Type: Article

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