Mitochondrial respiratory chain Complexes I and IV are impaired by β-amyloid via direct interaction and through Complex I-dependent ROS production, respectively

Mitochondrion

Volumn 13, Issue 4, 2013, Pages 298-311

  Bobba, A ^a   Amadoro, G ^b   Valenti, D ^a   Corsetti, V ^c   Lassandro, R ^d   Atlante, A ^a  

^a CNR   (Italy)

^b INSTITUTE OF TRANSLATIONAL PHARMACOLOGY   (Italy)

^c EUROPEAN BRAIN RESEARCH INSTITUTE   (Italy)

^d CNR   (Italy)

Author keywords

Amyloid; Cerebellar granule cells; Mitochondria; Respiratory chain complexes; ROS

Indexed keywords

AMYLOID BETA PROTEIN; CYTOCHROME C OXIDASE; GLUTATHIONE; GLUTATHIONE DISULFIDE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE);

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; BRAIN HOMOGENATE; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVITY; GRANULE CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; LIPID PEROXIDATION; MEMBRANE DAMAGE; MITOCHONDRIAL ENERGY TRANSFER; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RAT; RESPIRATORY CHAIN;

AMYLOID BETA-PEPTIDES; ANIMALS; CELLS, CULTURED; CEREBELLUM; ELECTRON TRANSPORT COMPLEX I; ELECTRON TRANSPORT COMPLEX IV; HUMANS; MITOCHONDRIA; RATS, WISTAR; REACTIVE OXYGEN SPECIES;

EID: 84876732347     PISSN: 15677249     EISSN: 18728278     Source Type: Journal    
DOI: 10.1016/j.mito.2013.03.008     Document Type: Article

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