Amyloid-β peptide binds to cytochrome C oxidase subunit 1

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Hernandez Zimbron, Luis Fernando ^a   Luna Muñoz, Jose ^b   Mena, Raul ^b   Vazquez Ramirez, Ricardo ^a   Kubli Garfias, Carlos ^a   Cribbs, David H ^c,d   Manoutcharian, Karen ^a   Gevorkian, Goar ^a  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^b DEPARTAMENTO DE FÍSICA   (Mexico)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; CYTOCHROME C OXIDASE; CYTOCHROME C OXIDASE SUBUNIT 1; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; BACTERIOPHAGE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; HUMAN TISSUE; MOLECULAR DYNAMICS; NEUROBLASTOMA CELL; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION;

AMINO ACID SEQUENCE; AMYLOID BETA-PEPTIDES; ANIMALS; CATTLE; ELECTRON TRANSPORT COMPLEX IV; HUMANS; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY;

EID: 84865200019     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0042344     Document Type: Article

References (60)

1. Masters CL, Simms G, Weinmann NA, Multhaup G, McDonald BL, et al. (1985) Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci U S A 82: 4245-4249.
2. Walsh DM, Selkoe DJ, (2004) Deciphering the molecular basis of memory failure in Alzheimer's disease. Neuron 44: 181-193.
3. Wirths O, Multhaup G, Bayer TA, (2004) A modified beta-amyloid hypothesis: intraneuronal accumulation of the beta-amyloid peptide- the first step of a fatal cascade. J Neurochem 91: 513-520.
4. Haass C, Selkoe DJ, (2007) Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat Rev Mol Cell Biol 8: 101-112.
5. LaFerla F, Green KN, Oddo S, (2007) Intracellular amyloid-β in Alzheimer's disease. Nat Rev Neurosci 8: 499-509.
6. Gouras GK, Tampellini D, Takahashi RH, Capetillo-Zarate E, (2010) Intraneuronal beta-amyloid accumulation and synapse pathology in Alzheimer's disease. Acta Neuropathol 119: 523-541.
7. Ballard C, Gauthier S, Corbett A, Brayne C, Aarsland D, et al. (2011) Alzheimer's disease. The Lancet 377: 1019-1031.
8. Ferreira ST, Klein WL, (2011) The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer's disease. Neurobiol Learn Mem 96: 529-543.
9. Butterfield DA, Boyd-Kimball D, (2004) Amyloid beta-peptide (1-42) contributes to the oxidative stress and neurodegeneration found in Alzheimer disease brain. Brain Pathol 14: 426-432.
10. Huang X, Moir RD, Tanzi RE, Bush AI, Rogers JT, (2004) Redox-active metals, oxidative stress, and Alzheimer's disease pathology. Ann NY Acad Sci 1012: 153-163.
11. Blurton-Jones M, LaFerla FM, (2006) Pathways by which Abeta facilitates tau pathology. Curr Alzheimer Res 3: 437-448.
12. Demuro A, Parker I, Stutzmann GE, (2010) Calcium signaling and amyloid toxicity in Alzheimer disease. J Biol Chem 285: 12463-12468.
13. Frautschy SA, Cole GM, (2010) Why pleiotropic interventions are needed for Alzheimer's disease. Mol Neurobiol 41: 392-409.
14. Bossy-Wetzel E, Schwarzenbacher R, Lipton SA, (2004) Molecular pathways to neurodegeneration. Nat Med 10: S2-S9.
15. Canevari L, Abramov AY, Duchen MR, (2004) Toxicity of amyloid β peptide: tales of calcium, mitochondria, and oxidative stress. Neurochem Res 29: 637-650.
16. Tillement L, Lecanu L, Papadopoulos V, (2011) Alzheimer's disease: effects of β-amyloid on mitochondria. Mitochondrion 11: 13-21.
17. Eckert A, Schmitt K, Gotz J, (2011) Mitochondria dysfunction - the beginning of the end in Alzheimer's disease? Separate and synergistic modes of tau and amyloid-b toxicity. Alzheimers Res Ther 3: 15.
18. Moreira PI, Santos MS, Moreno A, Rego AC, Oliveira C, (2002) Effect of amyloid beta-peptide on permeability transition pore: a comparative study. J Neurosci Res 69: 257-267.
19. Casley CS, Canevari L, Land JM, Clark JB, Sharpe MA, (2002) β-Amyloid inhibits integrated mitochondrial respiration and key enzyme activities. J Neurochem 80: 91-100.
20. Tillement L, Lecanu L, Yao W, Greeson J, Papadopoulos V, (2006) The spirostenol (22R, 25R)-20α-spirost-5-en-3β-yl hexanoate blocks mitochondrial uptake of Aβ in neuronal cells and prevents Aβ-induced impairment of mitochondrial function. Steroids 71: 725-735.
21. Wang X, Su B, Lee H-g, Li X, Perry G, et al. (2009) Impaired balance of mitochondrial fission and fussion in Alzheimer's disease. J Neurosci 29: 9090-9103.
22. Santos RX, Correia SC, Wang X, Perry G, Smith MA, et al. (2010) A synergistic dysfunction of mitochondrial fission/fusion dynamics and miitophagy in Alzheimer's disease. J Alzheimers Dis 20: S401-S412.
23. Hauptmann S, Scherping I, Drose S, Brandt U, Schulz KL, et al. (2009) Mitochondrial dysfunction: an early event in Alzheimer pathology accumulates with age in AD transgenic mice. Neurobiol Aging 30: 1574-1586.
24. Canevari L, Clark JB, Bates TE, (1999) Beta-amyloid fragment 25-35 selectively decreases complex IV activity in isolated mitochondria. FEBS Lett 457: 131-134.
25. Crouch PJ, Blake R, Duce JA, Ciccotosto GD, Li QX, et al. (2005) Copper-dependent inhibition of human cytochrome c oxidase by a dimeric comformer of amyloid-β 1-42. J Neurosci 25: 672-679.
26. Cassano T, Serviddio G, Gaetani S, Romano A, Dipasquale P, et al. (2011) Glutamatergic alterations and mitochondrial impairment in a murine model of Alzheimer disease. Neurobiol Aging doi:10.1016/j.neurobiolaging.2011.09.021.
27. Lustbader JW, Cirilli M, Lin C, Xu HW, Takuma K, et al. (2004) ABAD directly links Aβ to mitochondrial toxicity in Alzheimer's disease. Science 304: 448-452.
28. Yan SD, Fu J, Soto C, Chen X, Zhu H, et al. (1997) An intracellular protein that binds amyloid-β peptide and mediates neurotoxicity in Alzheimer's disease. Nature 389: 689-695.
29. Takuma K, Yao J, Huang J, Xu H, Chen X, et al. (2005) ABAD enhances A beta-induced cell stress via mitochondrial dysfunction. FASEB J 19: 597-598.
30. Yan SD, Stern DM, (2005) Mitochondrial dysfunction and Alzheimer's disease: role of amyloid-beta peptide alcohol dehydrogenase (ABAD). Int J Exp Pathol 86: 161-171.
31. Yao J, Du H, Yan S, Fang F, Wang C, et al. (2011) Inhibition of amyloid-beta (Aβ) peptide-binding alcohol dehydrogenase-Aβ interaction reduces Aβ accumulation and improves mitochondrial function in a mouse model of Alzheimer's disease. J Neurosci 31: 2313-2320.
32. Munguia ME, Govezensky T, Martinez R, Manoutcharian K, Gevorkian G, (2006) Identification of amyloid-beta 1-42 binding protein fragments by screening of a human brain cDNA library. Neurosci Lett 397: 79-82.
33. Gevorkian G, Gonzalez-Noriega A, Acero G, Ordoñez J, Michalak C, et al. (2008) Amyloid-β peptide binds to microtubule-associated protein 1B (MAP1B). Neurochem Int 52: 1030-1036.
34. Medecigo M, Manoutcharian K, Vasilevko V, Govezensky T, Munguia ME, et al. (2010) Novel amyloid-beta specific scFv and VH antibody fragments from human and mouse phage display antibody libraries. J Neuroimmunol 223: 104-114.
35. McKhann G, Drachman D, Folstein M, Katzman R, Price D, et al. (1984) Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human services Task Force on Alzheimer's Disease. Neurology 34: 939-944.
36. Luna-Muñoz J, Peralta-Ramirez J, Chavez-Macias L, Harrington CR, Wischik CM, et al. (2008) Thiazin red as a neuropathological toll for the rapid diagnosis of Alzheimer's disease in tissue imprints. Acta Neuropathol 116: 507-515.
37. Perez-Garmendia R, Ibarra-Bracamontes V, Vasilevko V, Luna-Munoz J, Mena R, et al. (2010) Anti-11 [E]-pyroglutamate-modified amyloid β antibodies cross-react with other pathological Aβ species: relevante for immunotherapy. J Neuroimmunol 229: 248-255.
38. Coles M, Bicknell W, Watson AA, Fairlie DP, Craik DJ, (1998) Solution Structure of Amyloid-β Peptide (1-40) in Water-Micelle Environment. Is the Membrane-Spanning Domain Where We Think It Is? Biochemistry 37: 11064-11077.
39. HyperChem Professional release 8.0., 2007. Molecular Modeling System. Hypercube Inc.
40. Muramoto K, Ohtab K, Shinzawa-Itoh K, Kandaa K, Taniguchi M, (2010) Bovine Cytochrome C Oxidase Structures Enable O2 Reduction with Minimization of Reactive Oxygen and Provide a Proton-Pumping Gate. Proc Natl Acad Sci U.S.A 107: 7740-7745.
41. Hess B, Bekker H, Berendsen HJC, Fraajie JGEM, (1997) LINCS: A Linear Constraint Solver Molecular Simulations. J Comput Chem 18: 1463-1472.
42. Van der Spoel D, Lindahl E, Hess B, Groenhof G, Mark AE, et al. (2005) GROMACS: Fast, Flexible, and Free. J Comp Chem 26: 1701-1718.
43. MacKerell AD Jr, Bashford D, Bellott M, Dunbrack RL Jr, Evanseck JD, et al. (1998) All-atom Empirical Potential for Molecular Modeling and Dynamics Studies of Proteins. J Phys Chem B 102: 3586-3616.
44. Van der Spoel D, Lindahl E, Hess B, Groenhof G, Mark AE, Berendsen HJC, (2005) GROMACS: Fast, flexible, and free. J Comp Chem 26: 1701-1718.
45. Humphrey W, Dalke A, Schulten K, (1996) VMD- Visual Molecular Dynamics. J Mol Graph 14: 33-38.
46. Asami-Odaka A, Ishibashi Y, Kikuchi T, Kitada C, Suzuki N, (1995) Long amyloid b-protein secreted from wild-type human neuroblastoma IMR-32 cells. Biochemistry 34: 10272-10278.
47. Aleardi AM, Benard G, Augereau O, Malgat M, Talbot JC, et al. (2005) Gradual alteration of mitochondrial structure and function by β-amyloids: importance of membrane viscosity changes, energy deprivation, reactive oxygen species production, and cytochrome c release. J Bioenerg Biomembr 37: 207-225.
48. Caspersen C, Wang N, Yao J, Sosunov A, Chen X, et al. (2005) Mitochondrial Abeta: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease. FASEB J 19: 2040-2041.
49. Manczak M, Anekonda TS, Henson E, Park BS, Quinn J, et al. (2006) Mitochondria are a direct site of Ab accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression. Hum Mol Genet 15: 1437-1449.
50. Hansson Petersen CA, Alikhani N, Behbahani H, Wiehager B, Pavlov PF, et al. (2008) The amyloid beta-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae. Proc Natl Acad Sci U S A 105: 13145-13150.
51. Singh P, Suman S, Chandna S, Das TK, (2009) Possible role of amyloid-beta, adenine nucleotide translocase and cyclophilin-D interaction in mitochondrial dysfunction of Alzheimer's disease. Bioinformation 3: 440-445.
52. Du H, Guo L, Zhang W, Rydzewska M, Yan S, (2011) Cyclophilin D deficiency improves mitochondrial function and learning and memory in aging Alzheimer disease mouse model. Neurobiol Aging 32: 398-406.
53. Pavlov PF, Wiehager B, Sakai J, Frykman S, Behbahani H, et al. (2011) Mitochondrial g-secretase participates in the metabolism of mitochondria-associated amyloid precursor protein. FASEB J 25: 78-88.
54. Blass JP, Sheu RK, Gibson GE, (2000) Inherent abnormalities in energy metabolism in Alzheimer disease. Interaction with cerebrovascular compromise. Ann N Y Acad Sci 903: 204-221.
55. Yao J, Irwin R, Zhao L, Nilsen J, Hamilton RT, et al. (2009) Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A 106: 14670-14675.
56. Du H, Guo L, Yan S, Sosunov AA, McKhann GM, et al. (2010) Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model. Proc Natl Acad Sci U S A 107: 18670-18675.
57. Dragicevic N, Mamcarz M, Zhu Y, Buzzeo R, Tan J, et al. (2010) Mitochondrial amyloid-beta levels are associated Ruth the extent of mitochondrial dysfunction in different brain regions and the degree of cognitive impairment in Alzheimer's transgenic mice. J Alzheimers Dis 20: S535-S550.
58. Cardoso SM, Santos S, Swerdlow RH, Oliveira CR, (2001) Functional mitochondia are required for amyloid b-mediated neurotoxicity. FASEB J 15: 1439-1441.
59. Fukui H, Diaz F, Garcia S, Moraes CT, (2007) Cytochrome c oxidase deficiency in neurons decreases both oxidative stress and amyloid formation in a Mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A 104: 14163-14168.
60. Yoshikawa S, Shinzawa-Itoh K, Nakashima R, Yaono R, Yamashita E, et al. (1998) Redox-coupled crystal structural changes in bovine heart cytochrome c oxidase. Science 280: 1723-1729.