The expression of several mitochondrial and nuclear genes encoding the subunits of electron transport chain enzyme complexes, cytochrome c oxidase, and NADH dehydrogenase, in different brain regions in Alzheimer's disease

Neurochemical Research

Volumn 24, Issue 6, 1999, Pages 767-774

  Aksenov, Michael Y ^a   Tucker, H Michael ^b   Nair, Prakash ^b   Aksenova, Marina V ^b   Butterfield, D Allan ^b   Estus, Steven ^b   Markesbery, William R ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b NONE

Author keywords

Alzheimer's disease; Cytochrome c oxidase; Gene expression; MRNA; NADH dehydrogenase; RT PCR

Indexed keywords

CYTOCHROME C OXIDASE; MESSENGER RNA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; UBIQUINOL CYTOCHROME C REDUCTASE;

AEROBIC METABOLISM; AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN MITOCHONDRION; CELL NUCLEUS; CEREBELLUM; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; HIPPOCAMPUS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MITOCHONDRIAL RESPIRATION; NUCLEOTIDE SEQUENCE; PARIETAL LOBE; PRIORITY JOURNAL; RESPIRATORY CHAIN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ALZHEIMER DISEASE; BASE SEQUENCE; BRAIN; CELL NUCLEUS; DNA PRIMERS; ELECTRON TRANSPORT; ELECTRON TRANSPORT COMPLEX IV; HUMANS; MITOCHONDRIA; NADH DEHYDROGENASE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 0032971621     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1020783614031     Document Type: Article

References (56)

1. Harman, D. 1995. Free radical theory of aging: Alzheimer's disease pathogenesis. Age 18:97-119.
2. Bowling, A. C., and Beal, M. F. 1995. Bioenergetic and oxidative stress in neurodegenerative diseases. Life Sciences. 56: 1151-1171.
3. Butterfield, D. A. 1997. β-Amyloid-associated free radical oxidative stress and neurotoxicity: implications for Alzheimer's disease. Chem. Res. Toxicol. 10:495-506.
4. Markesbery, W. R. 1997. Oxidative stress hypothesis in Alzheimer's disease. Free Radic. Biol. Med. 23:134-147.
5. Parker, W. D. Jr., Parks, J., Filley, C. M., and Kleinschmidt-Demasters, B. K. 1994. Electron transport chain defects in Alzheimer's disease brain. Neurology. 44:1090-1096.
6. Mutisya, E. M., Bowling, A. C., and Beal, M. F. 1994. Cortical cytochrome oxidase activity is reduced in Alzheimer's disease. J. Neurochem. 63:2179-2184.
7. Beal, M. F. 1996. Mitochondria, free radicals, and neurodegeneration. Curr. Opin. Neurobiol. 6:661-666.
8. Wong-Riley, M., Antuono, P., Ho, K. C., Egan, R., Hevner, R., Liebl, W., Huang, Z., Rachel, R., and Jones, J. 1997. Cytochrome oxidase in Alzheimer's disease: biochemical, histochemical, and immunohistochemical analyses of the visual and other systems. Vision Res. 37:3593-3608.
9. Sheenan, J. P., Swerdlow, R. H., Miller, S. W., Davis, R. E., Parks, J. K., Parker, W. D., and Tuttle, J. B. 1997. Calcium homeostasis and reactive oxygen species production in cells transformed by mitochondria from individuals with sporadic Alzheimer's disease. J. Neurosci. 17:4612-4622.
10. Parker, W. D. Jr., Filley, C. M., and Parks, J. K. 1990. Cytochrome oxidase deficiency in Alzheimer's disease. Neurology. 40: 1302-1303.
11. Chandrasekaran, K., Hatanpaa, K., Brady, D. R., and Rapoport, S.I. 1996. Evidence for physiological down-regulation of brain oxidative phosphorylation in Alzheimer's disease. Exp. Neurol. 142:80-88.
12. Rapoport, S. I., Hatanpaa, K., Brady, D. R., and Chandrasekaran, K. 1996. Brain energy metabolism, cognitive function and down-regulated oxidative phosphorylation in Alzheimer disease. Neurodegeneration. 5:473-476.
13. Kish, S. J. 1997. Brain energy metabolizing enzymes in Alzheimer's disease: alpha-ketoglutarate dehydrogenase complex and cytochrome oxidase. Ann. NY Acad. Sci. 826: 218-228.
14. Meier-Ruge, W. A., and Bertoni-Freddari, C. 1997. Pathogenesis of decreased glucose turnover and oxidative phosphorylation in ischemic and trauma-induced dementia of the Alzheimer type. Ann. NY Acad. Sci. 826:229-241
15. Fukuyama, R., Hatanpaa, K., Rapoport, S. I., and Chandrasekaran, K. 1996. Gene expression of ND4, a subunit of complex I of oxidative phosphorylation in mitochondria, is decreased in temporal cortex of brains of Alzheimer's disease patients. Brain Res. 713:290-293.
16. Chandrasekaran, K. Hatanpaa, K., Rapoport, S.I., and Brady, D. R. 1997. Decreased, expression of nuclear and mitochondrial DNA-encoded genes of oxidative phosphorylation in association neocortex in Alzheimer disease. Mol. Brain Res. 44: 99-104.
17. Davey, G.P., Peuchen, S., and Clark, J. B. 1998. Energy thresholds in brain mitochondria. Potential involvement in neurodegeneration. J. Biol. Chem. 273:12753-12757.
18. Kish, S. J, Bergeron, C., Rajput, A., Dozic, S., Mastrogiacomo, F., Chang, L. J., Wilson, J. M., DiStefano, L. M., and Nobrega, J.N. 1992. Brain cytochrome oxidase in Alzheimer's disease. J. Neurochem. 59:776-779.
19. Simonian, N. A., and Hyman, B. T. 1993. Functional alterations in Alzheimer's disease: diminution of cytochrome oxidase in the hippocampal formation. J. Neuropathol. Exp. Neurol. 52: 580-585.
20. Changnon, P., Betard, C., Robitaille., Y., Cholette, A., and Gauvreau, D. 1995. Distribution of brain cytochrome oxidase activity in various neurodegenerative diseases. Neuroreport. 6: 711-715.
21. Gonzalez-Lima, F., Valla, J., and Matos-Collazo, S. 1997. Quantitative cytochemistry of cytochrome oxidase and cellular morphometry of the inferior colliculus in control and Alzheimer's patients. Brain Res. 758:117-126.
22. Schagger, H., and Ohm, T. G. 1996. Human diseases with defects in oxidative phosphorylation. 2. F1F0 ATP-synthase defects in Alzheimer disease revealed by blue native polyacrylamide electrophoresis Eur. J. Biochem. 227:916-921.
23. Simonian, N. A., and Hyman, B. T. 1994. Functional alterations in Alzheimer's disease: Selective loss of mitochondrial-encoded cytochrome oxidase mRNA in the hippocampal formation. J. Neuropathol. Exp. Neurol. 53:508-512.
24. Parker, W. D. Jr., and Parks, J. K. 1995. Cytochrome c oxidase in Alzheimer's disease brain: purification and characterization. Neurology. 45:482-486.
25. Davis, R. E., Miller, S., Herrnstadt, C., Ghosh, S. S., Fahy, E., Shinobu, L. A., Galasko, D., Thal, L. J., Beal, M. F., Howell, N., and Parker, W. D. Jr. 1997. Mutations in mitochondrial cytochrome c oxidase genes segregated with late-onset Alzheimer disease. Proc. Natl. Acad. Sci. USA. 94:4526-4531.
26. Haycock, J. W., Jones, P., Harris, J. B., and Mantle, D. 1996. Differential susceptibility of human skeletal muscle proteins to free radical induced oxidative damage: a histochemical, immunocytochemical and electron microscopical study in vitro. Acta Neuropathol. (Berl.) 92:331-340.
27. Calpaldi, R. A. Structure and assembly of cytochrome c oxidase. 1990. Arch. Biochem. Biophys. 280:252-262.
28. Cooper, C. E., Nicholls, P., and Freedman, J. A. 1991. Cytochrome c oxidase: structure, function, and membrane topology of the polypeptide subunits. Biochem. Cell Biol. 69: 586-607.
29. Walker, J. E., Arizmendi, J. M., Dupuis, A., Fearnley, I. M., Finel, M., Medd, S. M., Pilkington, S. J., Runswick, M. J., and Skehel, J. M. 1992. Sequences of 20 subunits of NADH: ubiquinone oxidoreductase from bovine heart mitochondria. Application of a novel strategy for sequencing proteins using the polymerase chain reaction. J. Mol. Biol. 226:1051-1072.
30. Van den Bogert, C., De Vries, H., Holtrop, M., Muus, P., Dekker, H. L., Van Galen, M. J., Bolhuis, P. A., and Taanman, J. W. 1993. Regulation of the expression of mitochondrial proteins: relationship between mtDNA copy number and cytochrome-c oxidase activity in human cells and tissues. Biochim. Biophys. Acta. 1144:177-183.
31. Nie, F., and Wong-Riley, M. T. 1996. Mitochondrial- and nuclear-encoded subunits of cytochrome oxidase in neurons: differences in compartmental distribution, correlation with enzyme activity, and regulation by neuronal activity. J. Comp. Neurol. 373:139-155.
32. Selkoe, D. J. 1991. The molecular pathology of Alzheimer's disease. Neuron. 61:487-498.
33. Lewis, P. N., Lukiw, W. J., De Boni, U., and Crapper McLachlan, D. R. 1981. Changes in chromatin structure associated with Alzheimer's disease. J.Neurochem. 37:1193-1202.
34. Knezetic, J. A., and Luse, D. S. 1986. The presence of nucleosomes on a DNA template prevents initiation by RNA II polymerase in vitro. Cell. 45:95-104.
35. Mecocci, P., Beal, M. F., Cecchetti, R., Polidori, M. C., Cherubini, A., Chionne, F., Avellini L., Romano, G., and Senin, U. 1997. Mitochondrial membrane fluidity and oxidative damage to mitochondrial DNA in aged and AD human brain. Mol. Chem. Neuropathol. 31:53-64.
36. Mecocci, P., MacGarvey, U., and Beal, M. F. 1994. Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease. Ann. Neurol. 36:747-751.
37. Gabbita, S. P., Lovell, M. A., and Markesbery, W. R. 1998. Increased nuclear DNA oxidation in the brain in Alzheimer's disease. J. Neurochem. 71:2034-2090.
38. McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D. and Stadlan, E. M. 1984. Clinical diagnosis of Alzheimer's disease: report of the NINCDS ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease. Neurology. 34:939-944.
39. Khachaturian, Z. S. 1985. Diagnosis of Alzheimer's disease. Arch. Neurol. 42:1097-1105.
40. Mirra, S. S., Heyman, A., and McKeel, D. 1991. The Consorcium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standartization of the neuropathologic assessment of Alzheimer's disease. Neurology. 41:479-486.
41. National Institute on Aging and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's disease. 1997. Consensus Recommendations. Neurobiol. Aging. S1-S2.
42. Chromzynski, P., and Sacchi, N. 1987. Single-step method of RNA isolation by acid guanidinum thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
43. Manniatis T., Fritsch E. F., and Sambrook J. 1982. A Laboratory Manual. Molecular Cloning, Cold Spring Harbor Laboratory, New York.
44. Estus, S. 1997. Optimization and validation of RT-PCR as a tool to analyze apoptotic gene expression, Pages 67-84, in Poirier J., (ed.), NeuroMethods 29: Apoptosis techniques and protocols. Humana, Totowa, NJ.
45. Altschul, S. F., Madden, T. L., Schaffer, A. A., Zhang, J., Zhang, Z., Miller, W., and Lipman, D. J. 1997. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 25:3389-3402.
46. Anderson, S., Bankier, A. T., Barrell, B. G., de Bruijn, M. H. L., Coulson, A. R., Droin, J., Eperon, I. C., Nierlich, D. P., Roe, B. A., Sanger, F., Schreier, P. H., Smith, A. J. H., Staden, R., and Young, J. G. 1981. Sequence and organization of the human mitochondrial genome. Nature. 290:457-465.
47. Capitanio, N., Peccarisi, R., Capitanio., G., Villani, G., De Nitto, E., Scacco, S., and Papa, S. 1994. Role of nuclear-encoded subunits of mitochondrial. Biochemistry. 33:12521-12526.
48. Saiki, K., Nakamura, H., Mogi, T., and Anraku, Y. 1996. Probing a role of subunit of the Escherichia coli bo-type ubiquinol oxidase by deletion and cross-linking analyses. J. Biol. Chem. 271:15336-15340.
49. Hirano, M., Shtilbans, A., Mayeux, R., Davidson, M. M., DiMauro, S., Knowles, J. A., and Schon, E. A. 1997. Apparent mtDNA heteroplasmy in Alzheimer's disease patients and normals due to PCR amplification of nucleus-embedded mtDNA pseudogenes. Proc. Natl. Acad. Sci. USA. 94:14894-14899.
50. Hofhaus, G., Attardi, G. 1993. Lack of assembly of mitochondrial DNA-encoded subunits of respiratory NADH dehydrogenase and loss of enzyme activity in human cell mutant lacking the mitochondrial ND4 gene product. EMBO J. 12:3043-3048.
51. Crawford, D. R., Wang, Y., Schools, G.P., Kochheiser, J., Davies, K. J. 1997. Down-regulation of mammalian mitochondrial RNAs during oxidative stress. Free Radio. Biol. Med. 22: 551-559.
52. Sajdel-Sulkowska, E. M., Marotta, C. A. 1984. Alzheimer's disease brain: alterations in RNA levels and in a ribonuclease-inhibitor complex. Science. 225:947-949.
53. Taylor, G. R., Carte, G. I., Grow, T. J., Johnson, J. A., Fairbairn, A. F., Perry, E. K., Perry, R. H. 1986. Recovery and measurement of specific RNA species from postmortem brain tissue: A general reduction in Alzheimer's disease detected by molecular hybridization. Exp. Mol. Pathol. 44:111-116
54. Guillemette, J. G., Wong, L., Crapper McLachlan, D. R., Lewis, P. N. 1987. Characterization of messenger RNA from the cerebral cortex of control and Alzheimer-afflicted brain. J. Neurochem. 47:987-997.
55. Crapper McLachlan, D. R., Lukiw, W. J., Wong, L., Bergeron, C., Bech-Hansen, N. T. 1988. Selective messenger RNA reduction in Alzheimer-s disease. Mol. Brain Res. 15:681-690.
56. Aksenov, M. Y., Tucker, H. M., Nair, P., Aksenova, M. V., Butterfield, D. A., Estus, S., and Markesbery, W. R. 1999. The expression of key oxidative stress-handling genes in different brain regions in Alzheimer's disease. J. Mol. Neurosci. 11:151-164.