The complete spectrum of yeast chromosome instability genes identifies candidate cin cancer genes and functional roles for astra complex components

PLoS Genetics

Volumn 7, Issue 4, 2011, Pages

  Stirling, Peter C ^a   Bloom, Michelle S ^b   Solanki Patil, Tejomayee ^a   Smith, Stephanie ^b   Sipahimalani, Payal ^a   Li, Zhijian ^c   Kofoed, Megan ^a   Ben Aroya, Shay ^a   Myung, Kyungjae ^b   Hieter, Philip ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE;

ALLELE; ARTICLE; ASA1 GENE; CHROMOSOMAL INSTABILITY; CONTROLLED STUDY; EUKARYOTE; FUNGAL STRAIN; FUNGUS GROWTH; GENE IDENTIFICATION; GENETIC DATABASE; GENETIC SCREENING; NONHUMAN; PHENOTYPE; SACCHAROMYCES CEREVISIAE; SOMATIC MUTATION; TELOMERE; TORC1 GENE; TORP1 GENE; TTL1 GENE; TUMOR GENE; ESSENTIAL GENE; FUNGAL GENE; GENETIC COMPLEMENTATION; GENETICS; HUMAN; MUTATION; NEOPLASM;

EUKARYOTA; SACCHAROMYCES CEREVISIAE;

ALLELES; CHROMOSOMAL INSTABILITY; DATABASES, GENETIC; GENES, ESSENTIAL; GENES, FUNGAL; GENES, NEOPLASM; GENETIC COMPLEMENTATION TEST; HUMANS; MUTATION; NEOPLASMS; PHENOTYPE; SACCHAROMYCES CEREVISIAE; TELOMERE;

EID: 79955602011     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002057     Document Type: Article

References (39)

1. Cahill DP, Kinzler KW, Vogelstein B, Lengauer C, (1999) Genetic instability and darwinian selection in tumors. Trends Cell Biol 9: M57-60.
2. Schvartzman JM, Sotillo R, Benezra R, (2010) Mitotic chromosomal instability and cancer: mouse modelling of the human disease. Nat Rev Cancer 10: 102-115.
3. Barber TD, McManus K, Yuen KW, Reis M, Parmigiani G, et al. (2008) Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers. Proc Natl Acad Sci USA 105: 3443-3448.
4. Paulsen RD, Soni DV, Wollman R, Hahn AT, Yee MC, et al. (2009) A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability. Mol Cell 35: 228-239.
5. Ben-Aroya S, Coombes C, Kwok T, O'Donnell KA, Boeke JD, et al. (2008) Toward a comprehensive temperature-sensitive mutant repository of the essential genes of Saccharomyces cerevisiae. Mol Cell 30: 248-258.
6. Breslow DK, Cameron DM, Collins SR, Schuldiner M, Stewart-Ornstein J, et al. (2008) A comprehensive strategy enabling high-resolution functional analysis of the yeast genome. Nat Methods 5: 711-718.
7. Kanemaki M, Sanchez-Diaz A, Gambus A, Labib K, (2003) Functional proteomic identification of DNA replication proteins by induced proteolysis in vivo. Nature 423: 720-724.
8. Mnaimneh S, Davierwala AP, Haynes J, Moffat J, Peng WT, et al. (2004) Exploration of essential gene functions via titratable promoter alleles. Cell 118: 31-44.
9. Andersen MP, Nelson ZW, Hetrick ED, Gottschling DE, (2008) A genetic screen for increased loss of heterozygosity in Saccharomyces cerevisiae. Genetics 179: 1179-1195.
10. Ben-Aroya S, Agmon N, Yuen K, Kwok T, McManus K, et al. (2010) Proteasome nuclear activity affects chromosome stability by controlling the turnover of Mms22, a protein important for DNA repair. PLoS Genet 6: e1000852 doi:10.1371/journal.pgen.1000852.
11. Kanellis P, Gagliardi M, Banath JP, Szilard RK, Nakada S, et al. (2007) A screen for suppressors of gross chromosomal rearrangements identifies a conserved role for PLP in preventing DNA lesions. PLoS Genet 3: e134 doi:10.1371/journal.pgen.0030134.
12. Smith S, Hwang JY, Banerjee S, Majeed A, Gupta A, et al. (2004) Mutator genes for suppression of gross chromosomal rearrangements identified by a genome-wide screening in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 101: 9039-9044.
13. Yuen KW, Warren CD, Chen O, Kwok T, Hieter P, et al. (2007) Systematic genome instability screens in yeast and their potential relevance to cancer. Proc Natl Acad Sci USA 104: 3925-3930.
14. Shevchenko A, Roguev A, Schaft D, Buchanan L, Habermann B, et al. (2008) Chromatin Central: towards the comparative proteome by accurate mapping of the yeast proteomic environment. Genome Biol 9: R167.
15. Horejsí Z, Takai H, Adelman CA, Collis SJ, Flynn H, et al. (2010) CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability. Mol Cell 39: 839-850.
16. Hurov KE, Cotta-Ramusino C, Elledge SJ, (2010) A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability. Genes Dev 24: 1939-1950.
17. Izumi N, Yamashita A, Iwamatsu A, Kurata R, Nakamura H, et al. (2010) AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay. Sci Signal 3: ra27.
18. Takai H, Xie Y, de Lange T, Pavletich NP, (2010) Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes. Genes Dev 24: 2019-2030.
19. Spencer F, Gerring SL, Connelly C, Hieter P, (1990) Mitotic chromosome transmission fidelity mutants in Saccharomyces cerevisiae. Genetics 124: 237-249.
20. Daniel JA, Keyes BE, Ng YP, Freeman CO, Burke DJ, (2006) Diverse functions of spindle assembly checkpoint genes in Saccharomyces cerevisiae. Genetics 172: 53-65.
21. Ouspenski II, Elledge SJ, Brinkley BR, (1999) New yeast genes important for chromosome integrity and segregation identified by dosage effects on genome stability. Nucleic Acids Res 27: 3001-3008.
22. Veatch JR, McMurray MA, Nelson ZW, Gottschling DE, (2009) Mitochondrial dysfunction leads to nuclear genome instability via an iron-sulfur cluster defect. Cell 137: 1247-1258.
23. Forbes SA, Tang G, Bindal N, Bamford S, Dawson E, et al. (2010) COSMIC (the Catalogue of Somatic Mutations in Cancer): a resource to investigate acquired mutations in human cancer. Nucleic Acids Res 38: D652-657.
24. Futreal PA, Coin L, Marshall M, Down T, Hubbard T, et al. (2004) A census of human cancer genes. Nat Rev Cancer 4: 177-183.
25. Kaizuka T, Hara T, Oshiro N, Kikkawa U, Yonezawa K, et al. (2010) Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly. J Biol Chem 285: 20109-20116.
26. Huen J, Kakihara Y, Ugwu F, Cheung KL, Ortega J, et al. (2010) Rvb1-Rvb2: essential ATP-dependent helicases for critical complexes. Biochem Cell Biol 88: 29-40.
27. Anderson CM, Korkin D, Smith DL, Makovets S, Seidel JJ, et al. (2008) Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break. Genes Dev 22: 854-859.
28. Tong AH, Lesage G, Bader GD, Ding H, Xu H, et al. (2004) Global mapping of the yeast genetic interaction network. Science 303: 808-813.
29. Costanzo M, Baryshnikova A, Bellay J, Kim Y, Spear ED, et al. (2010) The genetic landscape of a cell. Science 327: 425-431.
30. Breitkreutz A, Choi H, Sharom JR, Boucher L, Neduva V, et al. (2010) A global protein kinase and phosphatase interaction network in yeast. Science 328: 1043-1046.
31. Takai H, Wang RC, Takai KK, Yang H, de Lange T, (2007) Tel2 regulates the stability of PI3K-related protein kinases. Cell 131: 1248-1259.
32. Loewith R, Jacinto E, Wullschleger S, Lorberg A, Crespo JL, et al. (2002) Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol Cell 10: 457-468.
33. Jacinto E, Guo B, Arndt KT, Schmelzle T, Hall MN, (2001) TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway. Mol Cell 8: 1017-1026.
34. Tate JJ, Cooper TG, (2008) Formalin can alter the intracellular localization of some transcription factors in Saccharomyces cerevisiae. FEMS Yeast Res 8: 1223-1235.
35. McLellan J, O'Neil N, Tarailo S, Stoepel J, Bryan J, et al. (2009) Synthetic lethal genetic interactions that decrease somatic cell proliferation in Caenorhabditis elegans identify the alternative RFC CTF18 as a candidate cancer drug target. Mol Biol Cell 20: 5306-5313.
36. de Hoon MJL, Imoto S, Nolan J Miyano S, (2004) Open Source Clustering Software. Bioinformatics 20: 1453-1454.
37. Ungar L, Yosef N, Sela Y, Sharan R, Ruppin E, et al. (2009) A genome-wide screen for essential yeast genes that affect telomere length maintenance. Nucleic Acids Res 37: 3840-3849.
38. Carroll SY, Stirling PC, Stimpson HE, Giesselmann E, Schmitt MJ, et al. (2009) A yeast killer toxin screen provides insights into a/b toxin entry, trafficking, and killing mechanisms. Dev Cell 17: 552-560.
39. Wang X, Proud CG, (2009) Nutrient control of TORC1, a cell-cycle regulator. Trends Cell Biol 19: 260-267.