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Volumn 53, Issue 5, 2006, Pages 843-853

Human Artificial Chromosomes: Potential Applications and Clinical Considerations

Author keywords

[No Author keywords available]

Indexed keywords

ARTIFICIAL CHROMOSOME; CHROMOSOME ANALYSIS; DNA DETERMINATION; DNA SEQUENCE; GENE THERAPY; GENE VECTOR; GENETIC DISORDER; GENETIC ENGINEERING; GENOMICS; HUMAN; REVIEW;

EID: 33749250791     PISSN: 00313955     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pcl.2006.08.013     Document Type: Review
Times cited : (26)

References (53)
  • 1
    • 0142084745 scopus 로고    scopus 로고
    • LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1
    • Hacein-Bey-Abina S., Von Calle C., Schmidt M., et al. LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science 302 5644 (2003) 415-419
    • (2003) Science , vol.302 , Issue.5644 , pp. 415-419
    • Hacein-Bey-Abina, S.1    Von Calle, C.2    Schmidt, M.3
  • 2
    • 0034328925 scopus 로고    scopus 로고
    • Gene therapy: trials and tribulations
    • Somia N., and Verma I.M. Gene therapy: trials and tribulations. Nat Rev Genet 1 2 (2000) 91-99
    • (2000) Nat Rev Genet , vol.1 , Issue.2 , pp. 91-99
    • Somia, N.1    Verma, I.M.2
  • 3
    • 0242367234 scopus 로고    scopus 로고
    • Gene therapy-new challenges ahead
    • Williams D.A., and Baum C. Gene therapy-new challenges ahead. Science 302 5644 (2003) 400-401
    • (2003) Science , vol.302 , Issue.5644 , pp. 400-401
    • Williams, D.A.1    Baum, C.2
  • 4
    • 0034629477 scopus 로고    scopus 로고
    • Gene therapist, heal thyself
    • Rosenberg L.E., and Schechter A.N. Gene therapist, heal thyself. Science 287 5459 (2000) 1751
    • (2000) Science , vol.287 , Issue.5459 , pp. 1751
    • Rosenberg, L.E.1    Schechter, A.N.2
  • 5
    • 3342878376 scopus 로고    scopus 로고
    • Prospects and implications of using chromatin insulators in gene therapy and transgenesis
    • Recillas-Targa F., Valvadez-Graham V., and Farrell C.M. Prospects and implications of using chromatin insulators in gene therapy and transgenesis. Bioessays 26 7 (2004) 796-807
    • (2004) Bioessays , vol.26 , Issue.7 , pp. 796-807
    • Recillas-Targa, F.1    Valvadez-Graham, V.2    Farrell, C.M.3
  • 6
    • 0037459109 scopus 로고    scopus 로고
    • Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling
    • Cleveland D.W., Mao Y., and Sullivan K.F. Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling. Cell 112 4 (2003) 407-421
    • (2003) Cell , vol.112 , Issue.4 , pp. 407-421
    • Cleveland, D.W.1    Mao, Y.2    Sullivan, K.F.3
  • 7
    • 0035432975 scopus 로고    scopus 로고
    • Determining centromere identity: cyclical stories and forking paths
    • Sullivan B.A., Blower M.D., and Karpen G.H. Determining centromere identity: cyclical stories and forking paths. Nat Rev Genet 2 8 (2001) 584-596
    • (2001) Nat Rev Genet , vol.2 , Issue.8 , pp. 584-596
    • Sullivan, B.A.1    Blower, M.D.2    Karpen, G.H.3
  • 8
    • 0032055381 scopus 로고    scopus 로고
    • Centromeres: the missing link in the development of human artificial chromosomes
    • Willard H.F. Centromeres: the missing link in the development of human artificial chromosomes. Curr Opin Genet Dev 8 2 (1998) 219-225
    • (1998) Curr Opin Genet Dev , vol.8 , Issue.2 , pp. 219-225
    • Willard, H.F.1
  • 9
    • 0035812788 scopus 로고    scopus 로고
    • Genomic and genetic definition of a functional human centromere
    • Schueler M.G., Higgins A.W., Rudd M.K., et al. Genomic and genetic definition of a functional human centromere. Science 294 5540 (2001) 109-115
    • (2001) Science , vol.294 , Issue.5540 , pp. 109-115
    • Schueler, M.G.1    Higgins, A.W.2    Rudd, M.K.3
  • 10
    • 0030910465 scopus 로고    scopus 로고
    • Formation of de novo centromeres and construction of first-generation human artificial microchromosomes
    • Harrington J.J., Van Bokkelen G., Mays R.W., et al. Formation of de novo centromeres and construction of first-generation human artificial microchromosomes. Nat Genet 15 4 (1997) 345-355
    • (1997) Nat Genet , vol.15 , Issue.4 , pp. 345-355
    • Harrington, J.J.1    Van Bokkelen, G.2    Mays, R.W.3
  • 11
    • 0031921127 scopus 로고    scopus 로고
    • Construction of YAC-based mammalian artificial chromosomes
    • Ikeno M., Grimes B., Okazaki T., et al. Construction of YAC-based mammalian artificial chromosomes. Nat Biotechnol 16 5 (1998) 431-439
    • (1998) Nat Biotechnol , vol.16 , Issue.5 , pp. 431-439
    • Ikeno, M.1    Grimes, B.2    Okazaki, T.3
  • 12
    • 8944236539 scopus 로고    scopus 로고
    • De novo chromosome formations by large scale amplification of the centromeric region of mouse chromosomes
    • Kereso J., Praznovsky T., Cserpan I., et al. De novo chromosome formations by large scale amplification of the centromeric region of mouse chromosomes. Chromosome Res 4 3 (1996) 226-239
    • (1996) Chromosome Res , vol.4 , Issue.3 , pp. 226-239
    • Kereso, J.1    Praznovsky, T.2    Cserpan, I.3
  • 13
    • 0035027365 scopus 로고    scopus 로고
    • Satellite DNA-based artificial chromosomes for use in gene therapy
    • Hadlackzky G. Satellite DNA-based artificial chromosomes for use in gene therapy. Curr Opin Mol Ther 3 2 (2001) 125-132
    • (2001) Curr Opin Mol Ther , vol.3 , Issue.2 , pp. 125-132
    • Hadlackzky, G.1
  • 14
    • 2942622704 scopus 로고    scopus 로고
    • Transfer and stable transgene expression of a mammalian artificial chromosome into bone marrow-derived human mesenchymal stem cells
    • Vanderbyl S., MacDonald G.N., Sidhu S., et al. Transfer and stable transgene expression of a mammalian artificial chromosome into bone marrow-derived human mesenchymal stem cells. Stem Cells 22 3 (2004) 324-333
    • (2004) Stem Cells , vol.22 , Issue.3 , pp. 324-333
    • Vanderbyl, S.1    MacDonald, G.N.2    Sidhu, S.3
  • 15
    • 28844439761 scopus 로고    scopus 로고
    • Transgene expression after stable transfer of a mammalian artificial chromosome into human hematopoietic cells
    • Vanderbyl S.L., Sullenbarger B., White N., et al. Transgene expression after stable transfer of a mammalian artificial chromosome into human hematopoietic cells. Exp Hematol 33 12 (2005) 1470-1476
    • (2005) Exp Hematol , vol.33 , Issue.12 , pp. 1470-1476
    • Vanderbyl, S.L.1    Sullenbarger, B.2    White, N.3
  • 16
    • 0027015611 scopus 로고
    • Targeted breakage of a human chromosome mediated by cloned, telomeric DNA
    • Itzhaki J.E., Barnett M.A., MacCarthy A.B., et al. Targeted breakage of a human chromosome mediated by cloned, telomeric DNA. Nat Genet 2 4 (1992) 283-287
    • (1992) Nat Genet , vol.2 , Issue.4 , pp. 283-287
    • Itzhaki, J.E.1    Barnett, M.A.2    MacCarthy, A.B.3
  • 17
    • 0033861799 scopus 로고    scopus 로고
    • Human mini-chromosomes with minimal centromeres
    • Yang J.W., Pendon C., Yang J., et al. Human mini-chromosomes with minimal centromeres. Hum Mol Genet 9 12 (2000) 1891-1902
    • (2000) Hum Mol Genet , vol.9 , Issue.12 , pp. 1891-1902
    • Yang, J.W.1    Pendon, C.2    Yang, J.3
  • 18
    • 0033124838 scopus 로고    scopus 로고
    • Generation of an ∼2.4-Mb human X centromere-based minichromosome by targeted telomere-associated chromosome fragmentation in DT40
    • Mills W., Critcher R., Lee C., et al. Generation of an ∼2.4-Mb human X centromere-based minichromosome by targeted telomere-associated chromosome fragmentation in DT40. Hum Mol Genet 8 5 (1999) 751-761
    • (1999) Hum Mol Genet , vol.8 , Issue.5 , pp. 751-761
    • Mills, W.1    Critcher, R.2    Lee, C.3
  • 19
    • 0036274392 scopus 로고    scopus 로고
    • Construction of neocentromere-based human minichromosomes for gene delivery and centromere studies
    • Wong L.H., Saffery R., and Choo K.H. Construction of neocentromere-based human minichromosomes for gene delivery and centromere studies. Gene Ther 9 11 (2002) 724-726
    • (2002) Gene Ther , vol.9 , Issue.11 , pp. 724-726
    • Wong, L.H.1    Saffery, R.2    Choo, K.H.3
  • 20
    • 0035725764 scopus 로고    scopus 로고
    • Insertion of a loxP site in a size-reduced human accessory chromosome
    • Moralli D., Vagnarelli P., Bensi M., et al. Insertion of a loxP site in a size-reduced human accessory chromosome. Cytogenet Cell Genet 94 3-4 (2001) 113-120
    • (2001) Cytogenet Cell Genet , vol.94 , Issue.3-4 , pp. 113-120
    • Moralli, D.1    Vagnarelli, P.2    Bensi, M.3
  • 21
    • 18844424225 scopus 로고    scopus 로고
    • Human artificial chromosome (HAC) vector provides long-term therapeutic transgene expression in normal human primary fibroblasts
    • Kakeda M., Hiratsuka M., Nagata K., et al. Human artificial chromosome (HAC) vector provides long-term therapeutic transgene expression in normal human primary fibroblasts. Gene Ther 12 10 (2005) 852-856
    • (2005) Gene Ther , vol.12 , Issue.10 , pp. 852-856
    • Kakeda, M.1    Hiratsuka, M.2    Nagata, K.3
  • 22
    • 0020521363 scopus 로고
    • Construction of artificial chromosomes in yeast
    • Murray A.W., and Szostak J.W. Construction of artificial chromosomes in yeast. Nature 305 5931 (1983) 189-193
    • (1983) Nature , vol.305 , Issue.5931 , pp. 189-193
    • Murray, A.W.1    Szostak, J.W.2
  • 23
    • 13744254178 scopus 로고    scopus 로고
    • Rapid creation of BAC-based human artificial chromosome vectors by transposition with synthetic alpha-satellite arrays
    • Basu J., Stromberg G., Compitello G., et al. Rapid creation of BAC-based human artificial chromosome vectors by transposition with synthetic alpha-satellite arrays. Nucleic Acids Res 33 2 (2005) 587-596
    • (2005) Nucleic Acids Res , vol.33 , Issue.2 , pp. 587-596
    • Basu, J.1    Stromberg, G.2    Compitello, G.3
  • 24
    • 26844440951 scopus 로고    scopus 로고
    • Efficient assembly of de novo human artificial chromosomes from large genomic loci
    • Basu J., Compitello G., Stromberg G., et al. Efficient assembly of de novo human artificial chromosomes from large genomic loci. BMC Biotechnol 5 (2005) 21
    • (2005) BMC Biotechnol , vol.5 , pp. 21
    • Basu, J.1    Compitello, G.2    Stromberg, G.3
  • 25
    • 0021234973 scopus 로고
    • DNA sequences of telomeres maintained in yeast
    • Shampay J., Szostak J.W., and Blackburn E.H. DNA sequences of telomeres maintained in yeast. Nature 310 5973 (1984) 154-157
    • (1984) Nature , vol.310 , Issue.5973 , pp. 154-157
    • Shampay, J.1    Szostak, J.W.2    Blackburn, E.H.3
  • 26
    • 0027230818 scopus 로고
    • Telomere directed fragmentation of mammalian chromosomes
    • Barnett M.A., Buckle V.J., Evans E.P., et al. Telomere directed fragmentation of mammalian chromosomes. Nucleic Acids Res 21 1 (1993) 27-36
    • (1993) Nucleic Acids Res , vol.21 , Issue.1 , pp. 27-36
    • Barnett, M.A.1    Buckle, V.J.2    Evans, E.P.3
  • 27
    • 0034235802 scopus 로고    scopus 로고
    • Mammalian artificial chromosome formation from circular alphoid input DNA does not require telomere repeats
    • Ebersole T.A., Ross A., Clark E., et al. Mammalian artificial chromosome formation from circular alphoid input DNA does not require telomere repeats. Hum Mol Genet 9 11 (2000) 1623-1631
    • (2000) Hum Mol Genet , vol.9 , Issue.11 , pp. 1623-1631
    • Ebersole, T.A.1    Ross, A.2    Clark, E.3
  • 28
    • 0026942264 scopus 로고
    • Mammalian origins of replication
    • Hamlin J.L. Mammalian origins of replication. Bioessays 14 10 (1992) 651-659
    • (1992) Bioessays , vol.14 , Issue.10 , pp. 651-659
    • Hamlin, J.L.1
  • 29
    • 0033472810 scopus 로고    scopus 로고
    • Replication origins of mammalian chromosomes: the happy few
    • Todorovic V., Falaschi A., and Giacca M. Replication origins of mammalian chromosomes: the happy few. Front Biosci 4 (1999) D859-D868
    • (1999) Front Biosci , vol.4
    • Todorovic, V.1    Falaschi, A.2    Giacca, M.3
  • 30
    • 0032516695 scopus 로고    scopus 로고
    • Genetic dissection of a mammalian replicator in the human beta-globin locus
    • Aladjem M.I., Rodewald L.W., Kolman J.K., et al. Genetic dissection of a mammalian replicator in the human beta-globin locus. Science 281 5379 (1998) 1005-1009
    • (1998) Science , vol.281 , Issue.5379 , pp. 1005-1009
    • Aladjem, M.I.1    Rodewald, L.W.2    Kolman, J.K.3
  • 31
    • 0142027869 scopus 로고    scopus 로고
    • Human artificial chromosomes with alpha satellite-based de novo centromeres show increased frequency of nondisjunction and anaphase lag
    • Rudd M.K., Mays R.W., Schwartz S., et al. Human artificial chromosomes with alpha satellite-based de novo centromeres show increased frequency of nondisjunction and anaphase lag. Mol Cell Biol 23 21 (2003) 7689-7697
    • (2003) Mol Cell Biol , vol.23 , Issue.21 , pp. 7689-7697
    • Rudd, M.K.1    Mays, R.W.2    Schwartz, S.3
  • 32
    • 0035989050 scopus 로고    scopus 로고
    • Alpha-satellite DNA and vector composition influence rates of human artificial chromosome formation
    • Grimes B.R., Rhoades A.A., and Willard H.F. Alpha-satellite DNA and vector composition influence rates of human artificial chromosome formation. Mol Ther 5 6 (2002) 798-805
    • (2002) Mol Ther , vol.5 , Issue.6 , pp. 798-805
    • Grimes, B.R.1    Rhoades, A.A.2    Willard, H.F.3
  • 33
    • 0037049465 scopus 로고    scopus 로고
    • CENP-B box is required for de novo centromere chromatin assembly on human alphoid DNA
    • Ohzeki J., Nakano M., Okada T., et al. CENP-B box is required for de novo centromere chromatin assembly on human alphoid DNA. J Cell Biol 159 5 (2002) 765-775
    • (2002) J Cell Biol , vol.159 , Issue.5 , pp. 765-775
    • Ohzeki, J.1    Nakano, M.2    Okada, T.3
  • 34
    • 14344271548 scopus 로고    scopus 로고
    • Construction of neocentromere-based human minichromosomes by telomere-associated chromosomal truncation
    • Saffery R., Wong L.H., Irvine D.V., et al. Construction of neocentromere-based human minichromosomes by telomere-associated chromosomal truncation. Proc Natl Acad Sci U S A 98 10 (2001) 5705-5710
    • (2001) Proc Natl Acad Sci U S A , vol.98 , Issue.10 , pp. 5705-5710
    • Saffery, R.1    Wong, L.H.2    Irvine, D.V.3
  • 35
    • 14844320024 scopus 로고    scopus 로고
    • Construction of a novel expression system on a human artificial chromosome
    • Otsuki A., Tahimic C.G., Tomimatsu N., et al. Construction of a novel expression system on a human artificial chromosome. Biochem Biophys Res Commun 329 3 (2005) 1018-1025
    • (2005) Biochem Biophys Res Commun , vol.329 , Issue.3 , pp. 1018-1025
    • Otsuki, A.1    Tahimic, C.G.2    Tomimatsu, N.3
  • 36
    • 27944464729 scopus 로고    scopus 로고
    • A novel human artificial chromosome vector provides effective cell lineage-specific transgene expression in human mesenchymal stem cells
    • Ren X., Katoh M., Hoshiya H., et al. A novel human artificial chromosome vector provides effective cell lineage-specific transgene expression in human mesenchymal stem cells. Stem Cells 23 10 (2005) 1608-1616
    • (2005) Stem Cells , vol.23 , Issue.10 , pp. 1608-1616
    • Ren, X.1    Katoh, M.2    Hoshiya, H.3
  • 37
    • 30544438571 scopus 로고    scopus 로고
    • Heat regulated production and secretion of insulin from a human artificial chromosome vector
    • Suda T., Katoh M., Hiratsuka M., et al. Heat regulated production and secretion of insulin from a human artificial chromosome vector. Biochem Biophys Res Commun 340 4 (2006) 1053-1061
    • (2006) Biochem Biophys Res Commun , vol.340 , Issue.4 , pp. 1053-1061
    • Suda, T.1    Katoh, M.2    Hiratsuka, M.3
  • 38
    • 0033776128 scopus 로고    scopus 로고
    • Manipulation of human minichromosomes to carry greater than megabase-sized chromosome inserts
    • Kuroiwa Y., Tomizuka K., Shinohara T., et al. Manipulation of human minichromosomes to carry greater than megabase-sized chromosome inserts. Nat Biotechnol 18 10 (2000) 1086-1090
    • (2000) Nat Biotechnol , vol.18 , Issue.10 , pp. 1086-1090
    • Kuroiwa, Y.1    Tomizuka, K.2    Shinohara, T.3
  • 39
    • 0036714713 scopus 로고    scopus 로고
    • Cloned transchromosomic calves producing human immunoglobulin
    • Kuroiwa Y., Kasinathan P., Choi Y.J., et al. Cloned transchromosomic calves producing human immunoglobulin. Nat Biotechnol 20 9 (2002) 889-894
    • (2002) Nat Biotechnol , vol.20 , Issue.9 , pp. 889-894
    • Kuroiwa, Y.1    Kasinathan, P.2    Choi, Y.J.3
  • 40
    • 0037235359 scopus 로고    scopus 로고
    • Artificial chromosome vectors and expression of complex proteins in transgenic animals
    • Robl J.M., Kasinathan P., Sullivan E., et al. Artificial chromosome vectors and expression of complex proteins in transgenic animals. Theriogenology 59 1 (2003) 107-113
    • (2003) Theriogenology , vol.59 , Issue.1 , pp. 107-113
    • Robl, J.M.1    Kasinathan, P.2    Sullivan, E.3
  • 41
    • 0032836450 scopus 로고    scopus 로고
    • Use of a human minichromosome as a cloning and expression vector for mammalian cells
    • Guiducci C., Ascenzioni F., Auriche C., et al. Use of a human minichromosome as a cloning and expression vector for mammalian cells. Hum Mol Genet 8 8 (1999) 1417-1424
    • (1999) Hum Mol Genet , vol.8 , Issue.8 , pp. 1417-1424
    • Guiducci, C.1    Ascenzioni, F.2    Auriche, C.3
  • 42
    • 0034925026 scopus 로고    scopus 로고
    • Functional complementation of a genetic deficiency with human artificial chromosomes
    • Mejia J.E., Willmott A., Levy E., et al. Functional complementation of a genetic deficiency with human artificial chromosomes. Am J Hum Genet 69 2 (2001) 315-326
    • (2001) Am J Hum Genet , vol.69 , Issue.2 , pp. 315-326
    • Mejia, J.E.1    Willmott, A.2    Levy, E.3
  • 43
    • 0034755391 scopus 로고    scopus 로고
    • Stable gene expression from a mammalian artificial chromosome
    • Grimes B.R., Schindelhauer D., McGill N.I., et al. Stable gene expression from a mammalian artificial chromosome. EMBO Rep 2 10 (2001) 910-914
    • (2001) EMBO Rep , vol.2 , Issue.10 , pp. 910-914
    • Grimes, B.R.1    Schindelhauer, D.2    McGill, N.I.3
  • 44
    • 0036786748 scopus 로고    scopus 로고
    • Generation of human artificial chromosomes expressing naturally controlled guanosine triphosphate cyclohydrolase I gene
    • Ikeno M., Inagaki H., Nagata K., et al. Generation of human artificial chromosomes expressing naturally controlled guanosine triphosphate cyclohydrolase I gene. Genes Cells 7 10 (2002) 1021-1032
    • (2002) Genes Cells , vol.7 , Issue.10 , pp. 1021-1032
    • Ikeno, M.1    Inagaki, H.2    Nagata, K.3
  • 45
    • 19544391818 scopus 로고    scopus 로고
    • Construction of human artificial chromosome vectors by recombineering
    • Kotzamanis G., Cheung W., Abdulrazzak H., et al. Construction of human artificial chromosome vectors by recombineering. Gene 351 (2005) 29-38
    • (2005) Gene , vol.351 , pp. 29-38
    • Kotzamanis, G.1    Cheung, W.2    Abdulrazzak, H.3
  • 46
    • 33749243471 scopus 로고    scopus 로고
    • A novel human artificial chromosome gene expression system using herpes simplex virus type 1 vectors
    • (Aug):11
    • Moralli D., Simpson K.M., Wade-Martins R., et al. A novel human artificial chromosome gene expression system using herpes simplex virus type 1 vectors. EMBO Rep (2006) (Aug):11
    • (2006) EMBO Rep
    • Moralli, D.1    Simpson, K.M.2    Wade-Martins, R.3
  • 47
    • 0034065843 scopus 로고    scopus 로고
    • Generation of transgenic mice and germline transmission of a mammalian artificial chromosome introduced into embryos by pronuclear microinjection
    • Co D.O., Borowoski A.H., Leung J.D., et al. Generation of transgenic mice and germline transmission of a mammalian artificial chromosome introduced into embryos by pronuclear microinjection. Chromosome Res 8 3 (2000) 183-191
    • (2000) Chromosome Res , vol.8 , Issue.3 , pp. 183-191
    • Co, D.O.1    Borowoski, A.H.2    Leung, J.D.3
  • 48
    • 1542299634 scopus 로고    scopus 로고
    • Erythrocyte ghost-mediated gene delivery for prolonged and blood targeted expression
    • Byun H.M., Suh D., Yoon H., et al. Erythrocyte ghost-mediated gene delivery for prolonged and blood targeted expression. Gene Ther 11 5 (2004) 492-496
    • (2004) Gene Ther , vol.11 , Issue.5 , pp. 492-496
    • Byun, H.M.1    Suh, D.2    Yoon, H.3
  • 49
    • 27544472925 scopus 로고    scopus 로고
    • Bacterial transfer of large functional genomic DNA into human cells
    • Laner A., Goussard S., Ramalho A.S., et al. Bacterial transfer of large functional genomic DNA into human cells. Gene Ther 12 21 (2005) 1559-1572
    • (2005) Gene Ther , vol.12 , Issue.21 , pp. 1559-1572
    • Laner, A.1    Goussard, S.2    Ramalho, A.S.3
  • 50
    • 18844363963 scopus 로고    scopus 로고
    • Artificial and engineered chromosomes: non-integrating vectors for gene therapy
    • Basu J., and Willard H.F. Artificial and engineered chromosomes: non-integrating vectors for gene therapy. Trends Mol Med 11 5 (2005) 251-258
    • (2005) Trends Mol Med , vol.11 , Issue.5 , pp. 251-258
    • Basu, J.1    Willard, H.F.2
  • 51
    • 0036748288 scopus 로고    scopus 로고
    • Functional human CFTR produced by a stable minichromosome
    • Auriche C., Carpani D., Conese M., et al. Functional human CFTR produced by a stable minichromosome. EMBO Rep 3 9 (2002) 862-868
    • (2002) EMBO Rep , vol.3 , Issue.9 , pp. 862-868
    • Auriche, C.1    Carpani, D.2    Conese, M.3
  • 52
    • 0036839549 scopus 로고    scopus 로고
    • Locus control regions
    • Li Q., Peterson K.R., Fang X., et al. Locus control regions. Blood 100 9 (2002) 3077-3086
    • (2002) Blood , vol.100 , Issue.9 , pp. 3077-3086
    • Li, Q.1    Peterson, K.R.2    Fang, X.3
  • 53
    • 0034904598 scopus 로고    scopus 로고
    • Silencing of gene expression: implications for design of retrovirus vectors
    • Pannell D., and Ellis J. Silencing of gene expression: implications for design of retrovirus vectors. Rev Med Virol 11 4 (2001) 205-217
    • (2001) Rev Med Virol , vol.11 , Issue.4 , pp. 205-217
    • Pannell, D.1    Ellis, J.2


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