A gene delivery system with a human artificial chromosome vector based on migration of mesenchymal stem cells towards human glioblastoma HTB14 cells

Neurological Research

Volumn 32, Issue 4, 2010, Pages 429-437

  Kinoshita, Yusuke ^a   Kamitani, Hideki ^a   Mamun, Mahabub Hasan ^a   Wasita, Brian ^a   Kazuki, Yasuhiro ^b   Hiratsuka, Masaharu ^c   Oshimura, Mitsuo ^b   Watanabe, Takashi ^a  

^a TOTTORI UNIVERSITY   (Japan)

^b TOTTORI UNIVERSITY   (Japan)

^c TOTTORI UNIVERSITY   (Japan)

Author keywords

Gene delivery system; Glioblastoma; Herpes simplex virus thymidine kinase gene; Human artificial chromosome vector; Mesenchymal stem cell; Migration

Indexed keywords

GANCICLOVIR; GREEN FLUORESCENT PROTEIN; RED FLUORESCENT PROTEIN; THYMIDINE KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTIFICIAL CHROMOSOME; BRAIN CORTEX; CELL MIGRATION; CONTROLLED STUDY; CORPUS CALLOSUM; FLUORESCENCE MICROSCOPY; GENE DELIVERY SYSTEM; GLIOBLASTOMA; HERPES SIMPLEX VIRUS; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MALE; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN;

ANIMALS; BRAIN NEOPLASMS; CELL LINE, TRANSFORMED; CELL MOVEMENT; CHROMOSOMES, ARTIFICIAL, HUMAN; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; GLIOBLASTOMA; HUMANS; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; MICE; MICE, NUDE; SIMPLEXVIRUS; THYMIDINE KINASE; TRANSPLANTATION, HETEROLOGOUS; TREATMENT OUTCOME;

EID: 77952208428     PISSN: 01616412     EISSN: None     Source Type: Journal    
DOI: 10.1179/174313209X455718     Document Type: Article

References (24)

1. Aboody KS, Brown A, Rainov NG, et al. Neural stem cells display extensive tropism for pathology in adult brain: Evidence from intracranial gliomas. Proc Natl Acad Sci USA 2002; 97: 12846-12851
2. Mahmood A, Lu D, Chopp M, et al. Intravenous administration of marrow stromal cells (MSCs) increases the expression of growth factors in rat brain after traumatic brain injury. J Neurotrauma 2004; 21: 33-39
3. Kurozumi K, Nakamura K, Tamiya T, et al. Mesenchymal stem cells that produce neurotrophic factors reduce ischemic damage in the rat middle cerebral artery occlusion model. Mol Ther 2005; 11: 96-104
4. Ehtesham M, Kabos P, Kabosova A, et al. The use of interleukin 12-secreting neural stem cells for the treatment of intracranial glioma. Cancer Res 2002; 62: 5657-5663
5. Ehtesham M, Yuan X, Kabos, et al. Glioma tropic neural stem cells consist of astrocytic precursors and their migratory capacity is mediated by CXCR4. Neoplasia 2004; 6:287-293
6. Namba H, Tagawa M, Iwadate Y, et al. Bystander effect-mediated therapy of experimental brain tumor by genetically engineered tumor cells. Hum Gene Ther 1998; 9: 5-11
7. Li S, Tokuyama T, Yamamoto J, et al. Bystander effect-mediated gene therapy of gliomas using genetically engineered neural stem cells. Cancer Gene Ther 2005; 2: 600-607
8. Soling A, Theiss C, Jungmichel S, et al. A dual function fusion protein of Herpes simplex virus type 1 thymidine kinase and firefly luciferase for noninvasive in vivo imaging of gene therapy in malignant glioma. Genet Vaccines Ther 2004; 2: 7
9. Hamada H, Kobune M, Nakamura K, et al. Mesenchymal stem cells (MSC) as therapeutic cytoreagents for gene therapy. Cancer Sci 2005; 96: 149-156
10. Nakamizo A, Marini F, Amano T, et al. Human bone marrowderived mesenchymal stem cells in the treatment of gliomas. Cancer Res 2005; 65: 3307-3318
11. Nakamura K, Ito Y, Kawano Y, et al. Antitumor effect of genetically engineered mesenchymal stem cells in a rat glioma model. Gene Ther 2004; 11: 1155-1164
12. Okamoto T, Aoyama T, Nakayama T, et al. Clonal heterogeneity in differentiation potential of immortalized human mesenchymal stem cells. Biochem Biophys Res Commun 2002; 295: 354-361
13. Kazuki Y, Hoshiya H, Kai Y, et al. Correction of a genetic defect in multipotent germline stem cells using a human artificial chromosome. Gene Ther 2008; 15: 617-624
14. Katoh M, Ayabe F, Norikane S, et al. Construction of a novel human artificial chromosome vector for gene delivery. Biochem Biophys Res Commun 2004; 321: 280-290 (Pubitemid 39055743)
15. Ren X, Katoh M, Hoshiya H, et al. A novel human artificial chromosome vector provides effective cell lineage-specific transgene expression in human mesenchymal stem cells. Stem Cells 2005; 23: 1608-1616
16. Ren X, Tahimic CG, Katoh M, et al. Human artificial chromosome vectors meet stem cells: New prospects for gene delivery. Stem Cell Rev 2006; 2: 43-50
17. Mageed AS, Pietryga DW, DeHeer DH, et al. Isolation of large numbers of mesenchymal stem cells from the washings of bone marrow collection bags: Characterization of fresh mesenchymal stem cells. Transplantation 2007; 83: 1019-1026
18. Bühring HJ, Battula VL, Treml S, et al. Novel markers for the prospective isolation of human MSC. Ann NY Acad Sci 2007; 1106: 262-267
19. Satake K, Lou J, Lenke LG, et al. Migration of mesenchymal stem cells through cerebrospinal fluid into injured spinal cord tissue. Spine 2004; 29: 1971-1979
20. Wennersten A, Meier X, Holmin S, et al. Proliferation, migration, and differentiation of human neural stem/progenitor cells after transplantation into a rat model of traumatic brain injury. J Neurosurg 2004; 100: 88-96
21. Schmidt NO, Przylecki W, Yang W, et al. Brain tumor tropism of transplanted human neural stem cells is induced by vascular endothelial growth factor. Neoplasia 2005; 7: 623-639
22. Shah K, Bureau E, Kim DE, et al. Glioma therapy and real-time imaging of neural precursor cell migration and tumor regression. Ann Neurol 2005; 57: 34-41
23. Shitara S, Kakeda M, Nagata K, et al. Telomerase-mediated lifespan extension of human primary fibroblasts by human artificial chromosome (HAC) vector. Biochem Biophys Res Commun 2008; 369: 807-811
24. Rainov NG. A phase III clinical evaluation of herpes simplex virus type 1 thymidine kinase and ganciclovir gene therapy as an adjuvant to surgical resection and radiation in adults with previously untreated glioblastoma multiforme. Hum Gene Ther 2000; 11: 2389-2401