Integration-free iPS cells engineered using human artificial chromosome vectors

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Hiratsuka, Masaharu ^a   Uno, Narumi ^b   Ueda, Kana ^b   Kurosaki, Hajime ^b   Imaoka, Natsuko ^b   Kazuki, Kanako ^c   Ueno, Etsuya ^b   Akakura, Yutaro ^b   Katoh, Motonobu ^a   Osaki, Mitsuhiko ^b   Kazuki, Yasuhiro ^b,c   Nakagawa, Masato ^d   Yamanaka, Shinya ^d   Oshimura, Mitsuo ^a,b,c,e  

^a TOTTORI UNIVERSITY   (Japan)

^b TOTTORI UNIVERSITY   (Japan)

^c TOTTORI UNIVERSITY   (Japan)

^d KYOTO UNIVERSITY   (Japan)

^e JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; GANCICLOVIR; THYMIDINE KINASE;

ANIMAL CELL; ARTICLE; ARTIFICIAL CHROMOSOME; CELL ISOLATION; CHIMERA; CONTROLLED STUDY; EMBRYO; EMBRYO CELL; FIBROBLAST; GENE CASSETTE; GENE DELIVERY SYSTEM; GENE EXPRESSION; GENE SILENCING; GENETIC CODE; GENETIC ENGINEERING; HERPES SIMPLEX VIRUS; HUMAN; INTERMETHOD COMPARISON; MOUSE; NONHUMAN; PLURIPOTENT STEM CELL; TERATOMA; ANIMAL; CELL ENGINEERING; CHO CELL; CRICETULUS; CYTOLOGY; GENE VECTOR; GENETICS; HAMSTER; METABOLISM; METHODOLOGY; SIMPLEXVIRUS; SUICIDE TRANSGENE;

IPS; SIMPLEXVIRUS;

ANIMALS; CELL ENGINEERING; CHO CELLS; CHROMOSOMES, ARTIFICIAL, HUMAN; CRICETINAE; CRICETULUS; FIBROBLASTS; GENES, TRANSGENIC, SUICIDE; GENETIC VECTORS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MICE; SIMPLEXVIRUS; THYMIDINE KINASE;

EID: 80053588682     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0025961     Document Type: Article

References (39)

1. Takahashi K, Yamanaka S, (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126: 663-676.
2. Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, et al. (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131: 861-872.
3. Yu JY, Vodyanik MA, Smuga-Otto K, Antosiewicz-Bourget J, Frane JL, et al. (2007) Induced pluripotent stem cell lines derived from human somatic cells. Science 318: 1917-1920.
4. Pauwels K, Gijsbers R, Toelen J, Schambach A, Willard-Gallo K, et al. (2009) State-of-the-Art Lentiviral Vectors for Research Use: Risk Assessment and Biosafety Recommendations. Current Gene Therapy 9: 459-474.
5. Brambrink T, Foreman R, Welstead GG, Lengner CJ, Wernig M, et al. (2008) Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells. Cell Stem Cell 2: 151-159.
6. Kaji K, Norrby K, Paca A, Mileikovsky M, Mohseni P, et al. (2009) Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Nature 458: 771-775.
7. Woltjen K, Michael IP, Mohseni P, Desai R, Mileikovsky M, et al. (2009) piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. Nature 458: 766-770.
8. Yusa K, Rad R, Takeda J, Bradley A, (2009) Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon. Nature Methods 6: 363-U369.
9. Stadtfeld M, Nagaya M, Utikal J, Weir G, Hochedlinger K, (2008) Induced Pluripotent Stem Cells Generated Without Viral Integration. Science 322: 945-949.
10. Fusaki N, Ban H, Nishiyama A, Saeki K, Hasegawa M, (2009) Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome. Proc Jpn Acad Ser B Phys Biol Sci 85: 348-362.
11. Yu JY, Hu KJ, Smuga-Otto K, Tian SL, Stewart R, et al. (2009) Human Induced Pluripotent Stem Cells Free of Vector and Transgene Sequences. Science 324: 797-801.
12. Okita K, Nakagawa M, Hong HJ, Ichisaka T, Yamanaka S, (2008) Generation of Mouse Induced Pluripotent Stem Cells Without Viral Vectors. Science 322: 949-953.
13. Jia FJ, Wilson KD, Sun N, Gupta DM, Huang M, et al. (2010) A nonviral minicircle vector for deriving human iPS cells. Nature Methods 7: 197-U146.
14. Zhou HY, Wu SL, Joo JY, Zhu SY, Han DW, et al. (2009) Generation of Induced Pluripotent Stem Cells Using Recombinant Proteins. Cell Stem Cell 4: 381-384.
15. Warren L, Manos PD, Ahfeldt T, Loh YH, Li H, et al. (2010) Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA. Cell Stem Cell 7: 618-630.
16. Kroon E, Martinson LA, Kadoya K, Bang AG, Kelly OG, et al. (2008) Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo. Nature Biotechnology 26: 443-452.
17. Katoh M, Ayabe F, Norikane S, Okada T, Masumoto H, et al. (2004) Construction of a novel human artificial chromosome vector for gene delivery. Biochemical and Biophysical Research Communications 321: 280-290.
18. Kazuki Y, Hoshiya H, Takiguchi M, Abe S, Iida Y, et al. (2011) Refined human artificial chromosome vectors for gene therapy and animal transgenesis. Gene Therapy 18: 384-393.
19. Hoshiya H, Kazuki Y, Abe S, Takiguchi M, Kajitani N, et al. (2009) A highly Stable and Nonintegrated Human Artificial Chromosome (HAC) Containing the 2.4 Mb Entire Human Dystrophin Gene. Molecular Therapy 17: 309-317.
20. Kazuki Y, Hoshiya H, Kai Y, Abe S, Takiguchi M, et al. (2008) Correction of a genetic defect in multipotent germline stem cells using a human artificial chromosome. Gene Therapy 15: 617-624.
21. Kakeda M, Hiratsuka M, Nagata K, Kuroiwa Y, Kakitani M, et al. (2005) Human artificial chromosome (HAC) vector provides long-term therapeutic transgene expression in normal human primary fibroblasts. Gene Therapy 12: 852-856.
22. Rudd MK, Mays RW, Schwartz S, Willard HF, (2003) Human artificial chromosomes with alpha satellite-based de novo centromeres show increased frequency of nondisjunction and anaphase lag. Molecular and Cellular Biology 23: 7689-7697.
23. Carey BW, Markoulaki S, Hanna J, Saha K, Gao Q, et al. (2009) Reprogramming of murine and human somatic cells using a single polycistronic vector. Proceedings of the National Academy of Sciences of the United States of America 106: 157-162.
24. Sommer CA, Stadtfeld M, Murphy GJ, Hochedlinger K, Kotton DN, et al. (2009) Induced Pluripotent Stem Cell Generation Using a Single Lentiviral Stem Cell Cassette. Stem Cells 27: 543-549.
25. Hong H, Takahashi K, Ichisaka T, Aoi T, Kanagawa O, et al. (2009) Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. Nature 460: 1132-U1195.
26. Kawamura T, Suzuki J, Wang YV, Menendez S, Morera LB, et al. (2009) Linking the p53 tumour suppressor pathway to somatic cell reprogramming. Nature 460: 1140-U1107.
27. Utikal J, Polo JM, Stadtfeld M, Maherali N, Kulalert W, et al. (2009) Immortalization eliminates a roadblock during cellular reprogramming into iPS cells. Nature 460: 1145-U1112.
28. Li H, Collado M, Villasante A, Strati K, Ortega S, et al. (2009) The Ink4/Arf locus is a barrier for iPS cell reprogramming. Nature 460: 1136-U1101.
29. Marion RM, Strati K, Li H, Murga M, Blanco R, et al. (2009) A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity. Nature 460: 1149-U1119.
30. Yagi T, Tokunaga T, Furuta Y, Nada S, Yoshida M, et al. (1993) A Novel ES Cell-Line, TT2, with High Germline-Differentiating Potency. Analytical Biochemistry 214: 70-76.
31. Tomizuka K, Yoshida H, Uejima H, Kugoh H, Sato K, et al. (1997) Functional expression and germline transmission of a human chromosome fragment in chimaeric mice. Nature Genetics 16: 133-143.
32. Hochedlinger K, Yamada Y, Beard C, Jaenisch R, (2005) Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues. Cell 121: 465-477.
33. Bass AJ, Watanabe H, Mermel CH, Yu SY, Perner S, et al. (2009) SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas. Nature Genetics 41: 1238-U1105.
34. Kazuki Y, Hiratsuka M, Takiguchi M, Osaki M, Kajitani N, et al. (2010) Complete Genetic Correction of iPS Cells From Duchenne Muscular Dystrophy. Molecular Therapy 18: 386-393.
35. Judson RL, Babiarz JE, Venere M, Blelloch R, (2009) Embryonic stem cell-specific microRNAs promote induced pluripotency. Nature Biotechnology 27: 459-461.
36. Iida Y, Kim JH, Kazuki Y, Hoshiya H, Takiguchi M, et al. (2010) Human Artificial Chromosome with a Conditional Centromere for Gene Delivery and Gene Expression. DNA Research 17: 293-301.
37. Papapetrou EP, Tomishima MJ, Chambers SM, Mica Y, Reed E, et al. (2009) Stoichiometric and temporal requirements of Oct4, Sox2, Klf4, and c-Myc expression for efficient human iPSC induction and differentiation. Proceedings of the National Academy of Sciences of the United States of America 106: 12759-12764.
38. Silva J, Nichols J, Theunissen TW, Guo G, van Oosten AL, et al. (2009) Nanog Is the Gateway to the Pluripotent Ground State. Cell 138: 722-737.
39. Lin TX, Chao C, Saito S, Mazur SJ, Murphy ME, et al. (2005) P53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression. Nature Cell Biology 7: 165-U180.