Human artificial chromosome (HAC) vector with a conditional centromere for correction of genetic deficiencies in human cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 50, 2011, Pages 20048-20053

  Kim, Jung Hyun ^a   Kononenko, Artem ^a   Erliandri, Indri ^a   Kim, Tae Aug ^a   Nakano, Megumi ^b   Iida, Yuichi ^b   Barrett, J Carl ^d   Oshimura, Mitsuo ^c   Masumoto, Hiroshi ^b   Earnshaw, William C ^e   Larionov, Vladimir ^a   Kouprina, Natalay ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b KAZUSA DNA RESEARCH INSTITUTE   (Japan)

^c TOTTORI UNIVERSITY   (Japan)

^d ASTRAZENECA   (United Kingdom)

^e UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Gene delivery vector; Gene therapy; Transformation associated recombination cloning

Indexed keywords

NIBRIN; VON HIPPEL LINDAU PROTEIN;

ARTICLE; ARTIFICIAL CHROMOSOME; CELL POPULATION; CENTROMERE; CHROMOSOME INACTIVATION; CONTROLLED STUDY; GENE DELIVERY SYSTEM; GENE EXPRESSION; GENE TARGETING; GENETIC DISORDER; HUMAN; HUMAN ARTIFICIAL CHROMOSOME VECTOR; HUMAN CELL; IN VITRO STUDY; PHENOTYPE; PRIORITY JOURNAL;

ANIMALS; AUTOANTIGENS; CELL CYCLE PROTEINS; CENTROMERE; CHO CELLS; CHROMOSOMAL PROTEINS, NON-HISTONE; CHROMOSOMES, ARTIFICIAL, HUMAN; CHROMOSOMES, ARTIFICIAL, YEAST; CLONING, MOLECULAR; CRICETINAE; CRICETULUS; GENE EXPRESSION; GENE THERAPY; GENETIC COMPLEMENTATION TEST; GENETIC VECTORS; GENOME, HUMAN; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; INTEGRASES; MUTAGENESIS, INSERTIONAL; NUCLEAR PROTEINS; RECOMBINATION, GENETIC; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 84055200818     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1114483108     Document Type: Article

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