Cucurbitacin i inhibits Rac1 activation in breast cancer cells by a reactive oxygen species-mediated mechanism and independently of janus tyrosine kinase 2 and P-Rex1s

Molecular Pharmacology

Volumn 83, Issue 5, 2013, Pages 1141-1154

  Lopez Haber, Cynthia ^a   Kazanietz, Marcelo G ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CUCURBITACIN I; EPIDERMAL GROWTH FACTOR RECEPTOR 3; JANUS KINASE 2 INHIBITOR; NEU DIFFERENTIATION FACTOR; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CANCER CELL; CELL MOTILITY; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IC 50; PRIORITY JOURNAL; RNA INTERFERENCE;

BREAST NEOPLASMS; CELL LINE, TUMOR; CELL MOVEMENT; FEMALE; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; JANUS KINASE 2; LIGANDS; MCF-7 CELLS; NEUREGULIN-1; RAC1 GTP-BINDING PROTEIN; REACTIVE OXYGEN SPECIES; RECEPTOR, ERBB-3; RHO-ASSOCIATED KINASES; RHOA GTP-BINDING PROTEIN; STAT3 TRANSCRIPTION FACTOR; STRESS FIBERS; TRITERPENES;

EID: 84876576531     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.112.084293     Document Type: Article

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