메뉴 건너뛰기




Volumn 287, Issue 6 50-6, 2004, Pages

EGFR-induced cell migration is mediated predominantly by the JAK-STAT pathway in primary esophageal keratinocytes

Author keywords

Akt; Cell migration; Epidermal growth factor receptor

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; INTERSTITIAL COLLAGENASE; JANUS KINASE; JANUS KINASE 2; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PROTEIN KINASE B; STAT PROTEIN; STAT1 PROTEIN; STAT3 PROTEIN;

EID: 9244264472     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.00253.2004     Document Type: Article
Times cited : (113)

References (41)
  • 1
    • 0037449752 scopus 로고    scopus 로고
    • Epidermal growth factor mediates increased cell proliferation, migration and aggregation in esophageal keratinocytes in vitro and in vivo
    • Andl CD, Mizushima T, Nakagawa H, Oyama K, Harada H, Chruma K, Herlyn M, and Rustgi AK. Epidermal growth factor mediates increased cell proliferation, migration and aggregation in esophageal keratinocytes in vitro and in vivo. J Biol Chem 278: 1824-1830, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 1824-1830
    • Andl, C.D.1    Mizushima, T.2    Nakagawa, H.3    Oyama, K.4    Harada, H.5    Chruma, K.6    Herlyn, M.7    Rustgi, A.K.8
  • 2
    • 0035881561 scopus 로고    scopus 로고
    • Membrane type I-matrix metalloproteinase-mediated degradation of type I collagen by oral squamous cell carcinoma cells
    • Aznavoorian S, Moore BA, Alexander-Lister LD, Hallit SL, Windsor LJ, and Engler JA. Membrane type I-matrix metalloproteinase-mediated degradation of type I collagen by oral squamous cell carcinoma cells. Cancer Res 61: 6264-6275, 2001.
    • (2001) Cancer Res , vol.61 , pp. 6264-6275
    • Aznavoorian, S.1    Moore, B.A.2    Alexander-Lister, L.D.3    Hallit, S.L.4    Windsor, L.J.5    Engler, J.A.6
  • 3
    • 0036173589 scopus 로고    scopus 로고
    • The JAK/STAT pathway is required for border cell migration during Drosophila oogenesis
    • Beccari S, Teixeira L, and Rorth P. The JAK/STAT pathway is required for border cell migration during Drosophila oogenesis. Mech Dev 111: 115-123, 2002.
    • (2002) Mech Dev , vol.111 , pp. 115-123
    • Beccari, S.1    Teixeira, L.2    Rorth, P.3
  • 5
    • 0036251154 scopus 로고    scopus 로고
    • Stat proteins and oncogenesis
    • Bromberg J. Stat proteins and oncogenesis. J Clin Invest 109: 1139-1142, 2002.
    • (2002) J Clin Invest , vol.109 , pp. 1139-1142
    • Bromberg, J.1
  • 6
    • 0034657336 scopus 로고    scopus 로고
    • The role of STATs in transcripuonal control and their impact on cellular function
    • Bromberg J and Darnell JE. The role of STATs in transcripuonal control and their impact on cellular function. Oncogene 19: 2468-2478, 2000.
    • (2000) Oncogene , vol.19 , pp. 2468-2478
    • Bromberg, J.1    Darnell, J.E.2
  • 9
    • 0028989350 scopus 로고
    • EGF receptor deletions define a region specifically mediating STAT transcription factor activation
    • Coffer PJ and Kruijer W. EGF receptor deletions define a region specifically mediating STAT transcription factor activation. Biochem Biophys Res Commun 210: 74-81, 1995.
    • (1995) Biochem Biophys Res Commun , vol.210 , pp. 74-81
    • Coffer, P.J.1    Kruijer, W.2
  • 10
    • 0029960791 scopus 로고    scopus 로고
    • STAT activation by epidermal growth factor (EGF) and amphiregulin. Requirement for the EGF receptor kinase, but not for tyrosine phosphorylation sites or JAK1
    • David M, Wong L, Flavell R, Thompson SA, Wells A, Larner AC, and Johnson GR. STAT activation by epidermal growth factor (EGF) and amphiregulin. Requirement for the EGF receptor kinase, but not for tyrosine phosphorylation sites or JAK1. J Biol Chem 271: 9185-9188, 1996.
    • (1996) J Biol Chem , vol.271 , pp. 9185-9188
    • David, M.1    Wong, L.2    Flavell, R.3    Thompson, S.A.4    Wells, A.5    Larner, A.C.6    Johnson, G.R.7
  • 11
    • 0033948436 scopus 로고    scopus 로고
    • The molecular genetics of chemotaxis: Sensing and responding to chemoattractant gradients
    • Firtel RA and Chung CY. The molecular genetics of chemotaxis: sensing and responding to chemoattractant gradients. Bioessays 22: 603-615, 2000.
    • (2000) Bioessays , vol.22 , pp. 603-615
    • Firtel, R.A.1    Chung, C.Y.2
  • 12
    • 0032950743 scopus 로고    scopus 로고
    • Fludarabine-induced immunosuppression is associated with inhibition of STAT1 signaling
    • Frank DA, Mahajan S, and Ritz J. Fludarabine-induced immunosuppression is associated with inhibition of STAT1 signaling. Nat Med 5: 444-447, 1999.
    • (1999) Nat Med , vol.5 , pp. 444-447
    • Frank, D.A.1    Mahajan, S.2    Ritz, J.3
  • 13
    • 0037205265 scopus 로고    scopus 로고
    • Spatial and temporal regulation of 3-phosphoinositides by PI3-kinase and PTEN mediates chemotaxis
    • Funamoto S, Meili R, Lee S, Parry L, and Firtel RA. Spatial and temporal regulation of 3-phosphoinositides by PI3-kinase and PTEN mediates chemotaxis. Cell 109: 611-623, 2002.
    • (2002) Cell , vol.109 , pp. 611-623
    • Funamoto, S.1    Meili, R.2    Lee, S.3    Parry, L.4    Firtel, R.A.5
  • 14
    • 0036929925 scopus 로고    scopus 로고
    • The Drosophila cytokine receptor Domeless controls border cell migration and epithelial polarization during oogenesis
    • Ghiglione C, Devergne O, Georgenthum E, Carballes F, Medioni C, Cerezo D, and Noselli S. The Drosophila cytokine receptor Domeless controls border cell migration and epithelial polarization during oogenesis. Development 129: 5437-5447, 2002.
    • (2002) Development , vol.129 , pp. 5437-5447
    • Ghiglione, C.1    Devergne, O.2    Georgenthum, E.3    Carballes, F.4    Medioni, C.5    Cerezo, D.6    Noselli, S.7
  • 15
    • 0013689209 scopus 로고    scopus 로고
    • Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor-mediated cell growth in vitro
    • Grandis JR, Drenning SD, Chakraborty A, Zhou MY, Zeng Q, Pitt AS, and Tweardy DJ. Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor-mediated cell growth in vitro. J Clin Invest 102: 1385-1392, 1998.
    • (1998) J Clin Invest , vol.102 , pp. 1385-1392
    • Grandis, J.R.1    Drenning, S.D.2    Chakraborty, A.3    Zhou, M.Y.4    Zeng, Q.5    Pitt, A.S.6    Tweardy, D.J.7
  • 16
    • 0037728809 scopus 로고    scopus 로고
    • The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines
    • Grille SJ, Bellacosa A, Upson J, Klein-Szanto AJ, van Roy F, Lee-Kwon W, Donowitz M, Tsichlis PN, and Larue L. The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines. Cancer Res 63: 2172-2178, 2003.
    • (2003) Cancer Res , vol.63 , pp. 2172-2178
    • Grille, S.J.1    Bellacosa, A.2    Upson, J.3    Klein-Szanto, A.J.4    Van Roy, F.5    Lee-Kwon, W.6    Donowitz, M.7    Tsichlis, P.N.8    Larue, L.9
  • 17
    • 0031763924 scopus 로고    scopus 로고
    • Duplication of a genomic region containing the Cdc2L1-2 and MMP21-22 genes on human chromosome 1p36.3 and their linkage to D1Z2
    • Gururajan R, Lahti JM, Grenet J, Easton J, Gruber I, Ambros PF, and Kidd VJ. Duplication of a genomic region containing the Cdc2L1-2 and MMP21-22 genes on human chromosome 1p36.3 and their linkage to D1Z2. Genome Res 8: 929-939, 1999.
    • (1999) Genome Res , vol.8 , pp. 929-939
    • Gururajan, R.1    Lahti, J.M.2    Grenet, J.3    Easton, J.4    Gruber, I.5    Ambros, P.F.6    Kidd, V.J.7
  • 18
    • 0035846549 scopus 로고    scopus 로고
    • Akt mediates Rac/Cdc42-regulated cell motility in growth factor-stimulated cells and in invasive PTEN knockout cells
    • Higuchi M, Masuyama N, Fukui Y, Suzuki A, and Gotoh Y. Akt mediates Rac/Cdc42-regulated cell motility in growth factor-stimulated cells and in invasive PTEN knockout cells. Curr Biol 11: 1958-1962, 2001.
    • (2001) Curr Biol , vol.11 , pp. 1958-1962
    • Higuchi, M.1    Masuyama, N.2    Fukui, Y.3    Suzuki, A.4    Gotoh, Y.5
  • 19
    • 0034306290 scopus 로고    scopus 로고
    • STAT proteins and transcriptional responses to extracellular signals
    • Horvath CM. STAT proteins and transcriptional responses to extracellular signals. Trends Biochem Sci 25: 496-450, 2000.
    • (2000) Trends Biochem Sci , vol.25 , pp. 496-450
    • Horvath, C.M.1
  • 20
    • 0036899655 scopus 로고    scopus 로고
    • The Jak/STAT pathway in model organisms: Emerging roles in cell movement
    • Hou SX, Zheng Z, Chen X, and Perrimon N. The Jak/STAT pathway in model organisms: emerging roles in cell movement. Dev Cell 3: 765-778, 2002.
    • (2002) Dev Cell , vol.3 , pp. 765-778
    • Hou, S.X.1    Zheng, Z.2    Chen, X.3    Perrimon, N.4
  • 21
    • 0036024855 scopus 로고    scopus 로고
    • STAT3 activation abrogates growth factor dependence and contributes to head and neck squamous cell carcinoma tumor growth in vivo
    • Kijima T, Niwa H, Steinman RA, Drenning SD, Gooding WE, Wentzel AL, Xi S, and Grandis JR. STAT3 activation abrogates growth factor dependence and contributes to head and neck squamous cell carcinoma tumor growth in vivo. Cell Growth Differ 13: 355-362, 2002.
    • (2002) Cell Growth Differ , vol.13 , pp. 355-362
    • Kijima, T.1    Niwa, H.2    Steinman, R.A.3    Drenning, S.D.4    Gooding, W.E.5    Wentzel, A.L.6    Xi, S.7    Grandis, J.R.8
  • 22
    • 0034852195 scopus 로고    scopus 로고
    • Akt/PKB promotes cancer cell invasion via increased motility and metalloproteinase production
    • Kim D, Kim S, Koh H, Yoon S, Chung A, Cho KS, and Chung J. Akt/PKB promotes cancer cell invasion via increased motility and metalloproteinase production. FASEB J 15: 1953-1962, 2001.
    • (2001) FASEB J , vol.15 , pp. 1953-1962
    • Kim, D.1    Kim, S.2    Koh, H.3    Yoon, S.4    Chung, A.5    Cho, K.S.6    Chung, J.7
  • 24
    • 0033152980 scopus 로고    scopus 로고
    • Identification and characterization of human MT5-MMP, a new membrane-bound activator of progelatinase is overexpressed in brain tumors
    • Llano E, Pendas AM, Freije JP, Nakano A, Knauper V, Murphy G, and Lopez-Otin C. Identification and characterization of human MT5-MMP, a new membrane-bound activator of progelatinase is overexpressed in brain tumors. Cancer Res 59: 2570-2576, 1999.
    • (1999) Cancer Res , vol.59 , pp. 2570-2576
    • Llano, E.1    Pendas, A.M.2    Freije, J.P.3    Nakano, A.4    Knauper, V.5    Murphy, G.6    Lopez-Otin, C.7
  • 25
    • 0041327718 scopus 로고    scopus 로고
    • Leading the way: Directional sensing through phosphatidylinositol 3-kinase and other signaling pathways
    • Merlot S and Firtel RA. Leading the way: directional sensing through phosphatidylinositol 3-kinase and other signaling pathways. J Cell Sci 116: 3471-3478, 2003.
    • (2003) J Cell Sci , vol.116 , pp. 3471-3478
    • Merlot, S.1    Firtel, R.A.2
  • 27
    • 0032819874 scopus 로고    scopus 로고
    • Evidence that the Dictyostelium Dd-STATa protein is a repressor that regulates commitment to stalk cell differentiation and is also required for efficient chemotaxis
    • Mohanty S, Jermyn KA, Early A, Kawata T, Aubry L, Ceccarelli A, Schaap P, Williams JG, and Firtel RA. Evidence that the Dictyostelium Dd-STATa protein is a repressor that regulates commitment to stalk cell differentiation and is also required for efficient chemotaxis. Development 126: 3391-3405, 1999.
    • (1999) Development , vol.126 , pp. 3391-3405
    • Mohanty, S.1    Jermyn, K.A.2    Early, A.3    Kawata, T.4    Aubry, L.5    Ceccarelli, A.6    Schaap, P.7    Williams, J.G.8    Firtel, R.A.9
  • 28
    • 0035823494 scopus 로고    scopus 로고
    • Roles of phosphatidylinositol 3-kinase in interferon-γ-dependent phosphorylation of STAT1 on serine 727 and activation of gene expression
    • Nguyen H, Ramana CV, Bayes J, and Stark GR. Roles of phosphatidylinositol 3-kinase in interferon-γ-dependent phosphorylation of STAT1 on serine 727 and activation of gene expression. J Biol Chem 276: 33361-33368, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 33361-33368
    • Nguyen, H.1    Ramana, C.V.2    Bayes, J.3    Stark, G.R.4
  • 29
    • 0036233585 scopus 로고    scopus 로고
    • Cytokine signaling in 2002: New surprises in the Jak/Stat pathway
    • O'Shea JJ, Gadina M, and Schreiber RD. Cytokine signaling in 2002: new surprises in the Jak/Stat pathway. Cell 109: 121-131, 2002.
    • (2002) Cell , vol.109 , pp. 121-131
    • O'Shea, J.J.1    Gadina, M.2    Schreiber, R.D.3
  • 30
    • 0035887436 scopus 로고    scopus 로고
    • Aktl induces extracellular matrix invasion and matrix metalloproteinase-2 activity in mouse mammary epithelial cells
    • Park BK, Zeng X, and Glazer RI. Aktl induces extracellular matrix invasion and matrix metalloproteinase-2 activity in mouse mammary epithelial cells. Cancer Res 61: 7647-7653, 2001.
    • (2001) Cancer Res , vol.61 , pp. 7647-7653
    • Park, B.K.1    Zeng, X.2    Glazer, R.I.3
  • 31
    • 0029133520 scopus 로고
    • Phosphorylation and activation of the DNA binding activity of purified Stat1 by the Janus protein-tyrosine kinases and the epidermal growth factor receptor
    • Quelle FW, Thierfelder W, Witthuhn BA, Tang B, Cohen S, and Ihle JN. Phosphorylation and activation of the DNA binding activity of purified Stat1 by the Janus protein-tyrosine kinases and the epidermal growth factor receptor. J Biol Chem 270: 20775-20780, 1995.
    • (1995) J Biol Chem , vol.270 , pp. 20775-20780
    • Quelle, F.W.1    Thierfelder, W.2    Witthuhn, B.A.3    Tang, B.4    Cohen, S.5    Ihle, J.N.6
  • 32
    • 0034635513 scopus 로고    scopus 로고
    • Polarization of chemoattractant receptor signaling during neutrophil chemotaxis
    • Servant G, Weiner OD, Herzmark P, Balla T, Sedat JW, and Bourne HR. Polarization of chemoattractant receptor signaling during neutrophil chemotaxis. Science 287: 1037-1040, 2000.
    • (2000) Science , vol.287 , pp. 1037-1040
    • Servant, G.1    Weiner, O.D.2    Herzmark, P.3    Balla, T.4    Sedat, J.W.5    Bourne, H.R.6
  • 33
    • 0035966321 scopus 로고    scopus 로고
    • Paracrine signaling through the JAK/STAT pathway activates invasive behavior of ovarian epithelial cells in Drosophila
    • Silver DL and Montell DJ. Paracrine signaling through the JAK/STAT pathway activates invasive behavior of ovarian epithelial cells in Drosophila. Cell 107: 831-841, 2001.
    • (2001) Cell , vol.107 , pp. 831-841
    • Silver, D.L.1    Montell, D.J.2
  • 35
    • 0033597213 scopus 로고    scopus 로고
    • p53 Down-regulates human matrix metalloproteinase-1 (collagenase-1) gene expression
    • Sun Y, Sun Y, Wenger L, Rutter JL, Brinckerhoff CE, and Cheung HS. p53 Down-regulates human matrix metalloproteinase-1 (collagenase-1) gene expression. J Biol Chem 274: 11535-11540, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 11535-11540
    • Sun, Y.1    Sun, Y.2    Wenger, L.3    Rutter, J.L.4    Brinckerhoff, C.E.5    Cheung, H.S.6
  • 36
    • 0031965888 scopus 로고    scopus 로고
    • v-src Activation of the collagenase-1 (matrix metalloproteinase-1) promoter through PEA3 and STAT: Requirement of extracellular signal-regulated kinases and inhibition by retinoic acid receptors
    • Vincenti MP, Schroen DJ, Coon CI, and Brinckerhoff CE. v-src Activation of the collagenase-1 (matrix metalloproteinase-1) promoter through PEA3 and STAT: requirement of extracellular signal-regulated kinases and inhibition by retinoic acid receptors. Mol Carcinog 21: 194-204, 1998.
    • (1998) Mol Carcinog , vol.21 , pp. 194-204
    • Vincenti, M.P.1    Schroen, D.J.2    Coon, C.I.3    Brinckerhoff, C.E.4
  • 37
    • 0036532115 scopus 로고    scopus 로고
    • Regulation of cell polarity during eukaryotic chemotaxis: The chemotactic compass
    • Weiner OD. Regulation of cell polarity during eukaryotic chemotaxis: the chemotactic compass. Curr Opin Cell Biol 14: 196-202, 2002.
    • (2002) Curr Opin Cell Biol , vol.14 , pp. 196-202
    • Weiner, O.D.1
  • 38
    • 0042421854 scopus 로고    scopus 로고
    • Platelet-derived growth factor (PDGF) stimulates glucose transport in 3T3-L1 adipocytes overexpressing PDGF receptor by a pathway independent of insulin receptor substrates
    • Whiteman EL, Chen JJ, and Birnbaum MJ. Platelet-derived growth factor (PDGF) stimulates glucose transport in 3T3-L1 adipocytes overexpressing PDGF receptor by a pathway independent of insulin receptor substrates. Endocrinology 144: 3811-3820, 2003.
    • (2003) Endocrinology , vol.144 , pp. 3811-3820
    • Whiteman, E.L.1    Chen, J.J.2    Birnbaum, M.J.3
  • 39
    • 0037163125 scopus 로고    scopus 로고
    • Identification of both positive and negative domains within the epidermal growth factor receptor COOH-terminal region for signal transducer and activator of transcription (STAT) activation
    • Xia L, Wang L, Chung AS, Ivanov SS, Ling MY, Dragoi AM, Platt A, Gilmer TM, Fu XY, and Chin YE. Identification of both positive and negative domains within the epidermal growth factor receptor COOH-terminal region for signal transducer and activator of transcription (STAT) activation. J Biol Chem 277: 30716-30723, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 30716-30723
    • Xia, L.1    Wang, L.2    Chung, A.S.3    Ivanov, S.S.4    Ling, M.Y.5    Dragoi, A.M.6    Platt, A.7    Gilmer, T.M.8    Fu, X.Y.9    Chin, Y.E.10
  • 40
    • 0035378669 scopus 로고    scopus 로고
    • Focal adhesion kinase activates Stat1 in integrin-mediated cell migration and adhesion
    • Xie B, Zhao J, Kitagawa M, Durbin J, Madri JA, Guan JL, and Fu XY. Focal adhesion kinase activates Stat1 in integrin-mediated cell migration and adhesion. J Biol Chem 276: 19512-19523, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 19512-19523
    • Xie, B.1    Zhao, J.2    Kitagawa, M.3    Durbin, J.4    Madri, J.A.5    Guan, J.L.6    Fu, X.Y.7
  • 41
    • 0141960055 scopus 로고    scopus 로고
    • Nuclear translocation of phosphorylated STAT3 is essential for VEGF-induced human dermal microvascular endothelial cell migration and tube formation
    • Yahata Y, Shirakata Y, Tokumaru S, Yamasaki K, Sayama K, Hanakawa Y, Detmar M, and Hashimoto K. Nuclear translocation of phosphorylated STAT3 is essential for VEGF-induced human dermal microvascular endothelial cell migration and tube formation. J Biol Chem 278: 40026-40031, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 40026-40031
    • Yahata, Y.1    Shirakata, Y.2    Tokumaru, S.3    Yamasaki, K.4    Sayama, K.5    Hanakawa, Y.6    Detmar, M.7    Hashimoto, K.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.