The glucagon-producing alpha cell: An electrophysiologically exceptional cell

Diabetologia

Volumn 53, Issue 9, 2010, Pages 1827-1830

  Braun, M ^a   Rorsman, P ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Alpha cells; Glucagon; Ion channels; Pancreatic islets; Voltage dependent inactivation

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM); GLUCAGON; POTASSIUM CHANNEL; VOLTAGE GATED CALCIUM CHANNEL; VOLTAGE GATED POTASSIUM CHANNEL;

CALCIUM TRANSPORT; CELL MEMBRANE DEPOLARIZATION; CELL MEMBRANE POTENTIAL; ELECTRIC ACTIVITY; ELECTROPHYSIOLOGY; GLUCAGON RELEASE; HORMONAL REGULATION; HORMONE SYNTHESIS; HUMAN; NERVE ENDING; NONHUMAN; NOTE; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PANCREAS ISLET DELTA CELL; PRIORITY JOURNAL; REGULATORY MECHANISM; ANIMAL; BIOLOGICAL MODEL; METABOLISM; PANCREAS ISLET;

ANIMALS; ELECTROPHYSIOLOGY; GLUCAGON; GLUCAGON-SECRETING CELLS; HUMANS; ISLETS OF LANGERHANS; MODELS, BIOLOGICAL; POTASSIUM CHANNELS, VOLTAGE-GATED;

EID: 77955551360     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-010-1823-8     Document Type: Note

References (20)

1. J Gromada I Franklin CB Wollheim 2007 Alpha-cells of the endocrine pancreas: 35 years of research but the enigma remains Endocr Rev 28 84 116 10.1210/er.2006-0007 1:CAS:528:DC%2BD2sXjtFCgsrY%3D 17261637 (Pubitemid 46220851)
2. P Rorsman SA Salehi F Abdulkader M Braun PE Macdonald 2008 K(ATP)-channels and glucose-regulated glucagon secretion Trends Endocrinol Metab 19 277 284 10.1016/j.tem.2008.07.003 1:CAS:528:DC%2BD1cXhtFCgurbP 18771934
3. + channels in the hypothalamus are essential for the maintenance of glucose homeostasis Nat Neurosci 4 507 512 1:CAS:528:DC%2BD3MXjt1ersbc%3D 11319559
4. 2+ channels J Gen Physiol 110 217 228 10.1085/jgp.110.3.217 1:CAS:528:DyaK2sXmt1Wlurs%3D 9276750 (Pubitemid 27388115)
5. S Barg J Galvanovskis SO Gopel P Rorsman L Eliasson 2000 Tight coupling between electrical activity and exocytosis in mouse glucagon-secreting alpha-cells Diabetes 49 1500 1510 10.2337/diabetes.49.9.1500 1:CAS:528:DC%2BD3cXmsVOrsb8%3D 10969834
6. 2+ channel properties Biochem Biophys Res Commun 345 340 344 10.1016/j.bbrc.2006. 04.066 1:CAS:528:DC%2BD28XkslSms74%3D 16678791
7. P Rorsman E Renstrom 2003 Insulin granule dynamics in pancreatic beta cells Diabetologia 46 1029 1045 10.1007/s00125-003-1153-1 1:CAS:528: DC%2BD3sXmtFCqtbg%3D 12879249 (Pubitemid 37041234)
8. + channels in rat pancreatic A-cells Pflugers Arch 438 428 436 10.1007/s004240051058 1:CAS:528:DyaK1MXms1ansLo%3D 10519134 (Pubitemid 29419895)
9. PE Macdonald YZ Marinis R Ramracheya, et al. 2007 A KATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans PLoS Biol 5 e143 10.1371/journal. pbio.0050143 17503968 (Pubitemid 46919946)
10. H Heimberg A De Vos K Moens, et al. 1996 The glucose sensor protein glucokinase is expressed in glucagon-producing alpha-cells Proc Natl Acad Sci USA 93 7036 7041 10.1073/pnas.93.14.7036 1:CAS:528:DyaK28Xkt1Whtr4%3D 8692940 (Pubitemid 26243497)
11. MA Ravier GA Rutter 2005 Glucose or insulin, but not zinc ions, inhibit glucagon secretion from mouse pancreatic alpha-cells Diabetes 54 1789 1797 10.2337/diabetes.54.6.1789 1:CAS:528:DC%2BD2MXltVait7k%3D 15919801 (Pubitemid 40770769)
12. I Atwater B Ribalet E Rojas 1979 Mouse pancreatic beta-cells: tetraethylammonium blockage of the potassium permeability increase induced by depolarization J Physiol 288 561 574 1:CAS:528:DyaE1MXktFOms7g%3D 381635
13. 2+ channels from secretory granules Cell Metab 10 455 465 10.1016/j.cmet.2009.09.011 1:CAS:528:DC%2BC3cXks1Clsr8%3D 19945403
14. M Willenborg H Ghaly K Hatlapatka K Urban U Panten I Rustenbeck 2010 The signalling role of action potential depolarization in insulin secretion: metabolism-dependent dissociation between action potential increase and secretion increase by TEA Biochem Pharmacol 80 104 112 10.1016/j.bcp.2010.03.014 1:CAS:528:DC%2BC3cXlt1Cgtbw%3D 20303336
15. + channels are positive regulators of alpha cell action potential generation and glucagon secretion Diabetologia. doi: 10.1007/s00125-010-1759-z
16. + channels J Physiol 528 509 520 10.1111/j.1469-7793. 2000.00509.x 1:CAS:528:DC%2BD3cXot1Ghs70%3D 11060128
17. Hille B (2001) Ion channels of excitable membranes. Sinauer, Sunderland
18. R Bardoni O Belluzzi 1994 Modifications of A-current kinetics in mammalian central neurones induced by extracellular zinc J Physiol 479 389 400 1:CAS:528:DyaK2MXhtFWku7c%3D 7530771
19. H Ishihara P Maechler A Gjinovci PL Herrera CB Wollheim 2003 Islet beta-cell secretion determines glucagon release from neighbouring alpha-cells Nat Cell Biol 5 330 335 10.1038/ncb951 1:CAS:528:DC%2BD3sXisFWrt7c%3D 12640462 (Pubitemid 36432297)
20. SJ Le Marchand DW Piston 2010 Glucose suppression of glucagon secretion: metabolic and calcium responses from alpha-cells in intact mouse pancreatic islets J Biol Chem 285 14389 14398 10.1074/jbc.M109.069195 20231269