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Volumn 13, Issue SUPPL. 1, 2011, Pages 95-105

Regulation of glucagon secretion by glucose: Paracrine, intrinsic or both?

Author keywords

Glucagon; Insulin; Paracrine; Type 2 diabetes; cell; cell

Indexed keywords

ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; ADRENALIN; DIAZOXIDE; GLUCAGON; GLUCOSE; INSULIN; SOMATOSTATIN; SULFONYLUREA; TOLBUTAMIDE; VOLTAGE DEPENDENT ANION CHANNEL;

EID: 79961189391     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/j.1463-1326.2011.01450.x     Document Type: Review
Times cited : (145)

References (64)
  • 2
    • 67349228410 scopus 로고    scopus 로고
    • The beta cell lesion in type 2 diabetes: there has to be a primary functional abnormality.
    • Kahn SE, Zraika S, Utzschneider KM, Hull RL. The beta cell lesion in type 2 diabetes: there has to be a primary functional abnormality. Diabetologia 2009; 52: 1003-1012.
    • (2009) Diabetologia , vol.52 , pp. 1003-1012
    • Kahn, S.E.1    Zraika, S.2    Utzschneider, K.M.3    Hull, R.L.4
  • 3
    • 24944577486 scopus 로고    scopus 로고
    • Alpha cell function in health and disease: influence of glucagon-like peptide-1.
    • Dunning BE, Foley JE, Ahren B. Alpha cell function in health and disease: influence of glucagon-like peptide-1. Diabetologia 2005; 48: 1700-1713.
    • (2005) Diabetologia , vol.48 , pp. 1700-1713
    • Dunning, B.E.1    Foley, J.E.2    Ahren, B.3
  • 4
    • 42549166531 scopus 로고    scopus 로고
    • Glucagon and hyperglycaemia in diabetes.
    • Cryer PE. Glucagon and hyperglycaemia in diabetes. Clin Sci (Lond) 2008; 114: 589-590.
    • (2008) Clin Sci (Lond) , vol.114 , pp. 589-590
    • Cryer, P.E.1
  • 5
    • 79551600048 scopus 로고    scopus 로고
    • Glucagon receptor knockout prevents insulin-deficient type 1 diabetes in mice.
    • Lee Y, Wang MY, Du XQ, Charron MJ, Unger RH. Glucagon receptor knockout prevents insulin-deficient type 1 diabetes in mice. Diabetes 2011; 60: 391-397.
    • (2011) Diabetes , vol.60 , pp. 391-397
    • Lee, Y.1    Wang, M.Y.2    Du, X.Q.3    Charron, M.J.4    Unger, R.H.5
  • 6
    • 35748957503 scopus 로고    scopus 로고
    • The physiology of glucagon-like peptide 1.
    • Holst JJ. The physiology of glucagon-like peptide 1. Physiol Rev 2007; 87: 1409-1439.
    • (2007) Physiol Rev , vol.87 , pp. 1409-1439
    • Holst, J.J.1
  • 7
    • 0042879951 scopus 로고    scopus 로고
    • Insulin granule dynamics in pancreatic beta cells.
    • Rorsman P, Renstrom E. Insulin granule dynamics in pancreatic beta cells. Diabetologia 2003; 46: 1029-1045.
    • (2003) Diabetologia , vol.46 , pp. 1029-1045
    • Rorsman, P.1    Renstrom, E.2
  • 9
    • 0142093526 scopus 로고    scopus 로고
    • Fatty acid metabolism and insulin secretion in pancreatic beta cells.
    • Yaney GC, Corkey BE. Fatty acid metabolism and insulin secretion in pancreatic beta cells. Diabetologia 2003; 46: 1297-1312.
    • (2003) Diabetologia , vol.46 , pp. 1297-1312
    • Yaney, G.C.1    Corkey, B.E.2
  • 10
    • 33846856711 scopus 로고    scopus 로고
    • Alpha-cells of the endocrine pancreas: 35 years of research but the enigma remains.
    • Gromada J, Franklin I, Wollheim CB. Alpha-cells of the endocrine pancreas: 35 years of research but the enigma remains. Endocr Rev 2007; 28: 84-116.
    • (2007) Endocr Rev , vol.28 , pp. 84-116
    • Gromada, J.1    Franklin, I.2    Wollheim, C.B.3
  • 11
    • 77958014883 scopus 로고    scopus 로고
    • Paracrinology of islets and the paracrinopathy of diabetes.
    • Unger RH, Orci L. Paracrinology of islets and the paracrinopathy of diabetes. Proc Natl Acad Sci USA 2010; 107: 16009-16012.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 16009-16012
    • Unger, R.H.1    Orci, L.2
  • 13
    • 0037385959 scopus 로고    scopus 로고
    • Islet beta-cell secretion determines glucagon release from neighbouring alpha-cells.
    • Ishihara H, Maechler P, Gjinovci A, Herrera PL, Wollheim CB. Islet beta-cell secretion determines glucagon release from neighbouring alpha-cells. Nat Cell Biol 2003; 5: 330-335.
    • (2003) Nat Cell Biol , vol.5 , pp. 330-335
    • Ishihara, H.1    Maechler, P.2    Gjinovci, A.3    Herrera, P.L.4    Wollheim, C.B.5
  • 14
    • 63249127193 scopus 로고    scopus 로고
    • Somatostatin secreted by islet delta-cells fulfills multiple roles as a paracrine regulator of islet function.
    • Hauge-Evans AC, King AJ, Carmignac D et al. Somatostatin secreted by islet delta-cells fulfills multiple roles as a paracrine regulator of islet function. Diabetes 2009; 58: 403-411.
    • (2009) Diabetes , vol.58 , pp. 403-411
    • Hauge-Evans, A.C.1    King, A.J.2    Carmignac, D.3
  • 16
    • 26844556580 scopus 로고    scopus 로고
    • Glucose stimulates glucagon release in single rat alpha-cells by mechanisms that mirror the stimulus-secretion coupling in beta-cells.
    • Olsen HL, Theander S, Bokvist K et al. Glucose stimulates glucagon release in single rat alpha-cells by mechanisms that mirror the stimulus-secretion coupling in beta-cells. Endocrinology 2005; 146: 4861-4870.
    • (2005) Endocrinology , vol.146 , pp. 4861-4870
    • Olsen, H.L.1    Theander, S.2    Bokvist, K.3
  • 17
    • 20044374696 scopus 로고    scopus 로고
    • Beta-cell secretory products activate alpha-cell ATP-dependent potassium channels to inhibit glucagon release.
    • Franklin I, Gromada J, Gjinovci A, Theander S, Wollheim CB. Beta-cell secretory products activate alpha-cell ATP-dependent potassium channels to inhibit glucagon release. Diabetes 2005; 54: 1808-1815.
    • (2005) Diabetes , vol.54 , pp. 1808-1815
    • Franklin, I.1    Gromada, J.2    Gjinovci, A.3    Theander, S.4    Wollheim, C.B.5
  • 18
    • 0024337849 scopus 로고
    • Cyclic AMP raises cytoplasmic calcium in pancreatic alpha 2-cells by mobilizing calcium incorporated in response to glucose.
    • Johansson H, Gylfe E, Hellman B. Cyclic AMP raises cytoplasmic calcium in pancreatic alpha 2-cells by mobilizing calcium incorporated in response to glucose. Cell Calcium 1989; 10: 205-211.
    • (1989) Cell Calcium , vol.10 , pp. 205-211
    • Johansson, H.1    Gylfe, E.2    Hellman, B.3
  • 20
    • 27844448098 scopus 로고    scopus 로고
    • Regulation of glucagon secretion at low glucose concentrations: evidence for adenosine triphosphate-sensitive potassium channel involvement.
    • Munoz A, Hu M, Hussain K et al. Regulation of glucagon secretion at low glucose concentrations: evidence for adenosine triphosphate-sensitive potassium channel involvement. Endocrinology 2005; 146: 5514-5521.
    • (2005) Endocrinology , vol.146 , pp. 5514-5521
    • Munoz, A.1    Hu, M.2    Hussain, K.3
  • 22
    • 0033850226 scopus 로고    scopus 로고
    • Tight coupling between electrical activity and exocytosis in mouse glucagon-secreting alpha-cells.
    • Barg S, Galvanovskis J, Gopel SO, Rorsman P, Eliasson L. Tight coupling between electrical activity and exocytosis in mouse glucagon-secreting alpha-cells. Diabetes 2000; 49: 1500-1510.
    • (2000) Diabetes , vol.49 , pp. 1500-1510
    • Barg, S.1    Galvanovskis, J.2    Gopel, S.O.3    Rorsman, P.4    Eliasson, L.5
  • 23
    • 77956364291 scopus 로고    scopus 로고
    • Membrane potential-dependent inactivation of voltage-gated ion channels in alpha-cells inhibits glucagon secretion from human islets.
    • Ramracheya R, Ward C, Shigeto M et al. Membrane potential-dependent inactivation of voltage-gated ion channels in alpha-cells inhibits glucagon secretion from human islets. Diabetes 2010; 59: 2198-2208.
    • (2010) Diabetes , vol.59 , pp. 2198-2208
    • Ramracheya, R.1    Ward, C.2    Shigeto, M.3
  • 24
    • 1842422955 scopus 로고    scopus 로고
    • Glucose inhibition of glucagon secretion from rat alpha-cells is mediated by GABA released from neighboring beta-cells.
    • Wendt A, Birnir B, Buschard K et al. Glucose inhibition of glucagon secretion from rat alpha-cells is mediated by GABA released from neighboring beta-cells. Diabetes 2004; 53: 1038-1045.
    • (2004) Diabetes , vol.53 , pp. 1038-1045
    • Wendt, A.1    Birnir, B.2    Buschard, K.3
  • 25
    • 33847012550 scopus 로고    scopus 로고
    • Glucose-dependent regulation of gamma-aminobutyric acid (GABA A) receptor expression in mouse pancreatic islha-cells.
    • Bailey SJ, Ravier MA, Rutter GA. Glucose-dependent regulation of gamma-aminobutyric acid (GABA A) receptor expression in mouse pancreatic islet alpha-cells. Diabetes 2007; 56: 320-327.
    • (2007) Diabetes , vol.56 , pp. 320-327
    • Bailey, S.J.1    Ravier, M.A.2    Rutter, G.A.3
  • 26
    • 77954252193 scopus 로고    scopus 로고
    • Gamma-aminobutyric acid (GABA) is an autocrine excitatory transmitter in human pancreatic beta-cells.
    • Braun M, Ramracheya R, Bengtsson M et al. Gamma-aminobutyric acid (GABA) is an autocrine excitatory transmitter in human pancreatic beta-cells. Diabetes 2010; 59: 1694-1701.
    • (2010) Diabetes , vol.59 , pp. 1694-1701
    • Braun, M.1    Ramracheya, R.2    Bengtsson, M.3
  • 27
    • 0017225581 scopus 로고
    • The Banting Memorial Lecture 1975. Diabetes and the alpha cell.
    • Unger RH. The Banting Memorial Lecture 1975. Diabetes and the alpha cell. Diabetes 1976; 25: 136-151.
    • (1976) Diabetes , vol.25 , pp. 136-151
    • Unger, R.H.1
  • 28
    • 33144467088 scopus 로고    scopus 로고
    • The unique cytoarchitecture of human pancreatic islets has implications for islet cell function.
    • Cabrera O, Berman DM, Kenyon NS et al. The unique cytoarchitecture of human pancreatic islets has implications for islet cell function. Proc Natl Acad Sci USA 2006; 103: 2334-2339.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 2334-2339
    • Cabrera, O.1    Berman, D.M.2    Kenyon, N.S.3
  • 29
    • 67650686039 scopus 로고    scopus 로고
    • Somatostatin release, electrical activity, membrane currents and exocytosis in human pancreatic delta cells.
    • Braun M, Ramracheya R, Amisten S et al. Somatostatin release, electrical activity, membrane currents and exocytosis in human pancreatic delta cells. Diabetologia 2009; 52: 1566-1578.
    • (2009) Diabetologia , vol.52 , pp. 1566-1578
    • Braun, M.1    Ramracheya, R.2    Amisten, S.3
  • 30
    • 33749347851 scopus 로고    scopus 로고
    • Paradoxical stimulation of glucagon secretion by high glucose concentrations.
    • Salehi A, Vieira E, Gylfe E. Paradoxical stimulation of glucagon secretion by high glucose concentrations. Diabetes 2006; 55: 2318-2323.
    • (2006) Diabetes , vol.55 , pp. 2318-2323
    • Salehi, A.1    Vieira, E.2    Gylfe, E.3
  • 31
    • 72249093748 scopus 로고    scopus 로고
    • Beta-cell-mediated signaling predominates over direct alpha-cell signaling in the regulation of glucagon secretion in humans.
    • Cooperberg BA, Cryer PE. Beta-cell-mediated signaling predominates over direct alpha-cell signaling in the regulation of glucagon secretion in humans. Diabetes Care 2009; 32: 2275-2280.
    • (2009) Diabetes Care , vol.32 , pp. 2275-2280
    • Cooperberg, B.A.1    Cryer, P.E.2
  • 32
    • 33644748390 scopus 로고    scopus 로고
    • Pancreatic beta-cells secrete insulin in fast- and slow-release forms.
    • Michael DJ, Ritzel RA, Haataja L, Chow RH. Pancreatic beta-cells secrete insulin in fast- and slow-release forms. Diabetes 2006; 55: 600-607.
    • (2006) Diabetes , vol.55 , pp. 600-607
    • Michael, D.J.1    Ritzel, R.A.2    Haataja, L.3    Chow, R.H.4
  • 34
    • 0030245732 scopus 로고    scopus 로고
    • Neurotransmitter-induced inhibition of exocytosis in insulin-secreting beta cells by activation of calcineurin.
    • Renstrom E, Ding WG, Bokvist K, Rorsman P. Neurotransmitter-induced inhibition of exocytosis in insulin-secreting beta cells by activation of calcineurin. Neuron 1996; 17: 513-522.
    • (1996) Neuron , vol.17 , pp. 513-522
    • Renstrom, E.1    Ding, W.G.2    Bokvist, K.3    Rorsman, P.4
  • 35
    • 0035449109 scopus 로고    scopus 로고
    • Somatostatin inhibits exocytosis in rat pancreatic alpha-cells by G(i2)-dependent activation of calcineurin and depriming of secretory granules.
    • Gromada J, Hoy M, Buschard K, Salehi A, Rorsman P. Somatostatin inhibits exocytosis in rat pancreatic alpha-cells by G(i2)-dependent activation of calcineurin and depriming of secretory granules. J Physiol 2001; 535: 519-532.
    • (2001) J Physiol , vol.535 , pp. 519-532
    • Gromada, J.1    Hoy, M.2    Buschard, K.3    Salehi, A.4    Rorsman, P.5
  • 36
    • 84880505498 scopus 로고
    • Islet activating protein (IAP) derived from the culture supernatant fluid of Bordetella pertussis: effect on spontaneous diabetic rats.
    • Toyota T, Kakizaki M, Kimura K et al. Islet activating protein (IAP) derived from the culture supernatant fluid of Bordetella pertussis: effect on spontaneous diabetic rats. Diabetologia 1978; 14: 319-323.
    • (1978) Diabetologia , vol.14 , pp. 319-323
    • Toyota, T.1    Kakizaki, M.2    Kimura, K.3
  • 38
    • 0037020148 scopus 로고    scopus 로고
    • Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose.
    • Shiota C, Larsson O, Shelton KD et al. Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose. J Biol Chem 2002; 277: 37176-37183.
    • (2002) J Biol Chem , vol.277 , pp. 37176-37183
    • Shiota, C.1    Larsson, O.2    Shelton, K.D.3
  • 40
    • 33645966526 scopus 로고    scopus 로고
    • K(ATP) channels and insulin secretion: a key role in health and disease.
    • Ashcroft FM. K(ATP) channels and insulin secretion: a key role in health and disease. Biochem Soc Trans 2006; 34: 243-246.
    • (2006) Biochem Soc Trans , vol.34 , pp. 243-246
    • Ashcroft, F.M.1
  • 43
    • 0033064018 scopus 로고    scopus 로고
    • Somatostatin induces hyperpolarization in pancreatic islha cells by activating a G protein-gated K+ channel.
    • Yoshimoto Y, Fukuyama Y, Horio Y et al. Somatostatin induces hyperpolarization in pancreatic islet alpha cells by activating a G protein-gated K+ channel. FEBS Lett 1999; 444: 265-269.
    • (1999) FEBS Lett , vol.444 , pp. 265-269
    • Yoshimoto, Y.1    Fukuyama, Y.2    Horio, Y.3
  • 45
    • 77952003470 scopus 로고    scopus 로고
    • Glucose suppression of glucagon secretion: metabolic and calcium responses from alpha-cells in intact mouse pancreatic islets.
    • Le Marchand SJ, Piston DW. Glucose suppression of glucagon secretion: metabolic and calcium responses from alpha-cells in intact mouse pancreatic islets. J Biol Chem 2010; 285: 14389-14398.
    • (2010) J Biol Chem , vol.285 , pp. 14389-14398
    • Le Marchand, S.J.1    Piston, D.W.2
  • 48
    • 34250307235 scopus 로고    scopus 로고
    • A KATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans.
    • MacDonald PE, De Marinis YZ, Ramracheya R et al. A KATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans. PLoS Biol 2007; 5: e143.
    • (2007) PLoS Biol , vol.5
    • MacDonald, P.E.1    De Marinis, Y.Z.2    Ramracheya, R.3
  • 49
    • 20044394745 scopus 로고    scopus 로고
    • Glucose or insulin, but not zinc ions, inhibit glucagon secretion from mouse pancreatic alpha-cells.
    • Ravier MA, Rutter GA. Glucose or insulin, but not zinc ions, inhibit glucagon secretion from mouse pancreatic alpha-cells. Diabetes 2005; 54: 1789-1797.
    • (2005) Diabetes , vol.54 , pp. 1789-1797
    • Ravier, M.A.1    Rutter, G.A.2
  • 50
    • 61749086774 scopus 로고    scopus 로고
    • Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes.
    • Girard CA, Wunderlich FT, Shimomura K et al. Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes. J Clin Invest 2009; 119: 80-90.
    • (2009) J Clin Invest , vol.119 , pp. 80-90
    • Girard, C.A.1    Wunderlich, F.T.2    Shimomura, K.3
  • 51
    • 0034677634 scopus 로고    scopus 로고
    • Targeted overactivity of beta cell K(ATP) channels induces profound neonatal diabetes.
    • Koster JC, Marshall BA, Ensor N, Corbett JA, Nichols CG. Targeted overactivity of beta cell K(ATP) channels induces profound neonatal diabetes. Cell 2000; 100: 645-654.
    • (2000) Cell , vol.100 , pp. 645-654
    • Koster, J.C.1    Marshall, B.A.2    Ensor, N.3    Corbett, J.A.4    Nichols, C.G.5
  • 53
    • 20244376316 scopus 로고    scopus 로고
    • Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients.
    • Anello M, Lupi R, Spampinato D et al. Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients. Diabetologia 2005; 48: 282-289.
    • (2005) Diabetologia , vol.48 , pp. 282-289
    • Anello, M.1    Lupi, R.2    Spampinato, D.3
  • 55
    • 0033944152 scopus 로고    scopus 로고
    • Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats.
    • Spanswick D, Smith MA, Mirshamsi S, Routh VH, Ashford ML. Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats. Nat Neurosci 2000; 3: 757-758.
    • (2000) Nat Neurosci , vol.3 , pp. 757-758
    • Spanswick, D.1    Smith, M.A.2    Mirshamsi, S.3    Routh, V.H.4    Ashford, M.L.5
  • 56
    • 3042737834 scopus 로고    scopus 로고
    • + channel-dependent pathway in mouse islets and beta-cells.
    • + channel-dependent pathway in mouse islets and beta-cells. Diabetes 2004; 53: 1765-1772.
    • (2004) Diabetes , vol.53 , pp. 1765-1772
    • Nunemaker, C.S.1    Zhang, M.2    Satin, L.S.3
  • 57
    • 0019946118 scopus 로고
    • Stimulatory effects of tolbutamide infusion on plasma glucagon in insulin-dependent diabetic subjects.
    • Bohannon NV, Lorenzi M, Grodsky GM, Karam JH. Stimulatory effects of tolbutamide infusion on plasma glucagon in insulin-dependent diabetic subjects. J Clin Endocrinol Metab 1982; 54: 459-462.
    • (1982) J Clin Endocrinol Metab , vol.54 , pp. 459-462
    • Bohannon, N.V.1    Lorenzi, M.2    Grodsky, G.M.3    Karam, J.H.4
  • 58
    • 0842334505 scopus 로고    scopus 로고
    • The insulin secretagogues glibenclamide and repaglinide do not influence growth hormone secretion in humans but stimulate glucagon secretion during profound insulin deficiency.
    • Ostergard T, Degn KB, Gall MA et al. The insulin secretagogues glibenclamide and repaglinide do not influence growth hormone secretion in humans but stimulate glucagon secretion during profound insulin deficiency. J Clin Endocrinol Metab 2004; 89: 297-302.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 297-302
    • Ostergard, T.1    Degn, K.B.2    Gall, M.A.3
  • 59
    • 0036227054 scopus 로고    scopus 로고
    • Intraislet hyperinsulinemia prevents the glucagon response to hypoglycemia despite an intact autonomic response.
    • Banarer S, McGregor VP, Cryer PE. Intraislet hyperinsulinemia prevents the glucagon response to hypoglycemia despite an intact autonomic response. Diabetes 2002; 51: 958-965.
    • (2002) Diabetes , vol.51 , pp. 958-965
    • Banarer, S.1    McGregor, V.P.2    Cryer, P.E.3
  • 60
    • 0033304547 scopus 로고    scopus 로고
    • Oral glibenclamide suppresses glucagon secretion during insulin-induced hypoglycemia in patients with type 2 diabetes.
    • Landstedt-Hallin L, Adamson U, Lins PE. Oral glibenclamide suppresses glucagon secretion during insulin-induced hypoglycemia in patients with type 2 diabetes. J Clin Endocrinol Metab 1999; 84: 3140-3145.
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 3140-3145
    • Landstedt-Hallin, L.1    Adamson, U.2    Lins, P.E.3
  • 61
    • 63449087896 scopus 로고    scopus 로고
    • Insulin signaling in alpha cells modulates glucagon secretion in vivo.
    • Kawamori D, Kurpad AJ, Hu J et al. Insulin signaling in alpha cells modulates glucagon secretion in vivo. Cell Metab 2009; 9: 350-361.
    • (2009) Cell Metab , vol.9 , pp. 350-361
    • Kawamori, D.1    Kurpad, A.J.2    Hu, J.3
  • 62
    • 7044249536 scopus 로고    scopus 로고
    • Palmitate stimulation of glucagon secretion in mouse pancreatic alpha-cells results from activation of L-type calcium channels and elevation of cytoplasmic calcium.
    • Olofsson CS, Salehi A, Gopel SO, Holm C, Rorsman P. Palmitate stimulation of glucagon secretion in mouse pancreatic alpha-cells results from activation of L-type calcium channels and elevation of cytoplasmic calcium. Diabetes 2004; 53: 2836-2843.
    • (2004) Diabetes , vol.53 , pp. 2836-2843
    • Olofsson, C.S.1    Salehi, A.2    Gopel, S.O.3    Holm, C.4    Rorsman, P.5
  • 63
    • 0017625206 scopus 로고
    • Hormonal regulation during prolonged exercise.
    • Galbo H, Richter EA, Hilsted J et al. Hormonal regulation during prolonged exercise. Ann NY Acad Sci 1977; 301: 72-80.
    • (1977) Ann NY Acad Sci , vol.301 , pp. 72-80
    • Galbo, H.1    Richter, E.A.2    Hilsted, J.3
  • 64
    • 79961183439 scopus 로고    scopus 로고
    • GLP-1 inhibits glucagon secretion from human alpha cells by a direct effect.
    • Ramracheya RD, Ward C, Abdulkader F et al. GLP-1 inhibits glucagon secretion from human alpha cells by a direct effect. Diabetologia 2010; 53(Suppl 1): A642.
    • (2010) Diabetologia , vol.53 , Issue.SUPPL. 1
    • Ramracheya, R.D.1    Ward, C.2    Abdulkader, F.3


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