Insulin control of glycogen metabolism in knockout mice lacking the muscle-specific protein phosphatase pp1g/rgl

Molecular and Cellular Biology

Volumn 21, Issue 8, 2001, Pages 2683-2694

  Suzuki, Y ^a   Lanner, C ^a   Kim, J H ^a   Giuseppe Vilardo, P ^a   Zhang, H ^a   Yang, J ^a   Cooper, L D ^a   Steele, M ^a   Kennedy, A ^a   Bock, C B ^a   Scrimgeour, A ^a   Lawrence J C , Jr ^a   Depaoli Roach, A A ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE PHOSPHATE; DNA; GLUCOSE 6 PHOSPHATE; GLYCOGEN; GLYCOGEN PHOSPHORYLASE; GLYCOGEN SYNTHASE; INSULIN; PHOSPHOPROTEIN PHOSPHATASE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FEMALE; GLUCOSE TOLERANCE; GLUCOSE TRANSPORT; GLYCOGEN METABOLISM; HEART MUSCLE; INSULIN RESPONSE; KNOCKOUT MOUSE; MOUSE; MUSCLE METABOLISM; NONHUMAN; PRIORITY JOURNAL; SKELETAL MUSCLE;

ANIMALS; BASE SEQUENCE; DNA PRIMERS; ENZYME ACTIVATION; FEMALE; GLUCOSE; GLYCOGEN; GLYCOGEN SYNTHASE; INSULIN; INSULIN RESISTANCE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUSCLE, SKELETAL; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN SUBUNITS;

ANIMALIA;

EID: 0035081285     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.8.2683-2694.2001     Document Type: Article

References (67)

1. Phosphorylase a is an allosteric inhibitor of the glycogen and microsomal forms of rat hepatic protein phosphatase-1
2. The control of protein phosphatase-1 by targetting subunits. The major myosin phosphatase in avian smooth muscle is a novel form of protein phosphatase-1
3. Inhibitor-2 functions like a chaperone to fold three expressed isoforms of mammalian protein phosphatase-1 into a conformation with the specificity and regulatory properties of the native enzyme
4. Isolation and characterization of PNUTS. A putative protein phosphatase 1 nuclear targeting subunit
5. Spinophilin, a novel protein phosphatase 1 binding protein localized to dendritic spines
6. PPPlR6, a novel member of the family of glycogen-targetting subunits of protein phosphatase 1
7. Site-directed point mutations in embryonic stem cells: A gene-targeting tag-and-exchange strategy
8. Control of glycogen synthesis is shared between glucose transport and glycogen synthase in skeletal muscle fibers
9. Regulation of both glycogen synthase and PHAS-I by insulin in rat skeletal muscle involves mitogen-activated protein kinase-independent and rapamycin-sensitive pathways
10. The structure and mechanism of protein phosphatases: Insights into catalysis and regulation
11. Determination with hexakinase and glucose-6-phosphate dehydrogenase
12. Overexpression of protein targeting to glycogen (PTG) in rat hepatocytes causes profound activation of glycogen synthesis independent of normal hormone- and substrate-mediated regulatory mechanisms
13. Inactivation of nuclear inhibitory polypeptides of proteinphosphatase-1 (NIPP-1) by protein kinase A
14. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
15. The activation of glycogen synthase by insulin switches from kinase inhibition to phosphatase activation during adipogenesis in 3T3-L1 cells
16. The regulation of glycogen synthase by protein phosphatase 1 in 3T3-L1 adipocytes. Evidence for a potential role for DARPP-32 in insulin action
17. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
18. Insulin activates protein kinase B, inhibits glycogen synthase kinase-3 and activates glycogen synthase by rapamycininsensitive pathways in skeletal muscle and adipose tissue
19. The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization
20. The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle
21. Serine/threonine protein phosphatases in the control of cell function
22. Glycogen metabolism in transgenic mice overexpressing or deficient in the glycogen/sarcoplasmic reticulum-associated phosphatase, PP1G
23. Loss of the hepatic glycogen-binding subunit (GL) of protein phosphatase 1 underlies deficient glycogen synthesis in insulin-dependent diabetic rats and in adrenalectomized starved rats
24. Amino acid sequence and expression of the hepatic glycogen-binding (GL)subunit of protein phosphatase-1
25. Amino acid sequence of a novel protein phosphatase 1 binding protein (R5) which is related to the liver- and muscle-specific glycogen binding subunits of protein phosphatase 1
26. Identification of binding sites on protein targeting to glycogen for enzymes of glycogen metabolism
27. Distinctive regulatory and metabolic properties of glycogen-targeting subunits of protein phosphatase-1 (PTG, GL, GM/RG1) expressed in hepatocytes
28. Radioactive method for the assay of glycogen phosphorylases
29. A widespread amino acid polymorphism at codon 905 of the glycogen-associated regulatory subunit of protein phosphatase-1 is associated with insulin resistance and hypersecretion of insulin
30. Overexpression of glutamine:fructose-6-phosphate amidotransferase in transgenic mice leads to insulin resistance
31. Interaction of the ribosomal protein, L5, with protein phosphatase type 1
32. On target with a new mechanism for the regulation of protein phosphorylation
33. Phospholamban: A protein coming of age
34. Insights into insulin resistance and type 2 diabetes from knockout mouse models
35. Obesity and insulin resistance
36. GL, of the glycogen-associated type 1 protein phosphatase, PP1G
37. Hormonal control of glycogen synthase in rat hemidiaphragms. Effects of insulin and epinephrine on the distribution of phosphate between two cyanogen bromide fragments
38. New insights into the role and mechanism of glycogen synthase activation by insulin
39. Mitogenactivated protein kinase kinase inhibition does not block the stimulation of glucose utilization by insulin
40. Phosphorylase phosphatase: New horizons for an old enzyme
41. Glycogen synthase association with the striated muscle glycogen-targeting subunit of protein phosphatase-1. Synthase activation involves scaffolding regulated by beta-adrenergic signaling
42. Insulin-stimulated phosphorylation of the protein phosphatase-1 striated muscle glycogen-targeting subunit and activation of glycogen synthase
43. Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of beta-agonist stimulation
44. Identification of the major protein phosphatases in mammalian cardiac muscle which dephosphorylate phospholamban
45. DARPP-32 and phosphatase inhibitor-1, two structurally related inhibitors of protein phosphatase-1, are both present in striatonigral neurons
46. The molecular mechanism by which adrenalin inhibits glycogen synthesis
47. Physiologic importance of protein phosphatase inhibitors
48. PTG, a protein phosphatase 1-binding protein with a role in glycogen metabolism
49. The effect of modulating the glycogenassociated regulatory subunit of protein phosphatase-1 on insulin action in rat skeletal muscle cells
50. Adenovirus-mediated expression of a naturally occurring Asp905Tyr variant of the glycogen-associated regulatory subunit of protein phosphatase-1 in L6 myotubes
51. Multisite and hierarchal protein phosphorylation
52. Inhibitor-1 is not required for the activation of glycogen synthase by insulin in skeletal muscle
53. Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes: Evidence for the involvement of phosphoinositide 3-kinase and p70 ribosomal protein-S6 kinase
54. Cellular mechanisms of insulin resistance
55. Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy
56. Insulin action in denervated rat hemidiaphragms. Decreased hormonal stimulation of glycogen synthesis involves both glycogen synthase and glucose transport
57. New insight into the regulation of liver glycogen metabolism by glucose
58. The protein phosphatases involved in cellular regulation. Purification and characterisation of the glycogen-bound form of protein phosphatase-1 from rabbit skeletal muscle
59. Molecular cloning and expression of the regulatory (RGL) subunit of the glycogen-associated protein phosphatase
60. A rapid filter paper assay for UDPglucose-glycogen glucosyltransferase, including an improved biosynthesis of UDP-14C-glucose
61. Effect of glucose phosphorylation on the activation by insulin of skeletal muscle glycogen synthase
62. Phosphorylation of the skeletal muscle glycogen-targetting subunit of protein phosphatase 1 in response to adrenaline in vivo
63. A conserved domain for glycogen binding in protein phosphatase-1 targeting subunits
64. A common variant in PPP1R3 associated with insulin resistance and type 2 diabetes
65. Overexpression of the glycogen targeting (G(M)) subunit of protein phosphatase-1
66. Interaction of inhibitor-2 with the catalytic subunit of type 1 protein phosphatase. Identification of a sequence analogous to the consensus type 1 protein phosphatase-binding motif