Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: Implications on anti-glucagon therapies for diabetes

BMC Genomics

Volumn 12, Issue , 2011, Pages

  Yang, Jianxin ^a   MacDougall, Margit L ^a   McDowell, Michael T ^a   Xi, Li ^a   Wei, Ru ^a   Zavadoski, William J ^a   Molloy, Mark P ^b   Baker, John D ^a,c   Kuhn, Max ^a   Cabrera, Over ^a   Treadway, Judith L ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^b MACQUARIE UNIVERSITY   (Australia)

^c JOHNSON AND JOHNSON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ALPHA ENOLASE; AMINO ACID; ARGININE; ASPARAGINE; ASPARTIC ACID; BILE ACID; CHOLESTEROL; CYSTEINE; FRUCTOSE BISPHOSPHATE ALDOLASE; FUMARATE HYDRATASE; GLUCAGON RECEPTOR; GLUCAGON RECEPTOR ANTAGONIST; GLUCOSE; GLUCOSE 6 PHOSPHATE ISOMERASE; GLUCOSIDASE; GLUTAMIC ACID; GLUTAMINE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GLYCINE; HISTIDINE; HORMONE RECEPTOR BLOCKING AGENT; LIPID; LYSINE; MESSENGER RNA; METHIONINE; PROLINE; PYRUVATE KINASE; UNCLASSIFIED DRUG; AMINO ACID DERIVATIVE; ANTIDIABETIC AGENT;

AMINO ACID METABOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBOHYDRATE METABOLISM; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; DIABETES MELLITUS; DOWN REGULATION; DRUG ACTIVITY; FATTY ACID OXIDATION; FATTY ACID SYNTHESIS; GENE EXPRESSION PROFILING; GENETIC TRANSCRIPTION; GENOMICS; GLUCOGENESIS; GLYCOLYSIS; LIPID METABOLISM; LIVER; MALE; MASS SPECTROMETRY; METABOLOMICS; MOUSE; NONHUMAN; POLYOMIC; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEOMICS; TRANSCRIPTOMICS; UPREGULATION; BIOSYNTHESIS; CATABOLISM; COHORT ANALYSIS; EMBRYO; GLUCONEOGENESIS; KNOCKOUT MOUSE; LIVER METABOLISM; METABOLIC REGULATION; METABOLITE; NON INSULIN DEPENDENT DIABETES MELLITUS; PROTEIN DEPLETION; RECEPTOR BLOCKING; ANIMAL; DRUG ANTAGONISM; GENE INACTIVATION; GENETICS; METABOLISM;

MUS;

AMINO ACIDS; ANIMALS; CARBOHYDRATE METABOLISM; DIABETES MELLITUS; GENE EXPRESSION PROFILING; GENE KNOCKOUT TECHNIQUES; HYPOGLYCEMIC AGENTS; LIPID METABOLISM; LIVER; MALE; MICE; PROTEOMICS; RECEPTORS, GLUCAGON; RNA, MESSENGER;

EID: 79957641481     PISSN: None     EISSN: 14712164     Source Type: Journal    
DOI: 10.1186/1471-2164-12-181     Document Type: Article

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