메뉴 건너뛰기




Volumn 10, Issue 2, 2013, Pages

Chemical kinetic mechanistic models to investigate cancer biology and impact cancer medicine

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BIOLOGICAL MODEL; COMPUTER SIMULATION; GENETICS; HUMAN; METABOLISM; MUTATION; NEOPLASM; SIGNAL TRANSDUCTION; SYSTEMS BIOLOGY;

EID: 84876241551     PISSN: 14783967     EISSN: 14783975     Source Type: Journal    
DOI: 10.1088/1478-3975/10/2/026004     Document Type: Article
Times cited : (3)

References (60)
  • 1
    • 0035902115 scopus 로고    scopus 로고
    • Proliferation, cell cycle and apoptosis in cancer
    • 10.1038/35077213 0028-0836
    • Evan G I and Vousden K H 2001 Proliferation, cell cycle and apoptosis in cancer Nature 411 342-48
    • (2001) Nature , vol.411 , Issue.6835 , pp. 342-348
    • Evan, G.I.1    Vousden, K.H.2
  • 2
    • 0035256698 scopus 로고    scopus 로고
    • Untangling the ErbB signalling network
    • 10.1038/35052073 1471-0072
    • Yarden Y and Sliwkowski M X 2001 Untangling the ErbB signalling network Nature Rev. Mol. Cell Biol. 2 127-37
    • (2001) Nature Rev. Mol. Cell Biol. , vol.2 , Issue.2 , pp. 127-137
    • Yarden, Y.1    Sliwkowski, M.X.2
  • 3
    • 77956141521 scopus 로고    scopus 로고
    • Phosphotyrosine signaling: Evolving a new cellular communication system
    • 10.1016/j.cell.2010.08.023 0092-8674
    • Lim W A and Pawson T 2010 Phosphotyrosine signaling: evolving a new cellular communication system Cell 142 661-7
    • (2010) Cell , vol.142 , Issue.5 , pp. 661-667
    • Lim, W.A.1    Pawson, T.2
  • 4
    • 84855795110 scopus 로고    scopus 로고
    • MEK1/2 dual-specificity protein kinases: Structure and regulation
    • 10.1016/j.bbrc.2011.11.145 0006-291X
    • Roskoski R Jr 2012 MEK1/2 dual-specificity protein kinases: structure and regulation Biochem. Biophys. Res. Commun. 417 5-10
    • (2012) Biochem. Biophys. Res. Commun. , vol.417 , Issue.1 , pp. 5-10
    • Roskoski Jr., R.1
  • 5
    • 0026608787 scopus 로고
    • Nuclear localization and regulation of erk- and rsk-encoded protein kinases
    • Chen R H, Sarnecki C and Blenis J 1992 Nuclear localization and regulation of erk- and rsk-encoded protein kinases Mol. Cell Biol. 12 915-27 (available at http://mcb.asm.org/content/12/3/915.long)
    • (1992) Mol. Cell Biol. , vol.12 , pp. 915-927
    • Chen, R.H.1    Sarnecki, C.2    Blenis, J.3
  • 7
  • 8
    • 84856013431 scopus 로고    scopus 로고
    • Clonal evolution in cancer
    • 10.1038/nature10762 0028-0836
    • Greaves M and Maley C C 2012 Clonal evolution in cancer Nature 481 306-13
    • (2012) Nature , vol.481 , Issue.7381 , pp. 306-313
    • Greaves, M.1    Maley, C.C.2
  • 9
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • 10.1038/nature07385 0028-0836
    • McLendon R et al 2008 Comprehensive genomic characterization defines human glioblastoma genes and core pathways Nature 455 1061-8
    • (2008) Nature , vol.455 , Issue.7216 , pp. 1061-1068
    • McLendon, R.1
  • 10
    • 54549094903 scopus 로고    scopus 로고
    • Somatic mutations affect key pathways in lung adenocarcinoma
    • 10.1038/nature07423 0028-0836
    • Ding L et al 2008 Somatic mutations affect key pathways in lung adenocarcinoma Nature 455 1069-75
    • (2008) Nature , vol.455 , Issue.7216 , pp. 1069-1075
    • Ding, L.1
  • 12
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • 10.1016/S0092-8674(00)81683-9 0092-8674
    • Hanahan D and Weinberg R A 2000 The hallmarks of cancer Cell 100 57-70
    • (2000) Cell , vol.100 , Issue.1 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 13
    • 52149123619 scopus 로고    scopus 로고
    • Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
    • 10.1126/science.1164368 0036-8075
    • Jones S et al 2008 Core signaling pathways in human pancreatic cancers revealed by global genomic analyses Science 321 1801-6
    • (2008) Science , vol.321 , Issue.5897 , pp. 1801-1806
    • Jones, S.1
  • 14
    • 18444374405 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in human cancer
    • 10.1038/nature00766 0028-0836
    • Davies H et al 2002 Mutations of the BRAF gene in human cancer Nature 417 949-54
    • (2002) Nature , vol.417 , Issue.6892 , pp. 949-954
    • Davies, H.1
  • 15
    • 9244222261 scopus 로고    scopus 로고
    • Targeted cancer therapy
    • 10.1038/nature03095 0028-0836
    • Sawyers C 2004 Targeted cancer therapy Nature 432 294-7
    • (2004) Nature , vol.432 , Issue.7015 , pp. 294-297
    • Sawyers, C.1
  • 16
    • 37249003928 scopus 로고    scopus 로고
    • Oncogene addiction: Setting the stage for molecularly targeted cancer therapy
    • 10.1101/gad.1609907 0890-9369
    • Sharma S V and Settleman J 2007 Oncogene addiction: setting the stage for molecularly targeted cancer therapy Genes Dev. 21 3214-31
    • (2007) Genes Dev. , vol.21 , Issue.24 , pp. 3214-3231
    • Sharma, S.V.1    Settleman, J.2
  • 17
    • 40849147041 scopus 로고    scopus 로고
    • EGFR antagonists in cancer treatment
    • 10.1056/NEJMra0707704 0028-4793
    • Ciardiello F and Tortora G 2008 EGFR antagonists in cancer treatment New Engl. J. Med. 358 1160-74
    • (2008) New Engl. J. Med. , vol.358 , Issue.11 , pp. 1160-1174
    • Ciardiello, F.1    Tortora, G.2
  • 18
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • 10.1056/NEJMoa040938 0028-4793
    • Lynch T J et al 2004 Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib New Engl. J. Med. 350 2129-39
    • (2004) New Engl. J. Med. , vol.350 , Issue.21 , pp. 2129-2139
    • Lynch, T.J.1
  • 19
    • 4444344330 scopus 로고    scopus 로고
    • EGF receptor gene mutations are common in lung cancers from 'never smokers' and are associated with sensitivity of tumors to gefitinib and erlotinib
    • 10.1073/pnas.0405220101 0027-8424
    • Pao W et al 2004 EGF receptor gene mutations are common in lung cancers from 'never smokers' and are associated with sensitivity of tumors to gefitinib and erlotinib Proc. Natl Acad. Sci. USA 101 13306-11
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , Issue.36 , pp. 13306-13311
    • Pao, W.1
  • 20
    • 18244371651 scopus 로고    scopus 로고
    • Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
    • 10.1371/journal.pmed.0020073 1549-1277
    • Pao W, Miller V A, Politi K A, Riely G J, Somwar R, Zakowski M F, Kris M G and Varmus H 2005 Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain PLoS Med. 2 e73
    • (2005) PLoS Med. , vol.2 , Issue.3 , pp. 73
    • Pao, W.1    Miller, V.A.2    Politi, K.A.3    Riely, G.J.4    Somwar, R.5    Zakowski, M.F.6    Kris, M.G.7    Varmus, H.8
  • 21
    • 52749099497 scopus 로고    scopus 로고
    • Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: A systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer
    • 10.1016/S1470-2045(08)70206-7 1470-2045
    • Linardou H, Dahabreh I J, Kanaloupiti D, Siannis F, Bafaloukos D, Kosmidis P, Papadimitriou C A and Murray S 2008 Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer Lancet Oncol. 9 962-72
    • (2008) Lancet Oncol. , vol.9 , Issue.10 , pp. 962-972
    • Linardou, H.1    Dahabreh, I.J.2    Kanaloupiti, D.3    Siannis, F.4    Bafaloukos, D.5    Kosmidis, P.6    Papadimitriou, C.A.7    Murray, S.8
  • 22
    • 34249933404 scopus 로고    scopus 로고
    • Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: A phase III trial of the National Cancer Institute of Canada Clinical Trials Group
    • 10.1200/JCO.2006.07.9525 0732-183X
    • Moore M J et al 2007 Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group J. Clin. Oncol. 25 1960-6
    • (2007) J. Clin. Oncol. , vol.25 , Issue.15 , pp. 1960-1966
    • Moore, M.J.1
  • 23
    • 34249075147 scopus 로고    scopus 로고
    • MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
    • 10.1126/science.1141478 0036-8075
    • Engelman J A et al 2007 MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling Science 316 1039-43
    • (2007) Science , vol.316 , Issue.5827 , pp. 1039-1043
    • Engelman, J.A.1
  • 26
    • 77949732073 scopus 로고    scopus 로고
    • RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
    • 10.1038/nature08902 0028-0836
    • Poulikakos P I, Zhang C, Bollag G, Shokat K M and Rosen N 2010 RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF Nature 464 427-30
    • (2010) Nature , vol.464 , Issue.7287 , pp. 427-430
    • Poulikakos, P.I.1    Zhang, C.2    Bollag, G.3    Shokat, K.M.4    Rosen, N.5
  • 27
    • 77949685981 scopus 로고    scopus 로고
    • RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
    • 10.1038/nature08833 0028-0836
    • Hatzivassiliou G et al 2010 RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth Nature 464 431-5
    • (2010) Nature , vol.464 , Issue.7287 , pp. 431-435
    • Hatzivassiliou, G.1
  • 28
    • 74849109743 scopus 로고    scopus 로고
    • Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF
    • 10.1016/j.cell.2009.12.040 0092-8674
    • Heidorn S J et al 2010 Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF Cell 140 209-21
    • (2010) Cell , vol.140 , Issue.2 , pp. 209-221
    • Heidorn, S.J.1
  • 29
    • 0037264633 scopus 로고    scopus 로고
    • Targeting RAS signalling pathways in cancer therapy
    • 10.1038/nrc969 1474-175X
    • Downward J 2003 Targeting RAS signalling pathways in cancer therapy Nature Rev. Cancer 3 11-22
    • (2003) Nature Rev. Cancer , vol.3 , Issue.1 , pp. 11-22
    • Downward, J.1
  • 30
    • 0037716676 scopus 로고    scopus 로고
    • Building with a scaffold: Emerging strategies for high- to low-level cellular modeling
    • 10.1016/S0167-7799(03)00115-X 0167-7799
    • Ideker T and Lauffenburger D 2003 Building with a scaffold: emerging strategies for high- to low-level cellular modeling Trends Biotechnol. 21 255-62
    • (2003) Trends Biotechnol. , vol.21 , Issue.6 , pp. 255-262
    • Ideker, T.1    Lauffenburger, D.2
  • 31
    • 79952643760 scopus 로고    scopus 로고
    • Network news: Innovations in 21st century systems biology
    • 10.1016/j.cell.2011.03.008 0092-8674
    • Arkin A P and Schaffer D V 2011 Network news: innovations in 21st century systems biology Cell 144 844-9
    • (2011) Cell , vol.144 , Issue.6 , pp. 844-849
    • Arkin, A.P.1    Schaffer, D.V.2
  • 34
    • 0037047611 scopus 로고    scopus 로고
    • MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network
    • 10.1126/science.1068873 0036-8075
    • Bhalla U S, Ram P T and Iyengar R 2002 MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network Science 297 1018-23
    • (2002) Science , vol.297 , Issue.5583 , pp. 1018-1023
    • Bhalla, U.S.1    Ram, P.T.2    Iyengar, R.3
  • 35
    • 0036212767 scopus 로고    scopus 로고
    • Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors
    • 10.1038/nbt0402-370 1087-0156
    • Schoeberl B, Eichler-Jonsson C, Gilles E D and Muller G 2002 Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors Nature Biotechnol. 20 370-5
    • (2002) Nature Biotechnol. , vol.20 , Issue.4 , pp. 370-375
    • Schoeberl, B.1    Eichler-Jonsson, C.2    Gilles, E.D.3    Muller, G.4
  • 36
    • 0037044575 scopus 로고    scopus 로고
    • The IkappaB-NF-kappaB signaling module: Temporal control and selective gene activation
    • 10.1126/science.1071914 0036-8075
    • Hoffmann A, Levchenko A, Scott M L and Baltimore D 2002 The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation Science 298 1241-5
    • (2002) Science , vol.298 , Issue.5596 , pp. 1241-1245
    • Hoffmann, A.1    Levchenko, A.2    Scott, M.L.3    Baltimore, D.4
  • 37
    • 66249136447 scopus 로고    scopus 로고
    • Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis
    • 10.1038/nature08012 0028-0836
    • Spencer S L, Gaudet S, Albeck J G, Burke J M and Sorger P K 2009 Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis Nature 459 428-32
    • (2009) Nature , vol.459 , Issue.7245 , pp. 428-432
    • Spencer, S.L.1    Gaudet, S.2    Albeck, J.G.3    Burke, J.M.4    Sorger, P.K.5
  • 38
    • 58249092059 scopus 로고    scopus 로고
    • Digital signaling and hysteresis characterize ras activation in lymphoid cells
    • 10.1016/j.cell.2008.11.051 0092-8674
    • Das J, Ho M, Zikherman J, Govern C, Yang M, Weiss A, Chakraborty A K and Roose J P 2009 Digital signaling and hysteresis characterize ras activation in lymphoid cells Cell 136 337-51
    • (2009) Cell , vol.136 , Issue.2 , pp. 337-351
    • Das, J.1    Ho, M.2    Zikherman, J.3    Govern, C.4    Yang, M.5    Weiss, A.6    Chakraborty, A.K.7    Roose, J.P.8
  • 39
    • 35348988164 scopus 로고    scopus 로고
    • Network analysis of oncogenic Ras activation in cancer
    • 10.1126/science.1144642 0036-8075
    • Stites E C, Trampont P C, Ma Z and Ravichandran K S 2007 Network analysis of oncogenic Ras activation in cancer Science 318 463-7
    • (2007) Science , vol.318 , Issue.5849 , pp. 463-467
    • Stites, E.C.1    Trampont, P.C.2    Ma, Z.3    Ravichandran, K.S.4
  • 40
    • 12344296457 scopus 로고    scopus 로고
    • A reductionist's systems biology: Opinion
    • 10.1016/j.ceb.2004.12.012 0955-0674
    • Sorger P K 2005 A reductionist's systems biology: opinion Curr. Opin. Cell Biol. 17 9-11
    • (2005) Curr. Opin. Cell Biol. , vol.17 , Issue.1 , pp. 9-11
    • Sorger, P.K.1
  • 41
    • 63449108226 scopus 로고    scopus 로고
    • A systems perspective of ras signaling in cancer
    • 10.1158/1078-0432.CCR-08-2753 1078-0432
    • Stites E C and Ravichandran K S 2009 A systems perspective of ras signaling in cancer Clin. Cancer Res. 15 1510-3
    • (2009) Clin. Cancer Res. , vol.15 , Issue.5 , pp. 1510-1513
    • Stites, E.C.1    Ravichandran, K.S.2
  • 42
    • 80052211582 scopus 로고    scopus 로고
    • Rapid phospho-turnover by receptor tyrosine kinases impacts downstream signaling and drug binding
    • 10.1016/j.molcel.2011.07.014 1097-2765
    • Kleiman L B, Maiwald T, Conzelmann H, Lauffenburger D A and Sorger P K 2011 Rapid phospho-turnover by receptor tyrosine kinases impacts downstream signaling and drug binding Mol. Cell. 43 723-37
    • (2011) Mol. Cell. , vol.43 , Issue.5 , pp. 723-737
    • Kleiman, L.B.1    Maiwald, T.2    Conzelmann, H.3    Lauffenburger, D.A.4    Sorger, P.K.5
  • 43
    • 70449513896 scopus 로고    scopus 로고
    • Computational modelling of cancerous mutations in the EGFR/ERK signalling pathway
    • 10.1186/1752-0509-3-100 1752-0509
    • Orton R J, Adriaens M E, Gormand A, Sturm O E, Kolch W and Gilbert D R 2009 Computational modelling of cancerous mutations in the EGFR/ERK signalling pathway BMC Syst. Biol. 3 100
    • (2009) BMC Syst. Biol. , vol.3 , Issue.1 , pp. 100
    • Orton, R.J.1    Adriaens, M.E.2    Gormand, A.3    Sturm, O.E.4    Kolch, W.5    Gilbert, D.R.6
  • 44
    • 84864012288 scopus 로고    scopus 로고
    • Negative feedback and adaptive resistance to the targeted therapy of cancer
    • 10.1158/2159-8290.CD-12-0018 2159-8274
    • Chandarlapaty S 2012 Negative feedback and adaptive resistance to the targeted therapy of cancer Cancer Discovery 2 311-9
    • (2012) Cancer Discovery , vol.2 , Issue.4 , pp. 311-319
    • Chandarlapaty, S.1
  • 46
    • 0142027814 scopus 로고    scopus 로고
    • Structure and function of the feed-forward loop network motif
    • 10.1073/pnas.2133841100 0027-8424
    • Mangan S and Alon U 2003 Structure and function of the feed-forward loop network motif Proc. Natl Acad. Sci. USA 100 11980-5
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , Issue.21 , pp. 11980-11985
    • Mangan, S.1    Alon, U.2
  • 49
    • 29144435996 scopus 로고    scopus 로고
    • Computational modelling of the receptor-tyrosine-kinase-activated MAPK pathway
    • 10.1042/BJ20050908 0264-6021
    • Orton R J, Sturm O E, Vyshemirsky V, Calder M, Gilbert D R and Kolch W 2005 Computational modelling of the receptor-tyrosine-kinase-activated MAPK pathway Biochem. J. 392 249-61
    • (2005) Biochem. J. , vol.392 , Issue.2 , pp. 249-261
    • Orton, R.J.1    Sturm, O.E.2    Vyshemirsky, V.3    Calder, M.4    Gilbert, D.R.5    Kolch, W.6
  • 50
    • 84868376130 scopus 로고    scopus 로고
    • Multiscale models of cell signaling
    • 10.1007/s10439-012-0560-1 0090-6964
    • Bajikar S S and Janes K A 2012 Multiscale models of cell signaling Ann. Biomed. Eng. 40 2319-27
    • (2012) Ann. Biomed. Eng. , vol.40 , Issue.11 , pp. 2319-2327
    • Bajikar, S.S.1    Janes, K.A.2
  • 51
    • 33747366698 scopus 로고    scopus 로고
    • Rules for modeling signal-transduction systems
    • Hlavacek W S, Faeder J R, Blinov M L, Posner R G, Hucka M and Fontana W 2006 Rules for modeling signal-transduction systems Sci. STKE re6 pp 1-18 (available at http://stke.sciencemag.org/cgi/content/abstract/sigtrans;2006/344/ re6)
    • (2006) Sci. STKE , vol.6 , pp. 1-18
    • Hlavacek, W.S.1    Faeder, J.R.2    Blinov, M.L.3    Posner, R.G.4    Hucka, M.5    Fontana, W.6
  • 52
    • 10244219918 scopus 로고    scopus 로고
    • BioNetGen: Software for rule-based modeling of signal transduction based on the interactions of molecular domains
    • 10.1093/bioinformatics/bth378 1367-4803
    • Blinov M L, Faeder J R, Goldstein B and Hlavacek W S 2004 BioNetGen: software for rule-based modeling of signal transduction based on the interactions of molecular domains Bioinformatics 20 3289-91
    • (2004) Bioinformatics , vol.20 , Issue.17 , pp. 3289-3291
    • Blinov, M.L.1    Faeder, J.R.2    Goldstein, B.3    Hlavacek, W.S.4
  • 54
    • 79551555393 scopus 로고    scopus 로고
    • Efficient modeling, simulation and coarse-graining of biological complexity with NFsim
    • 10.1038/nmeth.1546 1548-7091
    • Sneddon M W, Faeder J R and Emonet T 2011 Efficient modeling, simulation and coarse-graining of biological complexity with NFsim Nature Methods 8 177-83
    • (2011) Nature Methods , vol.8 , Issue.2 , pp. 177-183
    • Sneddon, M.W.1    Faeder, J.R.2    Emonet, T.3
  • 55
    • 79952779822 scopus 로고    scopus 로고
    • Development of novel combination therapies
    • 10.1056/NEJMp1101548 0028-4793
    • Woodcock J, Griffin J P and Behrman R E 2011 Development of novel combination therapies New Engl. J. Med. 364 985-7
    • (2011) New Engl. J. Med. , vol.364 , Issue.11 , pp. 985-987
    • Woodcock, J.1    Griffin, J.P.2    Behrman, R.E.3
  • 56
    • 79952395270 scopus 로고    scopus 로고
    • Cancer genomics: From discovery science to personalized medicine
    • 10.1038/nm.2323 1078-8956
    • Chin L, Andersen J N and Futreal P A 2011 Cancer genomics: from discovery science to personalized medicine Nature Med. 17 297-303
    • (2011) Nature Med. , vol.17 , Issue.3 , pp. 297-303
    • Chin, L.1    Andersen, J.N.2    Futreal, P.A.3
  • 57
    • 84855929701 scopus 로고    scopus 로고
    • Systems cancer medicine: Towards realization of predictive, preventive, personalized and participatory (P4) medicine
    • 10.1111/j.1365-2796.2011.02498.x 0954-6820
    • Tian Q, Price N D and Hood L 2012 Systems cancer medicine: towards realization of predictive, preventive, personalized and participatory (P4) medicine J. Intern. Med. 271 111-21
    • (2012) J. Intern. Med. , vol.271 , Issue.2 , pp. 111-121
    • Tian, Q.1    Price, N.D.2    Hood, L.3
  • 58
    • 84863393678 scopus 로고    scopus 로고
    • Cancer genomics: Technology, discovery, and translation
    • 10.1200/JCO.2011.39.2316 0732-183X
    • Tran B et al 2012 Cancer genomics: technology, discovery, and translation J. Clin. Oncol. 30 647-60
    • (2012) J. Clin. Oncol. , vol.30 , Issue.6 , pp. 647-660
    • Tran, B.1
  • 59
    • 82655184653 scopus 로고    scopus 로고
    • Personalized oncology through integrative high-throughput sequencing: A pilot study
    • 10.1126/scitranslmed.3003161 1946-6234
    • Roychowdhury S et al 2011 Personalized oncology through integrative high-throughput sequencing: a pilot study Sci. Transl. Med. 3 1-10
    • (2011) Sci. Transl. Med. , vol.3 , Issue.111
    • Roychowdhury, S.1
  • 60
    • 79951906119 scopus 로고    scopus 로고
    • Pilot study using molecular profiling of patients' tumors to find potential targets and select treatments for their refractory cancers
    • 10.1200/JCO.2009.26.5983 0732-183X
    • Von Hoff D D et al 2010 Pilot study using molecular profiling of patients' tumors to find potential targets and select treatments for their refractory cancers J. Clin. Oncol. 28 4877-83
    • (2010) J. Clin. Oncol. , vol.28 , Issue.33 , pp. 4877-4883
    • Von Hoff, D.D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.