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Volumn 288, Issue 13, 2013, Pages 9293-9302

EP2 receptor signaling pathways regulate classical activation of microglia

Author keywords

[No Author keywords available]

Indexed keywords

ACETOXYMETHYL ESTERS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; INFLAMMATORY MEDIATORS; LIPOPOLYSACCHARIDES; PROTEIN EXPRESSIONS; PROTEIN MEASUREMENT; RECEPTOR SIGNALING; SIGNALING PATHWAYS;

EID: 84875992394     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.455816     Document Type: Article
Times cited : (90)

References (59)
  • 1
    • 35548986304 scopus 로고    scopus 로고
    • Microglia: Active sensor and versatile effector cells in the normal and pathologic brain
    • Hanisch, U. K., and Kettenmann, H. (2007) Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nat. Neurosci. 10, 1387-1394
    • (2007) Nat. Neurosci. , vol.10 , pp. 1387-1394
    • Hanisch, U.K.1    Kettenmann, H.2
  • 2
    • 33845217688 scopus 로고    scopus 로고
    • The cellular response in neuroinflammation: The role of leukocytes, microglia and astrocytes in neuronal death and survival
    • Carson, M. J., Thrash, J. C., and Walter, B. (2006) The cellular response in neuroinflammation: the role of leukocytes, microglia and astrocytes in neuronal death and survival. Clin. Neurosci. Res. 6, 237-245
    • (2006) Clin. Neurosci. Res. , vol.6 , pp. 237-245
    • Carson, M.J.1    Thrash, J.C.2    Walter, B.3
  • 3
    • 0030222037 scopus 로고    scopus 로고
    • Microglia: A sensor for pathological events in the CNS
    • Kreutzberg, G. W. (1996) Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 19, 312-318
    • (1996) Trends Neurosci , vol.19 , pp. 312-318
    • Kreutzberg, G.W.1
  • 4
    • 33744977037 scopus 로고    scopus 로고
    • Microglia and the control of autoreactive T cell responses
    • Melchior, B., Puntambekar, S. S., and Carson, M. J. (2006) Microglia and the control of autoreactive T cell responses. Neurochem. Int. 49, 145-153
    • (2006) Neurochem. Int. , vol.49 , pp. 145-153
    • Melchior, B.1    Puntambekar, S.S.2    Carson, M.J.3
  • 5
    • 33747463996 scopus 로고    scopus 로고
    • Microglia biology in health and disease
    • Garden, G. A., and Möller, T. (2006) Microglia biology in health and disease. J. Neuroimmune Pharmacol. 1, 127-137
    • (2006) J. Neuroimmune Pharmacol. , vol.1 , pp. 127-137
    • Garden, G.A.1    Möller, T.2
  • 6
    • 80054741188 scopus 로고    scopus 로고
    • Ablation of cyclooxygenase- 2 in forebrain neurons is neuroprotective and dampens brain inflammation after status epilepticus
    • Serrano, G. E., Lelutiu, N., Rojas, A., Cochi, S., Shaw, R., Makinson, C. D., Wang, D., FitzGerald, G. A., and Dingledine, R. (2011) Ablation of cyclooxygenase- 2 in forebrain neurons is neuroprotective and dampens brain inflammation after status epilepticus. J. Neurosci. 31, 14850-14860
    • (2011) J. Neurosci. , vol.31 , pp. 14850-14860
    • Serrano, G.E.1    Lelutiu, N.2    Rojas, A.3    Cochi, S.4    Shaw, R.5    Makinson, C.D.6    Wang, D.7    Fitzgerald, G.A.8    Dingledine, R.9
  • 7
    • 0027290813 scopus 로고
    • Expression of a mitogen-inducible cyclooxygenase in brain neurons: Regulation by synaptic activity and glucocorticoids
    • Yamagata, K., Andreasson, K. I., Kaufmann, W. E., Barnes, C. A., and Worley, P. F. (1993) Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids. Neuron 11, 371-386
    • (1993) Neuron , vol.11 , pp. 371-386
    • Yamagata, K.1    Andreasson, K.I.2    Kaufmann, W.E.3    Barnes, C.A.4    Worley, P.F.5
  • 8
    • 0034692689 scopus 로고    scopus 로고
    • Regulation of prostaglandin E2 biosynthesis by inducible membrane-associated prostaglandin E2 synthase that acts in concert with cyclooxygenase-2
    • Murakami, M., Naraba, H., Tanioka, T., Semmyo, N., Nakatani, Y., Kojima, F., Ikeda, T., Fueki, M., Ueno, A., Oh, S., and Kudo, I. (2000) Regulation of prostaglandin E2 biosynthesis by inducible membrane-associated prostaglandin E2 synthase that acts in concert with cyclooxygenase-2. J. Biol. Chem. 275, 32783-32792
    • (2000) J. Biol. Chem. , vol.275 , pp. 32783-32792
    • Murakami, M.1    Naraba, H.2    Tanioka, T.3    Semmyo, N.4    Nakatani, Y.5    Kojima, F.6    Ikeda, T.7    Fueki, M.8    Ueno, A.9    Oh, S.10    Kudo, I.11
  • 9
    • 0034693050 scopus 로고    scopus 로고
    • Molecular identification of cytosolic prostaglandin E2 synthase that is functionally coupled with cyclooxygenase-1 in immediate prostaglandin E2 biosynthesis
    • Tanioka, T., Nakatani, Y., Semmyo, N., Murakami, M., and Kudo, I. (2000) Molecular identification of cytosolic prostaglandin E2 synthase that is functionally coupled with cyclooxygenase-1 in immediate prostaglandin E2 biosynthesis. J. Biol. Chem. 275, 32775-32782
    • (2000) J. Biol. Chem. , vol.275 , pp. 32775-32782
    • Tanioka, T.1    Nakatani, Y.2    Semmyo, N.3    Murakami, M.4    Kudo, I.5
  • 10
    • 0141733073 scopus 로고    scopus 로고
    • Cellular prostaglandin E2 production by membrane-bound prostaglandin e synthase-2 via both cyclooxygenases-1 and -2
    • Murakami, M., Nakashima, K., Kamei, D., Masuda, S., Ishikawa, Y., Ishii, T., Ohmiya, Y., Watanabe, K., and Kudo, I. (2003) Cellular prostaglandin E2 production by membrane-bound prostaglandin E synthase-2 via both cyclooxygenases-1 and -2. J. Biol. Chem. 278, 37937-37947
    • (2003) J. Biol. Chem. , vol.278 , pp. 37937-37947
    • Murakami, M.1    Nakashima, K.2    Kamei, D.3    Masuda, S.4    Ishikawa, Y.5    Ishii, T.6    Ohmiya, Y.7    Watanabe, K.8    Kudo, I.9
  • 11
    • 0032823306 scopus 로고    scopus 로고
    • Prostanoid receptors: Structures, properties, and functions
    • Narumiya, S., Sugimoto, Y., and Ushikubi, F. (1999) Prostanoid receptors: structures, properties, and functions. Physiol. Rev. 79, 1193-1226
    • (1999) Physiol. Rev. , vol.79 , pp. 1193-1226
    • Narumiya, S.1    Sugimoto, Y.2    Ushikubi, F.3
  • 12
    • 53249131262 scopus 로고    scopus 로고
    • Therapeutic targets in prostaglandin E2 signaling for neurologic disease
    • Cimino, P. J., Keene, C. D., Breyer, R. M., Montine, K. S., and Montine, T. J. (2008) Therapeutic targets in prostaglandin E2 signaling for neurologic disease. Curr. Med. Chem. 15, 1863-1869
    • (2008) Curr. Med. Chem. , vol.15 , pp. 1863-1869
    • Cimino, P.J.1    Keene, C.D.2    Breyer, R.M.3    Montine, K.S.4    Montine, T.J.5
  • 13
    • 77953638394 scopus 로고    scopus 로고
    • The prostaglandin E2 E-prostanoid 4 receptor exerts anti-inflammatory effects in brain innate immunity
    • Shi, J., Johansson, J., Woodling, N. S., Wang, Q., Montine, T. J., and Andreasson, K. (2010) The prostaglandin E2 E-prostanoid 4 receptor exerts anti-inflammatory effects in brain innate immunity. J. Immunol. 184, 7207-7218
    • (2010) J. Immunol. , vol.184 , pp. 7207-7218
    • Shi, J.1    Johansson, J.2    Woodling, N.S.3    Wang, Q.4    Montine, T.J.5    Andreasson, K.6
  • 14
    • 0032902146 scopus 로고    scopus 로고
    • Prostaglandin e receptor subtypes in cultured rat microglia and their role in reducing lipopolysaccharideinduced interleukin-1β production
    • Caggiano, A. O., and Kraig, R. P. (1999) Prostaglandin E receptor subtypes in cultured rat microglia and their role in reducing lipopolysaccharideinduced interleukin-1β production. J. Neurochem. 72, 565-575
    • (1999) J. Neurochem. , vol.72 , pp. 565-575
    • Caggiano, A.O.1    Kraig, R.P.2
  • 15
    • 0031571317 scopus 로고    scopus 로고
    • IL-12 production by central nervous system microglia is inhibited by astrocytes
    • Aloisi, F., Penna, G., Cerase, J., Menéndez Iglesias, B., and Adorini, L. (1997) IL-12 production by central nervous system microglia is inhibited by astrocytes. J. Immunol. 159, 1604-1612
    • (1997) J. Immunol. , vol.159 , pp. 1604-1612
    • Aloisi, F.1    Penna, G.2    Cerase, J.3    Menéndez Iglesias, B.4    Adorini, L.5
  • 16
    • 0343990850 scopus 로고    scopus 로고
    • Analysis of B7-1 and B7-2 costimulatory ligands in cultured mouse microglia: Upregulation by interferon-γ and lipopolysaccharide and downregulation by interleukin-10, prostaglandin E2 and cyclic AMPelevating agents
    • Menèndez Iglesias, B., Cerase, J., Ceracchini, C., Levi, G., and Aloisi, F. (1997) Analysis of B7-1 and B7-2 costimulatory ligands in cultured mouse microglia: upregulation by interferon-γ and lipopolysaccharide and downregulation by interleukin-10, prostaglandin E2 and cyclic AMPelevating agents. J. Neuroimmunol. 72, 83-93
    • (1997) J. Neuroimmunol. , vol.72 , pp. 83-93
    • Menèndez Iglesias, B.1    Cerase, J.2    Ceracchini, C.3    Levi, G.4    Aloisi, F.5
  • 17
    • 0031081781 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase expression in activated rat microglial cultures is downregulated by exogenous prostaglandin E2 and by cyclooxygenase inhibitors
    • Minghetti, L., Nicolini, A., Polazzi, E., Créminon, C., Maclouf, J., and Levi, G. (1997) Inducible nitric oxide synthase expression in activated rat microglial cultures is downregulated by exogenous prostaglandin E2 and by cyclooxygenase inhibitors. Glia 19, 152-160
    • (1997) Glia , vol.19 , pp. 152-160
    • Minghetti, L.1    Nicolini, A.2    Polazzi, E.3    Créminon, C.4    Maclouf, J.5    Levi, G.6
  • 18
    • 0033564234 scopus 로고    scopus 로고
    • Opposite effects of interferon-γ and prostaglandin E2 on tumor necrosis factor and interleukin-10 production in microglia: A regulatory loop controlling microglia pro- and anti-inflammatory activities
    • Aloisi, F., De Simone, R., Columba-Cabezas, S., and Levi, G. (1999) Opposite effects of interferon-γ and prostaglandin E2 on tumor necrosis factor and interleukin-10 production in microglia: a regulatory loop controlling microglia pro- and anti-inflammatory activities. J. Neurosci. Res. 56, 571-580
    • (1999) J. Neurosci. Res. , vol.56 , pp. 571-580
    • Aloisi, F.1    De Simone, R.2    Columba-Cabezas, S.3    Levi, G.4
  • 19
    • 0036527429 scopus 로고    scopus 로고
    • Protein kinases-the major drug targets of the twentyfirst century?
    • Cohen, P. (2002) Protein kinases-the major drug targets of the twentyfirst century? Nat. Rev. Drug Discov. 1, 309-315
    • (2002) Nat. Rev. Drug Discov. , vol.1 , pp. 309-315
    • Cohen, P.1
  • 21
    • 77949538387 scopus 로고    scopus 로고
    • Epac: Defining a new mechanism for cAMP action
    • Gloerich, M., and Bos, J. L. (2010) Epac: defining a new mechanism for cAMP action. Annu. Rev. Pharmacol. Toxicol. 50, 355-375
    • (2010) Annu. Rev. Pharmacol. Toxicol. , vol.50 , pp. 355-375
    • Gloerich, M.1    Bos, J.L.2
  • 22
    • 17144380506 scopus 로고    scopus 로고
    • Microglia lacking e prostanoid receptor subtype 2 have enhanced Aβ phagocytosis yet lack Aβ-activated neurotoxicity
    • Shie, F. S., Breyer, R. M., and Montine, T. J. (2005) Microglia lacking E prostanoid receptor subtype 2 have enhanced Aβ phagocytosis yet lack Aβ-activated neurotoxicity. Am. J. Pathol. 166, 1163-1172
    • (2005) Am. J. Pathol. , vol.166 , pp. 1163-1172
    • Shie, F.S.1    Breyer, R.M.2    Montine, T.J.3
  • 23
    • 33846668868 scopus 로고    scopus 로고
    • Prostaglandin E2 receptor subtype 2 (EP2) regulates microglial activation and associated neurotoxicity induced by aggregated α-synuclein
    • Jin, J., Shie, F. S., Liu, J., Wang, Y., Davis, J., Schantz, A. M., Montine, K. S., Montine, T. J., and Zhang, J. (2007) Prostaglandin E2 receptor subtype 2 (EP2) regulates microglial activation and associated neurotoxicity induced by aggregated α-synuclein. J. Neuroinflammation 4, 2
    • (2007) J. Neuroinflammation , vol.4 , pp. 2
    • Jin, J.1    Shie, F.S.2    Liu, J.3    Wang, Y.4    Davis, J.5    Schantz, A.M.6    Montine, K.S.7    Montine, T.J.8    Zhang, J.9
  • 24
    • 54849418885 scopus 로고    scopus 로고
    • The prostaglandin E2 EP2 receptor accelerates disease progression and inflammation in a model of amyotrophic lateral sclerosis
    • Liang, X., Wang, Q., Shi, J., Lokteva, L., Breyer, R. M., Montine, T. J., and Andreasson, K. (2008) The prostaglandin E2 EP2 receptor accelerates disease progression and inflammation in a model of amyotrophic lateral sclerosis. Ann. Neurol. 64, 304-314
    • (2008) Ann. Neurol. , vol.64 , pp. 304-314
    • Liang, X.1    Wang, Q.2    Shi, J.3    Lokteva, L.4    Breyer, R.M.5    Montine, T.J.6    Andreasson, K.7
  • 25
    • 27444436866 scopus 로고    scopus 로고
    • Microglial EP2 is critical to neurotoxicity from activated cerebral innate immunity
    • Shie, F. S., Montine, K. S., Breyer, R. M., and Montine, T. J. (2005) Microglial EP2 is critical to neurotoxicity from activated cerebral innate immunity. Glia 52, 70-77
    • (2005) Glia , vol.52 , pp. 70-77
    • Shie, F.S.1    Montine, K.S.2    Breyer, R.M.3    Montine, T.J.4
  • 26
    • 84874483489 scopus 로고    scopus 로고
    • Inhibition of the prostaglandin receptor EP2 following status epilepticus reduces delayed mortality and brain inflammation
    • (February 11), 10.1073/pnas.1218498110
    • Jiang, J., Quan, Y., Ganesh, T., Pouliot, W. A., Dudek, F. E., and Dingledine, R. (February 11, 2013) Inhibition of the prostaglandin receptor EP2 following status epilepticus reduces delayed mortality and brain inflammation. Proc. Natl. Acad. Sci. U.S.A. 10.1073/pnas.1218498110
    • Proc. Natl. Acad. Sci. U.S.A. , pp. 2013
    • Jiang, J.1    Quan, Y.2    Ganesh, T.3    Pouliot, W.A.4    Dudek, F.E.5    Dingledine, R.6
  • 29
    • 84872713352 scopus 로고    scopus 로고
    • Role of prostaglandin receptor EP2 in the regulations of cancer cell proliferation, invasion, and inflammation
    • Jiang, J., and Dingledine, R. (2013) Role of prostaglandin receptor EP2 in the regulations of cancer cell proliferation, invasion, and inflammation. J. Pharmacol. Exp. Ther. 344, 360-367
    • (2013) J. Pharmacol. Exp. Ther. , vol.344 , pp. 360-367
    • Jiang, J.1    Dingledine, R.2
  • 30
    • 69249218888 scopus 로고    scopus 로고
    • Regulation of Fcγ receptors and immunoglobulin G-mediated phagocytosis in mouse microglia
    • Quan, Y., Möller, T., and Weinstein, J. R. (2009) Regulation of Fcγ receptors and immunoglobulin G-mediated phagocytosis in mouse microglia. Neurosci. Lett. 464, 29-33
    • (2009) Neurosci. Lett. , vol.464 , pp. 29-33
    • Quan, Y.1    Möller, T.2    Weinstein, J.R.3
  • 31
    • 79551671360 scopus 로고    scopus 로고
    • High glucose stimulates TNFα and MCP-1 expression in rat microglia via ROS and NF-κB pathways
    • Quan, Y., Jiang, C. T., Xue, B., Zhu, S. G., and Wang, X. (2011) High glucose stimulates TNFα and MCP-1 expression in rat microglia via ROS and NF-κB pathways. Acta Pharmacol. Sin. 32, 188-193
    • (2011) Acta Pharmacol. Sin. , vol.32 , pp. 188-193
    • Quan, Y.1    Jiang, C.T.2    Xue, B.3    Zhu, S.G.4    Wang, X.5
  • 32
    • 0037129827 scopus 로고    scopus 로고
    • Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes
    • RESEARCH0034
    • Vandesompele, J., De Preter, K., Pattyn, F., Poppe, B., Van Roy, N., De Paepe, A., and Speleman, F. (2002) Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 3, RESEARCH0034
    • (2002) Genome Biol. , vol.3
    • Vandesompele, J.1    De Preter, K.2    Pattyn, F.3    Poppe, B.4    Van Roy, N.5    De Paepe, A.6    Speleman, F.7
  • 33
    • 59849125611 scopus 로고    scopus 로고
    • Thrombin-induced regulation of CD95(Fas) expression in the N9 microglial cell line: Evidence for involvement of proteinase-activated receptor(1) and extracellular signal-regulated kinase 1/2
    • Weinstein, J. R., Zhang, M., Kutlubaev, M., Lee, R., Bishop, C., Andersen, H., Hanisch, U. K., and Möller, T. (2009) Thrombin-induced regulation of CD95(Fas) expression in the N9 microglial cell line: evidence for involvement of proteinase-activated receptor(1) and extracellular signal-regulated kinase 1/2. Neurochem. Res. 34, 445-452
    • (2009) Neurochem. Res. , vol.34 , pp. 445-452
    • Weinstein, J.R.1    Zhang, M.2    Kutlubaev, M.3    Lee, R.4    Bishop, C.5    Andersen, H.6    Hanisch, U.K.7    Möller, T.8
  • 34
    • 35848968007 scopus 로고    scopus 로고
    • High glucose stimulates GRO secretion from rat microglia via ROS, PKC, and NF-κB pathways
    • Quan, Y., Du, J., and Wang, X. (2007) High glucose stimulates GRO secretion from rat microglia via ROS, PKC, and NF-κB pathways. J. Neurosci. Res. 85, 3150-3159
    • (2007) J. Neurosci. Res. , vol.85 , pp. 3150-3159
    • Du Quan, Y.J.1    Wang, X.2
  • 35
    • 67650485985 scopus 로고    scopus 로고
    • Alternative activation of macrophages: An immunologic functional perspective
    • Martinez, F. O., Helming, L., and Gordon, S. (2009) Alternative activation of macrophages: an immunologic functional perspective. Annu. Rev. Immunol. 27, 451-483
    • (2009) Annu. Rev. Immunol. , vol.27 , pp. 451-483
    • Martinez, F.O.1    Helming, L.2    Gordon, S.3
  • 36
    • 0030871070 scopus 로고    scopus 로고
    • Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells
    • Kiriyama, M., Ushikubi, F., Kobayashi, T., Hirata, M., Sugimoto, Y., and Narumiya, S. (1997) Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br. J. Pharmacol. 122, 217-224
    • (1997) Br. J. Pharmacol. , vol.122 , pp. 217-224
    • Kiriyama, M.1    Ushikubi, F.2    Kobayashi, T.3    Hirata, M.4    Sugimoto, Y.5    Narumiya, S.6
  • 39
    • 0029860018 scopus 로고    scopus 로고
    • Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity
    • Engh, R. A., Girod, A., Kinzel, V., Huber, R., and Bossemeyer, D. (1996) Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity. J. Biol. Chem. 271, 26157-26164
    • (1996) J. Biol. Chem. , vol.271 , pp. 26157-26164
    • Engh, R.A.1    Girod, A.2    Kinzel, V.3    Huber, R.4    Bossemeyer, D.5
  • 40
    • 0034306450 scopus 로고    scopus 로고
    • Specificity and mechanism of action of some commonly used protein kinase inhibitors
    • Davies, S. P., Reddy, H., Caivano, M., and Cohen, P. (2000) Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem. J. 351, 95-105
    • (2000) Biochem. J. , vol.351 , pp. 95-105
    • Davies, S.P.1    Reddy, H.2    Caivano, M.3    Cohen, P.4
  • 42
    • 67449092561 scopus 로고    scopus 로고
    • Enhanced Rap1 activation and insulin secretagogue properties of an acetoxymethyl ester of an Epac-selective cyclicAMPanalog in rat INS-1 cells: Studies with 8-pCPT-2′-O-Me-cAMP-AM
    • Chepurny, O. G., Leech, C. A., Kelley, G. G., Dzhura, I., Dzhura, E., Li, X., Rindler, M. J., Schwede, F., Genieser, H. G., and Holz, G. G. (2009) Enhanced Rap1 activation and insulin secretagogue properties of an acetoxymethyl ester of an Epac-selective cyclicAMPanalog in rat INS-1 cells: studies with 8-pCPT-2′-O-Me-cAMP-AM. J. Biol. Chem. 284, 10728-10736
    • (2009) J. Biol. Chem. , vol.284 , pp. 10728-10736
    • Chepurny, O.G.1    Leech, C.A.2    Kelley, G.G.3    Dzhura, I.4    Dzhura, E.5    Li, X.6    Rindler, M.J.7    Schwede, F.8    Genieser, H.G.9    Holz, G.G.10
  • 43
    • 84861573952 scopus 로고    scopus 로고
    • 5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP
    • Chen, H., Tsalkova, T., Mei, F. C., Hu, Y., Cheng, X., and Zhou, J. (2012) 5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP. Bioorg. Med. Chem. Lett. 22, 4038-4043
    • (2012) Bioorg. Med. Chem. Lett. , vol.22 , pp. 4038-4043
    • Chen, H.1    Tsalkova, T.2    Mei, F.C.3    Hu, Y.4    Cheng, X.5    Zhou, J.6
  • 45
  • 46
    • 4344645719 scopus 로고    scopus 로고
    • Selective COX-2 inhibition prevents progressive dopamine neuron degeneration in a rat model of Parkinson's disease
    • Sánchez-Pernaute, R., Ferree, A., Cooper, O., Yu, M., Brownell, A. L., and Isacson, O. (2004) Selective COX-2 inhibition prevents progressive dopamine neuron degeneration in a rat model of Parkinson's disease. J. Neuroinflammation 1, 6
    • (2004) J. Neuroinflammation , vol.1 , pp. 6
    • Sánchez-Pernaute, R.1    Ferree, A.2    Cooper, O.3    Yu, M.4    Brownell, A.L.5    Isacson, O.6
  • 47
    • 77049101945 scopus 로고    scopus 로고
    • Cell death mechanisms in the early stages of acute glutamate neurotoxicity
    • Kumar, A., Singh, R. L., and Babu, G. N. (2010) Cell death mechanisms in the early stages of acute glutamate neurotoxicity. Neurosci. Res. 66, 271-278
    • (2010) Neurosci. Res. , vol.66 , pp. 271-278
    • Kumar, A.1    Singh, R.L.2    Babu, G.N.3
  • 48
    • 77950458426 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase is present in motor neuron mitochondria and Schwann cells and contributes to disease mechanisms in ALS mice
    • Chen, K., Northington, F. J., and Martin, L. J. (2010) Inducible nitric oxide synthase is present in motor neuron mitochondria and Schwann cells and contributes to disease mechanisms in ALS mice. Brain Struct. Funct. 214, 219-234
    • (2010) Brain Struct. Funct. , vol.214 , pp. 219-234
    • Chen, K.1    Northington, F.J.2    Martin, L.J.3
  • 49
    • 0035925020 scopus 로고    scopus 로고
    • Enhancement of T helper2 response in the absence of interleukin (IL-)6; An inhibition of IL-4-mediated T helper2 cell differentiation by IL-6
    • Tanaka, T., Katada, Y., Higa, S., Fujiwara, H., Wang, W., Saeki, Y., Ohshima, S., Okuda, Y., Suemura, M., and Kishimoto, T. (2001) Enhancement of T helper2 response in the absence of interleukin (IL-)6; an inhibition of IL-4-mediated T helper2 cell differentiation by IL-6. Cytokine 13, 193-201
    • (2001) Cytokine , vol.13 , pp. 193-201
    • Tanaka, T.1    Katada, Y.2    Higa, S.3    Fujiwara, H.4    Wang, W.5    Saeki, Y.6    Ohshima, S.7    Okuda, Y.8    Suemura, M.9    Kishimoto, T.10
  • 50
    • 0033667998 scopus 로고    scopus 로고
    • Impaired inflammatory response and increased oxidative stress and neurodegeneration after brain injury in interleukin-6-deficient mice
    • Penkowa, M., Giralt, M., Carrasco, J., Hadberg, H., and Hidalgo, J. (2000) Impaired inflammatory response and increased oxidative stress and neurodegeneration after brain injury in interleukin-6-deficient mice. Glia 32, 271-285
    • (2000) Glia , vol.32 , pp. 271-285
    • Penkowa, M.1    Giralt, M.2    Carrasco, J.3    Hadberg, H.4    Hidalgo, J.5
  • 52
    • 0031985903 scopus 로고    scopus 로고
    • Regulation of monocyte IL-10 synthesis by endogenous IL-1 and TNF-α: Role of the p38 and p42/44 mitogen-activated protein kinases
    • Foey, A. D., Parry, S. L., Williams, L. M., Feldmann, M., Foxwell, B. M., and Brennan, F. M. (1998) Regulation of monocyte IL-10 synthesis by endogenous IL-1 and TNF-α: role of the p38 and p42/44 mitogen-activated protein kinases. J. Immunol. 160, 920-928
    • (1998) J. Immunol. , vol.160 , pp. 920-928
    • Foey, A.D.1    Parry, S.L.2    Williams, L.M.3    Feldmann, M.4    Foxwell, B.M.5    Brennan, F.M.6
  • 53
    • 75949102620 scopus 로고    scopus 로고
    • Chronic expression of low levels of tumor necrosis factor-α in the substantia nigra elicits progressive neurodegeneration, delayed motor symptoms and microglia/macrophage activation
    • De Lella Ezcurra, A. L., Chertoff, M., Ferrari, C., Graciarena, M., and Pitossi, F. (2010) Chronic expression of low levels of tumor necrosis factor-α in the substantia nigra elicits progressive neurodegeneration, delayed motor symptoms and microglia/macrophage activation. Neurobiol. Dis. 37, 630-640
    • (2010) Neurobiol. Dis. , vol.37 , pp. 630-640
    • De Lella Ezcurra, A.L.1    Chertoff, M.2    Ferrari, C.3    Graciarena, M.4    Pitossi, F.5
  • 54
    • 0031583918 scopus 로고    scopus 로고
    • Microglial phagocytosis is modulated by pro- and anti-inflammatory cytokines
    • von Zahn, J., Möller, T., Kettenmann, H., and Nolte, C. (1997) Microglial phagocytosis is modulated by pro- and anti-inflammatory cytokines. Neuroreport 8, 3851-3856
    • (1997) Neuroreport , vol.8 , pp. 3851-3856
    • Von Zahn, J.1    Möller, T.2    Kettenmann, H.3    Nolte, C.4
  • 55
    • 76749163675 scopus 로고    scopus 로고
    • Imipramine, in part through tumor necrosis factor α inhibition, prevents cognitive decline and β-amyloid accumulation in a mouse model of Alzheimer's disease
    • Chavant, F., Deguil, J., Pain, S., Ingrand, I., Milin, S., Fauconneau, B., Pérault-Pochat, M. C., and Lafay-Chebassier, C. (2010) Imipramine, in part through tumor necrosis factor α inhibition, prevents cognitive decline and β-amyloid accumulation in a mouse model of Alzheimer's disease. J. Pharmacol. Exp. Ther. 332, 505-514
    • (2010) J. Pharmacol. Exp. Ther. , vol.332 , pp. 505-514
    • Chavant, F.1    Deguil, J.2    Pain, S.3    Ingrand, I.4    Milin, S.5    Fauconneau, B.6    Pérault-Pochat, M.C.7    Lafay-Chebassier, C.8
  • 56
    • 70449525704 scopus 로고    scopus 로고
    • Chemokines and chemokine receptors: Standing at the crossroads of immunobiology and neurobiology
    • Ransohoff, R. M. (2009) Chemokines and chemokine receptors: standing at the crossroads of immunobiology and neurobiology. Immunity 31, 711-721
    • (2009) Immunity , vol.31 , pp. 711-721
    • Ransohoff, R.M.1
  • 58
    • 33751118764 scopus 로고    scopus 로고
    • Short communication: Differences between macrophages and dendritic cells in the cyclic AMP-dependent regulation of lipopolysaccharide-induced cytokine and chemokine synthesis
    • Aronoff, D. M., Carstens, J. K., Chen, G. H., Toews, G. B., and Peters- Golden, M. (2006) Short communication: differences between macrophages and dendritic cells in the cyclic AMP-dependent regulation of lipopolysaccharide- induced cytokine and chemokine synthesis. J. Interferon Cytokine Res. 26, 827-833
    • (2006) J. Interferon Cytokine Res. , vol.26 , pp. 827-833
    • Aronoff, D.M.1    Carstens, J.K.2    Chen, G.H.3    Toews, G.B.4    Peters- Golden, M.5
  • 59
    • 80054902517 scopus 로고    scopus 로고
    • Differential roles of PKA and epac on the production of cytokines in the endotoxin-stimulated primary cultured microglia
    • Liu, J., Zhao, X., Cao, J., Xue, Q., Feng, X., Liu, X., Zhang, F., and Yu, B. (2011) Differential roles of PKA and epac on the production of cytokines in the endotoxin-stimulated primary cultured microglia. J. Mol. Neurosci. 45, 186-193
    • (2011) J. Mol. Neurosci. , vol.45 , pp. 186-193
    • Liu, J.1    Zhao, X.2    Cao, J.3    Xue, Q.4    Feng, X.5    Liu, X.6    Zhang, F.7    Yu, B.8


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