5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 12, 2012, Pages 4038-4043

  Chen, Haijun ^a   Tsalkova, Tamara ^a,b   Mei, Fang C ^a,b   Hu, Yaohua ^a,b   Cheng, Xiaodong ^a,b   Zhou, Jia ^a  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Antagonists; Exchange proteins directly activated by cAMP (Epac); Pyrimidine analogues; Structure activity relationship (SAR)

Indexed keywords

5 CYANO 6 OXO 1,6 DIHYDRO PYRIMIDINE DERIVATIVE; ANTIPORTER; CYCLIC AMP; ESI 08; EXCHANGE PROTEIN DIRECTLY ACTIVATED BY CAMP; EXCHANGE PROTEIN DIRECTLY ACTIVATED BY CAMP ANTAGONIST; HJC 0197; HJC 0198; PROTEIN INHIBITOR; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; HIGH THROUGHPUT SCREENING; MOLECULAR DOCKING; PROTEIN FUNCTION; PROTEIN PROCESSING; STRUCTURE ACTIVITY RELATION;

COMPUTER SIMULATION; CYCLIC AMP; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HEK293 CELLS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MODELS, MOLECULAR; NITRILES; PHOSPHORYLATION; PROTEIN ISOFORMS; PROTO-ONCOGENE PROTEINS C-AKT; PYRIMIDINES; SIGNAL TRANSDUCTION; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84861573952     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.04.082     Document Type: Article

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