Small molecule antagonist reveals seizure-induced mediation of neuronal injury by prostaglandin E2 receptor subtype EP2

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 8, 2012, Pages 3149-3154

  Jiang, Jianxiong ^a   Ganesh, Thota ^a   Du, Yuhong ^a   Quan, Yi ^a   Serrano, Geidy ^a   Qui, Min ^a   Speigel, Iris ^a   Rojas, Asheebo ^a   Lelutiu, Nadia ^a   Dingledine, Raymond ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Brain inflammation; cAMP; Epilepsy; Neurodegeneration; Neuroprotection

Indexed keywords

3 ARYL ACRYLAMIDE; ACRYLAMIDE; BRD 0188; BRD 0828; BRD 1045; BRD 1869; BRD 2998; BRD 3695; BRD 3752; BRD 3773; BRD 4220; BRD 4980; BRD 5749; BRD 5930; BRD 6818; BRD 7071; BRD 7446; BRD 7647; BRD 7657; BRD 7868; BRD 8899; BRD 9573; BRD 9949; CYCLOOXYGENASE 2; MESSENGER RNA; PILOCARPINE; PROSTAGLANDIN E RECEPTOR 2; PROSTAGLANDIN E RECEPTOR 4; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; EPILEPTIC STATE; HIPPOCAMPUS; HUMAN; MICROGLIA; NERVE CELL LESION; PRIORITY JOURNAL; UPREGULATION;

ANIMALS; CELL DEATH; CYCLOOXYGENASE 2; ENZYME INDUCTION; HUMANS; MICE; MICE, INBRED C57BL; MICROGLIA; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PROSTAGLANDIN E, EP2 SUBTYPE; SEIZURES; SMALL MOLECULE LIBRARIES; STATUS EPILEPTICUS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84857408957     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1120195109     Document Type: Article

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