Lipopolysaccharide-binding protein is required to combat a murine gram- negative bacterial infection

Nature

Volumn 389, Issue 6652, 1997, Pages 742-745

  Jack, Robert S ^a   Fan, Xiaolong ^a   Bernheiden, Martin ^a   Rune, Gabriele ^a   Ehlers, Monika ^a   Weber, Albert ^a   Kirsch, Gerhard ^a   Mentel, Renate ^a   Fürll, Birgit ^a   Freudenberg, Marina ^b   Schmitz, Gerd ^c   Stelter, Felix ^a   Schütt, Christine ^a  

^a UNIVERSITY OF GREIFSWALD   (Germany)

^b MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

^c UNIVERSITY HOSPITAL REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; CD14 ANTIGEN; CELL SURFACE RECEPTOR; HIGH DENSITY LIPOPROTEIN; LIPOPOLYSACCHARIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL OUTER MEMBRANE; CONTROLLED STUDY; FEMALE; GRAM NEGATIVE INFECTION; IMMUNE RESPONSE; INFECTION CONTROL; INFLAMMATION; LIVER CELL; MACROPHAGE; MALE; MOUSE; NONHUMAN; PERITONEUM; PRIORITY JOURNAL; SALMONELLA TYPHIMURIUM; SALMONELLOSIS; SPLEEN CELL;

ACUTE-PHASE PROTEINS; ANIMALS; ANTIGENS, CD14; CARRIER PROTEINS; CHO CELLS; CRICETINAE; FEMALE; LIPOPOLYSACCHARIDES; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; SALMONELLA INFECTIONS, ANIMAL; SALMONELLA TYPHIMURIUM;

EID: 0030685133     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/39622     Document Type: Article

References (18)

1. Rietschel, E. T. et al. Bacterial endotoxin: molecular relationships of structure to activity and function. FASEB J. 8, 217-225 (1994).
2. Schumann, R. R. et al. Structure and function of lipopolysaccharide binding protein. Science 249, 1429-1431 (1990).
3. Wright, S. D., Ramos, R. A., Tobias, P. S., Ulevitch, R. J. & Mathison, J. C. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249, 1431-1433 (1990).
4. Tobias, P. S., Soldau, K., Gegner, J. A., Mintz, D. & Ulevitch, R. J. Lipopolysaccharide binding protein mediated complexation of lipopolysaccharide witb soluble CD14. J. Biol. Chem. 270, 10482-10488 (1995).
5. Tobias, P., Soldau, K. & Ulevitch, R. J. Isolation of a lipopolysaccharide binding acute phase reactant from rabbit serum. J. Exp. Med. 164, 777-793 (1986).
6. Wurfel, M. M., Kunitake, S. T., Lichenstein, H., Kane, J. P. & Wright, S. D. Lipopolysaccharide (LPS)- binding protein is carried on lipoproteins and acts as a cofactor in the neutralization of LPS. J. Exp. Med. 180, 1025-1035 (1994).
7. Wurfel, M. M. & Wright, S. D. Lipopolysaccharide binding protein and soluble CD14 transfer lipopolysaccharide to phospholipid bilayers. J. Imtnunol. 158, 3925-3934 (1997).
8. Nowicka, G., Brüning, T., Böttcher, A., Kahl, G. & Scmitz, G. Macrophage interaction of HDL subclasses separated by free flow isotachophoresis. J. Lipid Res. 31, 1947-1963 (1990).
9. Nowicka, G., Brüning, T., Grothaus, B., Kahl, G. & Schmitz, G. Characterisation of apolipoprotein B containing lipoproteins separated by preparative free flow isotachophoresis. J. Lipid Res. 31, 1173- 1186 (1990).
10. Schmitz, G., Möllers, C., Böttcher, A. & Ploch, J. in Handbook of Lipoprotein Testing (eds Rifai, N., Warnick, G. R. & Dominiczak, M. H.) 477-495 (AACC, Washington DC, 1997).
11. Ulevitch, R. J. The preparation and characterisation of a radioiodinated bacterial lipopolysaccharide. Immunochemistry 15, 157-164 (1978).
12. Haziot, A. et al. Resistance to endotoxin shock and reduced dissemination of Gram negative bacteria in CP14 deficient mice. Immunity 4, 407-414 (1996).
13. Gallay, P., Heumann, D., Le Roy, D., Barras, C. & Glauser, M.-P. Mode of action of antilipopolysaccharide binding protein antibodies for prevention of endotoxemic shock in mice. Proc. Natl Acad. Sci. USA 91, 7922-7926 (1994).
14. Galanos, C., Freudenberg, M. A. & Reutter, W. Galactosamine induced sensitizauon to the lethal effects of endotoxin. Proc. Natl Acad. Sci. USA 76, 5939-5943 (1979).
15. Grunwald, U. et al. Monocytes can phagocytose Gram-negative bacteria by a CD14 dependent mechanism. J. Immunol. 157, 4119-4125 (1996).
16. Jack, R. S., Grunwald, U., Stelter, F., Workalemahu, G. & Schütt, C. Both membrane bound and soluble forms of CD 14 bind to Gram-negative bacteria. Eur. J. Immunol. 25, 1436-1441 (1995).
17. Freudenberg, M. A. & Galanos, C. Tumor necrosis factor alpha mediates lethal activity of killed Gram- negative and Gram-positive bacteria in D-galactosamine-treated mice. Infect. Immun. 59, 2110-2113 (1991).
18. Schütt, C. et al. Human monocytes lacking the membrane-bound form of the bacterial lipopoly- saccharide (LPS) receptor CD14 can mount an LPS-induced oxidative burst response mediated by a soluble form of CD 14. Res. Immunol. 146, 339-350 (1995).