-
1
-
-
47549090432
-
TGFbeta in cancer
-
Massague J. TGFbeta in cancer. Cell 2008; 134: 215-230.
-
(2008)
Cell
, vol.134
, pp. 215-230
-
-
Massague, J.1
-
2
-
-
77952896646
-
TGFbeta signalling: A complex web in cancer progression
-
Ikushima H, Miyazono K. TGFbeta signalling: A complex web in cancer progression. Nat Rev Cancer 2010; 10: 415-424.
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 415-424
-
-
Ikushima, H.1
Miyazono, K.2
-
3
-
-
23044466047
-
Specificity and versatility in TGF-beta signaling through Smads
-
Feng XH, Derynck R. Specificity and versatility in TGF-beta signaling through Smads. Annu Rev Cell Dev Biol 2005; 21: 659-693.
-
(2005)
Annu Rev Cell Dev Biol
, vol.21
, pp. 659-693
-
-
Feng, X.H.1
Derynck, R.2
-
4
-
-
30944444113
-
Alterations in components of the TGF-beta superfamily signaling pathways in human cancer
-
Levy L, Hill CS. Alterations in components of the TGF-beta superfamily signaling pathways in human cancer. Cytokine Growth Factor Rev 2006; 17: 41-58.
-
(2006)
Cytokine Growth Factor Rev
, vol.17
, pp. 41-58
-
-
Levy, L.1
Hill, C.S.2
-
5
-
-
77953695161
-
Cellular and molecular basis for the regulation of inflammation by TGF-beta
-
Yoshimura A, Wakabayashi Y, Mori T. Cellular and molecular basis for the regulation of inflammation by TGF-beta. J Biochem 2010; 147: 781-792.
-
(2010)
J Biochem
, vol.147
, pp. 781-792
-
-
Yoshimura, A.1
Wakabayashi, Y.2
Mori, T.3
-
6
-
-
0042307513
-
The two faces of transforming growth factor beta in carcinogenesis
-
Roberts AB, Wakefield LM. The two faces of transforming growth factor beta in carcinogenesis. Proc Natl Acad Sci USA 2003; 100: 8621-8623.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 8621-8623
-
-
Roberts, A.B.1
Wakefield, L.M.2
-
7
-
-
24944497786
-
Non-Smad TGF-beta signals
-
Moustakas A, Heldin CH. Non-Smad TGF-beta signals. J Cell Sci 2005; 118: 3573-3584.
-
(2005)
J Cell Sci
, vol.118
, pp. 3573-3584
-
-
Moustakas, A.1
Heldin, C.H.2
-
8
-
-
84859919529
-
Tumor-promoting functions of transforming growth factor-beta in progression of cancer
-
Miyazono K, Ehata S, Koinuma D. Tumor-promoting functions of transforming growth factor-beta in progression of cancer. Ups J Med Sci 2012; 117: 143-152.
-
(2012)
Ups J Med Sci
, vol.117
, pp. 143-152
-
-
Miyazono, K.1
Ehata, S.2
Koinuma, D.3
-
9
-
-
70350497349
-
Autocrine TGF-beta signaling maintains tumorigenicity of glioma-initiating cells through Sry-related HMG-box factors
-
Ikushima H, Todo T, Ino Y, Takahashi M, Miyazawa K, Miyazono K. Autocrine TGF-beta signaling maintains tumorigenicity of glioma-initiating cells through Sry-related HMG-box factors. Cell Stem Cell 2009; 5: 504-514.
-
(2009)
Cell Stem Cell
, vol.5
, pp. 504-514
-
-
Ikushima, H.1
Todo, T.2
Ino, Y.3
Takahashi, M.4
Miyazawa, K.5
Miyazono, K.6
-
10
-
-
63249123273
-
TGF-beta increases glioma-initiating cell self-renewal through the induction of LIF in human glioblastoma
-
Penuelas S, Anido J, Prieto-Sanchez RM, Folch G, Barba I, Cuartas I et al. TGF-beta increases glioma-initiating cell self-renewal through the induction of LIF in human glioblastoma. Cancer Cell 2009; 15: 315-327.
-
(2009)
Cancer Cell
, vol.15
, pp. 315-327
-
-
Penuelas, S.1
Anido, J.2
Prieto-Sanchez, R.M.3
Folch, G.4
Barba, I.5
Cuartas, I.6
-
11
-
-
43049165453
-
The epithelialmesenchymal transition generates cells with properties of stem cells
-
Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, Zhou AY et al. The epithelialmesenchymal transition generates cells with properties of stem cells. Cell 2008; 133: 704-715.
-
(2008)
Cell
, vol.133
, pp. 704-715
-
-
Mani, S.A.1
Guo, W.2
Liao, M.J.3
Eaton, E.N.4
Ayyanan, A.5
Zhou, A.Y.6
-
12
-
-
80755141299
-
Nodal/Activin signaling drives self-renewal and tumorigenicity of pancreatic cancer stem cells and provides a target for combined drug therapy
-
Lonardo E, Hermann PC, Mueller MT, Huber S, Balic A, Miranda-Lorenzo I et al. Nodal/Activin signaling drives self-renewal and tumorigenicity of pancreatic cancer stem cells and provides a target for combined drug therapy. Cell Stem Cell 2011; 9: 433-446.
-
(2011)
Cell Stem Cell
, vol.9
, pp. 433-446
-
-
Lonardo, E.1
Hermann, P.C.2
Mueller, M.T.3
Huber, S.4
Balic, A.5
Miranda-Lorenzo, I.6
-
13
-
-
76249087423
-
TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia
-
Naka K, Hoshii T, Muraguchi T, Tadokoro Y, Ooshio T, Kondo Y et al. TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia. Nature 2010; 463: 676-680.
-
(2010)
Nature
, vol.463
, pp. 676-680
-
-
Naka, K.1
Hoshii, T.2
Muraguchi, T.3
Tadokoro, Y.4
Ooshio, T.5
Kondo, Y.6
-
14
-
-
0031438047
-
TGF-beta signalling from cell membrane to nucleus through SMAD proteins
-
Heldin CH, Miyazono K, ten Dijke P. TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature 1997; 390: 465-471.
-
(1997)
Nature
, vol.390
, pp. 465-471
-
-
Heldin, C.H.1
Miyazono, K.2
Ten Dijke, P.3
-
15
-
-
0038682002
-
Mechanisms of TGF-beta signaling from cell membrane to the nucleus
-
Shi Y, Massague J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 2003; 113: 685-700.
-
(2003)
Cell
, vol.113
, pp. 685-700
-
-
Shi, Y.1
Massague, J.2
-
16
-
-
70349312354
-
ChIP-seq: Advantages and challenges of a maturing technology
-
Park PJ. ChIP-seq: Advantages and challenges of a maturing technology. Nat Rev Genet 2009; 10: 669-680.
-
(2009)
Nat Rev Genet
, vol.10
, pp. 669-680
-
-
Park, P.J.1
-
17
-
-
70449711243
-
Computation for ChIP-seq and RNA-seq studies
-
Pepke S, Wold B, Mortazavi A. Computation for ChIP-seq and RNA-seq studies. Nat Methods 2009; 6: S22-S32.
-
(2009)
Nat Methods
, vol.6
-
-
Pepke, S.1
Wold, B.2
Mortazavi, A.3
-
18
-
-
80155137594
-
Master transcription factors determine cell-type-specific responses to TGF-beta signaling
-
Mullen AC, Orlando DA, Newman JJ, Loven J, Kumar RM, Bilodeau S et al. Master transcription factors determine cell-type-specific responses to TGF-beta signaling. Cell 2011; 147: 565-576.
-
(2011)
Cell
, vol.147
, pp. 565-576
-
-
Mullen, A.C.1
Orlando, D.A.2
Newman, J.J.3
Loven, J.4
Kumar, R.M.5
Bilodeau, S.6
-
19
-
-
80155123782
-
Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration
-
Trompouki E, Bowman TV, Lawton LN, Fan ZP, Wu DC, DiBiase A et al. Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration. Cell 2011; 147: 577-589.
-
(2011)
Cell
, vol.147
, pp. 577-589
-
-
Trompouki, E.1
Bowman, T.V.2
Lawton, L.N.3
Fan, Z.P.4
Wu, D.C.5
DiBiase, A.6
-
20
-
-
44649117905
-
Integration of external signaling pathways with the core transcriptional network in embryonic stem cells
-
Chen X, Xu H, Yuan P, Fang F, Huss M, Vega VB et al. Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell 2008; 133: 1106-1117.
-
(2008)
Cell
, vol.133
, pp. 1106-1117
-
-
Chen, X.1
Xu, H.2
Yuan, P.3
Fang, F.4
Huss, M.5
Vega, V.B.6
-
21
-
-
79960745768
-
ChIP-seq defined genome-wide map of TGFbeta/SMAD4 targets: Implications with clinical outcome of ovarian cancer
-
Kennedy BA, Deatherage DE, Gu F, Tang B, Chan MW, Nephew KP et al. ChIP-seq defined genome-wide map of TGFbeta/SMAD4 targets: Implications with clinical outcome of ovarian cancer. PLoS One 2011; 6: E22606.
-
(2011)
PLoS One
, vol.6
-
-
Kennedy, B.A.1
Deatherage, D.E.2
Gu, F.3
Tang, B.4
Chan, M.W.5
Nephew, K.P.6
-
22
-
-
75649127963
-
Bone morphogenetic protein receptors and signal transduction
-
Miyazono K, Kamiya Y, Morikawa M. Bone morphogenetic protein receptors and signal transduction. J Biochem 2010; 147: 35-51.
-
(2010)
J Biochem
, vol.147
, pp. 35-51
-
-
Miyazono, K.1
Kamiya, Y.2
Morikawa, M.3
-
23
-
-
0032572723
-
Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription
-
Zhang Y, Feng XH, Smad Derynck R. and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription. Nature 1998; 394: 909-913.
-
(1998)
Nature
, vol.394
, pp. 909-913
-
-
Zhang, Y.1
Feng, X.H.2
Smad Derynck, R.3
-
24
-
-
58149468095
-
Chromatin immunoprecipitation on microarray analysis of Smad2/3 binding sites reveals roles of ETS1 and TFAP2A in transforming growth factor beta signaling
-
Koinuma D, Tsutsumi S, Kamimura N, Taniguchi H, Miyazawa K, Sunamura M et al. Chromatin immunoprecipitation on microarray analysis of Smad2/3 binding sites reveals roles of ETS1 and TFAP2A in transforming growth factor beta signaling. Mol Cell Biol 2009; 29: 172-186.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 172-186
-
-
Koinuma, D.1
Tsutsumi, S.2
Kamimura, N.3
Taniguchi, H.4
Miyazawa, K.5
Sunamura, M.6
-
25
-
-
71049163832
-
Promoter-wide analysis of Smad4 binding sites in human epithelial cells
-
Koinuma D, Tsutsumi S, Kamimura N, Imamura T, Aburatani H, Miyazono K. Promoter-wide analysis of Smad4 binding sites in human epithelial cells. Cancer Sci 2009; 100: 2133-2142.
-
(2009)
Cancer Sci
, vol.100
, pp. 2133-2142
-
-
Koinuma, D.1
Tsutsumi, S.2
Kamimura, N.3
Imamura, T.4
Aburatani, H.5
Miyazono, K.6
-
26
-
-
80051520491
-
E2A function as SMAD/FOXH1 cofactors
-
Yoon SJ, Wills AE, Chuong E, Gupta R, HEB Baker JC. and E2A function as SMAD/FOXH1 cofactors. Genes Dev 2011; 25: 1654-1661.
-
(2011)
Genes Dev
, vol.25
, pp. 1654-1661
-
-
Yoon, S.J.1
Wills, A.E.2
Chuong, E.3
Gupta, R.4
Heb Baker, J.C.5
-
27
-
-
56549112482
-
An Idlike molecule, HHM, is a synexpression group-restricted regulator of TGF-beta signalling
-
Ikushima H, Komuro A, Isogaya K, Shinozaki M, Hellman U, Miyazawa K et al. An Idlike molecule, HHM, is a synexpression group-restricted regulator of TGF-beta signalling. EMBO J 2008; 27: 2955-2965.
-
(2008)
EMBO J
, vol.27
, pp. 2955-2965
-
-
Ikushima, H.1
Komuro, A.2
Isogaya, K.3
Shinozaki, M.4
Hellman, U.5
Miyazawa, K.6
-
28
-
-
33748208668
-
C/EBPbeta at the core of the TGFbeta cytostatic response and its evasion in metastatic breast cancer cells
-
Gomis RR, Alarcon C, Nadal C, Van Poznak C, Massague J. C/EBPbeta at the core of the TGFbeta cytostatic response and its evasion in metastatic breast cancer cells. Cancer Cell 2006; 10: 203-214.
-
(2006)
Cancer Cell
, vol.10
, pp. 203-214
-
-
Gomis, R.R.1
Alarcon, C.2
Nadal, C.3
Van Poznak, C.4
Massague, J.5
-
29
-
-
42049092376
-
Genome-wide identification of Smad/Foxh1 targets reveals a role for Foxh1 in retinoic acid regulation and forebrain development
-
Silvestri C, Narimatsu M, von Both I, Liu Y, Tan NB, Izzi L et al. Genome-wide identification of Smad/Foxh1 targets reveals a role for Foxh1 in retinoic acid regulation and forebrain development. Dev Cell 2008; 14: 411-423.
-
(2008)
Dev Cell
, vol.14
, pp. 411-423
-
-
Silvestri, C.1
Narimatsu, M.2
Von Both, I.3
Liu, Y.4
Tan, N.B.5
Izzi, L.6
-
30
-
-
80051537445
-
Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs
-
Kim SW, Yoon SJ, Chuong E, Oyolu C, Wills AE, Gupta R et al. Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs. Dev Biol 2011; 357: 492-504.
-
(2011)
Dev Biol
, vol.357
, pp. 492-504
-
-
Kim, S.W.1
Yoon, S.J.2
Chuong, E.3
Oyolu, C.4
Wills, A.E.5
Gupta, R.6
-
31
-
-
33748075143
-
A FoxO-Smad synexpression group in human keratinocytes
-
Gomis RR, Alarcon C, He W, Wang Q, Seoane J, Lash A et al. A FoxO-Smad synexpression group in human keratinocytes. Proc Natl Acad Sci USA 2006; 103: 12747-12752.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 12747-12752
-
-
Gomis, R.R.1
Alarcon, C.2
He, W.3
Wang, Q.4
Seoane, J.5
Lash, A.6
-
32
-
-
0032527756
-
TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300
-
Janknecht R, Wells NJ, Hunter T. TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300. Genes Dev 1998; 12: 2114-2119.
-
(1998)
Genes Dev
, vol.12
, pp. 2114-2119
-
-
Janknecht, R.1
Wells, N.J.2
Hunter, T.3
-
33
-
-
0032528236
-
The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation
-
Feng XH, Zhang Y, Wu RY, Derynck R. The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation. Genes Dev 1998; 12: 2153-2163.
-
(1998)
Genes Dev
, vol.12
, pp. 2153-2163
-
-
Feng, X.H.1
Zhang, Y.2
Wu, R.Y.3
Derynck, R.4
-
34
-
-
0038369998
-
A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells
-
Kang Y, Chen CR, Massague J. A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells. Mol Cell 2003; 11: 915-926.
-
(2003)
Mol Cell
, vol.11
, pp. 915-926
-
-
Kang, Y.1
Chen, C.R.2
Massague, J.3
-
35
-
-
78649986150
-
TGF-beta receptor inhibitors target the CD44(high)/Id1(high) glioma-initiating cell population in human glioblastoma
-
Anido J, Saez-Borderias A, Gonzalez-Junca A, Rodon L, Folch G, Carmona MA et al. TGF-beta receptor inhibitors target the CD44(high)/Id1(high) glioma-initiating cell population in human glioblastoma. Cancer Cell 2010; 18: 655-668.
-
(2010)
Cancer Cell
, vol.18
, pp. 655-668
-
-
Anido, J.1
Saez-Borderias, A.2
Gonzalez-Junca, A.3
Rodon, L.4
Folch, G.5
Carmona, M.A.6
-
36
-
-
70350780570
-
Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways
-
Alarcon C, Zaromytidou AI, Xi Q, Gao S, Yu J, Fujisawa S et al. Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways. Cell 2009; 139: 757-769.
-
(2009)
Cell
, vol.139
, pp. 757-769
-
-
Alarcon, C.1
Zaromytidou, A.I.2
Xi, Q.3
Gao, S.4
Yu, J.5
Fujisawa, S.6
-
37
-
-
33846688094
-
Balancing BMP signaling through integrated inputs into the Smad1 linker
-
Sapkota G, Alarcon C, Spagnoli FM, Brivanlou AH, Massague J. Balancing BMP signaling through integrated inputs into the Smad1 linker. Mol Cell 2007; 25: 441-454.
-
(2007)
Mol Cell
, vol.25
, pp. 441-454
-
-
Sapkota, G.1
Alarcon, C.2
Spagnoli, F.M.3
Brivanlou, A.H.4
Massague, J.5
-
38
-
-
0030773834
-
Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1
-
Kretzschmar M, Doody J, Massague J. Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1. Nature 1997; 389: 618-622.
-
(1997)
Nature
, vol.389
, pp. 618-622
-
-
Kretzschmar, M.1
Doody, J.2
Massague, J.3
-
39
-
-
2942650916
-
In vivo convergence of BMP and MAPK signaling pathways: Impact of differential Smad1 phosphorylation on development and homeostasis
-
Aubin J, Davy A, Soriano P. In vivo convergence of BMP and MAPK signaling pathways: Impact of differential Smad1 phosphorylation on development and homeostasis. Genes Dev 2004; 18: 1482-1494.
-
(2004)
Genes Dev
, vol.18
, pp. 1482-1494
-
-
Aubin, J.1
Davy, A.2
Soriano, P.3
-
40
-
-
36248995245
-
Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal
-
Fuentealba LC, Eivers E, Ikeda A, Hurtado C, Kuroda H, Pera EM et al. Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal. Cell 2007; 131: 980-993.
-
(2007)
Cell
, vol.131
, pp. 980-993
-
-
Fuentealba, L.C.1
Eivers, E.2
Ikeda, A.3
Hurtado, C.4
Kuroda, H.5
Pera, E.M.6
-
41
-
-
79959640061
-
A Smad action turnover switch operated by WW domain readers of a phosphoserine code
-
Aragon E, Goerner N, Zaromytidou AI, Xi Q, Escobedo A, Massague J et al. A Smad action turnover switch operated by WW domain readers of a phosphoserine code. Genes Dev 2011; 25: 1275-1288.
-
(2011)
Genes Dev
, vol.25
, pp. 1275-1288
-
-
Aragon, E.1
Goerner, N.2
Zaromytidou, A.I.3
Xi, Q.4
Escobedo, A.5
Massague, J.6
-
42
-
-
0033549789
-
SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation
-
Zhu H, Kavsak P, Abdollah S, Wrana JL, Thomsen GHA. SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. Nature 1999; 400: 687-693.
-
(1999)
Nature
, vol.400
, pp. 687-693
-
-
Zhu, H.1
Kavsak, P.2
Abdollah, S.3
Wrana, J.L.4
Thomsen, G.H.A.5
-
43
-
-
15944370597
-
NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor
-
Kuratomi G, Komuro A, Goto K, Shinozaki M, Miyazawa K, Miyazono K et al. NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor. Biochem J 2005; 386: 461-470.
-
(2005)
Biochem J
, vol.386
, pp. 461-470
-
-
Kuratomi, G.1
Komuro, A.2
Goto, K.3
Shinozaki, M.4
Miyazawa, K.5
Miyazono, K.6
-
44
-
-
70350785179
-
Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling
-
Gao S, Alarcon C, Sapkota G, Rahman S, Chen PY, Goerner N et al. Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling. Mol Cell 2009; 36: 457-468.
-
(2009)
Mol Cell
, vol.36
, pp. 457-468
-
-
Gao, S.1
Alarcon, C.2
Sapkota, G.3
Rahman, S.4
Chen, P.Y.5
Goerner, N.6
-
45
-
-
58149093172
-
FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination
-
Dupont S, Mamidi A, Cordenonsi M, Montagner M, Zacchigna L, Adorno M et al. FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination. Cell 2009; 136: 123-135.
-
(2009)
Cell
, vol.136
, pp. 123-135
-
-
Dupont, S.1
Mamidi, A.2
Cordenonsi, M.3
Montagner, M.4
Zacchigna, L.5
Adorno, M.6
-
46
-
-
80455143831
-
USP15 is a deubiquitylating enzyme for receptor-activated SMADs
-
Inui M, Manfrin A, Mamidi A, Martello G, Morsut L, Soligo S et al. USP15 is a deubiquitylating enzyme for receptor-activated SMADs. Nat Cell Biol 2011; 13: 1368-1375.
-
(2011)
Nat Cell Biol
, vol.13
, pp. 1368-1375
-
-
Inui, M.1
Manfrin, A.2
Mamidi, A.3
Martello, G.4
Morsut, L.5
Soligo, S.6
-
47
-
-
78649294528
-
PARP-1 attenuates Smad-mediated transcription
-
Lonn P, van der Heide LP, Dahl M, Hellman U, Heldin CH, Moustakas A. PARP-1 attenuates Smad-mediated transcription. Mol Cell 2010; 40: 521-532.
-
(2010)
Mol Cell
, vol.40
, pp. 521-532
-
-
Lonn, P.1
Van Der Heide, L.P.2
Dahl, M.3
Hellman, U.4
Heldin, C.H.5
Moustakas, A.6
-
48
-
-
80055110244
-
Poly(ADP-ribose) polymerase 1 is indispensable for transforming growth factor-beta Induced Smad3 activation in vascular smooth muscle cell
-
Huang D, Wang Y, Wang L, Zhang F, Deng S, Wang R et al. Poly(ADP-ribose) polymerase 1 is indispensable for transforming growth factor-beta Induced Smad3 activation in vascular smooth muscle cell. PLoS One 2011; 6: E27123.
-
(2011)
PLoS One
, vol.6
-
-
Huang, D.1
Wang, Y.2
Wang, L.3
Zhang, F.4
Deng, S.5
Wang, R.6
-
49
-
-
0032014216
-
Human Smad3 and Smad4 are sequence-specific transcription activators
-
Zawel L, Dai JL, Buckhaults P, Zhou S, Kinzler KW, Vogelstein B et al. Human Smad3 and Smad4 are sequence-specific transcription activators. Mol Cell 1998; 1: 611-617.
-
(1998)
Mol Cell
, vol.1
, pp. 611-617
-
-
Zawel, L.1
Dai, J.L.2
Buckhaults, P.3
Zhou, S.4
Kinzler, K.W.5
Vogelstein, B.6
-
50
-
-
0033534573
-
Alternatively spliced variant of Smad2 lacking exon 3. Comparison with wild-type Smad2 and Smad3
-
Yagi K, Goto D, Hamamoto T, Takenoshita S, Kato M, Miyazono K. Alternatively spliced variant of Smad2 lacking exon 3. Comparison with wild-type Smad2 and Smad3. J Biol Chem 1999; 274: 703-709.
-
(1999)
J Biol Chem
, vol.274
, pp. 703-709
-
-
Yagi, K.1
Goto, D.2
Hamamoto, T.3
Takenoshita, S.4
Kato, M.5
Miyazono, K.6
-
51
-
-
0038820062
-
Features of a Smad3 MH1-DNA complex. Roles of water and zinc in DNA binding
-
Chai J, Wu JW, Yan N, Massague J, Pavletich NP, Shi Y. Features of a Smad3 MH1-DNA complex. Roles of water and zinc in DNA binding. J Biol Chem2003; 278: 20327-20331.
-
J Biol Chem2003
, vol.278
, pp. 20327-20331
-
-
Chai, J.1
Wu, J.W.2
Yan, N.3
Massague, J.4
Pavletich, N.P.5
Shi, Y.6
-
52
-
-
0032483544
-
Crystal structure of a Smad MH1 domain bound to DNA: Insights on DNA binding in TGF-beta signaling
-
Shi Y, Wang YF, Jayaraman L, Yang H, Massague J, Pavletich NP. Crystal structure of a Smad MH1 domain bound to DNA: Insights on DNA binding in TGF-beta signaling. Cell 1998; 94: 585-594.
-
(1998)
Cell
, vol.94
, pp. 585-594
-
-
Shi, Y.1
Wang, Y.F.2
Jayaraman, L.3
Yang, H.4
Massague, J.5
Pavletich, N.P.6
-
53
-
-
77953728005
-
Structure of Smad1 MH1/DNA complex reveals distinctive rearrangements of BMP and TGF-beta effectors
-
BabuRajendran N, Palasingam P, Narasimhan K, Sun W, Prabhakar S, Jauch R et al. Structure of Smad1 MH1/DNA complex reveals distinctive rearrangements of BMP and TGF-beta effectors. Nucleic Acids Res 2010; 38: 3477-3488.
-
(2010)
Nucleic Acids Res
, vol.38
, pp. 3477-3488
-
-
BabuRajendran, N.1
Palasingam, P.2
Narasimhan, K.3
Sun, W.4
Prabhakar, S.5
Jauch, R.6
-
54
-
-
79959814756
-
Graded Nodal/Activin signaling titrates conversion of quantitative phospho-Smad2 levels into qualitative embryonic stem cell fate decisions
-
Lee KL, Lim SK, Orlov YL, Yit le Y, Yang H, Ang LT et al. Graded Nodal/Activin signaling titrates conversion of quantitative phospho-Smad2 levels into qualitative embryonic stem cell fate decisions. PLoS Genet 2011; 7: E1002130.
-
(2011)
PLoS Genet
, vol.7
-
-
Lee, K.L.1
Lim, S.K.2
Orlov, Y.L.3
Yitle, Y.4
Yang, H.5
Ang, L.T.6
-
55
-
-
79956334619
-
High throughput determination of TGFbeta1/SMAD3 targets in A549 lung epithelial cells
-
Zhang Y, Handley D, Kaplan T, Yu H, Bais AS, Richards T et al. High throughput determination of TGFbeta1/SMAD3 targets in A549 lung epithelial cells. PLoS One 2011; 6: E20319.
-
(2011)
PLoS One
, vol.6
-
-
Zhang, Y.1
Handley, D.2
Kaplan, T.3
Yu, H.4
Bais, A.S.5
Richards, T.6
-
56
-
-
0030872367
-
Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic
-
Kim J, Johnson K, Chen HJ, Carroll S, Laughon A. Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic. Nature 1997; 388: 304-308.
-
(1997)
Nature
, vol.388
, pp. 304-308
-
-
Kim, J.1
Johnson, K.2
Chen, H.J.3
Carroll, S.4
Laughon, A.5
-
57
-
-
80455178772
-
ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif
-
Morikawa M, Koinuma D, Tsutsumi S, Vasilaki E, Kanki Y, Heldin CH et al. ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif. Nucleic Acids Res 2011; 39: 8712-8727.
-
(2011)
Nucleic Acids Res
, vol.39
, pp. 8712-8727
-
-
Morikawa, M.1
Koinuma, D.2
Tsutsumi, S.3
Vasilaki, E.4
Kanki, Y.5
Heldin, C.H.6
-
58
-
-
80051925342
-
Cell type-specific target selection by combinatorial binding of Smad2/3 proteins and hepatocyte nuclear factor 4alpha in HepG2 cells
-
Mizutani A, Koinuma D, Tsutsumi S, Kamimura N, Morikawa M, Suzuki HI et al. Cell type-specific target selection by combinatorial binding of Smad2/3 proteins and hepatocyte nuclear factor 4alpha in HepG2 cells. J Biol Chem2011; 286: 29848-29860.
-
(2011)
J Biol Chem
, vol.286
, pp. 29848-29860
-
-
Mizutani, A.1
Koinuma, D.2
Tsutsumi, S.3
Kamimura, N.4
Morikawa, M.5
Suzuki, H.I.6
-
59
-
-
77951935861
-
Genome-wide MyoD binding in skeletal muscle cells: A potential for broad cellular reprogramming
-
Cao Y, Yao Z, Sarkar D, Lawrence M, Sanchez GJ, Parker MH et al. Genome-wide MyoD binding in skeletal muscle cells: A potential for broad cellular reprogramming. Dev Cell 2010; 18: 662-674.
-
(2010)
Dev Cell
, vol.18
, pp. 662-674
-
-
Cao, Y.1
Yao, Z.2
Sarkar, D.3
Lawrence, M.4
Sanchez, G.J.5
Parker, M.H.6
-
60
-
-
77952567987
-
Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities
-
Heinz S, Benner C, Spann N, Bertolino E, Lin YC, Laslo P et al. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol Cell 2010; 38: 576-589.
-
(2010)
Mol Cell
, vol.38
, pp. 576-589
-
-
Heinz, S.1
Benner, C.2
Spann, N.3
Bertolino, E.4
Lin, Y.C.5
Laslo, P.6
-
61
-
-
79952184341
-
Chromatin accessibility pre-determines glucocorticoid receptor binding patterns
-
John S, Sabo PJ, Thurman RE, Sung MH, Biddie SC, Johnson TA et al. Chromatin accessibility pre-determines glucocorticoid receptor binding patterns. Nat Genet 2011; 43: 264-268.
-
(2011)
Nat Genet
, vol.43
, pp. 264-268
-
-
John, S.1
Sabo, P.J.2
Thurman, R.E.3
Sung, M.H.4
Biddie, S.C.5
Johnson, T.A.6
-
62
-
-
80455144479
-
Pioneer transcription factors: Establishing competence for gene expression
-
Zaret KS, Carroll JS. Pioneer transcription factors: Establishing competence for gene expression. Genes Dev 2011; 25: 2227-2241.
-
(2011)
Genes Dev
, vol.25
, pp. 2227-2241
-
-
Zaret, K.S.1
Carroll, J.S.2
-
63
-
-
66249105640
-
Visualisation and quantification of morphogen gradient formation in the zebrafish
-
Harvey SA, Smith JC. Visualisation and quantification of morphogen gradient formation in the zebrafish. PLoS Biol 2009; 7: E1000101.
-
(2009)
PLoS Biol
, vol.7
-
-
Harvey, S.A.1
Smith, J.C.2
-
64
-
-
0026442926
-
Responses of embryonic Xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm
-
Green JB, New HV, Smith JC. Responses of embryonic Xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm. Cell 1992; 71: 731-739.
-
(1992)
Cell
, vol.71
, pp. 731-739
-
-
Green, J.B.1
New, H.V.2
Smith, J.C.3
-
65
-
-
74949142886
-
Genome-wide mapping of SMAD target genes reveals the role of BMP signaling in embryonic stem cell fate determination
-
Fei T, Xia K, Li Z, Zhou B, Zhu S, Chen H et al. Genome-wide mapping of SMAD target genes reveals the role of BMP signaling in embryonic stem cell fate determination. Genome Res 2010; 20: 36-44.
-
(2010)
Genome Res
, vol.20
, pp. 36-44
-
-
Fei, T.1
Xia, K.2
Li, Z.3
Zhou, B.4
Zhu, S.5
Chen, H.6
-
66
-
-
81755163044
-
Activation of Bmp2-Smad1 signal and its regulation by coordinated alteration of H3K27 trimethylation in Ras-induced senescence
-
Kaneda A, Fujita T, Anai M, Yamamoto S, Nagae G, Morikawa M et al. Activation of Bmp2-Smad1 signal and its regulation by coordinated alteration of H3K27 trimethylation in Ras-induced senescence. PLoS Genet 2011; 7: E1002359.
-
(2011)
PLoS Genet
, vol.7
-
-
Kaneda, A.1
Fujita, T.2
Anai, M.3
Yamamoto, S.4
Nagae, G.5
Morikawa, M.6
-
67
-
-
77956213871
-
H3K27me3 regulates BMP activity in developing spinal cord
-
Akizu N, Estaras C, Guerrero L, Marti E, Martinez-Balbas MA. H3K27me3 regulates BMP activity in developing spinal cord. Development 2010; 137: 2915-2925.
-
(2010)
Development
, vol.137
, pp. 2915-2925
-
-
Akizu, N.1
Estaras, C.2
Guerrero, L.3
Marti, E.4
Martinez-Balbas, M.A.5
-
68
-
-
77956634439
-
Nodal signaling recruits the histone demethylase Jmjd3 to counteract polycomb-mediated repression at target genes
-
Dahle O, Kumar A, Kuehn MR. Nodal signaling recruits the histone demethylase Jmjd3 to counteract polycomb-mediated repression at target genes. Sci Signal 2010; 3: Ra48.
-
(2010)
Sci Signal
, vol.3
-
-
Dahle, O.1
Kumar, A.2
Kuehn, M.R.3
-
69
-
-
33646876973
-
Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway
-
He W, Dorn DC, Erdjument-Bromage H, Tempst P, Moore MA, Massague J. Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway. Cell 2006; 125: 929-941.
-
(2006)
Cell
, vol.125
, pp. 929-941
-
-
He, W.1
Dorn, D.C.2
Erdjument-Bromage, H.3
Tempst, P.4
Moore, M.A.5
Massague, J.6
-
70
-
-
84455167662
-
A poised chromatin platform for TGF-beta access to master regulators
-
Xi Q, Wang Z, Zaromytidou AI, Zhang XH, Chow-Tsang LF, Liu JX et al. A poised chromatin platform for TGF-beta access to master regulators. Cell 2011; 147: 1511-1524.
-
(2011)
Cell
, vol.147
, pp. 1511-1524
-
-
Xi, Q.1
Wang, Z.2
Zaromytidou, A.I.3
Zhang, X.H.4
Chow-Tsang, L.F.5
Liu, J.X.6
-
71
-
-
79959891289
-
Recruitment of TIF1gamma to chromatin via its PHD finger-bromodomain activates its ubiquitin ligase and transcriptional repressor activities
-
Agricola E, Randall RA, Gaarenstroom T, Dupont S, Hill CS. Recruitment of TIF1gamma to chromatin via its PHD finger-bromodomain activates its ubiquitin ligase and transcriptional repressor activities. Mol Cell 2011; 43: 85-96.
-
(2011)
Mol Cell
, vol.43
, pp. 85-96
-
-
Agricola, E.1
Randall, R.A.2
Gaarenstroom, T.3
Dupont, S.4
Hill, C.S.5
-
72
-
-
17044365440
-
Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase
-
Dupont S, Zacchigna L, Cordenonsi M, Soligo S, Adorno M, Rugge M et al. Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase. Cell 2005; 121: 87-99.
-
(2005)
Cell
, vol.121
, pp. 87-99
-
-
Dupont, S.1
Zacchigna, L.2
Cordenonsi, M.3
Soligo, S.4
Adorno, M.5
Rugge, M.6
-
73
-
-
68949213578
-
Insights from genomic profiling of transcription factors
-
Farnham PJ. Insights from genomic profiling of transcription factors. Nat Rev Genet 2009; 10: 605-616.
-
(2009)
Nat Rev Genet
, vol.10
, pp. 605-616
-
-
Farnham, P.J.1
-
74
-
-
67349199007
-
Expression of the leukemia oncogene Lmo2 is controlled by an array of tissue-specific elements dispersed over 100 kb and bound by Tal1/Lmo2 Ets, and Gata factors
-
Landry JR, Bonadies N, Kinston S, Knezevic K, Wilson NK, Oram SH et al. Expression of the leukemia oncogene Lmo2 is controlled by an array of tissue-specific elements dispersed over 100 kb and bound by Tal1/Lmo2, Ets, and Gata factors. Blood 2009; 113: 5783-5792.
-
(2009)
Blood
, vol.113
, pp. 5783-5792
-
-
Landry, J.R.1
Bonadies, N.2
Kinston, S.3
Knezevic, K.4
Wilson, N.K.5
Oram, S.H.6
-
75
-
-
33846490918
-
The SCL transcriptional network and BMP signaling pathway interact to regulate RUNX1 activity
-
Pimanda JE, Donaldson IJ, de Bruijn MF, Kinston S, Knezevic K, Huckle L et al. The SCL transcriptional network and BMP signaling pathway interact to regulate RUNX1 activity. Proc Natl Acad Sci USA 2007; 104: 840-845.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 840-845
-
-
Pimanda, J.E.1
Donaldson, I.J.2
De Bruijn, M.F.3
Kinston, S.4
Knezevic, K.5
Huckle, L.6
-
76
-
-
35748956435
-
An evaluation of 3C-based methods to capture DNA interactions
-
Simonis M, Kooren J, de Laat W. An evaluation of 3C-based methods to capture DNA interactions. Nat Methods 2007; 4: 895-901.
-
(2007)
Nat Methods
, vol.4
, pp. 895-901
-
-
Simonis, M.1
Kooren, J.2
De Laat, W.3
-
77
-
-
4644220664
-
A MyoD-generated feed-forward circuit temporally patterns gene expression during skeletal muscle differentiation
-
Penn BH, Bergstrom DA, Dilworth FJ, Bengal E, Tapscott SJ. A MyoD-generated feed-forward circuit temporally patterns gene expression during skeletal muscle differentiation. Genes Dev 2004; 18: 2348-2353.
-
(2004)
Genes Dev
, vol.18
, pp. 2348-2353
-
-
Penn, B.H.1
Bergstrom, D.A.2
Dilworth, F.J.3
Bengal, E.4
Tapscott, S.J.5
-
78
-
-
71649095998
-
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58
-
Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S et al. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell 2009; 17: 836-848.
-
(2009)
Dev Cell
, vol.17
, pp. 836-848
-
-
Yokoyama, S.1
Ito, Y.2
Ueno-Kudoh, H.3
Shimizu, H.4
Uchibe, K.5
Albini, S.6
-
79
-
-
0037137519
-
A gene-expression signature as a predictor of survival in breast cancer
-
van de Vijver MJ, He YD, van Veer LJ, Dai H, Hart AA, Voskuil DW et al. A gene-expression signature as a predictor of survival in breast cancer. N Engl J Med 2002; 347: 1999-2009.
-
(2002)
N Engl J Med
, vol.347
, pp. 1999-2009
-
-
Van De Vijver, M.J.1
He, Y.D.2
Van Veer, L.J.3
Dai, H.4
Hart, A.A.5
Voskuil, D.W.6
-
80
-
-
46249085489
-
Transforming growth factor-beta gene expression signature in mouse hepatocytes predicts clinical outcome in human cancer
-
Coulouarn C, Factor VM, Thorgeirsson SS. Transforming growth factor-beta gene expression signature in mouse hepatocytes predicts clinical outcome in human cancer. Hepatology 2008; 47: 2059-2067.
-
(2008)
Hepatology
, vol.47
, pp. 2059-2067
-
-
Coulouarn, C.1
Factor, V.M.2
Thorgeirsson, S.S.3
-
81
-
-
33845610993
-
Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells
-
Piccirillo SG, Reynolds BA, Zanetti N, Lamorte G, Binda E, Broggi G et al. Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells. Nature 2006; 444: 761-765.
-
(2006)
Nature
, vol.444
, pp. 761-765
-
-
Piccirillo, S.G.1
Reynolds, B.A.2
Zanetti, N.3
Lamorte, G.4
Binda, E.5
Broggi, G.6
|