Decreased vitamin B12 availability induces ER stress through impaired SIRT1-deacetylation of HSF1

Cell Death and Disease

Volumn 4, Issue 3, 2013, Pages

  Ghemrawi, R ^a   Pooya, S ^a   Lorentz, S ^a   Gauchotte, G ^a   Arnold, C ^a   Gueant, J L ^a   Battaglia Hsu, S F ^a  

^a UNIVERSITÉ DE LORRAINE   (France)

Author keywords

Acetylation; ER stress; HSF1; Methylation; SIRT1; Vitamin B12

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ACTIVATING TRANSCRIPTION FACTOR 6; CASPASE 3; CYANOCOBALAMIN; HEAT SHOCK TRANSCRIPTION FACTOR 1; INITIATION FACTOR 2; METHIONINE SYNTHASE; PROTEIN IRE1; S ADENOSYLMETHIONINE; SIRTUIN 1; SMALL INTERFERING RNA; TRANSCOBALAMIN; APOPTOSIS REGULATORY PROTEIN; CHAPERONE; DNA BINDING PROTEIN; HSF1 PROTEIN, MOUSE; SIRT1 PROTEIN, MOUSE; TRANSCRIPTION FACTOR;

ARTICLE; CELL PROLIFERATION; CELL STIMULATION; CHIMERA; DEACETYLATION; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; PHENOTYPE; PRIORITY JOURNAL; STABLE EXPRESSION; ACETYLATION; ANIMAL; BIOAVAILABILITY; DRUG ANTAGONISM; ENDOPLASMIC RETICULUM; GENETIC EPIGENESIS; GENETICS; METABOLISM; MOUSE; SIGNAL TRANSDUCTION; TRANSPORT AT THE CELLULAR LEVEL; TUMOR CELL LINE;

ACETYLATION; ANIMALS; APOPTOSIS REGULATORY PROTEINS; BIOLOGICAL AVAILABILITY; BIOLOGICAL TRANSPORT; CELL LINE, TUMOR; CELL PROLIFERATION; CHIMERA; DNA-BINDING PROTEINS; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; EPIGENESIS, GENETIC; MICE; MOLECULAR CHAPERONES; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SIRTUIN 1; TRANSCRIPTION FACTORS; VITAMIN B 12;

EID: 84875878106     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2013.69     Document Type: Article

References (47)

1. Spriggs KA, Bushell M, Willis AE. Translational regulation of gene expression during conditions of cell stress. Mol Cell 2010; 40: 228-237.
2. Bhate V, Deshpande S, Bhat D, Joshi N, Ladkat R, Watve S et al. Vitamin B12 status of pregnant Indian women and cognitive function in their 9-year-old children. Food Nutr Bull 2008; 29: 249-254.
3. Garrod MG, Green R, Allen LH, Mungas DM, Jagust WJ, Haan MN et al. Fraction of total plasma vitamin B12 bound to transcobalamin correlates with cognitive function in elderly Latinos with depressive symptoms. Clin Chem 2008; 54: 1210-1217.
4. Hooshmand B, Solomon A, Kareholt I, LeiviskaJ, Rusanen M, Ahtiluoto S et al. Homocysteine and holotranscobalamin and the risk of Alzheimer disease: a longitudinal study. Neurology 2010; 75: 1408-1414.
5. McCaddon A. Homocysteine and cognition-a historical perspective. J Alzheimers Dis 2006; 9: 361-380.
6. Pons L, Battaglia-Hsu SF, Orozco-Barrios CE, Ortiou S, Chery C, Alberto JM et al. Anchoring secreted proteins in endoplasmic reticulum by plant oleosin: the example of vitamin B12 cellular sequestration by transcobalamin. PloS one 2009; 4: e6325.
7. Battaglia-Hsu SF, Akchiche N, Noel N, Alberto JM, Jeannesson E, Daval JL et al. Vitamin B12 deficiency reduces proliferation and promotes differentiation of neuroblastoma cells and upregulates PP2A, proNGF and TACE. Proc Natl Acad Sci USA 2009; 16: 21930-21935.
8. Orozco-Barrios CE, Battaglia-Hsu SF, Arango-Rodriguez ML, Ayala-Davila J, Chery C, Alberto JM et al. Vitamin B12-impaired metabolism produces apoptosis and Parkinson phenotype in rats expressing the transcobalamin-oleosin chimera in substantia nigra. PloS One 2009; 4: e8268.
9. Lai SC, Nakayama Y, Sequeira JM, Quadros EV. Down-regulation of transcobalamin receptor TCblR/CD320 by siRNA inhibits cobalamin uptake and proliferation of cells in culture. Exp Cell Res 2011; 317: 1603-1607.
10. Kokame K, Kato H, Miyata T. Homocysteine-respondent genes in vascular endothelial cells identified by differential display analysis. GRP78/BiP and novel genes. J Biol Chem 1996; 271: 29659-29665.
11. Althausen S, PaschenW. Homocysteine-induced changes in mRNA levels of genes coding for cytoplasmic- and endoplasmic reticulum-resident stress proteins in neuronal cell cultures. Brain Res Mol Brain Res 2000; 84: 32-40.
12. Kokame K, Agarwala KL, Kato H, Miyata T. Herp, a new ubiquitin-like membrane protein induced by endoplasmic reticulum stress. J Biol Chem 2000; 275: 32846-32853.
13. Outinen PA, Sood SK, Liaw PC, Sarge KD, Maeda N, Hirsh J et al. Characterization of the stress-inducing effects of homocysteine. Biochem J 1998; 332: 213-221.
14. Brachmann CB, Sherman JM, Devine SE, Cameron EE, Pillus L, Boeke JD. The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability. Genes Dev 1995; 9: 2888-2902.
15. Ivy JM, Klar AJ, Hicks JB. Cloning and characterization of four SIR genes of Saccharomyces cerevisiae. Mol Cell Biol 1986; 6: 688-702.
16. Smith JS, Boeke JD. An unusual form of transcriptional silencing in yeast ribosomal DNA. Genes Dev 1997; 11: 241-254
17. Kaeberlein M, McVey M, Guarente L. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev 1999; 13: 2570-2580.
18. Tissenbaum HA, Guarente L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 2001; 410: 227-230.
19. Kwon HS, Ott M. The ups and downs of SIRT1. Trends Biochem Sci 2008; 33: 517-525.
20. Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 2004; 303: 2011-2015.
21. Luo J, Nikolaev AY, Imai S, Chen D, Su F, Shiloh A et al. Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 2001; 107: 137-148.
22. Westerheide SD, Anckar J, Stevens SM Jr., Sistonen L, Morimoto RI. Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1. Science 2009; 323: 1063-1066.
23. Grimm AA, Brace CS, Wang T, Stormo GD, Imai S. A nutrient-sensitive interaction between Sirt1 and HNF-1alpha regulates Crp expression. Aging cell 2011; 10: 305-317.
24. Strum JC, Johnson JH, Ward J, Xie H, Feild J, Hester A et al. MicroRNA 132 regulates nutritional stress-induced chemokine production through repression of SirT1. Mol Endocrinol 2009; 23: 1876-1884.
25. Garcia Moreno M, Gueant-Rodriguez RM, Pooya S, Brachet P, Alberto JM, Jeannesson E et al. Methyl donor deficiency induces cardiomyopathy through altered methylation/acetylation of PGC-1alpha by PRMT1 and SIRT1. J Pathol 2011; 225: 324-335.
26. Chen YR, Fang SR, Fu YC, Zhou XH, Xu MY, Xu WC. Calorie restriction on insulin resistance and expression of SIRT1 and SIRT4 in rats. Biochem Cell Biol 2010; 88: 715-722.
27. Deng XQ, Chen LL, Li NX. The expression of SIRT1 in nonalcoholic fatty liver disease induced by high-fat diet in rats. Liver Int 2007; 27: 708-715.
28. Heyward FD, Walton RG, Carle MS, Coleman MA, Garvey WT, Sweatt JD. Adult mice maintained on a high-fat diet exhibit object location memory deficits and reduced hippocampal SIRT1 gene expression. Neurobiol Learn Mem 2012; 98: 25-32.
29. Tang Y, Xu J, Qu W, Peng X, Xin P, Yang X et al. Resveratrol reduces vascular cell senescence through attenuation of oxidative stress by SIRT1/NADPH oxidase-dependent mechanisms. J Nutr Biochem 2012; 23: 1410-1416.
30. Chen X, Shen J, Prywes R. The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi. J Biol Chem 2002; 277: 13045-13052.
31. Shen J, Prywes R. ER stress signaling by regulated proteolysis of ATF6. Methods 2005; 35: 382-389.
32. Rosengren V, Johansson H, Lehtio J, Fransson L, Sjoholm A, Ortsater H. Thapsigargin down-regulates protein levels of GRP78/BiP in INS-1E cells. J Cell Biochem 2012; 113: 1635-1644.
33. Dolzhanskaya N, Merz G, Denman RB. Alternative splicing modulates protein arginine methyltransferase-dependent methylation of fragile X syndrome mental retardation protein. Biochemistry 2006; 45: 10385-10393.
34. Chen WY, Wang DH, Yen RC, Luo J, Gu W, Baylin SB. Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell 2005; 123: 437-448.
35. Matus S, Glimcher LH, Hetz C. Protein folding stress in neurodegenerative diseases: a glimpse into the ER. Curr Opin Cell Biol 2011; 23: 239-252.
36. Kim G, Meriin AB, Gabai VL, Christians E, Benjamin I, Wilson A et al. The heat shock transcription factor Hsf1 is downregulated in DNA damage-associated senescence, contributing to the maintenance of senescence phenotype. Aging cell 2012; 11: 617-627.
37. Werstuck GH, Lentz SR, Dayal S, Hossain GS, Sood SK, Shi YY et al. Homocysteineinduced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways. J Clin Invest 2001; 107: 1263-1273.
38. Huber K, Superti-Furga G. After the grape rush: sirtuins as epigenetic drug targets in neurodegenerative disorders. Bioorg Med Chem 2011; 19: 3616-3624.
39. Outeiro TF, Kontopoulos E, Altmann SM, Kufareva I, Strathearn KE, Amore AM et al. Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. Science 2007; 317: 516.
40. Holtz WA, O'Malley KL. Parkinsonian mimetics induce aspects of unfolded protein response in death of dopaminergic neurons. J Biol Chem 2003; 278: 19367-19377.
41. Ryu EJ, Harding HP, Angelastro JM, Vitolo OV, Ron D, Greene LA. Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease. J Neurosci 2002; 22: 10690-10698.
42. Silva RM, Ries V, Oo TF, Yarygina O, Jackson-Lewis V, Ryu EJ et al. CHOP/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of Parkinsonism. J Neurochem 2005; 95: 974-986.
43. Sado M, Yamasaki Y, Iwanaga T, Onaka Y, Ibuki T, Nishihara S et al. Protective effect against Parkinson's disease-related insultsthrough the activation of XBP1. Brain Res 2009; 1257: 16-24.
44. Egawa N, Yamamoto K, Inoue H, Hikawa R, Nishi K, Mori K et al. The endoplasmic reticulum stress sensor. ATF6 (alpha), protects against neurotoxin-induced dopaminergic neuronal death. J Biol Chem 2010; 286: 7947-7957.
45. De Lau LM, Koudstaal PJ, Witteman JC, Hofman A, Breteler MM. Dietary folate, vitamin B12, and vitamin B6 and the risk of Parkinson disease. Neurology 2006; 67: 315-318.
46. Miller JW, Shukitt-Hale B, Villalobos-Molina R, Nadeau MR, Selhub J, Joseph JA. Effect of L-dopa and the catechol-O-methyltransferase inhibitor Ro 41-0960 on sulphur amino acid metabolites in rats. Clin Neuropharmacol 1997; 20: 55-66.
47. Zuo J, Rungger D, Voellmy R. Multiple layers of regulation of human heat shock transcription factor 1. Mol Cell Biol 1995; 15: 4319-4330.