Vitamin B12-impaired metabolism produces apoptosis and Parkinson phenotype in rats expressing the transcobalamin-oleosin chimera in substantia nigra

PLoS ONE

Volumn 4, Issue 12, 2009, Pages

  Orozco Barrios, Carlos Enrique ^a,b   Battaglia Hsu, Shyue Fang ^b   Arango Rodriguez, Martha Ligia ^a   Ayala Davila, Jose ^a   Chery, Celine ^b   Alberto, Jean Marc ^b   Schroeder, Henry ^c   Daval, Jean Luc ^b   Martinez Fong, Daniel ^a   Gueant, Jean Louis ^b  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

^b UNIVERSITÉ DE LORRAINE   (France)

^c UNIVERSITÉ DE LORRAINE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CYANOCOBALAMIN; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; NEUROTENSIN; OLEOSIN; S ADENOSYLMETHIONINE; TRANSCOBALAMIN; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG; VEGETABLE PROTEIN; METHAMPHETAMINE;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL LOSS; CELL METABOLISM; CELL VIABILITY; CONTROLLED STUDY; CYANOCOBALAMIN DEFICIENCY; GENE CONSTRUCT; GENETIC TRANSFECTION; MALE; MOUSE; NERVE CELL; NEUROBLASTOMA CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PARKINSON DISEASE; PHENOTYPE; PLASMID; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; RAT; SUBSTANTIA NIGRA; ANIMAL; CELL SURVIVAL; DRUG EFFECT; ENZYMOLOGY; GENETICS; HUMAN; INTRACELLULAR SPACE; METABOLISM; NECROSIS; PATHOLOGY; PROTEIN TRANSPORT; TRANSGENE; TUMOR CELL LINE;

RATTUS;

ANIMALS; APOPTOSIS; BEHAVIOR, ANIMAL; CELL LINE, TUMOR; CELL SURVIVAL; HUMANS; INTRACELLULAR SPACE; METHAMPHETAMINE; MICE; NECROSIS; PARKINSON DISEASE; PLANT PROTEINS; PLASMIDS; PROTEIN TRANSPORT; RATS; RECOMBINANT FUSION PROTEINS; SUBSTANTIA NIGRA; TRANSCOBALAMINS; TRANSFECTION; TRANSGENES; VITAMIN B 12;

EID: 77949513226     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0008268     Document Type: Article

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