Methyl donor deficiency induces cardiomyopathy through altered methylation/acetylation of PGC-1α by PRMT1 and SIRT1

Journal of Pathology

Volumn 225, Issue 3, 2011, Pages 324-335

  Garcia, Maira Moreno ^a   Guéant Rodriguez, Rosa Maria ^a   Pooya, Shabnam ^a   Brachet, Patrick ^b   Alberto, Jean Marc ^a   Jeannesson, Elise ^a   Maskali, Fathia ^a   Gueguen, Naig ^c   Marie, Pierre Yves ^a   Lacolley, Patrick ^a   Herrmann, Markus ^d   Juillière, Yves ^a   Malthiery, Yves ^c   Guéant, Jean Louis ^a  

^a INSERM   (France)

^b INRA and University of Auvergne   (France)

^c UNIVERSITÉ D'ANGERS   (France)

^d SAARLAND UNIVERSITY   (Germany)

Author keywords

cardiomyopathy; epigenetics; fatty acid oxidation; folate; PGC 1 ; PPAR ; PRMT1; SIRT1; vitamin B12

Indexed keywords

ACYL COENZYME A; ACYLCARNITINE; ACYLCOA THIOESTERASE 2; BUTYRYL COENZYME A DEHYDROGENASE; ESTROGEN RELATED RECEPTOR ALPHA; FAT DROPLET; FATTY ACID BINDING PROTEIN; FATTY ACID BINDING PROTEIN 3; FLAVOPROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTEIN ARGININE METHYLTRANSFERASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE; SIRTUIN 1; THIOL ESTER HYDROLASE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ACETYLATION; ARTICLE; CARDIOMYOPATHY; CELL ENLARGEMENT; DIET; FATTY ACID OXIDATION; HEART MUSCLE; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; LACTATION; METHYLATION; MITOCHONDRION; POSITRON EMISSION TOMOGRAPHY; PREGNANCY; PRIORITY JOURNAL; WEANING;

ACETYLATION; ANIMALS; APOPTOSIS; CARDIOMYOPATHIES; CELL RESPIRATION; ENERGY METABOLISM; FATTY ACIDS; FEMALE; FOLIC ACID; HOMOCYSTEINE; METHYLATION; MITOCHONDRIA, HEART; OXIDATION-REDUCTION; POSITRON-EMISSION TOMOGRAPHY; PPAR ALPHA; PROTEIN-ARGININE N-METHYLTRANSFERASES; PROTEOMICS; RATS; RATS, WISTAR; RECEPTORS, ESTROGEN; RNA-BINDING PROTEINS; SIRTUIN 1; STRESS, PHYSIOLOGICAL; TRANSCRIPTION FACTORS; VITAMIN B DEFICIENCY;

EID: 80054758185     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2881     Document Type: Article

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