Homocysteine and holotranscobalamin and the risk of Alzheimer disease: A longitudinal study

Neurology

Volumn 75, Issue 16, 2010, Pages 1408-1414

  Hooshmand, B ^a,b   Solomon, A ^a,d   Kareholt I ^a   Leiviska J ^c   Rusanen, M ^d   Ahtiluoto, S ^c   Winblad, B ^a,b   Laatikainen, T ^c   Soininen, H ^d,e   Kivipelto, M ^a,b,d  

^a AGING RESEARCH CENTER   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^d UNIVERSITY OF EASTERN FINLAND   (Finland)

^e KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E4; CYANOCOBALAMIN; FOLIC ACID; HOLOTRANSCOBALAMIN; HOMOCYSTEINE; UNCLASSIFIED DRUG; TRANSCOBALAMIN;

AGED; AGING; ALLELE; ALZHEIMER DISEASE; ARTICLE; BLOOD PRESSURE; BODY MASS; CIGARETTE SMOKING; COMMUNITY LIVING; DISEASE ASSOCIATION; EDUCATIONAL STATUS; FEMALE; FINLAND; FOLLOW UP; HUMAN; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MINI MENTAL STATE EXAMINATION; PRIORITY JOURNAL; RISK FACTOR; STROKE; BLOOD; CARDIOVASCULAR DISEASE; DEMENTIA; MENTAL HEALTH; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; RISK;

AGED; AGING; ALZHEIMER DISEASE; BLOOD PRESSURE; BODY MASS INDEX; CARDIOVASCULAR DISEASES; DEMENTIA; FEMALE; FOLIC ACID; HOMOCYSTEINE; HUMANS; LONGITUDINAL STUDIES; MALE; MENTAL STATUS SCHEDULE; ODDS RATIO; RISK FACTORS; TRANSCOBALAMINS;

EID: 78049519410     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0b013e3181f88162     Document Type: Article

References (40)

1. Smith AD. The worldwide challenge of the dementias: a role for B vitamins and homocysteine? Food Nutr Bull 2008;29:S143-S172.
2. Refsum H, Smith AD, Ueland PM, et al. Facts and recommendations about total homocysteine determinations: an expert opinion. Clin Chem 2004;50:3-32.
3. Kivipelto M, Annerbo S, Hultdin J, et al. Homocysteine and holo-transcobalamin and the risk of dementia and Alzheimers disease: a prospective study. Eur J Neurol 2009;16:808-813.
4. Ravaglia G, Forti P, Maioli F, et al. Homocysteine and folate as risk factors for dementia and Alzheimer disease. Am J Clin Nutr 2005;82:636-643.
5. Seshadri S, Beiser A, Selhub J, et al. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med 2002;346:476-483.
6. Nurk E, Refsum H, Tell GS, et al. Plasma total homocysteine and memory in the elderly: the Hordaland Homocysteine Study. Ann Neurol 2005;58:847-857.
7. Haan MN, Miller JW, Aiello AE, et al. Homocysteine, B vitamins, and the incidence of dementia and cognitive impairment: results from the Sacramento Area Latino Study on Aging. Am J Clin Nutr 2007;85:511-517.
8. Zylberstein DE, Lissner L, Bjorkelund C, et al. Midlife homocysteine and late-life dementia in women: a prospective population study. Neurobiol Aging Epub 2009 Mar. 31.
9. Luchsinger JA, Tang MX, Shea S, Miller J, Green R, Mayeux R. Plasma homocysteine levels and risk of Alzheimer disease. Neurology 2004;62:1972-1976.
10. Kalmijn S, Launer LJ, Lindemans J, Bots ML, Hofman A, Breteler MM. Total homocysteine and cognitive decline in a community-based sample of elderly subjects: the Rotterdam Study. Am J Epidemiol 1999;150:283-289.
11. Wang HX, Wahlin A, Basun H, Fastbom J, Winblad B, Fratiglioni L. Vitamin B (12) and folate in relation to the development of Alzheimer's disease. Neurology 2001;56:1188-1194.
12. Clarke R, Birks J, Nexo E, et al. Low vitamin B-12 status and risk of cognitive decline in older adults. Am J Clin Nutr 2007;86:1384-1391.
13. Clarke R, Smith AD, Jobst KA, Refsum H, Sutton L, Ueland PM. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol 1998;55:1449-1455.
14. Vogiatzoglou A, Refsum H, Johnston C, et al. Vitamin B12 status and rate of brain volume loss in communitydwelling elderly. Neurology 2008;71:826-832.
15. de Lau LM, Smith AD, Refsum H, Johnston C, Breteler MM. Plasma vitamin B12 status and cerebral white-matter lesions. J Neurol Neurosurg Psychiatry 2009;80:149-157.
16. Hvas AM, Nexo E. Holotranscobalamin: a first choice assay for diagnosing early vitamin B deficiency? J Intern Med 2005;257:289-298.
17. Kivipelto M, Helkala EL, Hanninen T, et al. Midlife vascular risk factors and late-life mild cognitive impairment: a population-based study. Neurology 2001;56:1683-1689.
18. Folstein MF, Folstein SE, McHugh PR. "Mini-mental state": a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189-198.
19. Morris JC, Heyman A, Mohs RC, et al. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD): part I: clinical and neuropsychological assessment of Alzheimer's disease. Neurology 1989;39:1159-1165.
20. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 4th ed. Washington, DC: American Psychiatric Association; 1994.
21. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984;34:939-944.
22. Tsukamoto K, Watanabe T, Matsushima T, et al. Determination by PCR-RFLP of apo E genotype in a Japanese population. J Lab Clin Med 1993;121:598-602.
23. Annerbo S, Kivipelto M, Lokk J. A prospective study on the development of Alzheimer's disease with regard to thyroid-stimulating hormone and homocysteine. Dement Geriatr Cogn Disord 2009;28:275-280.
24. Refsum H, Smith AD. Low vitamin B-12 status in confirmed Alzheimer's disease as revealed by serum holotranscobalamin. J Neurol Neurosurg Psychiatry 2003;74:959-961.
25. Zetterberg H, Nexo E, Minthon L, et al. The transcobalamin 776C > G polymorphism may be a modifiable genetic risk factor for Alzheimer's disease. Int Psychogeriatr 2005;17:329-331.
26. McCaddon A, Blennow K, Hudson P, et al. Transcobalamin polymorphism and serum holo-transcobalamin in relation to Alzheimer's disease. Dement Geriatr Cogn Disord 2004;17:215-221.
27. Gorgone G, Ursini F, Altamura C, et al. Hyperhomocysteinemia, intima-media thickness and C677T MTHFR gene polymorphism: a correlation study in patients with cognitive impairment. Atherosclerosis 2009;206:309-313.
28. Chao CL, Kuo TL, Lee YT. Effects of methionine-induced hyperhomocysteinemia on endothelium-dependent vasodilation and oxidative status in healthy adults. Circulation 2000;101:485-490.
29. Wald DS, Law M, Morris JK. Homocysteine and cardiovascular disease: evidence on causality from a metaanalysis. BMJ 2002;325:1202.
30. Honig LS, Kukull W, Mayeux R. Atherosclerosis and AD: analysis of data from the US National Alzheimer's Coordinating Center. Neurology 2005;64:494-500.
31. Silvestrini M, Gobbi B, Pasqualetti P, et al. Carotid atherosclerosis and cognitive decline in patients with Alzheimer's disease. Neurobiol Aging 2009;30:1177-1183.
32. van Oijen M, de Jong FJ, Witteman JC, Hofman A, Koudstaal PJ, Breteler MM. Atherosclerosis and risk for dementia. Ann Neurol 2007;61:403-410.
33. Sai X, Kawamura Y, Kokame K, et al. Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilinmediated generation of amyloid beta-protein J Biol Chem 2002;277:12915-12920.
34. Ho PI, Collins SC, Dhitavat S, et al. Homocysteine potentiates beta-amyloid neurotoxicity: role of oxidative stress. J Neurochem 2001;78:249-253.
35. Kruman II, Culmsee C, Chan SL, et al. Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity. J Neurosci 2000;20:6920-6926.
36. Kruman II, Kumaravel TS, Lohani A, et al. Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease. J Neurosci 2002;22:1752-1762.
37. Hasegawa T, Ukai W, Jo DG, et al. Homocysteic acid induces intraneuronal accumulation of neurotoxic Abeta42: implications for the pathogenesis of Alzheimer's disease. J Neurosci Res 2005;80:869-876.
38. Smith AD, Refsum H. Vitamin B-12 and cognition in the elderly. Am J Clin Nutr 2009;89:707S-711S.
39. Lewington S, Thomsen T, Davidsen M, Sherliker P, Clarke R. Regression dilution bias in blood total and highdensity lipoprotein cholesterol and blood pressure in the Glostrup and Framingham prospective studies. J Cardiovasc Risk 2003;10:143-148.
40. Allen LH. How common is vitamin B-12 deficiency? Am J Clin Nutr 2009;89:693S-696S.